Details of the Target

General Information of Target

Target ID LDTP02634
Target Name Cadherin-1 (CDH1)
Gene Name CDH1
Gene ID 999
Synonyms
CDHE; UVO; Cadherin-1; CAM 120/80; Epithelial cadherin; E-cadherin; Uvomorulin; CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDC
TGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVG
HHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKS
NKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGN
AVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAI
AYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTAT
AVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAPNTPAWEAVYTILNDDG
GQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDV
NEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTG
AISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTI
FFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEV
GDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILAL
LILILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARP
EVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGS
EAASLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYGGGEDD
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Subcellular location
Cell junction, adherens junction
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.; E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.; (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria.
TTD ID
T08919
Uniprot ID
P12830
DrugMap ID
TTLAWO6
Ensemble ID
ENST00000261769.10
HGNC ID
HGNC:1748
ChEMBL ID
CHEMBL2321609

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS Insertion: p.G579RfsTer9 DBIA    Probe Info 
CAL148 SNV: p.D402N .
HCT116 Deletion: p.H121TfsTer94 .
HDMYZ SNV: p.L276P .
HT115 SNV: p.E648Ter .
IM95 Deletion: p.P126RfsTer89 DBIA    Probe Info 
KATOIII SNV: p.R154T .
KP4 SNV: p.A698P .
KYSE510 SNV: p.T427K DBIA    Probe Info 
LNCaP clone FGC SNV: p.P94T; p.P700S DBIA    Probe Info 
MDAMB453 SNV: p.W638Ter DBIA    Probe Info 
NCIH1048 Deletion: p.I542FfsTer15 .
NCIH2122 Deletion: p.E165_P170del .
NCIH82 SNV: p.H45L .
OCUM1 SNV: p.G212E .
PC9 SNV: p.F39L; p.T40K .
TE4 SNV: p.T340A DBIA    Probe Info 
TGBC52TKB SNV: p.D569E .
UMUC3 SNV: p.D549H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y755(16.28)  LDD3495  [1]
JZ128-DTB
 Probe Info  		C695(0.00); C688(0.00)  LDD0462  [2]
DBIA
 Probe Info  		C603(0.84)  LDD0078  [3]
N1
 Probe Info  		N.A.  LDD0245  [4]
IA-alkyne
 Probe Info  		C603(0.00); C60(0.00)  LDD0162  [5]
NAIA_5
 Probe Info  		C163(0.00); C603(0.00); C60(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C603(1.19)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C603(1.29)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C603(0.98)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C603(1.07)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C603(0.87)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C603(1.05)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C603(0.97)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C603(0.96)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C603(0.90)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C603(0.87)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C603(0.82)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C603(0.81)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C603(1.52)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C603(0.90)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C603(0.87)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C603(0.89)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C603(0.69)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C603(1.09)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C603(1.05)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C603(1.13)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C603(1.00)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C603(0.82)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C603(0.91)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C603(1.36)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C603(0.93)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C603(0.84)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C603(0.88)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C603(0.81)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C603(1.12)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C603(0.97)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C603(1.16)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C603(0.99)  LDD0562  [3]
 LDCM0259  AC14 HCT 116 C603(1.16)  LDD0576  [3]
 LDCM0270  AC15 HCT 116 C603(1.22)  LDD0587  [3]
 LDCM0276  AC17 HCT 116 C603(0.88)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C603(0.80)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C603(0.71)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C603(0.99)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C603(0.63)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C603(0.71)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C603(0.69)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C603(0.76)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C603(0.70)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C603(0.75)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C603(0.74)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C603(0.78)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C603(0.81)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C603(0.96)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C603(1.02)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C603(0.70)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C603(0.86)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C603(1.04)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C603(1.17)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C603(0.88)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C163(1.07)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C163(0.95)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C163(0.89)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C163(0.90); C603(1.11)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C163(1.01)  LDD1539  [7]
 LDCM0301  AC4 HCT 116 C603(1.12)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C163(1.21)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C163(0.88)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C163(0.98)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C163(1.06)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C163(1.17)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C163(1.16)  LDD1546  [7]
 LDCM0308  AC46 HCT 116 C603(1.40)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C603(1.02)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C603(1.10)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C603(0.79)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C603(0.99)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C603(1.01)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C603(0.99)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C603(0.90)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C603(0.97)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C603(1.10)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C603(0.88)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C603(0.87)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C603(0.29)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C603(0.25)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C603(0.57)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C603(1.15)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C603(0.63)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C603(0.67)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C603(0.31)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C603(0.54)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C603(0.68)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C603(0.09)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C603(0.10)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C603(0.09)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C603(0.86)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C603(0.80)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C603(1.24)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C603(0.81)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C603(0.95)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C603(0.85)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C603(1.05)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C603(0.97)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C603(0.99)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C603(0.97)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C603(1.05)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C603(1.16)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C603(1.00)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C603(1.10)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C603(0.88)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C603(0.72)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C603(0.76)  LDD0665  [3]
 LDCM0365  AC98 HCT 116 C603(1.20)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C603(1.11)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C603(1.20)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C603(1.17)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C603(1.03)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C603(0.84)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C603(1.07)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C603(1.07)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C603(1.21)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C603(1.06)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C603(1.22)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C603(1.43)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C603(1.04)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C603(1.26)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C603(1.17)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C603(0.98)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C603(1.13)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C603(1.51)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C603(0.84)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C603(1.43)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C603(1.15)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C603(0.94)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C603(0.85)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C603(1.08)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C603(1.71)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C603(1.44)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C163(1.01)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C163(1.02)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C163(0.94); C603(1.04)  LDD1593  [7]
 LDCM0390  CL12 HCT 116 C603(1.17)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C163(1.06)  LDD1595  [7]
 LDCM0392  CL121 HCT 116 C603(1.06)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C603(1.19)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C603(0.90)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C603(0.84)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C603(0.41)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C603(0.33)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C603(0.34)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C603(0.31)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C603(1.08)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C603(0.98)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C603(0.88)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C603(1.05)  LDD0720  [3]
 LDCM0404  CL17 HEK-293T C163(0.89)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C163(0.92)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C163(0.94)  LDD1610  [7]
 LDCM0407  CL2 HCT 116 C603(1.10)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C163(0.88)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C163(0.94)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C163(0.86); C603(1.33)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C163(1.21)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C163(1.14)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C163(0.89)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C163(1.03)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C163(0.86); C603(1.01)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C163(0.95)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C163(0.98)  LDD1621  [7]
 LDCM0418  CL3 HCT 116 C603(1.04)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C163(0.87)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C163(0.93)  LDD1624  [7]
 LDCM0421  CL32 HCT 116 C603(1.09)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C603(0.91)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C603(1.22)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C603(1.14)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C603(1.05)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C603(0.99)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C603(1.17)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C603(1.23)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C603(1.01)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C603(0.94)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C603(1.12)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C603(1.07)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C603(1.07)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C603(1.08)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C603(1.91)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C603(1.98)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C603(1.63)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C603(1.09)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C603(1.05)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C603(1.23)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C603(1.08)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C603(1.36)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C603(1.46)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C603(1.14)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C603(0.82)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C603(1.28)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C603(1.67)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C603(1.25)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C603(1.28)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C603(0.99)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C603(1.37)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C163(1.10)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C163(1.11)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C163(0.94); C603(0.88)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C163(0.81)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C163(0.90)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C163(0.91)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C163(0.96)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C163(0.93)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C163(0.88)  LDD1664  [7]
 LDCM0462  CL7 HCT 116 C603(1.04)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C163(0.82); C603(1.10)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C163(1.25)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C163(1.29)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C163(1.08)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C163(0.99)  LDD1670  [7]
 LDCM0469  CL76 HCT 116 C603(1.08)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C603(1.34)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C603(0.96)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C603(1.18)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C603(0.95)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C603(1.40)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C603(1.24)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C603(1.34)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C603(1.33)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C603(1.24)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C603(1.04)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C603(0.97)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C603(1.11)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C603(1.10)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C603(1.38)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C603(1.07)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C603(0.92)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C603(1.24)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C603(1.11)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C603(1.04)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C603(1.10)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C603(0.97)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C603(1.01)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C603(0.98)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C603(1.23)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C603(1.21)  LDD0811  [3]
 LDCM0634  CY-0357 Hep-G2 C603(50.00)  LDD2228  [6]
 LDCM0495  E2913 HEK-293T C163(0.81); C603(1.17)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C163(0.98); C603(1.00)  LDD1671  [7]
 LDCM0427  Fragment51 HCT 116 C603(1.12)  LDD0744  [3]
 LDCM0179  JZ128 PC-3 C695(0.00); C688(0.00)  LDD0462  [2]
 LDCM0022  KB02 HEK-293T C163(1.01)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C163(0.96)  LDD1497  [7]
 LDCM0024  KB05 COLO792 C603(1.58)  LDD3310  [8]
 LDCM0021  THZ1 HCT 116 C603(1.20)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell division cycle protein 27 homolog (CDC27) APC3/CDC27 family P30260
Phosphoserine aminotransferase (PSAT1) Class-V pyridoxal-phosphate-dependent aminotransferase family Q9Y617
Deoxyribonuclease-1-like 1 (DNASE1L1) DNase I family P49184
E3 SUMO-protein ligase PIAS4 (PIAS4) PIAS family Q8N2W9
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) PPP phosphatase family P62136
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) AGC Ser/Thr protein kinase family P17612
Serine/threonine-protein kinase D1 (PRKD1) CAMK Ser/Thr protein kinase family Q15139
TGF-beta receptor type-2 (TGFBR2) TKL Ser/Thr protein kinase family P37173
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Fibroblast growth factor receptor 1 (FGFR1) Tyr protein kinase family P11362
Proto-oncogene tyrosine-protein kinase Src (SRC) Tyr protein kinase family P12931
Tensin-3 (TNS3) PTEN phosphatase protein family Q68CZ2
Tryptophan 2,3-dioxygenase (TDO2) Tryptophan 2,3-dioxygenase family P48775
Protein MFI (MFI) . Q8NCR3
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) Mitochondrial carrier (TC 2.A.29) family Q02978
Cadherin-1 (CDH1) . P12830
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myoneurin (MYNN) Krueppel C2H2-type zinc-finger protein family Q9NPC7
THAP domain-containing protein 7 (THAP7) . Q9BT49
Zinc fingers and homeoboxes protein 1, isoform 2 (ZHX1-C8orf76) . Q96EF9
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Epithelial cell adhesion molecule (EPCAM) EPCAM family P16422
NXPE family member 1 (NXPE1) NXPE family Q8N323
Serpin H1 (SERPINH1) Serpin family P50454
Targeting protein for Xklp2 (TPX2) TPX2 family Q9ULW0
Catenin alpha-1 (CTNNA1) Vinculin/alpha-catenin family P35221
POC1 centriolar protein homolog A (POC1A) WD repeat POC1 family Q8NBT0
LIM domain and actin-binding protein 1 (LIMA1) . Q9UHB6
Melanoma-associated antigen 2 (MAGEA2; MAGEA2B) . P43356
Mitochondrial antiviral-signaling protein (MAVS) . Q7Z434
PML-RARA-regulated adapter molecule 1 (PRAM1) . Q96QH2
Protein ECT2 (ECT2) . Q9H8V3

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840