Details of the Target

General Information of Target

Target ID LDTP15351
Target Name DNA damage-induced apoptosis suppressor protein (DDIAS)
Gene Name DDIAS
Gene ID 220042
Synonyms
C11orf82; NOXIN; DNA damage-induced apoptosis suppressor protein; Nitric oxide-inducible gene protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLGTDRCVVEEWLSEFKALPDTQITSYAATLHRKKTLVPALYKVIQDSNNELLEPVCHQL
FELYRSSEVRLKRFTLQFLPELMWVYLRLTVSRDRQSNGCIEALLLGIYNLEIADKDGNN
KVLSFTIPSLSKPSIYHEPSTIGSMALTEGALCQHDLIRVVYSDLHPQRETFTAQNRFEV
LSFLMLCYNSAIVYMPASSYQSLCRMGSRVCVSGFPRQHEKHWKELCGRIVLDPEFMVQL
LTGVYYAMYNGQWDLGQEVLDDIIYRAQLELFSQPLLVANAMKNSLPFDAPDSTQEGQKV
LKVEVTPTVPRISRTAITTASIRRHRWRREGAEGVNGGEESVNLNDADEGFSSGASLSSQ
PIGTKPSSSSQRGSLRKVATGRSAKDKETASAIKSSESPRDSVVRKQYVQQPTDLSVDSV
ELTPMKKHLSLPAGQVVPKINSLSLIRTASASSSKSFDYVNGSQASTSIGVGTEGGTNLA
ANNANRYSTVSLQEDRLGQAGEGKELLSPGAPLTKQSRSPSFNMQLISQV
Target Bioclass
Other
Subcellular location
Cytoplasm
Function May be an anti-apoptotic protein involved in DNA repair or cell survival.
Uniprot ID
Q8IXT1
Ensemble ID
ENST00000329143.4
HGNC ID
HGNC:26351

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O SNV: p.N660S .
DU145 SNV: p.Q732Ter .
HCT116 SNV: p.R345Ter; p.Q844Ter .
HCT15 SNV: p.K265N .
HT115 SNV: p.L214F; p.F226L .
HT29 SNV: p.E102V .
KYM1 SNV: p.L503V .
MDAMB231 SNV: p.L592F .
NCIH358 SNV: p.I667F .
SKMM2 SNV: p.S403I .
SNGM Deletion: p.P381QfsTer42 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0221  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [2]
YN-1
 Probe Info  		N.A.  LDD0446  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0107  IAA HeLa N.A.  LDD0221  [1]

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.