Details of the Target

General Information of Target

Target ID	LDTP15152
Target Name	Myelin protein zero-like protein 3 (MPZL3)
Gene Name	MPZL3
Gene ID	196264
Synonyms	Myelin protein zero-like protein 3
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MAVSVLRLTVVLGLLVLFLTCYADDKPDKPDDKPDDSGKDPKPDFPKFLSLLGTEIIENA VEFILRSMSRSTGFMEFDDNEGKHSSK
Target Bioclass	Immunoglobulin
Family	Myelin P0 protein family
Subcellular location	Membrane
Function	Mediates homophilic cell-cell adhesion.
Uniprot ID	Q6UWV2
Ensemble ID	ENST00000278949.9
HGNC ID	HGNC:27279

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
JURKAT	SNV: p.S74N	.
LS123	Insertion: p.Q85SfsTer55	.
MFE319	SNV: p.A93V	.
MOLT4	SNV: p.G104E	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
JZ128-DTB Probe Info			N.A.	LDD0462	[1]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0179	JZ128	PC-3	N.A.	LDD0462	[1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Immunoglobulin

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Myelin protein zero-like protein 2 (MPZL2)				Myelin P0 protein family	O60487

References

1	A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.