Details of the Target

General Information of Target

Target ID LDTP18217
Target Name Integrator complex subunit 15 (INTS15)
Gene Name INTS15
Gene ID 79034
Synonyms
C7orf26; Integrator complex subunit 15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGAPLAVALGALHYLALFLQLGGATRPAGHAPWDNHVSGHALFTETPHDMTARTGEDVEM
ACSFRGSGSPSYSLEIQWWYVRSHRDWTDKQAWASNQLKASQQEDAGKEATKISVVKVVG
SNISHKLRLSRVKPTDEGTYECRVIDFSDGKARHHKVKAYLRVQPGENSVLHLPEAPPAA
PAPPPPKPGKELRKRSVDQEACSL
Target Bioclass
Other
Subcellular location
Nucleus
Function Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
Uniprot ID
Q96N11
Ensemble ID
ENST00000344417.10
HGNC ID
HGNC:21702

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC44 SNV: p.H321D .
HT SNV: p.F181L .
K562 SNV: p.F171V .
OVK18 Deletion: p.H408TfsTer34 .
RVH421 SNV: p.F405L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [1]
BTD
 Probe Info  		C145(1.04)  LDD2136  [2]
DBIA
 Probe Info  		C157(2.71); C158(2.71)  LDD0080  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C132(0.00); C367(0.00); C125(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C79(0.00); C145(0.00); C367(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C132(0.00); C125(0.00)  LDD0037  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C132(0.98); C157(1.03); C158(1.03); C367(0.63)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C132(0.86); C367(1.14)  LDD0532  [3]
 LDCM0216  AC100 HEK-293T C132(1.06)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C132(1.06)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C132(1.18)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C132(1.26)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C132(1.24)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C132(0.94)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C132(1.08)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C132(1.21)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C132(1.03)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C132(1.05)  LDD0823  [3]
 LDCM0226  AC11 HCT 116 C132(0.78); C367(1.01)  LDD0543  [3]
 LDCM0227  AC110 HEK-293T C132(1.43)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C132(1.67)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C132(1.42)  LDD0827  [3]
 LDCM0230  AC113 HCT 116 C132(1.06)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C132(1.10)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C132(1.06)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C132(0.89)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C132(1.07)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C132(0.81)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C132(1.20)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C132(0.89); C367(0.97)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C132(0.93)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C132(0.81)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C132(0.94)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C132(1.08)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C132(1.01)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C132(0.95)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C132(1.26)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C132(1.00)  LDD0562  [3]
 LDCM0246  AC128 PaTu 8988t C367(0.75); C132(0.94)  LDD1125  [3]
 LDCM0247  AC129 PaTu 8988t C367(0.79); C132(0.83)  LDD1126  [3]
 LDCM0249  AC130 PaTu 8988t C367(0.99); C132(0.90)  LDD1128  [3]
 LDCM0250  AC131 PaTu 8988t C367(1.12); C132(0.86)  LDD1129  [3]
 LDCM0251  AC132 PaTu 8988t C367(1.04); C132(1.02)  LDD1130  [3]
 LDCM0252  AC133 PaTu 8988t C367(0.93); C132(0.90)  LDD1131  [3]
 LDCM0253  AC134 PaTu 8988t C367(0.94); C132(1.02)  LDD1132  [3]
 LDCM0254  AC135 PaTu 8988t C367(0.99); C132(1.02)  LDD1133  [3]
 LDCM0255  AC136 PaTu 8988t C367(0.75); C132(0.98)  LDD1134  [3]
 LDCM0256  AC137 PaTu 8988t C367(0.78); C132(1.01)  LDD1135  [3]
 LDCM0257  AC138 PaTu 8988t C367(0.96); C132(0.98)  LDD1136  [3]
 LDCM0258  AC139 PaTu 8988t C367(0.77); C132(1.03)  LDD1137  [3]
 LDCM0259  AC14 HCT 116 C132(0.92); C367(0.84)  LDD0576  [3]
 LDCM0260  AC140 PaTu 8988t C367(0.77); C132(0.85)  LDD1139  [3]
 LDCM0261  AC141 PaTu 8988t C367(1.07); C132(0.82)  LDD1140  [3]
 LDCM0262  AC142 PaTu 8988t C367(0.96); C132(0.96)  LDD1141  [3]
 LDCM0263  AC143 HEK-293T C367(1.09)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C367(1.34)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C367(1.39)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C367(1.55)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C367(1.53)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C367(1.38)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C367(1.16)  LDD0867  [3]
 LDCM0270  AC15 HCT 116 C132(0.95); C367(1.17)  LDD0587  [3]
 LDCM0271  AC150 HEK-293T C367(1.26)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C367(1.34)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C367(1.24)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C367(1.25)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C367(1.18)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C367(1.24)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C367(1.65)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C367(1.87)  LDD2165  [3]
 LDCM0276  AC17 HCT 116 C132(1.22); C367(1.81)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C367(0.89); C132(1.05)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C367(1.00); C132(1.09)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C367(0.79); C157(0.96); C158(0.96); C132(0.99)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C132(1.08); C367(1.09)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C132(0.98); C367(1.20)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C132(0.96); C367(1.29)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C132(1.02); C367(1.07)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C132(1.02); C367(1.08)  LDD0601  [3]
 LDCM0285  AC25 PaTu 8988t C79(1.01); C367(0.87); C132(0.75)  LDD1164  [3]
 LDCM0286  AC26 PaTu 8988t C79(1.16); C367(1.26); C132(0.84)  LDD1165  [3]
 LDCM0287  AC27 PaTu 8988t C79(1.06); C367(1.17); C132(0.90)  LDD1166  [3]
 LDCM0288  AC28 PaTu 8988t C79(1.18); C367(1.35); C132(1.09)  LDD1167  [3]
 LDCM0289  AC29 PaTu 8988t C79(0.99); C367(1.30); C132(0.97)  LDD1168  [3]
 LDCM0290  AC3 HCT 116 C367(0.69); C132(0.90); C157(0.99); C158(0.99)  LDD0607  [3]
 LDCM0291  AC30 PaTu 8988t C79(1.34); C367(1.02); C132(0.88)  LDD1170  [3]
 LDCM0292  AC31 PaTu 8988t C79(0.96); C367(0.79); C132(0.96)  LDD1171  [3]
 LDCM0293  AC32 PaTu 8988t C79(1.13); C367(1.38); C132(1.20)  LDD1172  [3]
 LDCM0294  AC33 PaTu 8988t C79(0.84); C367(1.20); C132(1.01)  LDD1173  [3]
 LDCM0295  AC34 PaTu 8988t C79(1.35); C367(1.35); C132(0.91)  LDD1174  [3]
 LDCM0296  AC35 HCT 116 C367(0.73); C132(0.81)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C132(0.81); C367(0.85)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C132(0.71); C367(0.83)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C367(0.92); C132(0.93)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C367(0.51); C132(0.86)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C367(0.59); C157(0.95); C158(0.95); C132(0.98)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C367(0.79); C132(0.96)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C367(0.60); C132(0.79)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C367(0.76); C132(0.91)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C367(0.72); C132(0.97)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C367(0.62); C132(0.90)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C367(0.77); C132(0.88)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C132(1.05); C367(1.24)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C132(0.98); C367(1.26)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C132(0.89); C367(0.96)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C132(1.43); C367(1.59)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C367(0.40); C132(0.94); C157(1.00); C158(1.00)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C132(1.29); C367(1.44)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C367(0.90); C132(0.92)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C132(1.04); C367(1.13)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C132(1.13); C367(1.43)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C132(1.10); C367(1.21)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C132(1.39); C367(1.49)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C367(1.32); C132(1.54)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C157(1.03); C158(1.03)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C157(1.00); C158(1.00)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C157(1.16); C158(1.16)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C132(0.90); C367(1.08)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C157(1.06); C158(1.06)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C157(1.08); C158(1.08)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C157(1.03); C158(1.03)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C157(1.08); C158(1.08)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C157(1.11); C158(1.11)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C157(1.31); C158(1.31)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C157(1.27); C158(1.27)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C157(1.23); C158(1.23)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C367(0.80)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C367(0.94)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C132(0.94); C367(1.23)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C367(0.92)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C367(0.95)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C367(1.69)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C367(1.24)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C367(1.41)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C367(1.52)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C367(1.27)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C367(1.00)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C367(1.31)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C367(1.21)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C367(0.78); C132(0.99)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C367(1.13)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C367(0.20)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C367(1.15)  LDD0665  [3]
 LDCM0349  AC83 HEK-293T C132(1.00)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C132(0.97)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C132(0.84)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C132(0.94)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C132(1.00)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C132(1.00)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C132(1.02)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C132(0.97)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C132(0.97)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C132(0.92)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C132(1.06)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C132(1.11)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C132(1.11)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C132(1.11)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C132(1.38)  LDD0962  [3]
 LDCM0365  AC98 HEK-293T C132(1.17)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C132(0.88)  LDD0964  [3]
 LDCM0248  AKOS034007472 HCT 116 C132(1.06); C367(0.87)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C132(0.94); C367(1.12)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C367(1.13); C132(1.25)  LDD0592  [3]
 LDCM0367  CL1 HCT 116 C367(1.06); C132(1.06); C157(1.17); C158(1.17)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C367(1.04); C132(1.21); C157(1.26); C158(1.26)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C367(0.63); C132(0.97); C157(1.00); C158(1.00)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C132(0.84); C367(1.13)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C132(0.87); C367(0.94)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C132(0.85); C367(0.90)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C132(1.07); C367(1.23)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C367(0.89); C132(1.10)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C367(0.86); C132(1.26)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C367(0.84); C132(1.15)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C367(0.87); C132(1.16)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C367(1.01); C132(1.02)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C367(0.99); C132(1.41); C157(1.57); C158(1.57)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C367(0.96); C132(1.09)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C367(1.04); C132(1.12)  LDD0698  [3]
 LDCM0382  CL112 PaTu 8988t C79(1.62); C367(1.05); C132(0.89)  LDD1261  [3]
 LDCM0383  CL113 PaTu 8988t C79(1.15); C367(0.90); C132(0.92)  LDD1262  [3]
 LDCM0384  CL114 PaTu 8988t C79(0.87); C367(1.10); C132(1.01)  LDD1263  [3]
 LDCM0385  CL115 PaTu 8988t C79(1.07); C367(0.97); C132(0.95)  LDD1264  [3]
 LDCM0386  CL116 PaTu 8988t C79(1.17); C367(1.50); C132(1.12)  LDD1265  [3]
 LDCM0387  CL117 HCT 116 C367(1.02); C132(1.21)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C367(0.66); C132(0.90)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C367(0.92); C132(0.98)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C367(0.95); C157(1.24); C158(1.24); C132(1.37)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C367(0.52); C132(0.83)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C367(0.61); C132(1.07)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C132(1.09); C367(1.13)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C132(1.09); C367(1.21)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C132(1.33); C367(1.36)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C157(1.01); C158(1.01)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C157(1.03); C158(1.03)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C157(0.97); C158(0.97)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C157(1.03); C158(1.03)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C367(1.02); C157(1.03); C158(1.03); C132(1.36)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C157(0.88); C158(0.88); C367(1.15); C132(1.16)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C367(0.97); C157(1.00); C158(1.00); C132(1.09)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C132(0.88); C367(1.05)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C132(0.83); C367(1.57)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C132(0.93); C367(1.52)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C132(1.00); C367(1.18)  LDD1004  [3]
 LDCM0407  CL2 HCT 116 C132(0.93); C157(1.00); C158(1.00); C367(1.07)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C132(0.94); C367(1.21)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C132(0.93); C367(1.82)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C132(0.91); C367(1.38)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C132(0.86); C367(1.14)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C132(0.81); C367(1.21)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C132(0.94); C367(1.39)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C132(0.96); C367(1.03)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C132(0.89); C367(1.20)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C132(0.85); C367(1.32)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C132(0.85); C367(1.41)  LDD1015  [3]
 LDCM0418  CL3 HCT 116 C132(1.11); C157(1.03); C158(1.03); C367(0.97)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C132(0.96); C367(1.90)  LDD1017  [3]
 LDCM0420  CL31 PaTu 8988t C158(1.37); C157(1.37); C79(1.00); C367(0.87)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C158(1.75); C157(1.75); C79(1.14); C367(0.74)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C158(1.60); C157(1.60); C79(0.88); C367(0.99)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C158(1.28); C157(1.28); C79(1.11); C367(0.97)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C367(1.00); C132(1.25); C158(1.37); C157(1.37)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C158(1.63); C157(1.63); C79(0.35); C367(0.62)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C158(1.51); C157(1.51); C79(1.15); C367(0.77)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C158(1.11); C157(1.11); C79(1.19); C367(0.73)  LDD1307  [3]
 LDCM0429  CL4 HCT 116 C132(1.07); C157(0.82); C158(0.82); C367(1.01)  LDD0746  [3]
 LDCM0430  CL40 PaTu 8988t C158(1.05); C157(1.05); C79(0.98); C367(0.88)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C158(1.53); C157(1.53); C79(0.83); C367(0.83)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C158(1.54); C157(1.54); C79(1.03); C367(0.92)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C158(1.40); C157(1.40); C79(1.19); C367(1.12)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C158(1.16); C157(1.16); C79(1.14); C367(0.94)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C158(1.86); C157(1.86); C79(1.05); C367(1.02)  LDD1314  [3]
 LDCM0436  CL46 HCT 116 C157(0.74); C158(0.74)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C157(0.82); C158(0.82)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C157(1.08); C158(1.08)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C157(0.64); C158(0.64)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C132(1.27); C157(0.82); C158(0.82); C367(1.03)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C157(0.51); C158(0.51)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C157(0.86); C158(0.86)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C157(0.78); C158(0.78)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C157(0.70); C158(0.70)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C157(0.73); C158(0.73)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C157(0.75); C158(0.75)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C157(0.77); C158(0.77)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C157(0.57); C158(0.57)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C157(0.83); C158(0.83)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C157(0.94); C158(0.94)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C132(1.10); C157(1.05); C158(1.05); C367(0.97)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C157(1.16); C158(1.16)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C132(0.94); C367(0.91)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C132(0.98); C367(1.00)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C132(0.85); C367(0.78)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C132(0.94); C367(0.80)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C132(1.08); C367(0.96)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C132(1.10); C367(0.75)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C132(1.09); C367(0.73)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C132(0.86); C367(0.84)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C132(0.94); C367(0.96)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C132(1.30); C157(1.13); C158(1.13); C367(0.81)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C132(1.03); C367(1.01)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C132(0.86); C367(0.74)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C132(0.85); C367(0.84)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C132(1.08); C367(0.87)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C132(1.01); C367(0.82)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C132(1.13); C157(1.01); C158(1.01)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C132(1.08); C157(0.98); C158(0.98)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C132(1.02); C157(1.18); C158(1.18)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C132(1.30); C157(1.03); C158(1.03)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C132(1.39); C157(1.07); C158(1.07); C367(1.13)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C132(1.16); C157(1.00); C158(1.00)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C132(1.13); C157(1.07); C158(1.07)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C132(1.67); C157(1.36); C158(1.36)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C132(1.44); C157(1.23); C158(1.23)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C132(1.55); C157(1.48); C158(1.48)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C132(1.18); C157(1.08); C158(1.08)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C132(1.18); C157(1.10); C158(1.10)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C132(1.32); C157(1.19); C158(1.19)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C132(1.38); C157(1.34); C158(1.34)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C132(1.87); C157(1.67); C158(1.67)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C132(1.24); C157(0.90); C158(0.90); C367(1.33)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C132(1.13); C157(1.13); C158(1.13)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C132(0.82); C157(1.04); C158(1.04); C367(0.60)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C132(0.80); C157(1.20); C158(1.20); C367(0.56)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C132(0.83); C157(0.94); C158(0.94); C367(0.58)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C132(0.79); C157(0.97); C158(0.97); C367(0.55)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C132(0.74); C157(0.84); C158(0.84); C367(0.51)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C132(0.76); C157(0.94); C158(0.94); C367(0.45)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C132(1.00); C157(1.10); C158(1.10); C367(0.79)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C132(0.97); C157(1.04); C158(1.04); C367(0.78)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C132(0.93); C157(1.05); C158(1.05); C367(0.69)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C145(0.96); C132(0.91); C367(1.00); C79(0.99)  LDD1698  [8]
 LDCM0625  F8 Ramos C145(1.81); C132(1.00)  LDD2187  [9]
 LDCM0572  Fragment10 Ramos C145(1.03)  LDD2189  [9]
 LDCM0573  Fragment11 Ramos C145(0.60); C132(20.00)  LDD2190  [9]
 LDCM0574  Fragment12 Ramos C132(3.08)  LDD2191  [9]
 LDCM0575  Fragment13 Ramos C145(0.86); C132(0.76)  LDD2192  [9]
 LDCM0576  Fragment14 Ramos C145(2.07); C132(3.23)  LDD2193  [9]
 LDCM0580  Fragment21 Ramos C145(0.82)  LDD2195  [9]
 LDCM0582  Fragment23 Ramos C145(1.45)  LDD2196  [9]
 LDCM0578  Fragment27 Ramos C145(0.76); C132(0.82)  LDD2197  [9]
 LDCM0586  Fragment28 Ramos C145(0.93); C132(0.84)  LDD2198  [9]
 LDCM0588  Fragment30 Ramos C145(0.64); C132(1.61)  LDD2199  [9]
 LDCM0589  Fragment31 Ramos C145(0.87)  LDD2200  [9]
 LDCM0590  Fragment32 Ramos C145(1.54); C132(0.93)  LDD2201  [9]
 LDCM0468  Fragment33 HCT 116 C132(0.86); C367(0.78)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C145(0.62); C132(1.47)  LDD2203  [9]
 LDCM0427  Fragment51 PaTu 8988t C158(1.55); C157(1.55); C79(1.31); C367(0.91)  LDD1306  [3]
 LDCM0610  Fragment52 Ramos C132(0.69)  LDD2204  [9]
 LDCM0614  Fragment56 Ramos C145(1.00); C132(0.89)  LDD2205  [9]
 LDCM0569  Fragment7 Ramos C145(2.06); C132(1.18)  LDD2186  [9]
 LDCM0571  Fragment9 Ramos C132(0.91)  LDD2188  [9]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [1]
 LDCM0022  KB02 HCT 116 C157(2.71); C158(2.71)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C157(4.06); C158(4.06)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C157(2.86); C158(2.86)  LDD0082  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C145(1.04)  LDD2136  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C145(0.31)  LDD2141  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C145(1.60)  LDD2144  [2]

References

1 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578