Details of the Target

General Information of Target

Target ID LDTP10416
Target Name LIM domain-containing protein ajuba (AJUBA)
Gene Name AJUBA
Gene ID 84962
Synonyms
JUB; LIM domain-containing protein ajuba
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASPVAAQAGKLLRALALRPRFLAAGSQAVQLTSRRWLNLQEYQSKKLMSDNGVRVQRFF
VADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNVVGQLAKQM
IGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEV
AASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQV
EVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKYDLKYIGLD
GNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILV
NIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTNVQEAQKILNNSGLPITSAIDLED
AAKKAVASVAKK
Target Bioclass
Other
Family
Zyxin/ajuba family
Subcellular location
Cytoplasm, cytoskeleton
Function
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1.
Uniprot ID
Q96IF1
Ensemble ID
ENST00000262713.7
HGNC ID
HGNC:20250

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C4II Deletion: p.G68VfsTer174 DBIA    Probe Info 
COLO320 SNV: p.D58E DBIA    Probe Info 
HCT15 SNV: p.A191T .
JURKAT Deletion: p.D269TfsTer12 .
MCC13 Substitution: p.L358F .
MOLT4 SNV: p.G54W; p.L411S .
NCIH23 SNV: p.E327Ter DBIA    Probe Info 
REH SNV: p.Y85C .
SUPT1 SNV: p.D278Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.09  LDD0402  [1]
STPyne
 Probe Info  		K14(9.66); K7(7.96)  LDD0277  [2]
BTD
 Probe Info  		C426(1.44)  LDD2119  [3]
DBIA
 Probe Info  		C158(0.85)  LDD0078  [4]
NAIA_4
 Probe Info  		C158(0.00); C224(0.00); C270(0.00)  LDD2226  [5]
TFBX
 Probe Info  		C158(0.00); C270(0.00)  LDD0027  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0151  [8]
IPM
 Probe Info  		C224(0.00); C158(0.00); C182(0.00); C270(0.00)  LDD0147  [6]
W1
 Probe Info  		C426(0.00); C158(0.00)  LDD0236  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C158(1.07); C224(0.99)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C158(0.75); C224(0.59)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C158(0.96)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C158(0.94)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C158(0.92)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C158(1.34)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C158(1.35)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C158(1.22)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C158(1.21)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C158(0.49)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C158(3.14)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C158(3.18)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C158(0.84); C224(0.52)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C158(2.60)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C158(2.95)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C158(1.67)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C158(1.03); C463(0.58); C476(0.58)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C158(1.30)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C158(1.13)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C158(1.84)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C158(1.04)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C158(0.95)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C158(1.16)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C158(0.70); C224(0.83)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C158(1.32)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C158(0.90)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C158(1.07)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C158(0.91)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C158(0.90)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C158(1.07)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C158(2.30)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C158(1.89)  LDD0562  [4]
 LDCM0259  AC14 HCT 116 C158(0.71); C224(0.94)  LDD0576  [4]
 LDCM0263  AC143 HCT 116 C158(1.07); C510(0.57)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C510(0.87); C158(1.60)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C510(0.88); C158(1.28)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C510(0.99); C158(1.54)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C510(0.66); C158(1.57)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C510(0.61); C158(1.96)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C510(1.16); C158(1.85)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C158(0.72); C224(0.80)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C510(1.10); C158(1.34)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C510(0.60); C158(1.20)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C510(0.71); C158(1.70)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C510(0.94); C158(3.09)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C158(1.57); C510(0.70)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C158(1.85); C510(0.72)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C158(1.29); C510(1.28)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C158(1.46); C510(1.43)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C476(0.88); C463(0.90); C158(0.96); C224(1.18)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C224(0.89); C463(0.90); C158(0.92); C476(0.95)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C224(0.76); C158(0.94); C476(0.95); C463(0.97)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C224(0.99); C158(1.02)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C463(0.68); C476(0.72); C224(0.91); C158(0.95)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C476(0.68); C463(0.71); C224(0.81); C158(1.03)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C158(0.80); C476(0.81); C463(0.89); C224(1.08)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C463(0.66); C224(0.66); C476(0.75); C158(0.78)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C463(0.72); C158(0.78); C476(0.81); C224(1.01)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C463(1.57); C476(1.57); C158(1.60)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C463(0.97); C476(0.97); C158(1.60)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C463(1.26); C476(1.26); C158(2.26)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C463(1.24); C476(1.24); C158(1.64)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C463(1.67); C476(1.67); C158(2.23)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C158(0.92); C224(1.18)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C463(0.91); C476(0.91); C158(1.72)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C463(1.05); C476(1.05); C158(1.45)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C463(1.40); C476(1.40); C158(1.79)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C158(1.73); C463(1.95); C476(1.95)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C463(0.98); C476(0.98); C158(2.25)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C158(0.71)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C158(0.81)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C158(0.94)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C158(0.87)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C158(1.01)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C158(0.88); C224(0.90)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C158(1.04)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C158(0.71)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C158(1.09)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C158(0.92)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C158(0.86)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C158(1.19)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C510(1.51)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C510(0.82)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C510(0.80)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C510(1.52)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C158(0.92); C224(0.94)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C510(0.93)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C510(0.76)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C510(1.05)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C510(0.81)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C510(0.85)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C510(1.05)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C510(1.47)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C224(1.04); C158(1.08); C510(1.52)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C224(1.09); C158(1.11); C510(1.12)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C158(0.94); C224(1.07); C510(1.27)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C158(0.67); C224(0.87)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C158(1.04); C224(1.05); C510(1.25)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C158(0.96); C224(1.00); C510(1.06)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C224(0.95); C510(1.01); C158(1.51)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C510(0.72); C224(1.02); C158(1.14)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C510(0.88); C224(0.96); C158(1.51)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C158(0.41); C224(0.95); C510(1.03)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C158(0.40); C510(0.68); C224(1.06)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C158(0.50); C510(0.92); C224(1.22)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C463(0.84); C466(0.84); C476(0.84); C158(1.38)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C463(0.99); C466(0.99); C476(0.99); C158(1.29)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C224(0.65); C158(0.69)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C463(0.49); C466(0.49); C476(0.49); C158(1.02)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C463(0.75); C466(0.75); C476(0.75); C158(1.10)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C463(0.75); C466(0.75); C476(0.75); C158(1.55)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C463(0.84); C466(0.84); C476(0.84); C158(2.69)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C463(0.93); C466(0.93); C476(0.93); C158(1.80)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C463(1.31); C466(1.31); C476(1.31); C158(2.93)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C463(0.96); C466(0.96); C476(0.96); C158(1.58)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C463(0.79); C466(0.79); C476(0.79); C158(1.51)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C463(0.62); C466(0.62); C476(0.62); C158(1.20)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C463(0.92); C466(0.92); C476(0.92); C158(1.19)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C224(0.57); C158(0.64)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C463(0.84); C466(0.84); C476(0.84); C158(1.41)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C463(0.66); C466(0.66); C476(0.66); C158(1.18)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C463(0.65); C466(0.65); C476(0.65); C158(2.22)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C224(0.87); C466(1.46); C476(1.46)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C224(1.21); C466(1.55); C476(1.55)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C466(1.08); C476(1.08); C224(1.18)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C224(1.01); C466(1.46); C476(1.46)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C466(0.96); C476(0.96); C224(0.97)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C224(1.01); C466(1.52); C476(1.52)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C224(1.18); C466(1.60); C476(1.60)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C224(1.20); C466(1.28); C476(1.28)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C224(1.11); C466(1.58); C476(1.58)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C224(1.07); C466(1.52); C476(1.52)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C224(1.09); C466(1.16); C476(1.16)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C466(1.14); C476(1.14); C224(1.21)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C224(0.98); C466(1.29); C476(1.29)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C224(1.21); C466(1.55); C476(1.55)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C224(1.05); C466(1.47); C476(1.47)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C158(2.82)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C158(1.04)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C158(0.72); C224(0.67)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C224(0.63); C158(1.25)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C158(0.73); C224(0.92)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 11.55  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C158(0.85)  LDD0078  [4]
 LDCM0632  CL-Sc Hep-G2 C158(0.73)  LDD2227  [5]
 LDCM0367  CL1 HCT 116 C224(0.96); C463(1.05); C476(1.05); C158(1.61)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C224(0.85); C463(1.01); C476(1.01); C158(1.16)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C158(1.06); C224(1.67)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C158(0.66); C224(0.88)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C224(0.63); C158(0.76)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C224(0.59); C158(0.74)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C224(0.59); C158(0.82)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C224(0.63); C463(0.78); C158(0.84); C476(0.91)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C224(0.72); C476(0.84); C463(0.89); C158(1.17)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C224(0.67); C463(0.81); C476(1.00); C158(1.05)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C224(0.82); C463(0.90); C158(0.94); C476(0.99)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C224(0.89); C158(0.90); C476(0.97); C463(0.97)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C224(1.17); C463(1.23); C476(1.23); C158(1.41)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C224(0.85); C463(0.86); C476(1.04); C158(1.14)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C224(0.57); C463(0.80); C158(0.90); C476(1.01)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C463(1.13); C476(1.13); C158(1.38)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C463(1.06); C476(1.06); C158(1.69)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C463(0.86); C476(0.86); C158(2.48)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C463(1.03); C476(1.03); C158(1.62)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C463(1.35); C476(1.35); C158(2.25)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C158(1.56)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C158(1.31)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C158(0.97)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C463(1.04); C476(1.04); C224(1.18); C158(1.20)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C158(0.85)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C510(0.75)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C510(1.19)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C510(0.44)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C510(1.09)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C158(0.75); C224(0.86); C510(1.22)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C158(0.55); C510(0.77); C224(0.85)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C158(0.61); C224(0.84); C510(0.95)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C510(0.85); C224(0.86); C158(1.29)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C463(0.80); C476(0.80); C158(1.05); C224(1.15)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C224(0.76); C463(0.90); C476(0.90); C158(1.01)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C158(1.24); C463(1.27); C476(1.27); C224(1.43)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C158(1.11); C463(1.17); C476(1.17); C510(1.30)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C158(0.70); C463(0.77); C476(0.77); C510(0.97)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C158(0.76); C510(1.14); C463(1.32); C476(1.32)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C158(0.94); C510(1.10); C463(1.27); C476(1.27)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C463(1.01); C476(1.01); C224(1.24); C158(1.35)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C158(0.76); C510(1.04); C463(2.18); C476(2.18)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C158(0.96); C510(1.15); C463(1.20); C476(1.20)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C158(0.91); C510(0.96); C463(2.01); C476(2.01)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C158(1.10); C510(1.11); C463(1.59); C476(1.59)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C158(0.85); C510(0.93); C463(1.42); C476(1.42)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C158(0.97); C463(1.39); C466(1.83); C476(1.39)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C158(1.34); C463(1.10); C466(1.22); C476(1.10)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C158(0.90); C463(1.40); C466(1.81); C476(1.40)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C158(0.87); C463(1.44); C466(1.87); C476(1.44)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C158(0.83); C463(1.61); C466(1.92); C476(1.61)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C158(1.14); C224(0.93); C463(1.00); C476(1.00)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C158(1.12); C463(1.57); C466(2.14); C476(1.57)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C158(0.90); C224(1.09)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C158(1.08); C224(1.19)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C158(1.10); C224(1.67)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C158(0.92); C224(1.31)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C158(1.10); C224(1.01)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C158(1.05); C224(1.27)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C158(1.16); C224(1.15)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C158(1.02); C224(1.00)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C158(1.32); C224(1.17); C463(0.95); C476(0.95)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C158(1.16); C224(1.12)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C158(1.11); C224(0.68)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C158(0.90); C224(1.15)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C158(1.15); C224(1.69)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C158(1.04); C224(1.10)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C158(1.09); C224(1.05)  LDD0752  [4]
 LDCM0436  CL46 HEK-293T C270(0.84); C158(0.95)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C270(1.07); C158(0.88)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C270(0.98); C158(0.94)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C270(0.95)  LDD1643  [10]
 LDCM0440  CL5 HCT 116 C158(1.05); C224(1.21); C463(1.27); C476(1.27)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C158(1.05)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C270(0.98); C158(1.08); C224(1.05)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C270(0.90); C158(0.76)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C270(0.99); C158(0.91)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C270(0.93); C158(0.91)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C270(1.00); C158(1.24)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C270(1.05); C158(1.08)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C270(0.99); C158(0.95)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C270(0.99); C158(0.95)  LDD1653  [10]
 LDCM0451  CL6 HCT 116 C158(1.20); C224(1.49); C463(1.08); C476(1.08)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C270(1.00); C158(1.10)  LDD1655  [10]
 LDCM0453  CL61 HCT 116 C463(1.14); C466(1.09); C476(1.11)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C463(1.33); C466(1.58); C476(1.45)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C463(1.27); C466(1.22); C476(1.25)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C463(1.08); C466(1.16); C476(1.12)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C463(0.87); C466(1.33); C476(1.10)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C463(1.10); C466(1.45); C476(1.28)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C463(1.00); C466(1.45); C476(1.22)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C463(0.98); C466(1.39); C476(1.18)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C463(1.54); C466(1.16); C476(1.35)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C158(1.26); C224(1.12); C463(0.95); C476(0.95)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C463(1.22); C466(1.30); C476(1.26)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C463(0.88); C466(1.62); C476(1.25)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C463(1.03); C466(1.08); C476(1.05)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C463(1.11); C466(1.10); C476(1.10)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C463(1.37); C466(1.24); C476(1.30)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C158(1.03); C224(1.01)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C158(1.27); C224(1.01)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C158(1.09); C224(1.33)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C158(1.07); C224(0.98)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C158(1.46); C224(1.45); C463(1.19); C476(1.19)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C158(1.02); C224(1.21)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C158(0.87); C224(0.93)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C158(0.76); C224(0.78)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C158(1.17); C224(0.99)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C158(1.27); C224(1.15)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C158(0.93); C224(1.20)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C158(1.04); C224(1.02)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C158(0.75); C224(0.84)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C158(0.80); C224(1.02)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C158(0.96); C224(1.15)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C158(1.18); C224(1.00); C463(0.88); C476(0.88)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C158(1.36); C224(0.84)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C158(1.02); C224(1.20)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C158(1.02); C224(1.29)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C158(0.93); C224(1.46)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C158(1.29); C224(0.80)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C158(1.18); C224(0.87)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C158(0.90); C224(1.12)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C158(0.99); C224(1.48)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C158(1.08); C224(1.27)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C158(1.13); C224(1.46)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C270(1.02); C158(1.01)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C270(1.46); C158(1.36); C429(0.96)  LDD1702  [3]
 LDCM0468  Fragment33 HCT 116 C463(0.93); C466(1.28); C476(1.10)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C158(1.23); C224(1.02)  LDD0744  [4]
 LDCM0022  KB02 HEK-293T C270(1.06); C158(1.08)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C270(0.99); C158(1.28)  LDD1497  [10]
 LDCM0024  KB05 HMCB C270(1.70)  LDD3312  [11]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C426(1.44)  LDD2119  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C224(1.06)  LDD2123  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C158(0.87)  LDD2128  [3]
 LDCM0021  THZ1 HCT 116 C463(1.14); C466(1.14); C476(1.14); C403(1.05)  LDD2173  [4]
 LDCM0113  W17 Hep-G2 C224(3.55)  LDD0240  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phenylalanine--tRNA ligase, mitochondrial (FARS2) Class-II aminoacyl-tRNA synthetase family O95363
Serine/threonine-protein kinase LATS2 (LATS2) AGC Ser/Thr protein kinase family Q9NRM7
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cation channel sperm-associated protein 1 (CATSPER1) Cation channel sperm-associated (TC 1.A.1.19) family Q8NEC5
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 512B (ZNF512B) Krueppel C2H2-type zinc-finger protein family Q96KM6
Zinc finger protein SNAI1 (SNAI1) Snail C2H2-type zinc-finger protein family O95863
Transcription factor AP-4 (TFAP4) . Q01664
Zinc finger protein 541 (ZNF541) . Q9H0D2
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein sigma (SFN) 14-3-3 family P31947
Tektin-3 (TEKT3) Tektin family Q9BXF9
Placental protein 13-like (LGALS14) . Q8TCE9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
9 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840