Details of the Target

General Information of Target

Target ID LDTP01570
Target Name Tripartite motif-containing protein 16 (TRIM16)
Gene Name TRIM16
Gene ID 10626
Synonyms
EBBP; Tripartite motif-containing protein 16; EC 2.3.2.27; E3 ubiquitin-protein ligase TRIM16; Estrogen-responsive B box protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAELDLMAPGPLPRATAQPPAPLSPDSGSPSPDSGSASPVEEEDVGSSEKLGRETEEQDS
DSAEQGDPAGEGKEVLCDFCLDDTRRVKAVKSCLTCMVNYCEEHLQPHQVNIKLQSHLLT
EPVKDHNWRYCPAHHSPLSAFCCPDQQCICQDCCQEHSGHTIVSLDAARRDKEAELQCTQ
LDLERKLKLNENAISRLQANQKSVLVSVSEVKAVAEMQFGELLAAVRKAQANVMLFLEEK
EQAALSQANGIKAHLEYRSAEMEKSKQELERMAAISNTVQFLEEYCKFKNTEDITFPSVY
VGLKDKLSGIRKVITESTVHLIQLLENYKKKLQEFSKEEEYDIRTQVSAVVQRKYWTSKP
EPSTREQFLQYAYDITFDPDTAHKYLRLQEENRKVTNTTPWEHPYPDLPSRFLHWRQVLS
QQSLYLHRYYFEVEIFGAGTYVGLTCKGIDRKGEERNSCISGNNFSWSLQWNGKEFTAWY
SDMETPLKAGPFRRLGVYIDFPGGILSFYGVEYDTMTLVHKFACKFSEPVYAAFWLSKKE
NAIRIVDLGEEPEKPAPSLVGTAP
Target Bioclass
Enzyme
Family
TRIM/RBCC family
Subcellular location
Cytoplasm
Function
E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage.
Uniprot ID
O95361
Ensemble ID
ENST00000336708.11
HGNC ID
HGNC:17241

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MDAMB468 SNV: p.H117P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K331(1.82); K354(5.26); K394(0.10)  LDD0277  [1]
Probe 1
 Probe Info  		Y341(112.01)  LDD3495  [2]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [3]
DBIA
 Probe Info  		C459(0.73)  LDD0532  [4]
m-APA
 Probe Info  		N.A.  LDD2231  [5]
IA-alkyne
 Probe Info  		C77(0.00); C178(0.00); C286(0.00)  LDD0162  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
WYneO
 Probe Info  		N.A.  LDD0022  [7]
IPM
 Probe Info  		N.A.  LDD0147  [8]
TFBX
 Probe Info  		C286(0.00); C178(0.00)  LDD0148  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
Methacrolein
 Probe Info  		N.A.  LDD0218  [9]
NAIA_5
 Probe Info  		C178(0.00); C286(0.00)  LDD2223  [10]
HHS-465
 Probe Info  		N.A.  LDD2240  [11]
HHS-482
 Probe Info  		Y341(1.27); Y355(1.51); Y371(1.33)  LDD2239  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C459(0.73)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C459(2.86)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C459(0.61)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C459(0.66)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C459(0.59)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C459(0.48)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C459(0.47)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C459(0.52)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C459(0.48)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C459(0.52)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C459(0.88)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C459(0.79)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C459(0.54)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C459(0.61)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C459(0.62)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C178(1.08); C286(0.81)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C178(0.94); C286(0.98)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C178(1.02); C286(0.97)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C178(1.03); C286(1.11)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C178(1.11); C286(1.09)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C178(1.15); C286(1.12)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C178(0.89); C286(1.03)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C459(0.89)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C178(0.94); C286(1.03)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C178(0.86); C286(0.97)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C178(0.73); C286(0.98)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C178(1.12); C286(0.88)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C178(0.80); C286(0.85)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C178(0.71); C286(0.92)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C178(0.70); C286(0.89)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C178(0.83); C286(0.97)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C178(0.74)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C178(0.87)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C178(0.91)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C178(0.96)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C178(0.96)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C178(0.84)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C178(0.97)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C178(0.84)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C178(0.94)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C178(1.03)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C178(1.05)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C178(1.07)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C459(0.97)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C178(1.17)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C178(1.00)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C178(1.12)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C286(1.06)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C286(1.04)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C286(1.16)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C286(1.14)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C286(1.25)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C286(1.41)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C286(1.08)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C459(0.80)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C286(0.97)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C286(1.02)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C286(1.08)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C286(1.28)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C286(0.98)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C286(0.88)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C286(0.89)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C286(0.90)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C286(1.22)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C286(1.01)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C286(1.04)  LDD0595  [4]
 LDCM0280  AC20 HCT 116 C286(1.16)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C286(0.98)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C286(0.99)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C286(0.94)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C286(0.93)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C286(0.77)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C286(1.01)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C286(1.07)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C286(0.96)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C286(1.02)  LDD0606  [4]
 LDCM0291  AC30 HCT 116 C286(1.02)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C286(1.07)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C286(0.97)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C286(0.89)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C286(1.36)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C286(0.67); C178(0.80)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C178(1.00); C286(1.35)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C178(0.69); C286(0.88)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C286(0.84); C178(1.09)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C286(1.07); C178(1.12)  LDD0617  [4]
 LDCM0302  AC40 HCT 116 C178(0.85); C286(1.04)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C286(0.80); C178(0.83)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C178(0.94); C286(1.01)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C286(0.93); C178(1.08)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C178(0.77); C286(0.85)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C178(0.77); C286(1.24)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C459(1.06)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C459(0.81)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C459(2.03)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C459(0.39)  LDD0628  [4]
 LDCM0313  AC50 HCT 116 C459(0.58)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C459(1.21)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C459(0.76)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C459(0.53)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C459(0.80)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C459(0.44)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C459(0.30)  LDD0636  [4]
 LDCM0323  AC6 HCT 116 C459(0.92)  LDD0640  [4]
 LDCM0334  AC7 HCT 116 C459(0.94)  LDD0651  [4]
 LDCM0345  AC8 HCT 116 C459(0.78)  LDD0662  [4]
 LDCM0349  AC83 HCT 116 C459(0.47)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C459(0.48)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C459(0.73)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C459(0.61)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C459(1.10)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C459(0.59)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C459(0.54)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C459(0.99)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C459(0.36)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C459(0.41)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C459(0.67)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C459(0.74)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C459(1.20)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C459(0.58)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C459(0.53)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C459(0.14)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C459(0.47)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C459(1.01)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C459(0.85)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C459(0.55)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C101(1.29); C93(1.29); C96(1.29); C77(1.35)  LDD2171  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0632  CL-Sc Hep-G2 C178(1.51); C178(0.71)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C286(1.06)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C286(1.01)  LDD0685  [4]
 LDCM0370  CL101 HCT 116 C459(0.86)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C459(1.09)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C459(1.05)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C459(0.92)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C286(0.95)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C286(1.08)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C286(1.07)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C286(1.25)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C286(1.05)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C286(0.94)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C286(1.05)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C286(1.14)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C286(0.86)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C286(0.78)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C286(0.66)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C286(0.82)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C286(1.14)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C178(1.12); C286(1.15)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C286(0.97); C178(1.10)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C178(1.01); C286(1.19)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C286(1.03)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C286(0.95); C178(1.08)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C459(0.93)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C459(0.87)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C459(0.58)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C459(0.50)  LDD0712  [4]
 LDCM0400  CL13 HCT 116 C286(0.98)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C286(1.12)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C286(0.97)  LDD0719  [4]
 LDCM0407  CL2 HCT 116 C286(1.50)  LDD0724  [4]
 LDCM0418  CL3 HCT 116 C286(1.00)  LDD0735  [4]
 LDCM0429  CL4 HCT 116 C286(1.02)  LDD0746  [4]
 LDCM0440  CL5 HCT 116 C286(0.96)  LDD0757  [4]
 LDCM0451  CL6 HCT 116 C286(0.88)  LDD0768  [4]
 LDCM0453  CL61 HCT 116 C178(1.02)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C178(0.87)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C178(1.21)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C178(1.13)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C178(0.94)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C178(1.24)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C178(0.97)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C178(1.20)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C178(0.98)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C286(1.02)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C178(1.23)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C178(1.05)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C178(0.99)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C178(1.02)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C178(1.06)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C178(0.82)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C178(0.78)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C178(0.86)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C178(0.88)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C286(0.95)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C178(0.87)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C178(0.99)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C178(1.02)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C178(1.14)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C178(0.93)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C178(1.07)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C178(0.85)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C178(1.12)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C178(1.13)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C178(0.81)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C286(1.01)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C178(0.86)  LDD0802  [4]
 LDCM0634  CY-0357 Hep-G2 C178(0.38)  LDD2228  [10]
 LDCM0468  Fragment33 HCT 116 C178(1.05)  LDD0785  [4]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [3]
 LDCM0022  KB02 42-MG-BA C459(1.29)  LDD2244  [13]
 LDCM0023  KB03 A2058 C459(2.45)  LDD2670  [13]
 LDCM0024  KB05 Hs 936.T C459(1.68)  LDD3313  [13]
 LDCM0021  THZ1 HCT 116 C101(1.29); C93(1.29); C96(1.29); C77(1.35)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor E2F1 (E2F1) E2F/DP family Q01094
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vimentin (VIM) Intermediate filament family P08670
TERF1-interacting nuclear factor 2 (TINF2) . Q9BSI4

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840