Details of the Target
General Information of Target
| Target ID | LDTP14469 | |||||
|---|---|---|---|---|---|---|
| Target Name | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 (GNG7) | |||||
| Gene Name | GNG7 | |||||
| Gene ID | 2788 | |||||
| Synonyms |
GNGT7; Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 |
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| 3D Structure | ||||||
| Sequence |
MLRMRTAGWARGWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTG
SGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPS QSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERY ELLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGR SSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITD VNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRL DETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKI GRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQ NKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVV EVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDRE QTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGM VTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDP PRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLN YSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVN ESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVM ARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPN GQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQA VQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQMRLHPYITVFG |
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| Target Type |
Literature-reported
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| Target Bioclass |
Other
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| Family |
G protein gamma family
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| Subcellular location |
Cell membrane
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| Function |
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum.
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| TTD ID | ||||||
| Uniprot ID | ||||||
| DrugMap ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
JZ128-DTB Probe Info |
 |
N.A. | LDD0462 | [1] | |
|
DBIA Probe Info |
 |
C39(1.12) | LDD1508 | [2] | |
|
NAIA_5 Probe Info |
 |
N.A. | LDD2223 | [3] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0215 | AC10 | HEK-293T | C39(1.12) | LDD1508 | [2] |
| LDCM0277 | AC18 | HEK-293T | C39(1.05) | LDD1516 | [2] |
| LDCM0279 | AC2 | HEK-293T | C39(1.01) | LDD1518 | [2] |
| LDCM0286 | AC26 | HEK-293T | C39(0.93) | LDD1525 | [2] |
| LDCM0295 | AC34 | HEK-293T | C39(1.07) | LDD1534 | [2] |
| LDCM0304 | AC42 | HEK-293T | C39(1.23) | LDD1543 | [2] |
| LDCM0313 | AC50 | HEK-293T | C39(1.01) | LDD1552 | [2] |
| LDCM0321 | AC58 | HEK-293T | C39(1.06) | LDD1560 | [2] |
| LDCM0405 | CL18 | HEK-293T | C39(1.08) | LDD1609 | [2] |
| LDCM0419 | CL30 | HEK-293T | C39(1.00) | LDD1623 | [2] |
| LDCM0432 | CL42 | HEK-293T | C39(1.06) | LDD1636 | [2] |
| LDCM0445 | CL54 | HEK-293T | C39(1.13) | LDD1648 | [2] |
| LDCM0451 | CL6 | HEK-293T | C39(1.09) | LDD1654 | [2] |
| LDCM0458 | CL66 | HEK-293T | C39(1.12) | LDD1661 | [2] |
| LDCM0471 | CL78 | HEK-293T | C39(1.05) | LDD1674 | [2] |
| LDCM0485 | CL90 | HEK-293T | C39(1.13) | LDD1688 | [2] |
| LDCM0179 | JZ128 | PC-3 | N.A. | LDD0462 | [1] |
The Interaction Atlas With This Target
References