Details of the Target

General Information of Target

Target ID LDTP08807
Target Name Solute carrier family 66 member 2 (SLC66A2)
Gene Name SLC66A2
Gene ID 80148
Synonyms
PQLC1; Solute carrier family 66 member 2; PQ-loop repeat-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAEGLDWLLVPLHQLVSWGAAAAMVFGGVVPYVPQYRDIRRTQNADGFSTYVCLVLLVA
NILRILFWFGRRFESPLLWQSAIMILTMLLMLKLCTEVRVANELNARRRSFTAADSKDEE
VKVAPRRSFLDFDPHHFWQWSSFSDYVQCVLAFTGVAGYITYLSIDSALFVETLGFLAVL
TEAMLGVPQLYRNHRHQSTEGMSIKMVLMWTSGDAFKTAYFLLKGAPLQFSVCGLLQVLV
DLAILGQAYAFARHPQKPAPHAVHPTGTKAL
Target Bioclass
Transporter and channel
Subcellular location
Membrane
Uniprot ID
Q8N2U9
Ensemble ID
ENST00000357575.8
HGNC ID
HGNC:26188

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Rhomboid-related protein 4 (RHBDD1) Peptidase S54 family Q8TEB9
Transporter and channel
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bestrophin-2 (BEST2) Anion channel-forming bestrophin family Q8NFU1
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
H(+)/Cl(-) exchange transporter 7 (CLCN7) Chloride channel (TC 2.A.49) family P51798
Gap junction alpha-8 protein (GJA8) Connexin family P48165
Hippocampus abundant transcript-like protein 1 (MFSD14B) Major facilitator superfamily Q5SR56
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Mitochondrial outer membrane protein SLC25A46 (SLC25A46) Mitochondrial carrier (TC 2.A.29) family Q96AG3
Solute carrier family 35 member E3 (SLC35E3) TPT transporter family Q7Z769
Potassium channel subfamily K member 5 (KCNK5) Two pore domain potassium channel (TC 1.A.1.8) family O95279
Protrudin (ZFYVE27) . Q5T4F4
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-10 receptor subunit alpha (IL10RA) Type II cytokine receptor family Q13651
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
FUN14 domain-containing protein 2 (FUNDC2) FUN14 family Q9BWH2
Syntaxin-12 (STX12) Syntaxin family Q86Y82
Diablo IAP-binding mitochondrial protein (DIABLO) . Q9NR28
Transmembrane protein 80 (TMEM80) . Q96HE8

References

1 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.