Details of the Target

General Information of Target

Target ID LDTP02410
Target Name Glutathione S-transferase theta-2B (GSTT2B)
Gene Name GSTT2B
Gene ID 653689
Synonyms
GSTT2; Glutathione S-transferase theta-2B; EC 2.5.1.18; Glutathione S-transferase theta-2; GST class-theta-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLELFLDLVSQPSRAVYIFAKKNGIPLELRTVDLVKGQHKSKEFLQINSLGKLPTLKDG
DFILTESSAILIYLSCKYQTPDHWYPSDLQARARVHEYLGWHADCIRGTFGIPLWVQVLG
PLIGVQVPEEKVERNRTAMDQALQWLEDKFLGDRPFLAGQQVTLADLMALEELMQPVALG
YELFEGRPRLAAWRGRVEAFLGAELCQEAHSIILSILEQAAKKTLPTPSPEAYQAMLLRI
ARIP
Target Bioclass
Enzyme
Family
GST superfamily, Theta family
Subcellular location
Cytoplasm, cytosol
Function Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.
Uniprot ID
P0CG30
Ensemble ID
ENST00000290765.9
HGNC ID
HGNC:33437

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K53(1.71)  LDD2217  [1]
DBIA
 Probe Info  		C105(1.42)  LDD3332  [2]
IA-alkyne
 Probe Info  		C206(0.00); C105(0.00)  LDD0162  [3]
YN-1
 Probe Info  		N.A.  LDD0446  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2780 C105(1.61)  LDD2254  [2]
 LDCM0023  KB03 A2780 C105(1.82)  LDD2671  [2]
 LDCM0024  KB05 MKN45 C105(1.42)  LDD3332  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amitriptyline Small molecular drug DB00321
Deoxycholic Acid Small molecular drug DB03619
Glutathione Disulfide Small molecular drug DB03310

References

1 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.