Details of the Target

General Information of Target

Target ID LDTP04159
Target Name Sodium- and chloride-dependent GABA transporter 3 (SLC6A11)
Gene Name SLC6A11
Gene ID 6538
Synonyms
GABT3; GAT3; Sodium- and chloride-dependent GABA transporter 3; GAT-3; Solute carrier family 6 member 11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFV
LSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGIT
CWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENC
VEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICY
FCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWV
DAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMA
YEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVT
AVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVA
IFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKY
NNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKL
GVSPRMVTVNDCDAKLKSDGTIAAITEKETHF
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A11 subfamily
Subcellular location
Cell membrane
Function Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA). Can also mediate transport of beta-alanine and to a lower extent that of taurine and hypotaurine.
TTD ID
T38200
Uniprot ID
P48066
DrugMap ID
TTHVBOC
Ensemble ID
ENST00000254488.7
HGNC ID
HGNC:11044
ChEMBL ID
CHEMBL5208

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.D44G .
IM95 SNV: p.H38R .
MFE319 SNV: p.C242Y; p.E280D .
MOLT4 SNV: p.P547T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C28(0.00); C612(0.00)  LDD0241  [1]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [2]
DBIA
 Probe Info  		C612(1.82)  LDD0080  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
VSF
 Probe Info  		N.A.  LDD0007  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
W1
 Probe Info  		N.A.  LDD0236  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C612(1.19)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C612(0.92); C28(0.97)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C612(1.21)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C28(0.99)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C612(0.99); C28(0.92)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C612(0.93); C28(1.01)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C612(0.72)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C612(0.93); C28(0.88)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C612(1.37)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C612(1.07); C28(1.11)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C28(1.17)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C28(1.16)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C612(0.87); C28(0.84)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C612(0.84); C28(0.57)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C612(0.84); C28(0.88)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C612(0.80)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C612(0.93); C28(0.93)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C612(0.93)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C28(1.40)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C28(1.02)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C612(1.33)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C612(0.90); C28(1.00)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C612(0.97); C28(0.82)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C612(0.93); C28(0.87)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C612(1.17)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C612(0.99); C28(0.92)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C612(0.82)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C28(1.21)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C28(0.97)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C612(0.94); C28(1.11)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C612(0.93); C28(0.87)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C28(1.63)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C612(0.84); C28(0.90)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C612(1.06)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C612(1.00); C28(1.13)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C612(1.00)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C28(1.33)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C28(1.04)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C612(0.99); C28(0.83)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C612(0.93); C28(0.84)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C612(0.85); C28(1.11)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C612(0.81)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C28(0.69)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C612(0.97); C28(0.92)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C612(1.17)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C28(0.98)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C28(1.02)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C612(0.96); C28(0.99)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C612(1.14); C28(0.84)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C612(0.93); C28(0.92)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C612(1.02)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C612(0.84); C28(1.13)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C612(0.94)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C612(0.87); C28(0.92)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C28(1.23)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C28(0.84)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C612(0.97); C28(1.03)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C612(0.98); C28(0.97)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C612(0.93); C28(0.97)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C612(0.94); C28(0.71)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C612(1.07); C28(1.05)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C28(0.84)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C612(0.99)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C612(0.92); C28(0.93)  LDD1514  [8]
 LDCM0367  CL1 HEK-293T C612(0.73); C28(0.59)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C612(1.06); C28(1.32)  LDD1572  [8]
 LDCM0370  CL101 HEK-293T C612(1.02); C28(0.91)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C612(1.05); C28(0.95)  LDD1575  [8]
 LDCM0374  CL105 HEK-293T C612(1.05); C28(0.71)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C612(0.92); C28(0.79)  LDD1579  [8]
 LDCM0378  CL109 HEK-293T C612(1.00); C28(0.91)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C612(1.13); C28(0.86)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C612(0.92); C28(1.10)  LDD1584  [8]
 LDCM0383  CL113 HEK-293T C612(1.31); C28(0.70)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C612(0.94); C28(0.91)  LDD1588  [8]
 LDCM0387  CL117 HEK-293T C612(1.26); C28(0.74)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C612(0.99); C28(0.95)  LDD1592  [8]
 LDCM0390  CL12 HEK-293T C612(0.98); C28(1.31)  LDD1594  [8]
 LDCM0392  CL121 HEK-293T C612(1.11); C28(0.77)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C612(0.98); C28(0.76)  LDD1597  [8]
 LDCM0396  CL125 HEK-293T C612(0.97); C28(0.62)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C612(1.11); C28(0.93)  LDD1601  [8]
 LDCM0400  CL13 HEK-293T C612(1.37); C28(1.09)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C612(1.05); C28(1.20)  LDD1605  [8]
 LDCM0404  CL17 HEK-293T C612(0.86)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C612(0.94); C28(1.21)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C612(0.97)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C612(1.06); C28(1.06)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C28(1.22)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C28(1.03)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C612(1.01); C28(1.34)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C612(1.07); C28(0.85)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C612(0.92); C28(1.11)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C612(0.98); C28(0.93)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C612(0.86); C28(1.15)  LDD1618  [8]
 LDCM0417  CL29 HEK-293T C612(0.84)  LDD1621  [8]
 LDCM0419  CL30 HEK-293T C612(0.98); C28(1.04)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C612(1.26)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C28(1.08)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C28(0.91)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C612(1.04); C28(1.19)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C612(0.80); C28(0.78)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C612(0.86); C28(1.27)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C612(1.00); C28(0.94)  LDD1630  [8]
 LDCM0431  CL41 HEK-293T C612(0.96)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C612(1.01); C28(0.97)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C612(0.93)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C28(1.11)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C28(0.97)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C612(0.99); C28(1.40)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C612(0.99); C28(0.88)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C612(0.84); C28(1.15)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C612(0.97); C28(0.87)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C612(1.01)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C612(1.02); C28(1.17)  LDD1645  [8]
 LDCM0444  CL53 HEK-293T C612(1.27)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C612(1.23); C28(0.95)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C612(1.16)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C28(1.14)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C28(0.99)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C612(1.06); C28(1.25)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C612(1.11); C28(0.75)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C612(1.09); C28(1.05)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C612(0.79); C28(1.23)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C612(1.13); C28(0.88)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C612(1.05); C28(0.93)  LDD1657  [8]
 LDCM0457  CL65 HEK-293T C612(1.09)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C612(1.13); C28(0.96)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C612(0.87)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C28(0.98)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C28(1.06)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C612(1.03)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C612(1.06); C28(1.25)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C612(1.21); C28(0.84)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C612(0.99); C28(1.24)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C612(0.97); C28(0.67)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C612(0.99); C28(0.85)  LDD1670  [8]
 LDCM0470  CL77 HEK-293T C612(0.85)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C612(0.92); C28(0.97)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C612(1.24)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C28(1.32)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C28(1.05)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C28(0.97)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C612(0.89); C28(1.13)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C612(1.08); C28(0.89)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C612(0.86); C28(1.10)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C612(0.91); C28(0.81)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C612(1.04); C28(0.87)  LDD1683  [8]
 LDCM0483  CL89 HEK-293T C612(0.97)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C28(1.17)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C612(0.94); C28(0.93)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C612(1.08)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C28(1.18)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C28(0.98)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C612(0.96); C28(1.24)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C612(1.22); C28(0.86)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C612(0.83); C28(0.91)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C612(1.07); C28(1.09)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C612(0.93); C28(0.99)  LDD1696  [8]
 LDCM0427  Fragment51 HEK-293T C612(0.97); C28(1.05)  LDD1631  [8]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [2]
 LDCM0022  KB02 HCT 116 C612(1.82)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C612(1.33)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C612(1.39)  LDD0082  [3]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Guvacine Small molecular drug DB08848
Snap-5114 Small molecular drug D0H7WK

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402