Details of the Target
General Information of Target
Target ID | LDTP01673 | |||||
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Target Name | AP-2 complex subunit alpha-1 (AP2A1) | |||||
Gene Name | AP2A1 | |||||
Gene ID | 160 | |||||
Synonyms |
ADTAA; CLAPA1; AP-2 complex subunit alpha-1; 100 kDa coated vesicle protein A; Adaptor protein complex AP-2 subunit alpha-1; Adaptor-related protein complex 2 subunit alpha-1; Alpha-adaptin A; Alpha1-adaptin; Clathrin assembly protein complex 2 alpha-A large chain; Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit
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3D Structure | ||||||
Sequence |
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVC
KLLFIFLLGHDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDL ASRNPTFMCLALHCIANVGSREMGEAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASP DLVPMGEWTARVVHLLNDQHMGVVTAAVSLITCLCKKNPDDFKTCVSLAVSRLSRIVSSA STDLQDYTYYFVPAPWLSVKLLRLLQCYPPPEDAAVKGRLVECLETVLNKAQEPPKSKKV QHSNAKNAILFETISLIIHYDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSE FSHEAVKTHIDTVINALKTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYLETADYAI REEIVLKVAILAEKYAVDYSWYVDTILNLIRIAGDYVSEEVWYRVLQIVTNRDDVQGYAA KTVFEALQAPACHENMVKVGGYILGEFGNLIAGDPRSSPPVQFSLLHSKFHLCSVATRAL LLSTYIKFINLFPETKATIQGVLRAGSQLRNADVELQQRAVEYLTLSSVASTDVLATVLE EMPPFPERESSILAKLKRKKGPGAGSALDDGRRDPSSNDINGGMEPTPSTVSTPSPSADL LGLRAAPPPAAPPASAGAGNLLVDVFDGPAAQPSLGPTPEEAFLSELEPPAPESPMALLA DPAPAADPGPEDIGPPIPEADELLNKFVCKNNGVLFENQLLQIGVKSEFRQNLGRMYLFY GNKTSVQFQNFSPTVVHPGDLQTQLAVQTKRVAAQVDGGAQVQQVLNIECLRDFLTPPLL SVRFRYGGAPQALTLKLPVTINKFFQPTEMAAQDFFQRWKQLSLPQQEAQKIFKANHPMD AEVTKAKLLGFGSALLDNVDPNPENFVGAGIIQTKALQVGCLLRLEPNAQAQMYRLTLRT SKEPVSRHLCELLAQQF |
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Target Bioclass |
Transporter and channel
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Family |
Adaptor complexes large subunit family
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Subcellular location |
Cell membrane
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Function |
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID | ||||||
ChEMBL ID |
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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m-APA Probe Info |
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6.24 | LDD0402 | [1] | |
A-EBA Probe Info |
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5.18 | LDD0215 | [2] | |
CY-1 Probe Info |
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100.00 | LDD0243 | [3] | |
Probe 1 Probe Info |
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Y412(12.30); Y418(15.81) | LDD3495 | [4] | |
JZ128-DTB Probe Info |
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N.A. | LDD0462 | [5] | |
AHL-Pu-1 Probe Info |
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C331(2.08) | LDD0170 | [6] | |
DBIA Probe Info |
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C171(0.93); C225(0.93); C267(0.77); C331(0.93) | LDD0531 | [7] | |
ATP probe Probe Info |
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N.A. | LDD0199 | [8] | |
4-Iodoacetamidophenylacetylene Probe Info |
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C397(0.00); C331(0.00); C941(0.00); C533(0.00) | LDD0038 | [9] | |
IA-alkyne Probe Info |
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C397(0.00); C331(0.00); C492(0.00) | LDD0032 | [10] | |
IPIAA_H Probe Info |
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N.A. | LDD0030 | [11] | |
IPIAA_L Probe Info |
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C331(0.00); C354(0.00) | LDD0031 | [11] | |
Lodoacetamide azide Probe Info |
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C397(0.00); C941(0.00); C533(0.00); C970(0.00) | LDD0037 | [9] | |
BTD Probe Info |
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N.A. | LDD0004 | [12] | |
NAIA_4 Probe Info |
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C267(0.00); C283(0.00) | LDD2226 | [13] | |
TFBX Probe Info |
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C492(0.00); C533(0.00); C331(0.00) | LDD0027 | [14] | |
IPM Probe Info |
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C533(0.00); C492(0.00) | LDD0005 | [12] | |
STPyne Probe Info |
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N.A. | LDD0009 | [12] | |
1c-yne Probe Info |
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K907(0.00); K880(0.00) | LDD0228 | [15] | |
Acrolein Probe Info |
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C283(0.00); C397(0.00); C267(0.00); C354(0.00) | LDD0217 | [16] | |
Crotonaldehyde Probe Info |
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C283(0.00); C397(0.00); C267(0.00); C331(0.00) | LDD0219 | [16] | |
Methacrolein Probe Info |
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C331(0.00); C283(0.00); C267(0.00); C970(0.00) | LDD0218 | [16] | |
W1 Probe Info |
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C492(0.00); C283(0.00) | LDD0236 | [17] | |
AOyne Probe Info |
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4.70 | LDD0443 | [18] | |
NAIA_5 Probe Info |
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C397(0.00); C941(0.00); C533(0.00); C283(0.00) | LDD2223 | [13] |
PAL-AfBPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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STS-2 Probe Info |
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N.A. | LDD0138 | [19] | |
VE-P Probe Info |
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N.A. | LDD0396 | [20] |
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
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LDCM0548 | 1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one | MDA-MB-231 | C492(0.51); C283(0.76) | LDD2142 | [21] |
LDCM0502 | 1-(Cyanoacetyl)piperidine | MDA-MB-231 | C492(0.47) | LDD2095 | [21] |
LDCM0537 | 2-Cyano-N,N-dimethylacetamide | MDA-MB-231 | C492(0.87); C533(1.07) | LDD2130 | [21] |
LDCM0524 | 2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide | MDA-MB-231 | C533(1.17); C397(1.77); C283(1.26); C267(1.19) | LDD2117 | [21] |
LDCM0558 | 2-Cyano-N-phenylacetamide | MDA-MB-231 | C492(1.57); C533(1.02); C171(1.12) | LDD2152 | [21] |
LDCM0510 | 3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile | MDA-MB-231 | C492(1.26); C533(1.51) | LDD2103 | [21] |
LDCM0539 | 3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile | MDA-MB-231 | C492(0.42); C533(0.38) | LDD2132 | [21] |
LDCM0538 | 4-(Cyanoacetyl)morpholine | MDA-MB-231 | C492(0.70); C533(0.88); C171(0.65) | LDD2131 | [21] |
LDCM0025 | 4SU-RNA | DM93 | C331(2.08) | LDD0170 | [6] |
LDCM0214 | AC1 | HCT 116 | C171(0.93); C225(0.93); C267(0.77); C331(0.93) | LDD0531 | [7] |
LDCM0215 | AC10 | HCT 116 | C171(1.12); C225(0.69); C267(0.99); C331(1.08) | LDD0532 | [7] |
LDCM0216 | AC100 | HCT 116 | C171(0.57); C225(0.81); C267(0.84); C331(1.07) | LDD0533 | [7] |
LDCM0217 | AC101 | HCT 116 | C171(0.56); C225(1.01); C267(0.69); C331(1.07) | LDD0534 | [7] |
LDCM0218 | AC102 | HCT 116 | C171(0.68); C225(0.89); C267(0.84); C331(1.34) | LDD0535 | [7] |
LDCM0219 | AC103 | HCT 116 | C171(0.51); C225(1.03); C267(0.66); C331(0.88) | LDD0536 | [7] |
LDCM0220 | AC104 | HCT 116 | C171(0.66); C225(1.21); C267(1.04); C331(1.09) | LDD0537 | [7] |
LDCM0221 | AC105 | HCT 116 | C171(0.50); C225(0.97); C267(0.76); C331(1.15) | LDD0538 | [7] |
LDCM0222 | AC106 | HCT 116 | C171(0.50); C225(0.68); C267(0.66); C331(0.84) | LDD0539 | [7] |
LDCM0223 | AC107 | HCT 116 | C171(0.57); C225(0.92); C267(0.70); C331(1.05) | LDD0540 | [7] |
LDCM0224 | AC108 | HCT 116 | C171(0.58); C225(0.79); C267(0.69); C331(1.04) | LDD0541 | [7] |
LDCM0225 | AC109 | HCT 116 | C171(0.66); C225(1.09); C267(1.19); C331(1.05) | LDD0542 | [7] |
LDCM0226 | AC11 | HCT 116 | C171(0.94); C225(0.70); C267(1.01); C331(0.94) | LDD0543 | [7] |
LDCM0227 | AC110 | HCT 116 | C171(0.54); C225(0.75); C267(0.70); C331(0.90) | LDD0544 | [7] |
LDCM0228 | AC111 | HCT 116 | C171(0.51); C225(0.72); C267(0.69); C331(1.23) | LDD0545 | [7] |
LDCM0229 | AC112 | HCT 116 | C171(0.51); C225(0.78); C267(0.69); C331(0.94) | LDD0546 | [7] |
LDCM0230 | AC113 | HCT 116 | C171(0.95); C225(1.08); C267(1.23); C331(1.11) | LDD0547 | [7] |
LDCM0231 | AC114 | HCT 116 | C171(0.82); C225(1.14); C267(0.81); C331(0.88) | LDD0548 | [7] |
LDCM0232 | AC115 | HCT 116 | C171(0.83); C225(0.87); C267(0.89); C331(0.93) | LDD0549 | [7] |
LDCM0233 | AC116 | HCT 116 | C171(1.03); C225(1.06); C267(0.83); C331(1.21) | LDD0550 | [7] |
LDCM0234 | AC117 | HCT 116 | C171(0.91); C225(0.90); C267(0.94); C331(1.06) | LDD0551 | [7] |
LDCM0235 | AC118 | HCT 116 | C171(0.88); C225(1.05); C267(0.94); C331(1.00) | LDD0552 | [7] |
LDCM0236 | AC119 | HCT 116 | C171(0.90); C225(2.76); C267(0.99); C331(1.05) | LDD0553 | [7] |
LDCM0237 | AC12 | HCT 116 | C171(0.97); C225(0.69); C267(1.02); C331(1.15) | LDD0554 | [7] |
LDCM0238 | AC120 | HCT 116 | C171(1.06); C225(1.41); C267(0.88); C331(1.05) | LDD0555 | [7] |
LDCM0239 | AC121 | HCT 116 | C171(1.04); C225(0.82); C267(0.99); C331(1.09) | LDD0556 | [7] |
LDCM0240 | AC122 | HCT 116 | C171(0.84); C225(1.17); C267(0.75); C331(0.96) | LDD0557 | [7] |
LDCM0241 | AC123 | HCT 116 | C171(0.92); C225(0.77); C267(0.96); C331(1.08) | LDD0558 | [7] |
LDCM0242 | AC124 | HCT 116 | C171(0.91); C225(1.30); C267(0.96); C331(1.18) | LDD0559 | [7] |
LDCM0243 | AC125 | HCT 116 | C171(0.85); C225(1.30); C267(0.86); C331(1.10) | LDD0560 | [7] |
LDCM0244 | AC126 | HCT 116 | C171(0.85); C225(1.23); C267(0.91); C331(1.04) | LDD0561 | [7] |
LDCM0245 | AC127 | HCT 116 | C171(0.83); C225(1.19); C267(0.89); C331(0.98) | LDD0562 | [7] |
LDCM0246 | AC128 | HCT 116 | C171(1.22); C225(0.75); C267(1.27); C331(1.00) | LDD0563 | [7] |
LDCM0247 | AC129 | HCT 116 | C171(1.18); C225(0.71); C267(1.23); C331(1.15) | LDD0564 | [7] |
LDCM0249 | AC130 | HCT 116 | C171(1.55); C225(0.84); C267(1.12); C331(1.19) | LDD0566 | [7] |
LDCM0250 | AC131 | HCT 116 | C171(1.23); C225(0.71); C267(1.14); C331(1.07) | LDD0567 | [7] |
LDCM0251 | AC132 | HCT 116 | C171(1.53); C225(0.75); C267(1.00); C331(1.17) | LDD0568 | [7] |
LDCM0252 | AC133 | HCT 116 | C171(1.37); C225(0.88); C267(1.09); C331(1.30) | LDD0569 | [7] |
LDCM0253 | AC134 | HCT 116 | C171(1.15); C225(0.67); C267(0.90); C331(1.22) | LDD0570 | [7] |
LDCM0254 | AC135 | HCT 116 | C171(1.44); C225(0.79); C267(0.99); C331(1.12) | LDD0571 | [7] |
LDCM0255 | AC136 | HCT 116 | C171(1.22); C225(0.87); C267(0.88); C331(1.08) | LDD0572 | [7] |
LDCM0256 | AC137 | HCT 116 | C171(1.43); C225(0.81); C267(0.89); C331(0.86) | LDD0573 | [7] |
LDCM0257 | AC138 | HCT 116 | C171(1.14); C225(0.70); C267(0.72); C331(0.96) | LDD0574 | [7] |
LDCM0258 | AC139 | HCT 116 | C171(1.46); C225(0.72); C267(0.90); C331(1.12) | LDD0575 | [7] |
LDCM0259 | AC14 | HCT 116 | C171(0.94); C225(0.99); C267(1.28); C331(0.96) | LDD0576 | [7] |
LDCM0260 | AC140 | HCT 116 | C171(1.17); C225(0.80); C267(0.73); C331(1.06) | LDD0577 | [7] |
LDCM0261 | AC141 | HCT 116 | C171(1.28); C225(0.63); C267(0.74); C331(1.18) | LDD0578 | [7] |
LDCM0262 | AC142 | HCT 116 | C171(1.19); C225(1.07); C267(0.96); C331(1.30) | LDD0579 | [7] |
LDCM0263 | AC143 | HCT 116 | C171(0.92); C225(1.29); C331(0.98); C397(0.86) | LDD0580 | [7] |
LDCM0264 | AC144 | HCT 116 | C941(0.68); C533(0.72); C171(0.74); C331(0.76) | LDD0581 | [7] |
LDCM0265 | AC145 | HCT 116 | C941(0.77); C225(0.82); C533(0.82); C171(0.85) | LDD0582 | [7] |
LDCM0266 | AC146 | HCT 116 | C941(0.65); C171(0.70); C331(0.74); C830(0.78) | LDD0583 | [7] |
LDCM0267 | AC147 | HCT 116 | C171(0.74); C397(0.76); C533(0.82); C331(0.88) | LDD0584 | [7] |
LDCM0268 | AC148 | HCT 116 | C941(0.63); C331(0.67); C171(0.78); C225(0.78) | LDD0585 | [7] |
LDCM0269 | AC149 | HCT 116 | C941(0.62); C331(0.63); C171(0.74); C225(0.75) | LDD0586 | [7] |
LDCM0270 | AC15 | HCT 116 | C941(0.94); C830(0.96); C225(0.97); C397(1.00) | LDD0587 | [7] |
LDCM0271 | AC150 | HCT 116 | C171(0.80); C225(0.88); C397(0.91); C830(0.93) | LDD0588 | [7] |
LDCM0272 | AC151 | HCT 116 | C533(0.76); C171(0.76); C397(0.77); C941(0.78) | LDD0589 | [7] |
LDCM0273 | AC152 | HCT 116 | C941(0.71); C331(0.72); C225(0.74); C171(0.74) | LDD0590 | [7] |
LDCM0274 | AC153 | HCT 116 | C941(0.53); C225(0.63); C331(0.69); C171(0.75) | LDD0591 | [7] |
LDCM0621 | AC154 | HCT 116 | C171(0.71); C225(0.80); C331(0.83); C397(0.83) | LDD2158 | [7] |
LDCM0622 | AC155 | HCT 116 | C171(0.75); C225(0.67); C331(0.82); C397(0.91) | LDD2159 | [7] |
LDCM0623 | AC156 | HCT 116 | C171(0.90); C225(0.77); C331(1.21); C397(0.94) | LDD2160 | [7] |
LDCM0624 | AC157 | HCT 116 | C171(0.78); C225(0.82); C331(1.02); C397(1.15) | LDD2161 | [7] |
LDCM0276 | AC17 | HCT 116 | C267(0.79); C533(0.86); C492(0.88); C970(0.90) | LDD0593 | [7] |
LDCM0277 | AC18 | HCT 116 | C225(0.68); C267(0.71); C830(0.72); C941(0.79) | LDD0594 | [7] |
LDCM0278 | AC19 | HCT 116 | C267(0.70); C830(0.84); C533(0.88); C397(0.91) | LDD0595 | [7] |
LDCM0279 | AC2 | HCT 116 | C397(0.78); C331(0.85); C970(0.91); C225(0.95) | LDD0596 | [7] |
LDCM0280 | AC20 | HCT 116 | C267(0.80); C533(0.80); C492(0.84); C830(0.96) | LDD0597 | [7] |
LDCM0281 | AC21 | HCT 116 | C267(0.73); C225(0.81); C970(0.85); C492(0.88) | LDD0598 | [7] |
LDCM0282 | AC22 | HCT 116 | C533(0.83); C267(0.85); C492(0.90); C171(0.92) | LDD0599 | [7] |
LDCM0283 | AC23 | HCT 116 | C267(0.73); C533(0.80); C492(0.85); C830(0.91) | LDD0600 | [7] |
LDCM0284 | AC24 | HCT 116 | C267(0.90); C533(0.90); C970(0.93); C225(0.97) | LDD0601 | [7] |
LDCM0285 | AC25 | HCT 116 | C941(0.76); C171(0.82); C267(0.87); C331(0.94) | LDD0602 | [7] |
LDCM0286 | AC26 | HCT 116 | C397(0.76); C941(0.77); C225(0.78); C267(0.78) | LDD0603 | [7] |
LDCM0287 | AC27 | HCT 116 | C941(0.75); C171(0.80); C397(0.81); C225(0.91) | LDD0604 | [7] |
LDCM0288 | AC28 | HCT 116 | C941(0.76); C171(0.84); C397(0.88); C492(0.90) | LDD0605 | [7] |
LDCM0289 | AC29 | HCT 116 | C171(0.64); C941(0.72); C397(0.77); C492(0.81) | LDD0606 | [7] |
LDCM0290 | AC3 | HCT 116 | C397(0.85); C331(0.86); C970(0.96); C492(0.97) | LDD0607 | [7] |
LDCM0291 | AC30 | HCT 116 | C397(0.55); C941(0.67); C225(0.77); C267(0.80) | LDD0608 | [7] |
LDCM0292 | AC31 | HCT 116 | C941(0.73); C171(0.73); C397(0.77); C492(0.83) | LDD0609 | [7] |
LDCM0293 | AC32 | HCT 116 | C397(0.61); C171(0.63); C941(0.66); C331(0.77) | LDD0610 | [7] |
LDCM0294 | AC33 | HCT 116 | C941(0.71); C397(0.79); C331(0.81); C171(0.81) | LDD0611 | [7] |
LDCM0295 | AC34 | HCT 116 | C941(0.67); C267(0.76); C171(0.86); C331(0.87) | LDD0612 | [7] |
LDCM0296 | AC35 | HCT 116 | C970(0.88); C225(0.92); C267(0.93); C830(0.93) | LDD0613 | [7] |
LDCM0297 | AC36 | HCT 116 | C225(0.75); C492(0.85); C267(0.85); C171(0.88) | LDD0614 | [7] |
LDCM0298 | AC37 | HCT 116 | C830(0.77); C225(0.88); C267(0.91); C492(0.92) | LDD0615 | [7] |
LDCM0299 | AC38 | HCT 116 | C171(0.88); C492(0.93); C225(0.96); C941(0.98) | LDD0616 | [7] |
LDCM0300 | AC39 | HCT 116 | C492(0.89); C267(0.92); C941(0.92); C830(0.98) | LDD0617 | [7] |
LDCM0301 | AC4 | HCT 116 | C267(0.76); C397(0.82); C941(0.87); C225(0.88) | LDD0618 | [7] |
LDCM0302 | AC40 | HCT 116 | C830(0.89); C225(0.94); C397(0.97); C267(0.98) | LDD0619 | [7] |
LDCM0303 | AC41 | HCT 116 | C830(0.85); C397(0.87); C331(0.87); C171(0.90) | LDD0620 | [7] |
LDCM0304 | AC42 | HCT 116 | C225(0.82); C171(0.85); C830(0.90); C492(0.90) | LDD0621 | [7] |
LDCM0305 | AC43 | HCT 116 | C171(0.70); C941(0.81); C830(0.86); C267(0.89) | LDD0622 | [7] |
LDCM0306 | AC44 | HCT 116 | C970(0.96); C533(0.97); C492(0.98); C267(0.98) | LDD0623 | [7] |
LDCM0307 | AC45 | HCT 116 | C397(0.91); C533(0.91); C830(0.93); C267(0.94) | LDD0624 | [7] |
LDCM0308 | AC46 | HCT 116 | C225(0.75); C830(0.90); C941(0.91); C267(0.91) | LDD0625 | [7] |
LDCM0309 | AC47 | HCT 116 | C492(0.83); C129(0.88); C134(0.88); C267(0.89) | LDD0626 | [7] |
LDCM0310 | AC48 | HCT 116 | C267(0.72); C171(0.86); C970(0.86); C830(0.89) | LDD0627 | [7] |
LDCM0311 | AC49 | HCT 116 | C267(0.84); C225(0.86); C397(0.88); C830(0.93) | LDD0628 | [7] |
LDCM0312 | AC5 | HCT 116 | C267(0.80); C397(0.81); C970(0.88); C941(0.96) | LDD0629 | [7] |
LDCM0313 | AC50 | HCT 116 | C267(0.80); C225(0.91); C970(0.91); C830(0.94) | LDD0630 | [7] |
LDCM0314 | AC51 | HCT 116 | C492(0.93); C533(0.97); C830(0.97); C941(1.01) | LDD0631 | [7] |
LDCM0315 | AC52 | HCT 116 | C492(0.81); C830(0.84); C267(0.88); C171(0.92) | LDD0632 | [7] |
LDCM0316 | AC53 | HCT 116 | C129(0.77); C134(0.77); C267(0.86); C970(0.95) | LDD0633 | [7] |
LDCM0317 | AC54 | HCT 116 | C267(0.86); C970(0.96); C830(0.99); C492(0.99) | LDD0634 | [7] |
LDCM0318 | AC55 | HCT 116 | C267(0.84); C970(0.92); C941(0.93); C397(0.93) | LDD0635 | [7] |
LDCM0319 | AC56 | HCT 116 | C267(0.75); C397(0.87); C970(0.92); C830(0.93) | LDD0636 | [7] |
LDCM0320 | AC57 | HCT 116 | C267(0.66); C941(0.77); C397(0.85); C171(0.91) | LDD0637 | [7] |
LDCM0321 | AC58 | HCT 116 | C267(0.59); C941(0.63); C331(0.77); C397(0.85) | LDD0638 | [7] |
LDCM0322 | AC59 | HCT 116 | C941(0.74); C397(0.78); C267(0.81); C331(0.89) | LDD0639 | [7] |
LDCM0323 | AC6 | HCT 116 | C397(0.82); C225(0.83); C941(0.86); C331(0.89) | LDD0640 | [7] |
LDCM0324 | AC60 | HCT 116 | C267(0.58); C941(0.64); C397(0.72); C171(0.81) | LDD0641 | [7] |
LDCM0325 | AC61 | HCT 116 | C267(0.57); C941(0.60); C171(0.74); C397(0.77) | LDD0642 | [7] |
LDCM0326 | AC62 | HCT 116 | C941(0.68); C397(0.70); C267(0.76); C129(0.83) | LDD0643 | [7] |
LDCM0327 | AC63 | HCT 116 | C267(0.66); C941(0.70); C397(0.72); C331(0.82) | LDD0644 | [7] |
LDCM0328 | AC64 | HCT 116 | C397(0.67); C267(0.71); C941(0.72); C331(0.82) | LDD0645 | [7] |
LDCM0329 | AC65 | HCT 116 | C941(0.71); C397(0.73); C970(0.85); C267(0.85) | LDD0646 | [7] |
LDCM0330 | AC66 | HCT 116 | C941(0.74); C397(0.86); C331(0.86); C267(0.86) | LDD0647 | [7] |
LDCM0331 | AC67 | HCT 116 | C941(0.61); C397(0.62); C267(0.64); C331(0.73) | LDD0648 | [7] |
LDCM0332 | AC68 | HCT 116 | C171(0.80); C970(0.82); C129(0.82); C134(0.82) | LDD0649 | [7] |
LDCM0333 | AC69 | HCT 116 | C941(0.77); C830(0.82); C171(0.88); C970(0.90) | LDD0650 | [7] |
LDCM0334 | AC7 | HCT 116 | C225(0.66); C397(0.89); C331(0.93); C941(0.93) | LDD0651 | [7] |
LDCM0335 | AC70 | HCT 116 | C171(0.79); C830(0.86); C397(0.90); C970(0.92) | LDD0652 | [7] |
LDCM0336 | AC71 | HCT 116 | C129(0.71); C134(0.71); C171(0.94); C830(0.99) | LDD0653 | [7] |
LDCM0337 | AC72 | HCT 116 | C171(0.85); C970(0.91); C397(0.92); C129(0.94) | LDD0654 | [7] |
LDCM0338 | AC73 | HCT 116 | C171(0.79); C970(0.82); C397(0.86); C331(0.89) | LDD0655 | [7] |
LDCM0339 | AC74 | HCT 116 | C941(0.90); C171(0.92); C830(0.97); C129(1.12) | LDD0656 | [7] |
LDCM0340 | AC75 | HCT 116 | C171(0.84); C970(0.88); C129(0.88); C134(0.88) | LDD0657 | [7] |
LDCM0341 | AC76 | HCT 116 | C129(0.80); C134(0.80); C171(0.90); C331(1.06) | LDD0658 | [7] |
LDCM0342 | AC77 | HCT 116 | C129(0.85); C134(0.85); C941(0.86); C970(0.91) | LDD0659 | [7] |
LDCM0343 | AC78 | HCT 116 | C129(0.71); C134(0.71); C941(0.77); C171(0.81) | LDD0660 | [7] |
LDCM0344 | AC79 | HCT 116 | C171(0.91); C941(1.01); C397(1.01); C970(1.08) | LDD0661 | [7] |
LDCM0345 | AC8 | HCT 116 | C225(0.59); C941(0.83); C397(0.85); C267(0.88) | LDD0662 | [7] |
LDCM0346 | AC80 | HCT 116 | C129(0.83); C134(0.83); C171(0.89); C830(0.94) | LDD0663 | [7] |
LDCM0347 | AC81 | HCT 116 | C830(0.71); C129(0.73); C134(0.73); C970(0.87) | LDD0664 | [7] |
LDCM0348 | AC82 | HCT 116 | C830(0.81); C171(0.84); C129(0.87); C134(0.87) | LDD0665 | [7] |
LDCM0349 | AC83 | HCT 116 | C397(0.49); C171(0.85); C941(0.87); C970(0.92) | LDD0666 | [7] |
LDCM0350 | AC84 | HCT 116 | C397(0.47); C492(0.79); C970(0.82); C225(0.89) | LDD0667 | [7] |
LDCM0351 | AC85 | HCT 116 | C397(0.49); C492(0.68); C970(0.79); C941(0.81) | LDD0668 | [7] |
LDCM0352 | AC86 | HCT 116 | C397(0.57); C970(0.72); C331(0.88); C171(0.91) | LDD0669 | [7] |
LDCM0353 | AC87 | HCT 116 | C397(0.63); C267(0.88); C941(0.93); C171(0.98) | LDD0670 | [7] |
LDCM0354 | AC88 | HCT 116 | C397(0.72); C267(0.82); C171(0.85); C533(0.90) | LDD0671 | [7] |
LDCM0355 | AC89 | HCT 116 | C397(0.54); C492(0.78); C970(0.79); C171(0.85) | LDD0672 | [7] |
LDCM0357 | AC90 | HCT 116 | C970(0.71); C267(0.74); C492(0.96); C331(0.99) | LDD0674 | [7] |
LDCM0358 | AC91 | HCT 116 | C397(0.52); C492(0.74); C970(0.78); C171(0.96) | LDD0675 | [7] |
LDCM0359 | AC92 | HCT 116 | C397(0.48); C970(0.80); C492(0.81); C533(0.90) | LDD0676 | [7] |
LDCM0360 | AC93 | HCT 116 | C397(0.63); C492(0.70); C970(0.86); C941(0.88) | LDD0677 | [7] |
LDCM0361 | AC94 | HCT 116 | C397(0.56); C970(0.63); C492(0.75); C533(0.94) | LDD0678 | [7] |
LDCM0362 | AC95 | HCT 116 | C397(0.53); C171(0.73); C941(0.74); C331(0.88) | LDD0679 | [7] |
LDCM0363 | AC96 | HCT 116 | C397(0.54); C492(0.74); C970(0.75); C171(0.91) | LDD0680 | [7] |
LDCM0364 | AC97 | HCT 116 | C397(0.43); C492(0.59); C970(0.73); C171(0.82) | LDD0681 | [7] |
LDCM0365 | AC98 | HCT 116 | C171(0.47); C941(0.49); C397(0.59); C267(0.66) | LDD0682 | [7] |
LDCM0366 | AC99 | HCT 116 | C941(0.62); C397(0.72); C171(0.73); C267(0.74) | LDD0683 | [7] |
LDCM0545 | Acetamide | MDA-MB-231 | C492(0.73); C533(0.58); C171(0.51) | LDD2138 | [21] |
LDCM0520 | AKOS000195272 | MDA-MB-231 | C492(0.79); C533(0.88); C941(0.73); C225(1.13) | LDD2113 | [21] |
LDCM0248 | AKOS034007472 | HCT 116 | C171(1.07); C225(0.98); C267(1.05); C331(1.04) | LDD0565 | [7] |
LDCM0356 | AKOS034007680 | HCT 116 | C225(0.76); C397(0.85); C941(0.93); C331(0.93) | LDD0673 | [7] |
LDCM0275 | AKOS034007705 | HCT 116 | C397(0.79); C225(0.82); C941(0.84); C830(0.85) | LDD0592 | [7] |
LDCM0020 | ARS-1620 | HCC44 | C397(0.91); C171(1.09); C533(0.85) | LDD2171 | [7] |
LDCM0498 | BS-3668 | MDA-MB-231 | C492(0.84); C533(0.91); C941(0.57) | LDD2091 | [21] |
LDCM0108 | Chloroacetamide | HeLa | C354(0.00); C492(0.00); C283(0.00); C171(0.00) | LDD0222 | [16] |
LDCM0632 | CL-Sc | Hep-G2 | C397(2.64); C354(1.66); C331(1.04); C941(0.72) | LDD2227 | [13] |
LDCM0367 | CL1 | HCT 116 | C492(0.80); C225(0.85); C970(0.86); C397(0.88) | LDD0684 | [7] |
LDCM0368 | CL10 | HCT 116 | C397(0.55); C970(0.63); C941(0.82); C267(0.84) | LDD0685 | [7] |
LDCM0369 | CL100 | HCT 116 | C970(0.80); C267(0.80); C397(0.80); C331(0.90) | LDD0686 | [7] |
LDCM0370 | CL101 | HCT 116 | C225(0.69); C171(0.82); C941(0.83); C397(0.90) | LDD0687 | [7] |
LDCM0371 | CL102 | HCT 116 | C331(0.91); C225(0.93); C941(1.01); C267(1.05) | LDD0688 | [7] |
LDCM0372 | CL103 | HCT 116 | C225(0.81); C331(0.94); C533(0.98); C941(0.99) | LDD0689 | [7] |
LDCM0373 | CL104 | HCT 116 | C225(0.85); C331(0.89); C941(0.95); C397(0.97) | LDD0690 | [7] |
LDCM0374 | CL105 | HCT 116 | C267(0.63); C970(0.78); C830(0.85); C492(0.88) | LDD0691 | [7] |
LDCM0375 | CL106 | HCT 116 | C267(0.51); C225(0.69); C830(0.75); C970(0.75) | LDD0692 | [7] |
LDCM0376 | CL107 | HCT 116 | C267(0.72); C492(0.83); C941(0.89); C397(0.89) | LDD0693 | [7] |
LDCM0377 | CL108 | HCT 116 | C267(0.69); C397(0.92); C830(0.97); C225(1.00) | LDD0694 | [7] |
LDCM0378 | CL109 | HCT 116 | C267(0.67); C941(0.81); C397(0.84); C225(0.85) | LDD0695 | [7] |
LDCM0379 | CL11 | HCT 116 | C397(0.68); C492(0.84); C267(0.88); C533(0.91) | LDD0696 | [7] |
LDCM0380 | CL110 | HCT 116 | C267(0.65); C397(0.76); C492(0.82); C225(0.83) | LDD0697 | [7] |
LDCM0381 | CL111 | HCT 116 | C267(0.66); C397(0.77); C830(0.82); C533(0.86) | LDD0698 | [7] |
LDCM0382 | CL112 | HCT 116 | C941(0.72); C171(0.83); C492(0.85); C225(0.88) | LDD0699 | [7] |
LDCM0383 | CL113 | HCT 116 | C941(0.62); C171(0.69); C397(0.79); C267(0.79) | LDD0700 | [7] |
LDCM0384 | CL114 | HCT 116 | C941(0.70); C171(0.72); C397(0.76); C331(0.78) | LDD0701 | [7] |
LDCM0385 | CL115 | HCT 116 | C941(0.67); C397(0.69); C267(0.84); C171(0.84) | LDD0702 | [7] |
LDCM0386 | CL116 | HCT 116 | C331(0.71); C941(0.73); C171(0.73); C397(0.78) | LDD0703 | [7] |
LDCM0387 | CL117 | HCT 116 | C225(0.80); C830(0.90); C267(0.95); C970(1.02) | LDD0704 | [7] |
LDCM0388 | CL118 | HCT 116 | C225(0.85); C171(0.88); C830(0.94); C397(0.96) | LDD0705 | [7] |
LDCM0389 | CL119 | HCT 116 | C171(0.80); C830(0.88); C225(0.90); C492(0.92) | LDD0706 | [7] |
LDCM0390 | CL12 | HCT 116 | C397(0.60); C492(0.87); C941(0.95); C533(0.98) | LDD0707 | [7] |
LDCM0391 | CL120 | HCT 116 | C171(0.74); C397(0.87); C830(0.88); C267(0.90) | LDD0708 | [7] |
LDCM0392 | CL121 | HCT 116 | C492(0.59); C830(0.82); C970(0.83); C533(0.83) | LDD0709 | [7] |
LDCM0393 | CL122 | HCT 116 | C267(0.83); C970(0.86); C397(0.86); C941(0.86) | LDD0710 | [7] |
LDCM0394 | CL123 | HCT 116 | C129(0.76); C134(0.76); C970(0.77); C225(0.84) | LDD0711 | [7] |
LDCM0395 | CL124 | HCT 116 | C225(0.74); C129(0.86); C134(0.86); C171(0.87) | LDD0712 | [7] |
LDCM0396 | CL125 | HCT 116 | C941(0.87); C970(0.87); C397(0.88); C830(0.98) | LDD0713 | [7] |
LDCM0397 | CL126 | HCT 116 | C941(0.76); C267(0.81); C830(0.92); C331(0.95) | LDD0714 | [7] |
LDCM0398 | CL127 | HCT 116 | C267(0.76); C941(0.77); C397(0.83); C129(0.95) | LDD0715 | [7] |
LDCM0399 | CL128 | HCT 116 | C267(0.75); C941(0.77); C397(0.80); C171(0.92) | LDD0716 | [7] |
LDCM0400 | CL13 | HCT 116 | C970(0.76); C397(0.79); C225(0.84); C533(0.84) | LDD0717 | [7] |
LDCM0401 | CL14 | HCT 116 | C397(0.79); C225(0.85); C941(0.87); C267(0.90) | LDD0718 | [7] |
LDCM0402 | CL15 | HCT 116 | C941(0.73); C397(0.73); C970(0.78); C225(0.86) | LDD0719 | [7] |
LDCM0403 | CL16 | HCT 116 | C970(0.62); C171(0.72); C492(0.78); C397(0.80) | LDD0720 | [7] |
LDCM0404 | CL17 | HCT 116 | C970(0.60); C492(0.74); C397(0.77); C941(0.87) | LDD0721 | [7] |
LDCM0405 | CL18 | HCT 116 | C970(0.47); C397(0.71); C331(0.86); C171(0.88) | LDD0722 | [7] |
LDCM0406 | CL19 | HCT 116 | C970(0.57); C397(0.78); C171(0.78); C225(0.80) | LDD0723 | [7] |
LDCM0407 | CL2 | HCT 116 | C492(0.81); C397(0.85); C267(0.88); C970(0.89) | LDD0724 | [7] |
LDCM0408 | CL20 | HCT 116 | C970(0.59); C397(0.70); C171(0.81); C492(0.82) | LDD0725 | [7] |
LDCM0409 | CL21 | HCT 116 | C970(0.50); C331(0.76); C397(0.78); C171(0.81) | LDD0726 | [7] |
LDCM0410 | CL22 | HCT 116 | C970(0.59); C492(0.77); C533(0.81); C331(0.83) | LDD0727 | [7] |
LDCM0411 | CL23 | HCT 116 | C533(0.70); C970(0.73); C171(0.84); C397(0.92) | LDD0728 | [7] |
LDCM0412 | CL24 | HCT 116 | C970(0.63); C397(0.76); C492(0.78); C171(0.84) | LDD0729 | [7] |
LDCM0413 | CL25 | HCT 116 | C171(0.71); C225(0.98); C267(0.88); C331(1.02) | LDD0730 | [7] |
LDCM0414 | CL26 | HCT 116 | C171(0.94); C225(0.96); C267(0.79); C331(0.92) | LDD0731 | [7] |
LDCM0415 | CL27 | HCT 116 | C171(0.86); C225(1.13); C267(1.19); C331(0.90) | LDD0732 | [7] |
LDCM0416 | CL28 | HCT 116 | C171(0.69); C225(0.96); C267(0.94); C331(0.82) | LDD0733 | [7] |
LDCM0417 | CL29 | HCT 116 | C171(0.84); C225(1.00); C267(0.96); C331(0.81) | LDD0734 | [7] |
LDCM0418 | CL3 | HCT 116 | C171(1.37); C225(1.27); C267(0.94); C397(0.86) | LDD0735 | [7] |
LDCM0419 | CL30 | HCT 116 | C171(0.82); C225(1.01); C267(0.94); C331(0.97) | LDD0736 | [7] |
LDCM0420 | CL31 | HCT 116 | C171(1.02); C225(0.89); C267(0.58); C331(1.04) | LDD0737 | [7] |
LDCM0421 | CL32 | HCT 116 | C171(0.78); C225(0.97); C267(0.55); C331(0.92) | LDD0738 | [7] |
LDCM0422 | CL33 | HCT 116 | C171(0.76); C225(1.00); C267(0.38); C331(0.70) | LDD0739 | [7] |
LDCM0423 | CL34 | HCT 116 | C171(0.91); C225(0.88); C267(0.46); C331(1.05) | LDD0740 | [7] |
LDCM0424 | CL35 | HCT 116 | C171(0.89); C225(0.98); C267(0.58); C331(1.10) | LDD0741 | [7] |
LDCM0425 | CL36 | HCT 116 | C171(1.17); C225(0.82); C267(0.62); C331(1.10) | LDD0742 | [7] |
LDCM0426 | CL37 | HCT 116 | C171(0.99); C225(0.97); C267(0.53); C331(1.08) | LDD0743 | [7] |
LDCM0428 | CL39 | HCT 116 | C171(0.93); C225(0.97); C267(0.63); C331(0.97) | LDD0745 | [7] |
LDCM0429 | CL4 | HCT 116 | C171(1.25); C225(0.81); C267(0.93); C397(0.89) | LDD0746 | [7] |
LDCM0430 | CL40 | HCT 116 | C171(0.97); C225(0.82); C267(0.50); C331(0.87) | LDD0747 | [7] |
LDCM0431 | CL41 | HCT 116 | C171(0.96); C225(0.95); C267(0.67); C331(1.01) | LDD0748 | [7] |
LDCM0432 | CL42 | HCT 116 | C171(1.15); C225(0.83); C267(0.57); C331(0.87) | LDD0749 | [7] |
LDCM0433 | CL43 | HCT 116 | C171(0.91); C225(0.95); C267(0.49); C331(0.95) | LDD0750 | [7] |
LDCM0434 | CL44 | HCT 116 | C171(0.87); C225(1.04); C267(0.46); C331(1.03) | LDD0751 | [7] |
LDCM0435 | CL45 | HCT 116 | C171(0.98); C225(0.92); C267(0.44); C331(1.08) | LDD0752 | [7] |
LDCM0436 | CL46 | HCT 116 | C129(0.93); C134(0.93); C171(1.12); C225(0.80) | LDD0753 | [7] |
LDCM0437 | CL47 | HCT 116 | C129(0.98); C134(0.98); C171(1.25); C225(0.85) | LDD0754 | [7] |
LDCM0438 | CL48 | HCT 116 | C129(0.97); C134(0.97); C171(1.47); C225(0.94) | LDD0755 | [7] |
LDCM0439 | CL49 | HCT 116 | C129(0.83); C134(0.83); C171(1.39); C225(0.90) | LDD0756 | [7] |
LDCM0440 | CL5 | HCT 116 | C171(1.15); C225(1.19); C267(1.11); C397(0.98) | LDD0757 | [7] |
LDCM0441 | CL50 | HCT 116 | C129(0.96); C134(0.96); C171(1.26); C225(0.90) | LDD0758 | [7] |
LDCM0442 | CL51 | HCT 116 | C129(0.85); C134(0.85); C171(1.20); C225(0.90) | LDD0759 | [7] |
LDCM0443 | CL52 | HCT 116 | C129(0.78); C134(0.78); C171(1.04); C225(0.94) | LDD0760 | [7] |
LDCM0444 | CL53 | HCT 116 | C129(1.13); C134(1.13); C171(1.39); C225(0.88) | LDD0761 | [7] |
LDCM0445 | CL54 | HCT 116 | C129(0.89); C134(0.89); C171(1.24); C225(0.84) | LDD0762 | [7] |
LDCM0446 | CL55 | HCT 116 | C129(0.86); C134(0.86); C171(1.33); C225(0.94) | LDD0763 | [7] |
LDCM0447 | CL56 | HCT 116 | C129(1.20); C134(1.20); C171(1.30); C225(0.85) | LDD0764 | [7] |
LDCM0448 | CL57 | HCT 116 | C129(1.24); C134(1.24); C171(1.33); C225(0.93) | LDD0765 | [7] |
LDCM0449 | CL58 | HCT 116 | C129(1.05); C134(1.05); C171(1.26); C225(0.94) | LDD0766 | [7] |
LDCM0450 | CL59 | HCT 116 | C129(0.87); C134(0.87); C171(1.28); C225(1.01) | LDD0767 | [7] |
LDCM0451 | CL6 | HCT 116 | C171(0.88); C225(1.00); C267(0.78); C397(0.64) | LDD0768 | [7] |
LDCM0452 | CL60 | HCT 116 | C129(0.99); C134(0.99); C171(1.13); C225(0.85) | LDD0769 | [7] |
LDCM0453 | CL61 | HCT 116 | C171(0.88); C225(1.33); C267(1.04); C331(0.92) | LDD0770 | [7] |
LDCM0454 | CL62 | HCT 116 | C171(0.88); C225(1.18); C267(0.88); C331(0.93) | LDD0771 | [7] |
LDCM0455 | CL63 | HCT 116 | C171(0.90); C225(1.22); C267(0.88); C331(0.73) | LDD0772 | [7] |
LDCM0456 | CL64 | HCT 116 | C171(0.86); C225(1.69); C267(0.84); C331(0.95) | LDD0773 | [7] |
LDCM0457 | CL65 | HCT 116 | C171(0.97); C225(0.87); C267(1.00); C331(1.00) | LDD0774 | [7] |
LDCM0458 | CL66 | HCT 116 | C171(0.87); C225(2.22); C267(0.86); C331(0.93) | LDD0775 | [7] |
LDCM0459 | CL67 | HCT 116 | C171(0.92); C225(0.81); C267(0.85); C331(0.81) | LDD0776 | [7] |
LDCM0460 | CL68 | HCT 116 | C171(0.77); C225(0.74); C267(0.74); C331(0.99) | LDD0777 | [7] |
LDCM0461 | CL69 | HCT 116 | C171(0.74); C225(0.82); C267(0.67); C331(0.81) | LDD0778 | [7] |
LDCM0462 | CL7 | HCT 116 | C171(1.16); C225(1.14); C267(1.06); C397(0.76) | LDD0779 | [7] |
LDCM0463 | CL70 | HCT 116 | C171(0.78); C225(1.32); C267(0.75); C331(0.89) | LDD0780 | [7] |
LDCM0464 | CL71 | HCT 116 | C171(0.82); C225(0.96); C267(0.83); C331(0.89) | LDD0781 | [7] |
LDCM0465 | CL72 | HCT 116 | C171(0.96); C225(0.92); C267(1.04); C331(0.89) | LDD0782 | [7] |
LDCM0466 | CL73 | HCT 116 | C171(0.86); C225(1.00); C267(0.82); C331(0.78) | LDD0783 | [7] |
LDCM0467 | CL74 | HCT 116 | C171(0.89); C225(0.73); C267(0.86); C331(0.97) | LDD0784 | [7] |
LDCM0469 | CL76 | HCT 116 | C129(1.03); C134(1.03); C171(1.15); C225(0.78) | LDD0786 | [7] |
LDCM0470 | CL77 | HCT 116 | C129(1.14); C134(1.14); C171(1.04); C225(0.89) | LDD0787 | [7] |
LDCM0471 | CL78 | HCT 116 | C129(1.11); C134(1.11); C171(0.98); C225(1.01) | LDD0788 | [7] |
LDCM0472 | CL79 | HCT 116 | C129(1.23); C134(1.23); C171(1.07); C225(1.62) | LDD0789 | [7] |
LDCM0473 | CL8 | HCT 116 | C171(1.02); C225(1.46); C267(0.83); C397(0.83) | LDD0790 | [7] |
LDCM0474 | CL80 | HCT 116 | C129(1.11); C134(1.11); C171(1.20); C225(0.88) | LDD0791 | [7] |
LDCM0475 | CL81 | HCT 116 | C129(1.02); C134(1.02); C171(1.18); C225(0.98) | LDD0792 | [7] |
LDCM0476 | CL82 | HCT 116 | C129(1.00); C134(1.00); C171(1.31); C225(1.00) | LDD0793 | [7] |
LDCM0477 | CL83 | HCT 116 | C129(0.73); C134(0.73); C171(1.27); C225(0.92) | LDD0794 | [7] |
LDCM0478 | CL84 | HCT 116 | C129(0.77); C134(0.77); C171(0.98); C225(1.16) | LDD0795 | [7] |
LDCM0479 | CL85 | HCT 116 | C129(0.68); C134(0.68); C171(1.02); C225(1.06) | LDD0796 | [7] |
LDCM0480 | CL86 | HCT 116 | C129(0.76); C134(0.76); C171(1.10); C225(0.87) | LDD0797 | [7] |
LDCM0481 | CL87 | HCT 116 | C129(0.84); C134(0.84); C171(1.38); C225(0.72) | LDD0798 | [7] |
LDCM0482 | CL88 | HCT 116 | C129(0.80); C134(0.80); C171(1.32); C225(1.04) | LDD0799 | [7] |
LDCM0483 | CL89 | HCT 116 | C129(0.82); C134(0.82); C171(1.25); C225(1.12) | LDD0800 | [7] |
LDCM0484 | CL9 | HCT 116 | C171(1.13); C225(0.94); C267(0.91); C397(0.79) | LDD0801 | [7] |
LDCM0485 | CL90 | HCT 116 | C129(1.01); C134(1.01); C171(1.11); C225(0.64) | LDD0802 | [7] |
LDCM0486 | CL91 | HCT 116 | C171(1.14); C225(0.92); C267(0.83); C331(1.00) | LDD0803 | [7] |
LDCM0487 | CL92 | HCT 116 | C171(0.92); C225(0.85); C267(0.91); C331(1.07) | LDD0804 | [7] |
LDCM0488 | CL93 | HCT 116 | C171(1.03); C225(1.05); C267(0.88); C331(0.98) | LDD0805 | [7] |
LDCM0489 | CL94 | HCT 116 | C171(1.05); C225(0.86); C267(0.75); C331(0.78) | LDD0806 | [7] |
LDCM0490 | CL95 | HCT 116 | C171(0.93); C225(0.87); C267(0.75); C331(0.98) | LDD0807 | [7] |
LDCM0491 | CL96 | HCT 116 | C171(0.91); C225(0.87); C267(0.88); C331(0.89) | LDD0808 | [7] |
LDCM0492 | CL97 | HCT 116 | C171(0.99); C225(0.79); C267(0.80); C331(0.90) | LDD0809 | [7] |
LDCM0493 | CL98 | HCT 116 | C171(1.07); C225(1.08); C267(0.81); C331(0.89) | LDD0810 | [7] |
LDCM0494 | CL99 | HCT 116 | C171(1.00); C225(0.91); C267(0.90); C331(0.94) | LDD0811 | [7] |
LDCM0495 | E2913 | HEK-293T | C533(1.16); C225(0.89); C267(0.86); C354(0.98) | LDD1698 | [22] |
LDCM0213 | Electrophilic fragment 2 | MDA-MB-231 | C941(2.31) | LDD1702 | [21] |
LDCM0625 | F8 | Ramos | C492(1.10); C331(0.48) | LDD2187 | [23] |
LDCM0572 | Fragment10 | Ramos | C492(1.39); C331(0.83) | LDD2189 | [23] |
LDCM0573 | Fragment11 | Ramos | C492(1.96) | LDD2190 | [23] |
LDCM0574 | Fragment12 | Ramos | C492(1.21); C331(0.65) | LDD2191 | [23] |
LDCM0575 | Fragment13 | Ramos | C492(1.02); C331(0.90) | LDD2192 | [23] |
LDCM0576 | Fragment14 | Ramos | C492(1.09) | LDD2193 | [23] |
LDCM0579 | Fragment20 | Ramos | C492(1.18); C331(0.48) | LDD2194 | [23] |
LDCM0580 | Fragment21 | Ramos | C492(1.03); C331(0.77) | LDD2195 | [23] |
LDCM0582 | Fragment23 | Ramos | C492(1.97); C331(0.96) | LDD2196 | [23] |
LDCM0578 | Fragment27 | Ramos | C492(1.13); C331(0.75) | LDD2197 | [23] |
LDCM0586 | Fragment28 | Ramos | C492(0.83); C331(0.89) | LDD2198 | [23] |
LDCM0588 | Fragment30 | Ramos | C492(1.35); C331(1.18) | LDD2199 | [23] |
LDCM0589 | Fragment31 | Ramos | C492(1.40); C331(1.07) | LDD2200 | [23] |
LDCM0590 | Fragment32 | Ramos | C492(0.92); C331(0.61) | LDD2201 | [23] |
LDCM0468 | Fragment33 | HCT 116 | C171(0.90); C225(1.27); C267(0.81); C331(0.90) | LDD0785 | [7] |
LDCM0596 | Fragment38 | Ramos | C492(3.09); C331(1.56) | LDD2203 | [23] |
LDCM0566 | Fragment4 | Ramos | C492(1.02); C331(0.63) | LDD2184 | [23] |
LDCM0427 | Fragment51 | HCT 116 | C171(1.08); C225(1.01); C267(0.60); C331(0.91) | LDD0744 | [7] |
LDCM0610 | Fragment52 | Ramos | C492(1.47) | LDD2204 | [23] |
LDCM0614 | Fragment56 | Ramos | C492(1.27) | LDD2205 | [23] |
LDCM0569 | Fragment7 | Ramos | C492(1.40); C331(0.44) | LDD2186 | [23] |
LDCM0571 | Fragment9 | Ramos | C492(1.18); C331(0.76) | LDD2188 | [23] |
LDCM0107 | IAA | HeLa | C283(0.00); C941(0.00); H369(0.00); H340(0.00) | LDD0221 | [16] |
LDCM0179 | JZ128 | PC-3 | N.A. | LDD0462 | [5] |
LDCM0022 | KB02 | HEK-293T | C533(0.81); C171(0.96); C492(0.92); C267(0.93) | LDD1492 | [22] |
LDCM0023 | KB03 | HEK-293T | C533(0.92); C171(0.93); C492(0.98); C267(1.07) | LDD1497 | [22] |
LDCM0024 | KB05 | G361 | C397(3.60); C941(3.19); C267(2.23); C225(3.41) | LDD3311 | [24] |
LDCM0528 | N-(4-bromophenyl)-2-cyano-N-phenylacetamide | MDA-MB-231 | C492(0.79) | LDD2121 | [21] |
LDCM0109 | NEM | HeLa | H369(0.00); C283(0.00); C941(0.00); H340(0.00) | LDD0223 | [16] |
LDCM0496 | Nucleophilic fragment 11a | MDA-MB-231 | C492(1.00) | LDD2089 | [21] |
LDCM0497 | Nucleophilic fragment 11b | MDA-MB-231 | C492(1.47) | LDD2090 | [21] |
LDCM0499 | Nucleophilic fragment 12b | MDA-MB-231 | C492(1.52); C533(1.46) | LDD2092 | [21] |
LDCM0500 | Nucleophilic fragment 13a | MDA-MB-231 | C492(1.40); C533(1.02) | LDD2093 | [21] |
LDCM0503 | Nucleophilic fragment 14b | MDA-MB-231 | C533(0.11) | LDD2096 | [21] |
LDCM0504 | Nucleophilic fragment 15a | MDA-MB-231 | C492(0.85); C533(0.96); C331(1.05) | LDD2097 | [21] |
LDCM0505 | Nucleophilic fragment 15b | MDA-MB-231 | C492(1.22); C533(0.79) | LDD2098 | [21] |
LDCM0506 | Nucleophilic fragment 16a | MDA-MB-231 | C533(1.16); C267(0.88) | LDD2099 | [21] |
LDCM0507 | Nucleophilic fragment 16b | MDA-MB-231 | C492(0.52) | LDD2100 | [21] |
LDCM0508 | Nucleophilic fragment 17a | MDA-MB-231 | C533(1.26) | LDD2101 | [21] |
LDCM0511 | Nucleophilic fragment 18b | MDA-MB-231 | C492(0.60) | LDD2104 | [21] |
LDCM0512 | Nucleophilic fragment 19a | MDA-MB-231 | C492(1.43) | LDD2105 | [21] |
LDCM0513 | Nucleophilic fragment 19b | MDA-MB-231 | C492(0.54) | LDD2106 | [21] |
LDCM0514 | Nucleophilic fragment 20a | MDA-MB-231 | C492(1.02); C533(0.99); C941(1.12); C267(0.88) | LDD2107 | [21] |
LDCM0515 | Nucleophilic fragment 20b | MDA-MB-231 | C492(0.54); C283(0.62) | LDD2108 | [21] |
LDCM0516 | Nucleophilic fragment 21a | MDA-MB-231 | C492(0.90); C533(0.68); C941(0.54); C225(0.91) | LDD2109 | [21] |
LDCM0517 | Nucleophilic fragment 21b | MDA-MB-231 | C492(0.61) | LDD2110 | [21] |
LDCM0518 | Nucleophilic fragment 22a | MDA-MB-231 | C492(1.02); C533(1.12); C941(0.93) | LDD2111 | [21] |
LDCM0521 | Nucleophilic fragment 23b | MDA-MB-231 | C492(0.66) | LDD2114 | [21] |
LDCM0522 | Nucleophilic fragment 24a | MDA-MB-231 | C533(0.58) | LDD2115 | [21] |
LDCM0523 | Nucleophilic fragment 24b | MDA-MB-231 | C533(0.25) | LDD2116 | [21] |
LDCM0525 | Nucleophilic fragment 25b | MDA-MB-231 | C533(0.29) | LDD2118 | [21] |
LDCM0526 | Nucleophilic fragment 26a | MDA-MB-231 | C492(1.72); C533(1.31) | LDD2119 | [21] |
LDCM0527 | Nucleophilic fragment 26b | MDA-MB-231 | C492(0.70); C533(0.91); C941(0.64) | LDD2120 | [21] |
LDCM0529 | Nucleophilic fragment 27b | MDA-MB-231 | C533(0.13) | LDD2122 | [21] |
LDCM0530 | Nucleophilic fragment 28a | MDA-MB-231 | C492(0.98); C533(1.09); C225(0.74); C283(0.90) | LDD2123 | [21] |
LDCM0531 | Nucleophilic fragment 28b | MDA-MB-231 | C533(0.12); C267(1.09) | LDD2124 | [21] |
LDCM0532 | Nucleophilic fragment 29a | MDA-MB-231 | C492(1.04); C533(0.88); C397(1.18); C283(1.16) | LDD2125 | [21] |
LDCM0533 | Nucleophilic fragment 29b | MDA-MB-231 | C533(0.19) | LDD2126 | [21] |
LDCM0534 | Nucleophilic fragment 30a | MDA-MB-231 | C492(1.49); C533(1.17) | LDD2127 | [21] |
LDCM0535 | Nucleophilic fragment 30b | MDA-MB-231 | C533(1.17); C171(1.17); C941(0.84) | LDD2128 | [21] |
LDCM0536 | Nucleophilic fragment 31 | MDA-MB-231 | C492(1.39); C533(1.08) | LDD2129 | [21] |
LDCM0540 | Nucleophilic fragment 35 | MDA-MB-231 | C533(0.62) | LDD2133 | [21] |
LDCM0541 | Nucleophilic fragment 36 | MDA-MB-231 | C492(0.53); C533(0.49) | LDD2134 | [21] |
LDCM0542 | Nucleophilic fragment 37 | MDA-MB-231 | C533(1.34); C171(1.54); C941(1.28); C225(1.37) | LDD2135 | [21] |
LDCM0543 | Nucleophilic fragment 38 | MDA-MB-231 | C492(1.26); C533(1.06); C941(1.43); C267(1.58) | LDD2136 | [21] |
LDCM0544 | Nucleophilic fragment 39 | MDA-MB-231 | C492(1.20); C533(1.02); C397(1.04); C283(1.26) | LDD2137 | [21] |
LDCM0211 | Nucleophilic fragment 3b | MDA-MB-231 | C225(3.21); C492(1.85); C533(1.71) | LDD1700 | [21] |
LDCM0546 | Nucleophilic fragment 40 | MDA-MB-231 | C492(1.05); C533(0.98); C267(0.94) | LDD2140 | [21] |
LDCM0547 | Nucleophilic fragment 41 | MDA-MB-231 | C492(0.47); C533(0.24); C225(0.56) | LDD2141 | [21] |
LDCM0549 | Nucleophilic fragment 43 | MDA-MB-231 | C492(0.81); C533(0.94); C941(0.59) | LDD2143 | [21] |
LDCM0550 | Nucleophilic fragment 5a | MDA-MB-231 | C492(2.44); C533(1.12) | LDD2144 | [21] |
LDCM0551 | Nucleophilic fragment 5b | MDA-MB-231 | C492(1.00); C533(0.21); C225(0.46) | LDD2145 | [21] |
LDCM0552 | Nucleophilic fragment 6a | MDA-MB-231 | C492(1.09); C533(0.90) | LDD2146 | [21] |
LDCM0554 | Nucleophilic fragment 7a | MDA-MB-231 | C492(0.65); C533(0.67) | LDD2148 | [21] |
LDCM0555 | Nucleophilic fragment 7b | MDA-MB-231 | C533(0.20) | LDD2149 | [21] |
LDCM0556 | Nucleophilic fragment 8a | MDA-MB-231 | C492(0.65); C533(0.76) | LDD2150 | [21] |
LDCM0557 | Nucleophilic fragment 8b | MDA-MB-231 | C533(0.15); C331(0.35); C225(0.21) | LDD2151 | [21] |
LDCM0021 | THZ1 | HCT 116 | C397(0.91); C171(1.09); C533(0.85) | LDD2173 | [7] |
References