Details of the Target

General Information of Target

Target ID LDTP05746
Target Name COP9 signalosome complex subunit 1 (GPS1)
Gene Name GPS1
Gene ID 2873
Synonyms
COPS1; CSN1; COP9 signalosome complex subunit 1; SGN1; Signalosome subunit 1; G protein pathway suppressor 1; GPS-1; JAB1-containing signalosome subunit 1; Protein MFH
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPLPVQVFNLQGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYSGLMRIERL
QFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRSSLRELQNAPDAIPESG
VEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSN
ALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRGERDS
QTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLCALAT
FDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAP
HVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSH
SKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKSPPREGSQGELTP
ANSQSRMSTNM
Target Bioclass
Other
Family
CSN1 family
Subcellular location
Cytoplasm
Function
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
Uniprot ID
Q13098
Ensemble ID
ENST00000306823.10
HGNC ID
HGNC:4549

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.30  LDD0402  [1]
DBIA
 Probe Info  		C228(5.27); C238(1.87); C67(2.33)  LDD3311  [2]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [3]
BTD
 Probe Info  		C341(2.34)  LDD1700  [4]
AHL-Pu-1
 Probe Info  		C251(6.56); C67(2.07)  LDD0169  [5]
HHS-475
 Probe Info  		Y381(0.69)  LDD0264  [6]
HHS-465
 Probe Info  		Y381(2.67)  LDD2237  [7]
ATP probe
 Probe Info  		K337(0.00); K183(0.00)  LDD0199  [8]
1d-yne
 Probe Info  		N.A.  LDD0358  [9]
CY-1
 Probe Info  		K150(0.00); Y152(0.00)  LDD0246  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C192(0.00); C251(0.00); C175(0.00); C202(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C67(0.00); C251(0.00); C175(0.00)  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C251(0.00); C192(0.00); C175(0.00); C202(0.00)  LDD0037  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
WYneO
 Probe Info  		N.A.  LDD0022  [14]
Compound 10
 Probe Info  		N.A.  LDD2216  [15]
IPM
 Probe Info  		C251(0.00); C67(0.00)  LDD0147  [13]
NHS
 Probe Info  		N.A.  LDD0010  [14]
NPM
 Probe Info  		N.A.  LDD0016  [14]
STPyne
 Probe Info  		N.A.  LDD0009  [14]
VSF
 Probe Info  		N.A.  LDD0007  [14]
1c-yne
 Probe Info  		K76(0.00); K349(0.00); K224(0.00)  LDD0228  [9]
Acrolein
 Probe Info  		C175(0.00); C67(0.00); H95(0.00); C192(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [16]
Methacrolein
 Probe Info  		C67(0.00); C341(0.00)  LDD0218  [16]
W1
 Probe Info  		C175(0.00); C67(0.00)  LDD0236  [17]
NAIA_5
 Probe Info  		C192(0.00); C251(0.00); C341(0.00); C175(0.00)  LDD2223  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C341(0.56); C251(0.51)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C341(0.72)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C192(0.94); C341(1.13); C251(1.36); C67(0.70)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C341(0.95); C251(0.88)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C341(1.54); C251(0.79)  LDD2103  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C341(0.53)  LDD2131  [4]
 LDCM0025  4SU-RNA DM93 C67(3.31)  LDD0170  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C251(6.56); C67(2.07)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C192(0.92); C202(1.02); C175(0.96); C67(0.86)  LDD1507  [19]
 LDCM0215  AC10 HEK-293T C192(1.05); C202(1.01); C175(1.07); C67(0.92)  LDD1508  [19]
 LDCM0226  AC11 HEK-293T C192(0.91); C202(0.94); C175(1.03); C67(0.97)  LDD1509  [19]
 LDCM0237  AC12 HEK-293T C192(0.94); C202(0.96); C175(1.12); C67(0.93)  LDD1510  [19]
 LDCM0259  AC14 HEK-293T C192(1.06); C175(1.03); C67(1.08)  LDD1512  [19]
 LDCM0270  AC15 HEK-293T C192(1.09); C202(1.14); C175(1.17); C67(0.94)  LDD1513  [19]
 LDCM0276  AC17 HEK-293T C192(1.07); C202(0.95); C175(1.07); C67(0.92)  LDD1515  [19]
 LDCM0277  AC18 HEK-293T C192(1.06); C202(1.00); C175(1.02); C67(1.06)  LDD1516  [19]
 LDCM0278  AC19 HEK-293T C192(0.90); C202(0.87); C175(1.15); C67(1.03)  LDD1517  [19]
 LDCM0279  AC2 HEK-293T C192(1.05); C202(1.03); C175(1.23); C67(1.01)  LDD1518  [19]
 LDCM0280  AC20 HEK-293T C192(0.96); C202(0.95); C175(1.19); C67(0.98)  LDD1519  [19]
 LDCM0281  AC21 HEK-293T C192(1.05); C202(1.03); C175(1.09); C67(0.98)  LDD1520  [19]
 LDCM0282  AC22 HEK-293T C192(1.00); C175(1.07); C67(1.25)  LDD1521  [19]
 LDCM0283  AC23 HEK-293T C192(1.04); C202(1.15); C175(1.12); C67(1.11)  LDD1522  [19]
 LDCM0284  AC24 HEK-293T C192(1.04); C175(1.06); C67(1.03)  LDD1523  [19]
 LDCM0285  AC25 HEK-293T C192(1.00); C202(0.94); C175(1.03); C67(0.83)  LDD1524  [19]
 LDCM0286  AC26 HEK-293T C192(1.06); C202(1.00); C175(1.03); C67(0.92)  LDD1525  [19]
 LDCM0287  AC27 HEK-293T C192(1.04); C202(0.94); C175(1.08); C67(1.12)  LDD1526  [19]
 LDCM0288  AC28 HEK-293T C192(0.95); C202(0.99); C175(1.08); C67(1.01)  LDD1527  [19]
 LDCM0289  AC29 HEK-293T C192(1.02); C202(1.08); C175(0.99); C67(0.87)  LDD1528  [19]
 LDCM0290  AC3 HEK-293T C192(0.94); C202(1.01); C175(1.17); C67(0.89)  LDD1529  [19]
 LDCM0291  AC30 HEK-293T C192(1.02); C175(1.06); C67(1.00)  LDD1530  [19]
 LDCM0292  AC31 HEK-293T C192(1.06); C202(1.03); C175(1.07); C67(0.97)  LDD1531  [19]
 LDCM0293  AC32 HEK-293T C192(1.02); C175(1.05); C67(0.98)  LDD1532  [19]
 LDCM0294  AC33 HEK-293T C192(0.93); C202(0.96); C175(1.00); C67(0.88)  LDD1533  [19]
 LDCM0295  AC34 HEK-293T C192(1.10); C202(0.99); C175(1.07); C67(0.95)  LDD1534  [19]
 LDCM0296  AC35 HEK-293T C192(0.92); C202(0.90); C175(1.07); C67(1.12)  LDD1535  [19]
 LDCM0297  AC36 HEK-293T C192(0.92); C202(0.92); C175(0.98); C67(0.88)  LDD1536  [19]
 LDCM0298  AC37 HEK-293T C192(1.02); C202(1.05); C175(0.99); C67(0.90)  LDD1537  [19]
 LDCM0299  AC38 HEK-293T C192(1.04); C175(1.13); C67(1.14)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C192(1.12); C202(1.00); C175(1.05); C67(0.96)  LDD1539  [19]
 LDCM0301  AC4 HEK-293T C192(0.94); C202(0.88); C175(1.11); C67(1.01)  LDD1540  [19]
 LDCM0302  AC40 HEK-293T C192(1.12); C175(1.00); C67(0.96)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C192(0.99); C202(0.87); C175(0.96); C67(0.94)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C192(1.09); C202(0.94); C175(1.10); C67(0.94)  LDD1543  [19]
 LDCM0305  AC43 HEK-293T C192(0.87); C202(0.94); C175(1.12); C67(1.03)  LDD1544  [19]
 LDCM0306  AC44 HEK-293T C192(0.90); C202(0.98); C175(1.03); C67(0.82)  LDD1545  [19]
 LDCM0307  AC45 HEK-293T C192(0.96); C202(0.94); C175(1.05); C67(0.88)  LDD1546  [19]
 LDCM0308  AC46 HEK-293T C192(1.01); C175(1.15); C67(1.18)  LDD1547  [19]
 LDCM0309  AC47 HEK-293T C192(1.06); C202(1.15); C175(0.97); C67(1.00)  LDD1548  [19]
 LDCM0310  AC48 HEK-293T C192(1.14); C175(1.05); C67(0.96)  LDD1549  [19]
 LDCM0311  AC49 HEK-293T C192(0.95); C202(0.91); C175(1.01); C67(0.85)  LDD1550  [19]
 LDCM0312  AC5 HEK-293T C192(1.03); C202(1.00); C175(1.06); C67(0.87)  LDD1551  [19]
 LDCM0313  AC50 HEK-293T C192(1.06); C202(0.94); C175(1.09); C67(1.03)  LDD1552  [19]
 LDCM0314  AC51 HEK-293T C192(0.96); C202(0.98); C175(1.06); C67(1.04)  LDD1553  [19]
 LDCM0315  AC52 HEK-293T C192(0.94); C202(0.93); C175(1.09); C67(0.96)  LDD1554  [19]
 LDCM0316  AC53 HEK-293T C192(0.98); C202(1.06); C175(1.10); C67(0.99)  LDD1555  [19]
 LDCM0317  AC54 HEK-293T C192(0.99); C175(1.01); C67(1.04)  LDD1556  [19]
 LDCM0318  AC55 HEK-293T C192(1.06); C202(1.17); C175(1.07); C67(1.00)  LDD1557  [19]
 LDCM0319  AC56 HEK-293T C192(1.13); C175(1.19); C67(0.95)  LDD1558  [19]
 LDCM0320  AC57 HEK-293T C192(0.95); C202(0.98); C175(0.91); C67(1.00)  LDD1559  [19]
 LDCM0321  AC58 HEK-293T C192(1.12); C202(0.96); C175(1.09); C67(1.03)  LDD1560  [19]
 LDCM0322  AC59 HEK-293T C192(0.91); C202(0.92); C175(1.29); C67(1.06)  LDD1561  [19]
 LDCM0323  AC6 HEK-293T C192(0.97); C175(1.11); C67(0.94)  LDD1562  [19]
 LDCM0324  AC60 HEK-293T C192(0.97); C202(0.98); C175(1.10); C67(0.92)  LDD1563  [19]
 LDCM0325  AC61 HEK-293T C192(0.98); C202(1.05); C175(1.04); C67(0.93)  LDD1564  [19]
 LDCM0326  AC62 HEK-293T C192(1.05); C175(1.05); C67(1.11)  LDD1565  [19]
 LDCM0327  AC63 HEK-293T C192(1.11); C202(1.05); C175(1.02); C67(0.99)  LDD1566  [19]
 LDCM0328  AC64 HEK-293T C192(1.14); C175(1.06); C67(1.00)  LDD1567  [19]
 LDCM0334  AC7 HEK-293T C192(1.06); C202(1.07); C175(1.09); C67(1.02)  LDD1568  [19]
 LDCM0345  AC8 HEK-293T C192(1.16); C175(1.17); C67(0.90)  LDD1569  [19]
 LDCM0545  Acetamide MDA-MB-231 C341(0.54)  LDD2138  [4]
 LDCM0248  AKOS034007472 HEK-293T C192(1.01); C202(1.01); C175(1.04); C67(0.95)  LDD1511  [19]
 LDCM0356  AKOS034007680 HEK-293T C192(1.00); C202(0.92); C175(1.07); C67(0.92)  LDD1570  [19]
 LDCM0275  AKOS034007705 HEK-293T C192(1.01); C175(1.12); C67(0.95)  LDD1514  [19]
 LDCM0498  BS-3668 MDA-MB-231 C341(0.50)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa C67(0.00); C192(0.00)  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C251(20.00); C175(1.07); C251(1.05); C67(0.90)  LDD2227  [18]
 LDCM0367  CL1 HEK-293T C192(1.14); C202(1.04); C175(1.09)  LDD1571  [19]
 LDCM0368  CL10 HEK-293T C192(1.34); C175(1.31); C67(1.09)  LDD1572  [19]
 LDCM0369  CL100 HEK-293T C192(0.92); C202(0.92); C175(1.07); C67(1.02)  LDD1573  [19]
 LDCM0370  CL101 HEK-293T C192(1.07); C202(0.90); C175(1.04)  LDD1574  [19]
 LDCM0371  CL102 HEK-293T C192(0.95); C202(1.02); C175(1.01); C67(0.92)  LDD1575  [19]
 LDCM0372  CL103 HEK-293T C192(1.03); C202(1.00); C175(1.11); C67(0.96)  LDD1576  [19]
 LDCM0373  CL104 HEK-293T C192(1.12); C202(1.02); C175(1.10); C67(1.01)  LDD1577  [19]
 LDCM0374  CL105 HEK-293T C192(1.01); C202(0.90); C175(1.07)  LDD1578  [19]
 LDCM0375  CL106 HEK-293T C192(1.02); C202(1.04); C175(1.01); C67(1.01)  LDD1579  [19]
 LDCM0376  CL107 HEK-293T C192(0.98); C202(1.05); C175(1.07); C67(1.06)  LDD1580  [19]
 LDCM0377  CL108 HEK-293T C192(1.07); C202(0.87); C175(1.13); C67(1.06)  LDD1581  [19]
 LDCM0378  CL109 HEK-293T C192(1.04); C202(1.01); C175(0.96)  LDD1582  [19]
 LDCM0379  CL11 HEK-293T C192(1.16); C202(1.24); C175(1.21); C67(0.94)  LDD1583  [19]
 LDCM0380  CL110 HEK-293T C192(1.06); C202(1.02); C175(1.04); C67(0.96)  LDD1584  [19]
 LDCM0381  CL111 HEK-293T C192(1.02); C202(0.98); C175(1.04); C67(1.00)  LDD1585  [19]
 LDCM0382  CL112 HEK-293T C192(0.96); C202(0.89); C175(1.12); C67(0.91)  LDD1586  [19]
 LDCM0383  CL113 HEK-293T C192(1.08); C202(0.99); C175(0.95)  LDD1587  [19]
 LDCM0384  CL114 HEK-293T C192(1.07); C202(1.04); C175(1.05); C67(0.94)  LDD1588  [19]
 LDCM0385  CL115 HEK-293T C192(1.02); C202(1.03); C175(1.06); C67(0.98)  LDD1589  [19]
 LDCM0386  CL116 HEK-293T C192(0.99); C202(0.92); C175(1.12); C67(0.90)  LDD1590  [19]
 LDCM0387  CL117 HEK-293T C192(1.05); C202(0.99); C175(1.03)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C192(0.97); C202(0.97); C175(1.03); C67(0.89)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C192(1.04); C202(1.08); C175(1.22); C67(0.95)  LDD1593  [19]
 LDCM0390  CL12 HEK-293T C192(1.23); C175(1.23); C67(1.08)  LDD1594  [19]
 LDCM0391  CL120 HEK-293T C192(0.97); C202(1.02); C175(1.12); C67(0.93)  LDD1595  [19]
 LDCM0392  CL121 HEK-293T C192(1.08); C202(0.98); C175(1.06)  LDD1596  [19]
 LDCM0393  CL122 HEK-293T C192(0.98); C202(1.15); C175(1.00); C67(0.96)  LDD1597  [19]
 LDCM0394  CL123 HEK-293T C192(1.20); C202(1.24); C175(1.30); C67(0.92)  LDD1598  [19]
 LDCM0395  CL124 HEK-293T C192(1.00); C202(0.99); C175(1.04); C67(1.05)  LDD1599  [19]
 LDCM0396  CL125 HEK-293T C192(1.07); C202(1.00); C175(1.01)  LDD1600  [19]
 LDCM0397  CL126 HEK-293T C192(1.01); C202(1.03); C175(1.01); C67(1.01)  LDD1601  [19]
 LDCM0398  CL127 HEK-293T C192(1.00); C202(1.08); C175(1.09); C67(1.00)  LDD1602  [19]
 LDCM0399  CL128 HEK-293T C192(1.06); C202(1.03); C175(1.12); C67(0.98)  LDD1603  [19]
 LDCM0400  CL13 HEK-293T C192(0.90); C202(0.92); C175(0.95)  LDD1604  [19]
 LDCM0401  CL14 HEK-293T C192(0.90); C202(1.02); C175(1.03); C67(0.91)  LDD1605  [19]
 LDCM0402  CL15 HEK-293T C192(1.11); C202(1.12); C175(1.11); C67(1.01)  LDD1606  [19]
 LDCM0403  CL16 HEK-293T C192(0.98); C202(0.95); C175(1.16); C67(0.92)  LDD1607  [19]
 LDCM0404  CL17 HEK-293T C192(0.95); C202(1.05); C175(1.11); C67(0.79)  LDD1608  [19]
 LDCM0405  CL18 HEK-293T C192(1.11); C202(1.00); C175(1.00); C67(0.95)  LDD1609  [19]
 LDCM0406  CL19 HEK-293T C192(1.11); C202(1.05); C175(1.07); C67(0.90)  LDD1610  [19]
 LDCM0407  CL2 HEK-293T C192(0.91); C202(1.06); C175(1.00); C67(0.85)  LDD1611  [19]
 LDCM0408  CL20 HEK-293T C192(0.93); C202(1.02); C175(1.20); C67(0.81)  LDD1612  [19]
 LDCM0409  CL21 HEK-293T C192(1.27); C202(1.16); C175(1.12); C67(0.96)  LDD1613  [19]
 LDCM0410  CL22 HEK-293T C192(1.09); C175(1.14); C67(0.99)  LDD1614  [19]
 LDCM0411  CL23 HEK-293T C192(1.13); C202(1.22); C175(1.17); C67(0.91)  LDD1615  [19]
 LDCM0412  CL24 HEK-293T C192(1.19); C175(1.27); C67(1.03)  LDD1616  [19]
 LDCM0413  CL25 HEK-293T C192(1.03); C202(0.98); C175(1.06)  LDD1617  [19]
 LDCM0414  CL26 HEK-293T C192(0.94); C202(1.06); C175(0.91); C67(0.96)  LDD1618  [19]
 LDCM0415  CL27 HEK-293T C192(1.00); C202(1.08); C175(1.09); C67(1.05)  LDD1619  [19]
 LDCM0416  CL28 HEK-293T C192(1.06); C202(0.96); C175(1.08); C67(0.95)  LDD1620  [19]
 LDCM0417  CL29 HEK-293T C192(1.07); C202(1.05); C175(1.00); C67(0.87)  LDD1621  [19]
 LDCM0418  CL3 HEK-293T C192(1.04); C202(1.14); C175(1.23); C67(0.99)  LDD1622  [19]
 LDCM0419  CL30 HEK-293T C192(1.08); C202(1.03); C175(1.13); C67(0.96)  LDD1623  [19]
 LDCM0420  CL31 HEK-293T C192(1.00); C202(0.97); C175(1.05); C67(0.96)  LDD1624  [19]
 LDCM0421  CL32 HEK-293T C192(0.98); C202(1.01); C175(1.26); C67(0.93)  LDD1625  [19]
 LDCM0422  CL33 HEK-293T C192(1.30); C202(1.37); C175(1.26); C67(0.95)  LDD1626  [19]
 LDCM0423  CL34 HEK-293T C192(1.15); C175(1.34); C67(1.32)  LDD1627  [19]
 LDCM0424  CL35 HEK-293T C192(1.18); C202(1.18); C175(1.23); C67(0.98)  LDD1628  [19]
 LDCM0425  CL36 HEK-293T C192(1.28); C175(1.13); C67(1.06)  LDD1629  [19]
 LDCM0426  CL37 HEK-293T C192(1.04); C202(0.97); C175(0.99)  LDD1630  [19]
 LDCM0428  CL39 HEK-293T C192(1.01); C202(1.00); C175(1.15); C67(1.07)  LDD1632  [19]
 LDCM0429  CL4 HEK-293T C192(1.09); C202(1.06); C175(1.20); C67(0.93)  LDD1633  [19]
 LDCM0430  CL40 HEK-293T C192(1.16); C202(0.84); C175(1.05); C67(0.99)  LDD1634  [19]
 LDCM0431  CL41 HEK-293T C192(1.07); C202(1.05); C175(1.02); C67(0.84)  LDD1635  [19]
 LDCM0432  CL42 HEK-293T C192(1.09); C202(1.10); C175(0.97); C67(1.03)  LDD1636  [19]
 LDCM0433  CL43 HEK-293T C192(1.19); C202(0.98); C175(1.18); C67(1.00)  LDD1637  [19]
 LDCM0434  CL44 HEK-293T C192(1.03); C202(0.98); C175(1.10); C67(0.90)  LDD1638  [19]
 LDCM0435  CL45 HEK-293T C192(1.10); C202(1.11); C175(1.23); C67(0.89)  LDD1639  [19]
 LDCM0436  CL46 HEK-293T C192(1.16); C175(1.28); C67(1.13)  LDD1640  [19]
 LDCM0437  CL47 HEK-293T C192(1.10); C202(1.30); C175(1.14); C67(1.01)  LDD1641  [19]
 LDCM0438  CL48 HEK-293T C192(1.20); C175(1.24); C67(1.03)  LDD1642  [19]
 LDCM0439  CL49 HEK-293T C192(1.18); C202(1.10); C175(1.05)  LDD1643  [19]
 LDCM0440  CL5 HEK-293T C192(0.83); C202(0.99); C175(0.99); C67(0.76)  LDD1644  [19]
 LDCM0441  CL50 HEK-293T C192(0.96); C202(1.04); C175(1.07); C67(0.94)  LDD1645  [19]
 LDCM0443  CL52 HEK-293T C192(0.96); C202(0.97); C175(1.09); C67(0.81)  LDD1646  [19]
 LDCM0444  CL53 HEK-293T C192(1.03); C202(1.10); C175(0.98); C67(0.87)  LDD1647  [19]
 LDCM0445  CL54 HEK-293T C192(1.27); C202(1.17); C175(1.37); C67(0.93)  LDD1648  [19]
 LDCM0446  CL55 HEK-293T C192(0.98); C202(0.96); C175(1.25); C67(1.14)  LDD1649  [19]
 LDCM0447  CL56 HEK-293T C192(0.95); C202(1.09); C175(1.16); C67(1.04)  LDD1650  [19]
 LDCM0448  CL57 HEK-293T C192(1.19); C202(1.12); C175(1.05); C67(0.83)  LDD1651  [19]
 LDCM0449  CL58 HEK-293T C192(1.23); C175(1.11); C67(1.08)  LDD1652  [19]
 LDCM0450  CL59 HEK-293T C192(1.26); C202(1.17); C175(1.18); C67(1.01)  LDD1653  [19]
 LDCM0451  CL6 HEK-293T C192(1.16); C202(1.14); C175(1.00); C67(0.94)  LDD1654  [19]
 LDCM0452  CL60 HEK-293T C192(1.27); C175(1.13); C67(0.98)  LDD1655  [19]
 LDCM0453  CL61 HEK-293T C192(1.05); C202(1.01); C175(1.02)  LDD1656  [19]
 LDCM0454  CL62 HEK-293T C192(0.92); C202(1.04); C175(0.97); C67(1.03)  LDD1657  [19]
 LDCM0455  CL63 HEK-293T C192(1.00); C202(1.19); C175(1.18); C67(0.97)  LDD1658  [19]
 LDCM0456  CL64 HEK-293T C192(1.11); C202(1.12); C175(1.04); C67(0.96)  LDD1659  [19]
 LDCM0457  CL65 HEK-293T C192(0.98); C202(1.09); C175(1.06); C67(0.92)  LDD1660  [19]
 LDCM0458  CL66 HEK-293T C192(1.03); C202(1.01); C175(1.09); C67(0.91)  LDD1661  [19]
 LDCM0459  CL67 HEK-293T C192(0.94); C202(0.95); C175(1.27); C67(0.96)  LDD1662  [19]
 LDCM0460  CL68 HEK-293T C192(1.03); C202(1.07); C175(1.19); C67(0.95)  LDD1663  [19]
 LDCM0461  CL69 HEK-293T C192(1.11); C202(1.29); C175(1.19); C67(0.86)  LDD1664  [19]
 LDCM0462  CL7 HEK-293T C192(1.13); C202(1.15); C175(1.07); C67(0.98)  LDD1665  [19]
 LDCM0463  CL70 HEK-293T C192(1.13); C175(1.11); C67(1.01)  LDD1666  [19]
 LDCM0464  CL71 HEK-293T C192(1.19); C202(1.16); C175(1.32); C67(0.98)  LDD1667  [19]
 LDCM0465  CL72 HEK-293T C192(1.13); C175(1.23); C67(1.11)  LDD1668  [19]
 LDCM0466  CL73 HEK-293T C192(1.11); C202(1.05); C175(1.04)  LDD1669  [19]
 LDCM0467  CL74 HEK-293T C192(0.99); C202(1.06); C175(1.01); C67(0.95)  LDD1670  [19]
 LDCM0469  CL76 HEK-293T C192(0.98); C202(1.08); C175(1.00); C67(0.93)  LDD1672  [19]
 LDCM0470  CL77 HEK-293T C192(1.04); C202(0.95); C175(1.06); C67(0.91)  LDD1673  [19]
 LDCM0471  CL78 HEK-293T C192(1.06); C202(1.04); C175(1.09); C67(0.93)  LDD1674  [19]
 LDCM0472  CL79 HEK-293T C192(1.06); C202(0.95); C175(1.09); C67(1.09)  LDD1675  [19]
 LDCM0473  CL8 HEK-293T C192(1.24); C202(1.22); C175(1.47); C67(0.92)  LDD1676  [19]
 LDCM0474  CL80 HEK-293T C192(1.02); C202(1.08); C175(1.17); C67(1.00)  LDD1677  [19]
 LDCM0475  CL81 HEK-293T C192(1.07); C202(1.24); C175(1.05); C67(0.88)  LDD1678  [19]
 LDCM0476  CL82 HEK-293T C192(1.14); C175(1.16); C67(1.20)  LDD1679  [19]
 LDCM0477  CL83 HEK-293T C192(1.18); C202(1.26); C175(1.13); C67(1.01)  LDD1680  [19]
 LDCM0478  CL84 HEK-293T C192(1.29); C175(1.11); C67(0.97)  LDD1681  [19]
 LDCM0479  CL85 HEK-293T C192(1.09); C202(1.06); C175(0.93)  LDD1682  [19]
 LDCM0480  CL86 HEK-293T C192(0.95); C202(1.12); C175(1.11); C67(0.93)  LDD1683  [19]
 LDCM0481  CL87 HEK-293T C192(1.00); C202(1.07); C175(1.20); C67(1.01)  LDD1684  [19]
 LDCM0482  CL88 HEK-293T C192(0.97); C202(1.11); C175(1.11); C67(1.00)  LDD1685  [19]
 LDCM0483  CL89 HEK-293T C192(0.98); C202(0.99); C175(1.00); C67(0.84)  LDD1686  [19]
 LDCM0484  CL9 HEK-293T C192(1.10); C202(1.21); C175(1.20); C67(0.77)  LDD1687  [19]
 LDCM0485  CL90 HEK-293T C192(1.36); C202(1.08); C175(1.56); C67(0.91)  LDD1688  [19]
 LDCM0486  CL91 HEK-293T C192(1.07); C202(1.07); C175(1.27); C67(1.02)  LDD1689  [19]
 LDCM0487  CL92 HEK-293T C192(1.02); C202(1.05); C175(1.30); C67(0.94)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C192(1.18); C202(1.08); C175(1.14); C67(0.86)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C192(1.06); C175(1.11); C67(1.11)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C192(1.33); C202(1.24); C175(1.32); C67(1.07)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C192(1.23); C175(1.10); C67(0.98)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C192(1.03); C202(0.97); C175(1.01)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C192(0.91); C202(1.00); C175(1.12); C67(0.91)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C192(1.03); C202(1.17); C175(1.04); C67(0.99)  LDD1697  [19]
 LDCM0495  E2913 HEK-293T C192(0.95); C202(1.19); C175(1.13); C67(1.00)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C251(2.48); C341(1.29)  LDD1702  [4]
 LDCM0625  F8 Ramos C67(0.69); C251(1.17)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C67(0.45); C192(0.58); C251(1.24)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C67(0.25); C192(20.00); C251(0.97)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C67(0.63); C192(0.36); C251(0.96)  LDD2191  [20]
 LDCM0575  Fragment13 Ramos C67(1.14); C192(0.57); C251(0.90)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C67(0.93); C192(0.90); C251(1.50)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C67(0.46); C192(0.24); C251(1.19)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C67(1.21); C192(0.71); C251(0.77)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C67(0.93); C192(0.57); C251(0.42)  LDD2196  [20]
 LDCM0578  Fragment27 Ramos C67(1.12); C192(0.66); C251(0.87)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C67(0.76); C192(0.73); C251(1.03)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C67(1.24); C251(0.93)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C67(1.95); C251(1.71)  LDD2200  [20]
 LDCM0590  Fragment32 Ramos C67(0.65); C192(0.50); C251(0.51)  LDD2201  [20]
 LDCM0468  Fragment33 HEK-293T C192(0.99); C202(1.19); C175(1.25); C67(1.04)  LDD1671  [19]
 LDCM0596  Fragment38 Ramos C67(0.89); C192(0.57); C251(0.89)  LDD2203  [20]
 LDCM0566  Fragment4 Ramos C67(1.17); C251(1.11)  LDD2184  [20]
 LDCM0427  Fragment51 HEK-293T C192(0.98); C202(1.07); C175(0.98); C67(0.96)  LDD1631  [19]
 LDCM0610  Fragment52 Ramos C67(1.13); C251(1.33)  LDD2204  [20]
 LDCM0614  Fragment56 Ramos C67(1.36); C192(0.97); C251(1.11)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C67(0.40); C192(0.41); C251(0.68)  LDD2186  [20]
 LDCM0571  Fragment9 Ramos C67(0.43); C192(0.36); C251(1.14)  LDD2188  [20]
 LDCM0116  HHS-0101 DM93 Y381(0.69)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y381(1.09)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y381(1.20)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y381(1.27)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y381(1.14)  LDD0268  [6]
 LDCM0107  IAA HeLa H66(0.00); C67(0.00)  LDD0221  [16]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [3]
 LDCM0022  KB02 HEK-293T C192(0.84); C175(1.02)  LDD1492  [19]
 LDCM0023  KB03 HEK-293T C192(0.94); C175(0.90)  LDD1497  [19]
 LDCM0024  KB05 G361 C228(5.27); C238(1.87); C67(2.33)  LDD3311  [2]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C251(1.03)  LDD2102  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C192(1.34)  LDD2121  [4]
 LDCM0109  NEM HeLa H95(0.00); H361(0.00)  LDD0223  [16]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C341(0.62)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C341(1.27)  LDD2090  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C251(1.05)  LDD2093  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C251(0.23)  LDD2096  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C251(1.03)  LDD2097  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C192(0.87); C341(1.20); C251(0.91); C67(1.09)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C341(0.60)  LDD2100  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C341(0.67)  LDD2104  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C192(0.82); C251(0.46)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C192(0.94); C341(0.50); C251(0.62)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C341(0.72); C251(0.52)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C341(0.87)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C251(0.87)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C251(0.53)  LDD2115  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C251(0.41)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C341(0.26); C251(0.48)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C341(1.90); C251(1.69); C67(1.12)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C251(1.03)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C341(0.17)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C192(0.94); C251(0.65); C67(1.22)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C341(0.10); C251(0.29)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C192(0.76); C341(1.00); C251(0.73); C67(0.84)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C251(0.34)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C192(1.45); C251(0.93)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C341(1.07); C251(0.99)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C192(0.99); C341(0.98)  LDD2129  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C251(0.74)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C251(1.31)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C192(1.20); C341(1.21); C251(1.47)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C341(0.96); C251(0.86); C67(1.06)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C341(2.34)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C192(0.73); C341(0.92); C251(0.61)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C341(0.65); C251(0.50)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C341(0.49); C251(1.00)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C192(1.54); C341(1.98)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C251(0.14)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C251(0.84); C67(1.30)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C341(1.05)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C341(0.46)  LDD2148  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C251(0.27)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C341(0.45)  LDD2150  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C251(0.29)  LDD2151  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C341(1.63)  LDD2153  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
COP9 signalosome complex subunit 5 (COPS5) Peptidase M67A family Q92905
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CCR4-NOT transcription complex subunit 2 (CNOT2) CNOT2/3/5 family Q9NZN8
COP9 signalosome complex subunit 2 (COPS2) CSN2 family P61201
COP9 signalosome complex subunit 8 (COPS8) CSN8 family Q99627

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
10 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578