Details of the Target

General Information of Target

Target ID LDTP12559
Target Name Potassium voltage-gated channel subfamily H member 7 (KCNH7)
Gene Name KCNH7
Gene ID 90134
Synonyms
ERG3; Potassium voltage-gated channel subfamily H member 7; Ether-a-go-go-related gene potassium channel 3; ERG-3; Eag-related protein 3; Ether-a-go-go-related protein 3; hERG-3; Voltage-gated potassium channel subunit Kv11.3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASVLGSGRGSGGLSSQLKCKSKRRRRRRSKRKDKVSILSTFLAPFKHLSPGITNTEDDD
TLSTSSAEVKENRNVGNLAARPPPSGDRARGGAPGAKRKRPLEEGNGGHLCKLQLVWKKL
SWSVAPKNALVQLHELRPGLQYRTVSQTGPVHAPVFAVAVEVNGLTFEGTGPTKKKAKMR
AAELALRSFVQFPNACQAHLAMGGGPGPGTDFTSDQADFPDTLFQEFEPPAPRPGLAGGR
PGDAALLSAAYGRRRLLCRALDLVGPTPATPAAPGERNPVVLLNRLRAGLRYVCLAEPAE
RRARSFVMAVSVDGRTFEGSGRSKKLARGQAAQAALQELFDIQMPGHAPGRARRTPMPQE
FADSISQLVTQKFREVTTDLTPMHARHKALAGIVMTKGLDARQAQVVALSSGTKCISGEH
LSDQGLVVNDCHAEVVARRAFLHFLYTQLELHLSKRREDSERSIFVRLKEGGYRLRENIL
FHLYVSTSPCGDARLHSPYEITTDLHSSKHLVRKFRGHLRTKIESGEGTVPVRGPSAVQT
WDGVLLGEQLITMSCTDKIARWNVLGLQGALLSHFVEPVYLQSIVVGSLHHTGHLARVMS
HRMEGVGQLPASYRHNRPLLSGVSDAEARQPGKSPPFSMNWVVGSADLEIINATTGRRSC
GGPSRLCKHVLSARWARLYGRLSTRTPSPGDTPSMYCEAKLGAHTYQSVKQQLFKAFQKA
GLGTWVRKPPEQQQFLLTL
Target Bioclass
Transporter and channel
Family
Potassium channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv11.3/KCNH7 sub-subfamily
Subcellular location
Membrane
Function Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.
Uniprot ID
Q9NS40
Ensemble ID
ENST00000328032.8
HGNC ID
HGNC:18863
ChEMBL ID
CHEMBL2362996

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.T916I .
AN3CA SNV: p.W570Ter .
COLO792 SNV: p.V284A
Substitution: p.G748K		 .
CORL88 SNV: p.G660W .
EFO27 SNV: p.I329V; p.N822S .
HCC15 SNV: p.R394S; p.D777Y .
HEC1 SNV: p.R242W .
HT SNV: p.D882A .
HT115 SNV: p.L965R .
ICC108 SNV: p.T1027N .
IGR1 SNV: p.R20W .
IPC298 Deletion: p.N128IfsTer5 .
LUDLU1 Substitution: p.R92W .
MCC13 SNV: p.Q118Ter;p.E1023K
Substitution: p.G233K		 .
MEWO SNV: p.L498P
Substitution: p.P234F		 .
MOLT4 SNV: p.R993Ter .
NB1 SNV: p.L498Q .
NCIH1155 SNV: p.A870V .
NCIH2172 SNV: p.S974Ter .
NCIH23 SNV: p.D612H .
NCIH661 SNV: p.S349Ter .
PEO1 SNV: p.M880R .
REH SNV: p.R533H .
SHP77 SNV: p.A674D .
SKMEL2 SNV: p.V719A .
SKMEL5 SNV: p.Y619S .
SUPT1 SNV: p.R536C .
SW403 SNV: p.C557G .
SW948 SNV: p.F784S .
UACC257 SNV: p.Y815Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C743(0.68)  LDD2125  [1]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C743(0.68)  LDD2125  [1]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amiodarone Small molecular drug DB01118
Amitriptyline Small molecular drug DB00321
Doxazosin Small molecular drug DB00590
Enflurane Small molecular drug DB00228
Ibutilide Small molecular drug DB00308
Miconazole Small molecular drug DB01110
Promethazine Small molecular drug DB01069
Silodosin Small molecular drug DB06207
Terazosin Small molecular drug DB01162
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Vanoxerine Small molecular drug DB03701

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.