Details of the Target

General Information of Target

Target ID LDTP06119
Target Name Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3)
Gene Name GALNT3
Gene ID 2591
Synonyms
Polypeptide N-acetylgalactosaminyltransferase 3; EC 2.4.1.41; Polypeptide GalNAc transferase 3; GalNAc-T3; pp-GaNTase 3; Protein-UDP acetylgalactosaminyltransferase 3; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAHLKRLVKLHIKRHYHKKFWKLGAVIFFFIIVLVLMQREVSVQYSKEESRMERNMKNKN
KMLDLMLEAVNNIKDAMPKMQIGAPVRQNIDAGERPCLQGYYTAAELKPVLDRPPQDSNA
PGASGKAFKTTNLSVEEQKEKERGEAKHCFNAFASDRISLHRDLGPDTRPPECIEQKFKR
CPPLPTTSVIIVFHNEAWSTLLRTVHSVLYSSPAILLKEIILVDDASVDEYLHDKLDEYV
KQFSIVKIVRQRERKGLITARLLGATVATAETLTFLDAHCECFYGWLEPLLARIAENYTA
VVSPDIASIDLNTFEFNKPSPYGSNHNRGNFDWSLSFGWESLPDHEKQRRKDETYPIKTP
TFAGGLFSISKEYFEYIGSYDEEMEIWGGENIEMSFRVWQCGGQLEIMPCSVVGHVFRSK
SPHSFPKGTQVIARNQVRLAEVWMDEYKEIFYRRNTDAAKIVKQKAFGDLSKRFEIKHRL
QCKNFTWYLNNIYPEVYVPDLNPVISGYIKSVGQPLCLDVGENNQGGKPLIMYTCHGLGG
NQYFEYSAQHEIRHNIQKELCLHAAQGLVQLKACTYKGHKTVVTGEQIWEIQKDQLLYNP
FLKMCLSANGEHPSLVSCNPSDPLQKWILSQND
Target Bioclass
Enzyme
Family
Glycosyltransferase 2 family, GalNAc-T subfamily
Subcellular location
Golgi apparatus, Golgi stack membrane
Function
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, MUC2, MUC1A and MUC5AC. Probably glycosylates fibronectin in vivo. Glycosylates FGF23.
Uniprot ID
Q14435
Ensemble ID
ENST00000392701.8
HGNC ID
HGNC:4125
ChEMBL ID
CHEMBL4523291

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.L480H; p.G527D .
MEWO SNV: p.S368F DBIA    Probe Info 
MFE296 Deletion: p.P321del .
SBC5 Insertion: p.I215NfsTer11 DBIA    Probe Info 
TC71 SNV: p.G256C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
JZ128-DTB
 Probe Info  		C149(0.00); C173(0.00)  LDD0462  [1]
DBIA
 Probe Info  		C149(0.98)  LDD0531  [2]
IA-alkyne
 Probe Info  		C97(0.00); C173(0.00); C561(0.00); C149(0.00)  LDD0162  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
NAIA_5
 Probe Info  		C574(0.00); C181(0.00); C561(0.00); C149(0.00)  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C149(0.98)  LDD0531  [2]
 LDCM0216  AC100 HCT 116 C149(0.78)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C149(1.03)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C149(1.03)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C149(0.99)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C149(0.97)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C149(1.02)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C149(0.97)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C149(0.81)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C149(0.80)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C149(0.93)  LDD0542  [2]
 LDCM0227  AC110 HCT 116 C149(0.99)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C149(1.17)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C149(0.93)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C149(0.91)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C149(0.85)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C149(1.16)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C149(0.79)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C149(0.80)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C149(0.92)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C149(0.79)  LDD0553  [2]
 LDCM0238  AC120 HCT 116 C149(1.25)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C149(0.93)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C149(0.85)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C149(0.97)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C149(0.91)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C149(1.11)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C149(1.14)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C149(0.78)  LDD0562  [2]
 LDCM0276  AC17 HCT 116 C149(0.87)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C149(0.93)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C149(0.88)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C149(0.89)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C149(0.87)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C149(0.89)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C149(0.79)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C149(0.90)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C149(0.78)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C149(0.83)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C149(0.78)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C149(0.86)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C149(0.67)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C149(1.06)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C149(0.83)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C149(0.98)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C149(0.94)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C149(0.81)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C149(1.19)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C149(1.52)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C149(0.79)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C149(0.81)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C149(0.85)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C149(0.99)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C149(0.83)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C149(0.94)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C149(0.81)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C149(0.75)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C149(0.87)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C149(0.94)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C149(0.84)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C149(0.83)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C149(0.84)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C149(0.68)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C149(1.03)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C149(0.90)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C149(0.95)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C149(0.94)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C149(0.88)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C149(0.96)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C149(0.70)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C149(0.90)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C149(0.69)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C149(0.78)  LDD0636  [2]
 LDCM0332  AC68 HCT 116 C149(1.28)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C149(1.18)  LDD0650  [2]
 LDCM0335  AC70 HCT 116 C149(0.80)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C149(1.17)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C149(0.77)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C149(0.80)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C149(1.19)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C149(0.82)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C149(0.94)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C149(1.00)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C149(0.99)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C149(0.87)  LDD0661  [2]
 LDCM0346  AC80 HCT 116 C149(1.09)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C149(0.96)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C149(1.07)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C149(0.94)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C149(1.11)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C149(0.97)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C149(0.97)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C149(0.89)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C149(0.89)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C149(0.92)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C149(0.82)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C149(0.81)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C149(0.72)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C149(0.90)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C149(0.78)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C149(0.75)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C149(0.80)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C149(0.81)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C149(1.03)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C149(0.87)  LDD0683  [2]
 LDCM0367  CL1 HCT 116 C149(0.74)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C149(0.87)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C149(0.95)  LDD0686  [2]
 LDCM0374  CL105 HCT 116 C149(1.00)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C149(0.91)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C149(0.87)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C149(1.08)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C149(0.62)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C149(0.83)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C149(0.79)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C149(0.84)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C149(1.10)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C149(1.30)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C149(1.39)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C149(1.30)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C149(1.25)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C149(0.93)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C149(0.81)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C149(0.71)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C149(1.02)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C149(0.79)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C149(1.08)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C149(1.02)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C149(0.79)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C149(0.84)  LDD0712  [2]
 LDCM0400  CL13 HCT 116 C149(0.86)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C149(0.97)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C149(0.69)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C149(1.00)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C149(0.79)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C149(0.78)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C149(0.82)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C149(0.99)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C149(0.77)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C149(0.71)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C149(1.51)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C149(0.90)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C149(1.00)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C149(0.86)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C149(0.93)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C149(0.89)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C149(0.73)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C149(0.90)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C149(1.19)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C149(0.72)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C149(0.86)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C149(0.84)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C149(0.94)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C149(1.01)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C149(0.98)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C149(1.05)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C149(0.98)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C149(0.96)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C149(0.80)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C149(0.99)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C149(1.01)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C149(1.01)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C149(0.96)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C149(0.88)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C149(0.86)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C149(0.74)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C149(0.86)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C149(0.97)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C149(0.78)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C149(0.76)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C149(0.93)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C149(0.80)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C149(0.80)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C149(1.06)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C149(0.86)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C149(0.82)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C149(0.81)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C149(0.91)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C149(0.78)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C149(0.83)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C149(0.67)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C149(0.81)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C149(1.07)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C149(1.12)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C149(1.52)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C149(0.94)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C149(1.25)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C149(1.28)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C149(1.59)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C149(3.38)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C149(1.47)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C149(0.63)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C149(1.34)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C149(1.30)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C149(1.62)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C149(1.69)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C149(1.60)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C149(0.86)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C149(1.04)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C149(1.00)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C149(1.00)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C149(0.83)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C149(1.08)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C149(0.89)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C149(0.79)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C149(0.85)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C149(0.89)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C149(0.86)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C149(1.05)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C149(0.78)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C149(0.82)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C149(0.89)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C149(0.66)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C149(0.89)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C149(0.82)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C149(0.91)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C149(0.79)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C149(0.94)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C149(0.85)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C149(0.95)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C149(0.98)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C149(0.88)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C149(0.86)  LDD0811  [2]
 LDCM0468  Fragment33 HCT 116 C149(1.42)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C149(0.92)  LDD0744  [2]
 LDCM0179  JZ128 PC-3 C149(0.00); C173(0.00)  LDD0462  [1]
 LDCM0022  KB02 A2780 C561(1.66)  LDD2254  [6]
 LDCM0023  KB03 A2780 C561(1.98)  LDD2671  [6]
 LDCM0024  KB05 COLO792 C561(1.47)  LDD3310  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid protein-binding protein 2 (APPBP2) . Q92624

References

1 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840