Details of the Target

General Information of Target

Target ID LDTP10420
Target Name Germ cell-less protein-like 1 (GMCL1)
Gene Name GMCL1
Gene ID 64395
Synonyms
BTBD13; GCL; SPATA29; Germ cell-less protein-like 1; Spermatogenesis-associated protein 29
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADGGGGGGTGAVGGGGTSQASAGAATGATGASGGGGPINPASLPPGDPQLIALIVEQLK
SRGLFDSFRRDCLADVDTKPAYQNLRQKVDNFVSTHLDKQEWNPTMNKNQLRNGLRQSVV
QSGMLEAGVDRIISQVVDPKLNHIFRPQIERAIHEFLAAQKKAAVPAPPPEPEGQDPPAP
SQDTS
Target Bioclass
Enzyme
Subcellular location
Nucleus matrix
Function Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport.
Uniprot ID
Q96IK5
Ensemble ID
ENST00000282570.4
HGNC ID
HGNC:23843

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C440(0.74)  LDD0814  [1]
YN-1
 Probe Info  		N.A.  LDD0446  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HEK-293T C440(0.74)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C440(0.81)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C440(0.87)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C440(0.60)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C440(0.72)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C440(4.05)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C440(2.03)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C440(0.64)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C440(2.28)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C440(1.21)  LDD0823  [1]
 LDCM0227  AC110 HEK-293T C440(0.41)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C440(0.76)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C440(0.48)  LDD0827  [1]
 LDCM0230  AC113 HEK-293T C440(1.31)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C440(1.28)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C440(1.69)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C440(1.37)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C440(0.71)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C440(0.69)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C440(0.48)  LDD0834  [1]
 LDCM0238  AC120 HEK-293T C440(0.63)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C440(0.47)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C440(0.32)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C440(0.34)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C440(0.62)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C440(0.29)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C440(0.35)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C440(0.33)  LDD0843  [1]
 LDCM0246  AC128 HEK-293T C440(0.83)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C440(2.65)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C440(1.13)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C440(1.39)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C440(1.07)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C440(1.48)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C440(2.71)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C440(1.54)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C440(1.30)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C440(1.50)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C440(2.70)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C440(1.52)  LDD0856  [1]
 LDCM0260  AC140 HEK-293T C440(1.57)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C440(1.88)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C440(1.64)  LDD0860  [1]
 LDCM0263  AC143 HEK-293T C440(0.83)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C440(0.35)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C440(0.28)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C440(0.29)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C440(0.41)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C440(0.46)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C440(0.59)  LDD0867  [1]
 LDCM0271  AC150 HEK-293T C440(0.43)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C440(0.39)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C440(0.48)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C440(0.49)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C440(0.75)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C440(0.40)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C440(0.32)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C440(0.42)  LDD2165  [1]
 LDCM0276  AC17 HEK-293T C440(0.53)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C440(0.81)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C440(0.58)  LDD0876  [1]
 LDCM0280  AC20 HEK-293T C440(0.44)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C440(0.61)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C440(0.42)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C440(0.29)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C440(0.97)  LDD0882  [1]
 LDCM0285  AC25 HEK-293T C440(0.32)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C440(0.34)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C440(0.42)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C440(0.44)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C440(0.66)  LDD0887  [1]
 LDCM0291  AC30 HEK-293T C440(0.49)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C440(0.44)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C440(0.39)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C440(0.59)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C440(0.41)  LDD0893  [1]
 LDCM0308  AC46 HEK-293T C440(0.91)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C440(0.62)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C440(1.06)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C440(0.58)  LDD0909  [1]
 LDCM0313  AC50 HEK-293T C440(0.58)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C440(0.33)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C440(0.35)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C440(0.96)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C440(0.41)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C440(0.47)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C440(0.48)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C440(0.98)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C440(0.93)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C440(0.80)  LDD0920  [1]
 LDCM0324  AC60 HEK-293T C440(1.13)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C440(0.73)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C440(1.01)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C440(0.75)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C440(1.03)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C440(0.76)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C440(0.99)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C440(0.86)  LDD0929  [1]
 LDCM0332  AC68 HEK-293T C440(0.64)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C440(0.76)  LDD0931  [1]
 LDCM0335  AC70 HEK-293T C440(0.53)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C440(0.86)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C440(2.47)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C440(0.68)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C440(0.86)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C440(0.76)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C440(0.56)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C440(0.77)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C440(0.42)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C440(0.51)  LDD0942  [1]
 LDCM0346  AC80 HEK-293T C440(0.62)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C440(0.51)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C440(0.33)  LDD0946  [1]
 LDCM0349  AC83 HEK-293T C440(1.00)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C440(0.68)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C440(0.77)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C440(0.85)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C440(0.91)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C440(0.97)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C440(1.01)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C440(0.73)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C440(0.96)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C440(0.87)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C440(0.78)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C440(0.74)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C440(0.84)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C440(1.29)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C440(1.10)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C440(1.47)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C440(2.35)  LDD0964  [1]
 LDCM0374  CL105 HEK-293T C440(0.72)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C440(0.79)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C440(0.75)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C440(0.61)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C440(1.00)  LDD0976  [1]
 LDCM0380  CL110 HEK-293T C440(0.71)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C440(0.77)  LDD0979  [1]
 LDCM0382  CL112 HEK-293T C440(0.71)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C440(0.25)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C440(0.53)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C440(0.48)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C440(0.47)  LDD0984  [1]
 LDCM0392  CL121 HEK-293T C440(0.58)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C440(0.58)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C440(0.95)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C440(0.95)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C440(0.95)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C440(0.71)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C440(1.06)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C440(1.18)  LDD0997  [1]
 LDCM0453  CL61 HEK-293T C440(0.67)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C440(0.56)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C440(0.35)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C440(0.80)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C440(0.53)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C440(0.63)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C440(0.77)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C440(0.63)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C440(0.78)  LDD1059  [1]
 LDCM0463  CL70 HEK-293T C440(0.65)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C440(0.49)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C440(0.57)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C440(0.57)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C440(0.14)  LDD1065  [1]
 LDCM0469  CL76 HEK-293T C440(0.84)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C440(0.37)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C440(0.39)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C440(0.32)  LDD1070  [1]
 LDCM0474  CL80 HEK-293T C440(0.59)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C440(0.27)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C440(0.55)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C440(0.84)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C440(0.42)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C440(0.56)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C440(0.42)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C440(0.39)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C440(0.53)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C440(0.50)  LDD1081  [1]
 LDCM0485  CL90 HEK-293T C440(0.62)  LDD1083  [1]
 LDCM0468  Fragment33 HEK-293T C440(0.36)  LDD1066  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
mRNA cap guanine-N7 methyltransferase (RNMT) mRNA cap 0 methyltransferase family O43148
Cullin-3 (CUL3) Cullin family Q13618
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Serine/threonine-protein kinase tousled-like 2 (TLK2) Ser/Thr protein kinase family Q86UE8
E3 ubiquitin-protein ligase Midline-1 (MID1) TRIM/RBCC family O15344
E3 ubiquitin-protein ligase TRIM21 (TRIM21) TRIM/RBCC family P19474
SUMO-conjugating enzyme UBC9 (UBE2I) Ubiquitin-conjugating enzyme family P63279
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
E3 ubiquitin-protein ligase MYLIP (MYLIP) . Q8WY64
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Germ cell-less protein-like 1 (GMCL1) . Q96IK5
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Exocyst complex component 3 (EXOC3) SEC6 family O60645
TBC1 domain family member 1 (TBC1D1) . Q86TI0
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear factor interleukin-3-regulated protein (NFIL3) BZIP family Q16649
Zinc finger and BTB domain-containing protein 24 (ZBTB24) Krueppel C2H2-type zinc-finger protein family O43167
Zinc finger imprinted 2 (ZIM2) Krueppel C2H2-type zinc-finger protein family Q9NZV7
Zinc finger protein 23 (ZNF23) Krueppel C2H2-type zinc-finger protein family P17027
Transcriptional repressor protein YY1 (YY1) YY transcription factor family P25490
Forkhead box protein R1 (FOXR1) . Q6PIV2
Transcriptional regulator QRICH1 (QRICH1) . Q2TAL8
Zinc finger MYM-type protein 2 (ZMYM2) . Q9UBW7
Other
Click To Hide/Show 27 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein L6 (APOL6) Apolipoprotein L family Q9BWW8
Bystin (BYSL) Bystin family Q13895
Cysteine-rich hydrophobic domain-containing protein 2 (CHIC2) CHIC family Q9UKJ5
Death domain-associated protein 6 (DAXX) DAXX family Q9UER7
Protein FAM167A (FAM167A) FAM167 (SEC) family Q96KS9
Protein FAM50B (FAM50B) FAM50 family Q9Y247
G antigen 10 (GAGE10) GAGE family A6NGK3
G antigen 2B/2C (GAGE2B; GAGE2C) GAGE family Q13066
G antigen 5 (GAGE5) GAGE family Q13069
X antigen family member 2 (XAGE2) GAGE family Q96GT9
X antigen family member 3 (XAGE3) GAGE family Q8WTP9
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
Partitioning defective 6 homolog beta (PARD6B) PAR6 family Q9BYG5
PIH1 domain-containing protein 2 (PIH1D2) PIH1 family Q8WWB5
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
Protein SHQ1 homolog (SHQ1) SHQ1 family Q6PI26
Brain-enriched guanylate kinase-associated protein (BEGAIN) . Q9BUH8
Calcium and integrin-binding family member 3 (CIB3) . Q96Q77
Coiled-coil domain-containing protein 13 (CCDC13) . Q8IYE1
Elongin-A (ELOA) . Q14241
FLYWCH-type zinc finger-containing protein 1 (FLYWCH1) . Q4VC44
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Phostensin (PPP1R18) . Q6NYC8
Pre-B-cell leukemia transcription factor-interacting protein 1 (PBXIP1) . Q96AQ6
Ras GTPase-activating protein 1 (RASA1) . P20936
Zinc finger SWIM domain-containing protein 3 (ZSWIM3) . Q96MP5

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.