Details of the Target

General Information of Target

Target ID LDTP08863
Target Name Misshapen-like kinase 1 (MINK1)
Gene Name MINK1
Gene ID 50488
Synonyms
B55; MAP4K6; MINK; YSK2; ZC3; Misshapen-like kinase 1; EC 2.7.11.1; GCK family kinase MiNK; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Misshapen/NIK-related kinase; Mitogen-activated protein kinase kinase kinase kinase 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ
SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG
PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV
LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG
EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH
ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY
QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS
EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN
KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV
YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI
YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY
ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY
FMTLNRNCIMNW
Target Bioclass
Enzyme
Family
Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Subcellular location
Cytoplasm; Golgi apparatus
Function
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.; Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
Uniprot ID
Q8N4C8
Ensemble ID
ENST00000347992.11
HGNC ID
HGNC:17565
ChEMBL ID
CHEMBL5518

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.P95RfsTer10 .
AN3CA SNV: p.A753T .
CCK81 SNV: p.K452R .
CMK SNV: p.Q533H .
COLO792 SNV: p.T209I; p.A723V .
Ishikawa (Heraklio) 02 ER SNV: p.R509W .
KELLY SNV: p.E409Ter .
MCC13 Substitution: p.P654F .
MEWO Substitution: p.S478F .
MFE319 SNV: p.S309F .
PF382 SNV: p.A52V .
RL952 SNV: p.Q444Ter; p.P571Q .
SW756 SNV: p.T672A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K388(0.37); K502(0.12); K516(0.07); K590(10.00)  LDD0277  [1]
IA-alkyne
 Probe Info  		C202(10.00)  LDD2157  [2]
m-APA
 Probe Info  		11.44  LDD0403  [3]
DBIA
 Probe Info  		C129(1.04)  LDD0533  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
CY4
 Probe Info  		S682(0.00); S687(0.00); T681(0.00); N680(0.00)  LDD0247  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IPM
 Probe Info  		N.A.  LDD2156  [8]
AOyne
 Probe Info  		11.20  LDD0443  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C269(1.02)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C202(0.87); C269(1.05); C129(0.97)  LDD1508  [11]
 LDCM0216  AC100 HCT 116 C129(1.04)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C129(1.08)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C129(0.88)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C129(0.79)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C129(1.10)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C129(0.78)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C129(0.75)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C129(0.59)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C129(0.82)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C129(1.14)  LDD0542  [4]
 LDCM0226  AC11 HEK-293T C202(1.08); C269(1.03); C129(1.01)  LDD1509  [11]
 LDCM0227  AC110 HCT 116 C129(0.76)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C129(0.77)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C129(1.00)  LDD0546  [4]
 LDCM0237  AC12 HEK-293T C202(0.88); C269(0.91); C129(0.77)  LDD1510  [11]
 LDCM0246  AC128 HCT 116 C129(0.88)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C129(0.76)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C129(0.83)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C129(1.32)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C129(0.91)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C129(0.94)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C129(0.84)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C129(0.86)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C129(0.91)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C129(1.13)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C129(1.14)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C129(0.99)  LDD0575  [4]
 LDCM0259  AC14 HEK-293T C202(1.10); C269(1.01); C129(1.09)  LDD1512  [11]
 LDCM0260  AC140 HCT 116 C129(0.89)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C129(0.91)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C129(1.27)  LDD0579  [4]
 LDCM0270  AC15 HEK-293T C202(0.93); C269(1.08); C129(1.01)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C269(1.13)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C202(1.14); C269(0.97); C129(1.09)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C202(0.86); C269(0.92); C129(1.00)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C202(1.00); C269(1.02); C129(0.96)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C202(0.90); C269(0.88); C129(0.83)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C202(1.19); C269(1.10)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C202(1.23); C269(0.88); C129(0.97)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C202(0.86); C269(1.07); C129(1.04)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C202(0.97); C269(1.07); C129(1.13)  LDD1523  [11]
 LDCM0285  AC25 HEK-293T C269(0.96)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C202(0.96); C269(0.98); C129(1.15)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C202(0.99); C269(1.10); C129(0.94)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C202(0.87); C269(1.03); C129(1.09)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C202(0.89); C269(1.05)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C202(1.12); C269(1.14); C129(1.17)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C202(1.00); C269(0.87); C129(1.19)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C202(0.93); C269(1.02); C129(0.99)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C202(1.14); C269(0.95); C129(1.33)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C269(1.20)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C202(1.28); C269(1.03); C129(0.86)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C202(0.93); C269(1.08); C129(1.03)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C202(0.93); C269(1.06); C129(0.83)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C202(0.98); C269(1.05)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C202(1.32); C269(1.04); C129(1.19)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C202(0.94); C269(1.12); C129(1.00)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C202(1.03); C269(0.90); C129(0.94)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C202(1.05); C269(1.03); C129(1.10)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C269(1.13)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C202(0.79); C269(1.07); C129(1.19)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C202(1.15); C269(1.12); C129(1.14)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C202(1.08); C269(1.04); C129(1.10)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C202(1.31); C269(0.95)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C202(1.48); C269(0.96); C129(1.19)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C202(0.90); C269(1.03); C129(1.09)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C202(0.99); C269(1.01); C129(1.25)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C269(1.17)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C202(0.96); C269(1.12)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C202(1.05); C269(1.08); C129(1.23)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C202(1.07); C269(1.07); C129(0.99)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C202(0.94); C269(0.99); C129(0.91)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C202(0.99); C269(0.98)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C202(0.96); C269(0.96); C129(1.18)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C202(0.95); C269(0.96); C129(1.20)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C202(0.94); C269(0.95); C129(0.98)  LDD1558  [11]
 LDCM0320  AC57 HCT 116 C129(1.32)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C129(1.22)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C129(1.52)  LDD0639  [4]
 LDCM0323  AC6 HEK-293T C202(1.15); C269(0.98); C129(1.20)  LDD1562  [11]
 LDCM0324  AC60 HCT 116 C129(1.29)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C129(1.53)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C129(1.26)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C129(1.04)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C129(1.71)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C129(1.39)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C129(1.56)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C129(0.93)  LDD0648  [4]
 LDCM0334  AC7 HEK-293T C202(0.88); C269(1.03); C129(1.30)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C202(0.95); C269(1.03); C129(1.01)  LDD1569  [11]
 LDCM0365  AC98 HCT 116 C129(0.98)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C129(0.77)  LDD0683  [4]
 LDCM0248  AKOS034007472 HEK-293T C202(1.05); C269(1.05)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C269(1.18)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C202(0.93); C269(0.97); C129(0.98)  LDD1514  [11]
 LDCM0156  Aniline NCI-H1299 11.44  LDD0403  [3]
 LDCM0367  CL1 HEK-293T C269(1.15)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C202(0.78); C269(0.84); C129(0.99)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C202(1.53); C269(1.01)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C269(0.94)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C269(1.02)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C202(1.37); C269(0.96)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C202(1.08); C269(1.11)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C269(0.98)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C269(1.01)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C202(1.04); C269(0.94)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C202(1.44); C269(0.91)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C269(1.01)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C202(0.76); C269(1.14); C129(1.55)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C269(1.04)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C202(1.12); C269(1.04)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C202(1.21); C269(1.09)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C269(1.01)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C269(0.98)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C202(1.04); C269(1.09)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C202(1.06); C269(1.15)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C269(1.03)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C269(1.04)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C202(1.57); C269(0.96)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C202(0.81); C269(1.10); C129(1.07)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C202(0.87); C269(1.05)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C269(0.94)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C269(0.89)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C202(1.03); C269(1.02)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C202(1.14); C269(1.00)  LDD1599  [11]
 LDCM0396  CL125 HCT 116 C129(1.53)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C129(1.10)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C129(2.04)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C129(1.18)  LDD0716  [4]
 LDCM0400  CL13 HEK-293T C269(0.98)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C269(0.97)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C202(0.74); C269(0.92)  LDD1606  [11]
 LDCM0403  CL16 HCT 116 C129(1.43)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C129(1.22)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C129(1.50)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C129(1.08)  LDD0723  [4]
 LDCM0407  CL2 HEK-293T C269(1.07)  LDD1611  [11]
 LDCM0408  CL20 HCT 116 C129(1.12)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C129(1.09)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C129(1.42)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C129(1.37)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C129(1.29)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C129(1.21)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C129(1.71)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C129(1.17)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C129(1.54)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C129(1.29)  LDD0734  [4]
 LDCM0418  CL3 HEK-293T C202(0.84); C269(0.88)  LDD1622  [11]
 LDCM0419  CL30 HCT 116 C129(1.30)  LDD0736  [4]
 LDCM0420  CL31 HEK-293T C202(0.91); C269(1.19); C129(1.14)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C202(0.94); C269(0.95); C129(0.92)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C202(0.84); C269(1.14)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C202(0.88); C269(1.01); C129(1.14)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C202(0.73); C269(1.10); C129(1.25)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C202(0.87); C269(1.13); C129(1.09)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C269(0.97)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C202(1.10); C269(0.99)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C202(1.11); C269(0.99)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C202(0.94); C269(0.92)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C269(1.15)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C202(0.96); C269(1.14); C129(0.84)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C202(0.88); C269(1.05); C129(0.97)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C202(0.91); C269(1.06); C129(1.06)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C202(0.95); C269(1.12)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C202(0.71); C269(1.04); C129(1.17)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C202(0.77); C269(1.20); C129(1.43)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C202(0.83); C269(1.12); C129(1.16)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C269(1.00)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C269(1.18)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C269(0.92)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C202(0.95); C269(1.11)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C269(1.12)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C202(0.67); C269(1.04); C129(1.38)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C202(0.69); C269(1.14); C129(1.28)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C202(0.77); C269(1.13); C129(0.94)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C202(0.82); C269(1.00)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C202(0.85); C269(1.05); C129(1.58)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C202(0.77); C269(1.29); C129(1.20)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C202(0.81); C269(1.02); C129(1.16)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C202(0.89); C269(1.10); C129(1.34)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C269(0.95)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C269(1.01)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C202(1.05); C269(1.00)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C202(1.32); C269(0.98)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C269(1.22)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C202(0.95); C269(1.07); C129(1.44)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C202(0.81); C269(1.29); C129(1.03)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C202(0.77); C269(1.08); C129(0.91)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C202(0.83); C269(1.00)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C202(0.78); C269(1.22); C129(1.09)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C202(0.89); C269(1.03); C129(1.65)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C202(0.83); C269(1.21); C129(1.11)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C202(0.79); C269(1.14); C129(1.28)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C269(0.91)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C269(1.02)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C202(0.84); C269(1.11)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C269(1.13)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C202(0.93); C269(1.12); C129(1.08)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C202(0.77); C269(1.03); C129(1.42)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C202(0.70); C269(1.12); C129(0.83)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C202(0.87); C269(1.04); C129(0.94)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C202(0.95); C269(0.96)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C202(1.03); C269(1.03); C129(1.25)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C202(0.80); C269(1.08); C129(1.15)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C202(0.88); C269(1.10); C129(1.27)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C269(1.04)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C269(1.01)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C202(1.53); C269(0.99)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C202(1.15); C269(1.11)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C269(1.16)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C202(0.85); C269(0.98)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C202(0.59); C269(1.11); C129(0.98)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C202(0.83); C269(1.13); C129(0.97)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C202(0.95); C269(1.00); C129(0.95)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C202(0.79); C269(1.07)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C202(0.87); C269(0.98); C129(1.39)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C202(0.65); C269(1.05); C129(0.94)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C202(0.84); C269(0.94); C129(1.07)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C269(0.91)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C269(0.92)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C202(1.21); C269(0.96)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C202(1.04); C269(1.05)  LDD1698  [11]
 LDCM0468  Fragment33 HEK-293T C202(1.20); C269(1.05)  LDD1671  [11]
 LDCM0427  Fragment51 HEK-293T C269(0.98)  LDD1631  [11]
 LDCM0022  KB02 HEK-293T C269(1.01)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C269(1.11)  LDD1497  [11]
 LDCM0024  KB05 G361 C269(2.01)  LDD3311  [12]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) STE Ser/Thr protein kinase family O95819
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock factor protein 1 (HSF1) HSF family Q00613
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Immediate early response gene 5 protein (IER5) IER family Q5VY09

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840