Details of the Target

General Information of Target

Target ID LDTP09948
Target Name Peroxisomal membrane protein PEX13 (PEX13)
Gene Name PEX13
Gene ID 5194
Synonyms
Peroxisomal membrane protein PEX13; Peroxin-13
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEGSRGGPTCSGVGGRQDPVSGSGGCNFPEYELPELNTRAFHVGAFGELWRGRLRGAGD
LSLREPPASALPGSQAADSDREDAAVARDLDCSLEAAAELRAVCGLDKLKCLEDGEDPEV
IPENTDLVTLGVRKRFLEHREETITIDRACRQETFVYEMESHAIGKKPENSADMIEEGEL
ILSVNILYPVIFHKHKEHKPYQTMLVLGSQKLTQLRDSIRCVSDLQIGGEFSNTPDQAPE
HISKDLYKSAFFYFEGTFYNDKRYPECRDLSRTIIEWSESHDRGYGKFQTARMEDFTFND
LCIKLGFPYLYCHQGDCEHVIVITDIRLVHHDDCLDRTLYPLLIKKHWLWTRKCFVCKMY
TARWVTNNDSFAPEDPCFFCDVCFRMLHYDSEGNKLGEFLAYPYVDPGTFN
Target Bioclass
Transporter and channel
Family
Peroxin-13 family
Subcellular location
Peroxisome membrane
Function
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Involved in the import of PTS1- and PTS2-type containing proteins.
Uniprot ID
Q92968
Ensemble ID
ENST00000295030.6
HGNC ID
HGNC:8855

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [2]
AHL-Pu-1
 Probe Info  		C220(2.20)  LDD0170  [3]
IA-alkyne
 Probe Info  		C220(20.00)  LDD1709  [4]
DBIA
 Probe Info  		C220(1.01)  LDD1512  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C289
 Probe Info  		35.02  LDD1959  [7]
VE-P
 Probe Info  		N.A.  LDD0396  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C220(2.20)  LDD0170  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C220(4.07)  LDD0171  [3]
 LDCM0259  AC14 HEK-293T C220(1.01)  LDD1512  [5]
 LDCM0282  AC22 HEK-293T C220(1.47)  LDD1521  [5]
 LDCM0291  AC30 HEK-293T C220(1.24)  LDD1530  [5]
 LDCM0299  AC38 HEK-293T C220(0.93)  LDD1538  [5]
 LDCM0308  AC46 HEK-293T C220(1.04)  LDD1547  [5]
 LDCM0317  AC54 HEK-293T C220(1.11)  LDD1556  [5]
 LDCM0323  AC6 HEK-293T C220(1.01)  LDD1562  [5]
 LDCM0326  AC62 HEK-293T C220(1.01)  LDD1565  [5]
 LDCM0368  CL10 HEK-293T C220(1.42)  LDD1572  [5]
 LDCM0410  CL22 HEK-293T C220(1.36)  LDD1614  [5]
 LDCM0423  CL34 HEK-293T C220(1.15)  LDD1627  [5]
 LDCM0436  CL46 HEK-293T C220(0.93)  LDD1640  [5]
 LDCM0449  CL58 HEK-293T C220(1.10)  LDD1652  [5]
 LDCM0463  CL70 HEK-293T C220(1.54)  LDD1666  [5]
 LDCM0476  CL82 HEK-293T C220(1.17)  LDD1679  [5]
 LDCM0489  CL94 HEK-293T C220(0.88)  LDD1692  [5]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [2]
 LDCM0024  KB05 T cell C220(20.00)  LDD1709  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal biogenesis factor 19 (PEX19) Peroxin-19 family P40855
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 19 kDa (CEP19) CEP19 family Q96LK0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.