Details of the Target

General Information of Target

Target ID LDTP12908
Target Name Ubiquinone biosynthesis O-methyltransferase, mitochondrial (COQ3)
Gene Name COQ3
Gene ID 51805
Synonyms
Ubiquinone biosynthesis O-methyltransferase, mitochondrial; 3-demethylubiquinol 3-O-methyltransferase; EC 2.1.1.64; Polyprenyldihydroxybenzoate methyltransferase; EC 2.1.1.114
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERAISPGLLVRALLLLLLLLGLAARTVAAGRARGLPAPTAEAAFGLGAAAAPTSATRVP
AAGAVAAAEVTVEDAEALPAAAGEQEPRGPEPDDETELRPRGRSLVIISTLDGRIAALDP
ENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGALFQWDQDRESMETVPFTVES
LLESSYKFGDDVVLVGGKSLTTYGLSAYSGKVRYICSALGCRQWDSDEMEQEEDILLLQR
TQKTVRAVGPRSGNEKWNFSVGHFELRYIPDMETRAGFIESTFKPNENTEESKIISDVEE
QEAAIMDIVIKVSVADWKVMAFSKKGGHLEWEYQFCTPIASAWLLKDGKVIPISLFDDTS
YTSNDDVLEDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRISEKFPSSPKALESVTNE
NAIIPLPTIKWKPLIHSPSRTPVLVGSDEFDKCLSNDKFSHEEYSNGALSILQYPYDNGY
YLPYYKRERNKRSTQITVRFLDNPHYNKNIRKKDPVLLLHWWKEIVATILFCIIATTFIV
RRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLG
RGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLE
APPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSR
SFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGND
EGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAF
KPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWM
NGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVT
AMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYP
FSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDL
DFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN
Target Bioclass
Enzyme
Family
Class I-like SAM-binding methyltransferase superfamily, UbiG/COQ3 family
Subcellular location
Mitochondrion inner membrane
Function O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. {|HAMAP-Rule:MF_03190}.
Uniprot ID
Q9NZJ6
Ensemble ID
ENST00000254759.8
HGNC ID
HGNC:18175

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [2]
BTD
 Probe Info  		C186(0.57)  LDD2140  [3]
DBIA
 Probe Info  		C358(0.94)  LDD0078  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		C358(0.00); C186(0.00)  LDD0165  [7]
IPM
 Probe Info  		C358(0.00); C186(0.00)  LDD0025  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
ENE
 Probe Info  		N.A.  LDD0006  [9]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Phosphinate-6
 Probe Info  		C358(0.00); C186(0.00)  LDD0018  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		12.38  LDD1752  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C155(0.98)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C155(1.05)  LDD0532  [4]
 LDCM0216  AC100 HEK-293T C358(0.85)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C358(0.79)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C358(0.73)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C358(0.77)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C358(0.93)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C358(0.78)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C358(0.96)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C358(0.83)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C358(1.17)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C358(1.04)  LDD0823  [4]
 LDCM0226  AC11 HCT 116 C155(0.97)  LDD0543  [4]
 LDCM0227  AC110 HEK-293T C358(0.81)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C358(0.81)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C358(0.96)  LDD0827  [4]
 LDCM0230  AC113 HCT 116 C155(1.00)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C155(0.95)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C155(0.97)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C155(0.92)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C155(1.04)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C155(0.98)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C155(0.98)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C155(1.06)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C155(1.00)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C155(0.98)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C155(1.01)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C155(1.00)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C155(0.99)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C155(0.93)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C155(1.09)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C155(1.10)  LDD0562  [4]
 LDCM0246  AC128 PaTu 8988t C358(0.76)  LDD1125  [4]
 LDCM0247  AC129 PaTu 8988t C358(0.65)  LDD1126  [4]
 LDCM0249  AC130 PaTu 8988t C358(0.62)  LDD1128  [4]
 LDCM0250  AC131 PaTu 8988t C358(0.82)  LDD1129  [4]
 LDCM0251  AC132 PaTu 8988t C358(0.94)  LDD1130  [4]
 LDCM0252  AC133 PaTu 8988t C358(1.28)  LDD1131  [4]
 LDCM0253  AC134 PaTu 8988t C358(1.32)  LDD1132  [4]
 LDCM0254  AC135 PaTu 8988t C358(1.15)  LDD1133  [4]
 LDCM0255  AC136 PaTu 8988t C358(1.03)  LDD1134  [4]
 LDCM0256  AC137 PaTu 8988t C358(1.23)  LDD1135  [4]
 LDCM0257  AC138 PaTu 8988t C358(0.73)  LDD1136  [4]
 LDCM0258  AC139 PaTu 8988t C358(1.24)  LDD1137  [4]
 LDCM0259  AC14 HCT 116 C155(0.96)  LDD0576  [4]
 LDCM0260  AC140 PaTu 8988t C358(1.13)  LDD1139  [4]
 LDCM0261  AC141 PaTu 8988t C358(0.58)  LDD1140  [4]
 LDCM0262  AC142 PaTu 8988t C358(0.74)  LDD1141  [4]
 LDCM0263  AC143 HEK-293T C358(0.90)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C358(0.88)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C358(0.69)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C358(0.84)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C358(0.69)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C358(1.03)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C358(0.79)  LDD0867  [4]
 LDCM0270  AC15 HCT 116 C155(1.04)  LDD0587  [4]
 LDCM0271  AC150 HEK-293T C358(0.74)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C358(0.80)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C358(0.79)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C358(0.98)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C358(0.82)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C358(0.77)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C358(0.85)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C358(0.87)  LDD2165  [4]
 LDCM0276  AC17 HCT 116 C358(0.98)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C358(0.72)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C358(0.95)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C155(1.11)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C358(0.85)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C358(0.70)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C358(0.86)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C358(0.88)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C358(0.98)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C358(1.00)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C358(1.33)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C358(1.41)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C358(1.53)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C358(1.34)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C155(1.23)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C358(1.26)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C358(1.01)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C358(1.75)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C358(1.73)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C358(1.47)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C358(0.99); C155(1.16)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C358(0.90); C155(1.19)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C155(1.04); C358(1.26)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C358(1.01); C155(1.23)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C358(0.93); C155(1.06)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C155(1.33)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C155(1.06); C358(1.24)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C358(1.14); C155(1.21)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C155(1.05); C358(1.17)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C155(0.90); C358(1.26)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C155(1.09); C358(1.14)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C155(0.97); C358(1.31)  LDD0624  [4]
 LDCM0308  AC46 PaTu 8988t C155(0.81); C358(1.00)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C155(0.67); C358(1.40)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C155(0.65); C358(1.30)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C155(0.67); C358(1.37)  LDD1190  [4]
 LDCM0312  AC5 HCT 116 C155(1.42)  LDD0629  [4]
 LDCM0313  AC50 PaTu 8988t C155(0.74); C358(1.40)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C155(0.75); C358(0.76)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C155(0.70); C358(1.33)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C155(0.56); C358(2.52)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C155(0.54); C358(1.87)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C155(0.72); C358(1.06)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C155(0.60); C358(1.49)  LDD1198  [4]
 LDCM0320  AC57 PaTu 8988t C358(0.76)  LDD1199  [4]
 LDCM0321  AC58 PaTu 8988t C358(0.80)  LDD1200  [4]
 LDCM0322  AC59 PaTu 8988t C358(0.79)  LDD1201  [4]
 LDCM0323  AC6 HCT 116 C155(0.98)  LDD0640  [4]
 LDCM0324  AC60 PaTu 8988t C358(0.86)  LDD1203  [4]
 LDCM0325  AC61 PaTu 8988t C358(0.67)  LDD1204  [4]
 LDCM0326  AC62 PaTu 8988t C358(0.66)  LDD1205  [4]
 LDCM0327  AC63 PaTu 8988t C358(0.78)  LDD1206  [4]
 LDCM0328  AC64 PaTu 8988t C358(0.87)  LDD1207  [4]
 LDCM0329  AC65 PaTu 8988t C358(0.75)  LDD1208  [4]
 LDCM0330  AC66 PaTu 8988t C358(0.80)  LDD1209  [4]
 LDCM0331  AC67 PaTu 8988t C358(0.87)  LDD1210  [4]
 LDCM0332  AC68 HCT 116 C358(0.67)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C358(0.58)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C155(1.13)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C358(0.71)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C358(0.97)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C358(1.02)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C358(0.81)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C358(0.92)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C358(0.86)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C358(1.04)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C358(0.77)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C358(0.92)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C358(1.24)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C155(0.99)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C358(0.95)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C358(1.03)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C358(1.05)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C358(1.53)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C358(1.48)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C358(1.42)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C358(1.34)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C358(1.35)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C358(1.87)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C358(1.44)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C358(2.04)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C358(1.17)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C358(1.06)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C358(1.57)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C358(0.90)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C358(1.50)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C358(1.14)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C358(2.12)  LDD0681  [4]
 LDCM0365  AC98 HEK-293T C358(0.97)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C358(1.12)  LDD0964  [4]
 LDCM0248  AKOS034007472 HCT 116 C155(0.99)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C155(1.01)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C155(1.06)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 13.13  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C358(0.94)  LDD0078  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [11]
 LDCM0367  CL1 HCT 116 C155(1.33)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C155(0.90)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C155(1.04)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C155(1.03)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C155(0.92)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C155(1.05)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C155(1.07)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C358(0.84)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C358(0.62)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C358(0.82)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C358(0.72)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C358(0.67)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C155(1.23)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C358(0.84)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C358(0.88)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C358(1.07)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C358(1.47)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C358(1.56)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C358(1.02)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C358(1.50)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C155(0.82); C358(0.89)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C155(1.01); C358(1.22)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C155(1.01); C358(1.17)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C155(1.03)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C155(1.07); C358(1.08)  LDD0708  [4]
 LDCM0392  CL121 PaTu 8988t C155(0.78); C358(1.25)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C155(0.73); C358(1.30)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C155(0.60); C358(1.47)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C155(0.66); C358(1.65)  LDD1274  [4]
 LDCM0396  CL125 PaTu 8988t C358(1.51)  LDD1275  [4]
 LDCM0397  CL126 PaTu 8988t C358(1.26)  LDD1276  [4]
 LDCM0398  CL127 PaTu 8988t C358(0.72)  LDD1277  [4]
 LDCM0399  CL128 PaTu 8988t C358(0.88)  LDD1278  [4]
 LDCM0400  CL13 HCT 116 C155(1.12)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C155(1.05)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C155(1.47)  LDD0719  [4]
 LDCM0403  CL16 PaTu 8988t C155(0.63); C358(1.48)  LDD1282  [4]
 LDCM0404  CL17 PaTu 8988t C155(0.81); C358(0.99)  LDD1283  [4]
 LDCM0405  CL18 PaTu 8988t C155(0.60); C358(2.18)  LDD1284  [4]
 LDCM0406  CL19 PaTu 8988t C155(0.54); C358(1.72)  LDD1285  [4]
 LDCM0407  CL2 HCT 116 C155(1.06)  LDD0724  [4]
 LDCM0408  CL20 PaTu 8988t C155(0.35); C358(2.77)  LDD1287  [4]
 LDCM0409  CL21 PaTu 8988t C155(0.31); C358(2.66)  LDD1288  [4]
 LDCM0410  CL22 PaTu 8988t C155(0.48); C358(2.56)  LDD1289  [4]
 LDCM0411  CL23 PaTu 8988t C155(0.36); C358(1.81)  LDD1290  [4]
 LDCM0412  CL24 PaTu 8988t C155(0.39); C358(1.03)  LDD1291  [4]
 LDCM0413  CL25 PaTu 8988t C155(0.52); C358(0.96)  LDD1292  [4]
 LDCM0414  CL26 PaTu 8988t C155(0.48); C358(2.18)  LDD1293  [4]
 LDCM0415  CL27 PaTu 8988t C155(0.76); C358(0.96)  LDD1294  [4]
 LDCM0416  CL28 PaTu 8988t C155(0.37); C358(1.75)  LDD1295  [4]
 LDCM0417  CL29 PaTu 8988t C155(0.33); C358(2.85)  LDD1296  [4]
 LDCM0418  CL3 HCT 116 C155(1.07)  LDD0735  [4]
 LDCM0419  CL30 PaTu 8988t C155(0.34); C358(2.65)  LDD1298  [4]
 LDCM0420  CL31 HEK-293T C358(1.05)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C358(1.02)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C358(1.08)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C358(1.10)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C358(1.04)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C358(0.86)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C358(1.18)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C358(0.95)  LDD1026  [4]
 LDCM0429  CL4 HCT 116 C155(1.34)  LDD0746  [4]
 LDCM0430  CL40 HEK-293T C358(1.00)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C358(0.89)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C358(0.88)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C358(0.97)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C358(1.07)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C358(0.96)  LDD1033  [4]
 LDCM0436  CL46 HCT 116 C155(0.96)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C155(0.91)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C155(0.91)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C155(0.88)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C155(1.25)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C155(0.93)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C155(0.91)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C155(1.03)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C155(0.93)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C155(0.93)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C155(0.86)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C155(0.78)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C155(0.83)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C155(0.93)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C155(0.92)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C155(0.90)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C155(1.00)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C358(1.16)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C358(1.09)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C358(1.25)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C358(1.25)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C358(1.06)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C358(2.02)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C358(1.73)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C358(1.36)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C358(1.34)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C155(1.28)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C358(1.30)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C358(1.24)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C358(1.09)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C358(1.42)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C358(1.25)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C155(0.58)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C155(0.69)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C155(0.71)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C155(0.67)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C155(1.74)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C155(0.47)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C155(0.69)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C155(0.61)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C155(0.52)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C155(0.50)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C155(0.76)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C155(0.82)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C155(0.78)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C155(0.61)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C155(0.41)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C155(1.07)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C155(0.89)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C155(0.89)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C155(1.08)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C155(1.51)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C155(0.98)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C155(1.41)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C155(1.18)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C155(1.24)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C155(0.90)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C155(1.00)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C358(0.94); C155(0.26)  LDD1698  [15]
 LDCM0625  F8 Ramos C155(0.69); C358(2.09)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C155(0.70)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C155(1.36); C358(9.89)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C155(0.65); C358(1.57)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C155(0.66); C358(1.19)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C155(0.59); C358(0.69)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C155(0.72); C358(0.95)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C155(0.72); C358(1.26)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C155(0.62); C358(1.73)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C155(1.12); C358(1.15)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C155(0.51); C358(0.49)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C155(0.82); C358(1.15)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C155(0.81); C358(1.02)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C155(0.74)  LDD2201  [16]
 LDCM0468  Fragment33 HCT 116 C358(1.45)  LDD0785  [4]
 LDCM0596  Fragment38 Ramos C155(0.70); C358(1.12)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C155(0.67); C358(0.79)  LDD2184  [16]
 LDCM0427  Fragment51 HEK-293T C358(1.16)  LDD1025  [4]
 LDCM0610  Fragment52 Ramos C155(0.53); C358(2.02)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C155(0.67); C358(1.28)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C155(0.57); C358(0.63)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C155(0.65)  LDD2188  [16]
 LDCM0107  IAA HeLa N.A.  LDD0221  [11]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [2]
 LDCM0022  KB02 HCT 116 C358(1.52)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C358(1.24)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C358(1.51)  LDD0082  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C186(0.57)  LDD2140  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (COQ5) MenG/UbiE family Q5HYK3
Cysteine desulfurase (NFS1) Class-V pyridoxal-phosphate-dependent aminotransferase family Q9Y697
5-demethoxyubiquinone hydroxylase, mitochondrial (COQ7) COQ7 family Q99807
Tyrosine-protein phosphatase non-receptor type 9 (PTPN9) Protein-tyrosine phosphatase family P43378
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (COQ6) UbiH/COQ6 family Q9Y2Z9
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sorting nexin-1 (SNX1) Sorting nexin family Q13596
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial (COQ4) COQ4 family Q9Y3A0
Alpha-tocopherol transfer protein (TTPA) . P49638

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578