Details of the Target

General Information of Target

Target ID LDTP11651
Target Name Paternally-expressed gene 3 protein (PEG3)
Gene Name PEG3
Gene ID 5178
Synonyms
KIAA0287; ZSCAN24; Paternally-expressed gene 3 protein; Zinc finger and SCAN domain-containing protein 24
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTAPAGPRGSETERLLTPNPGYGTQAGPSPAPPTPPEEEDLRRRLKYFFMSPCDKFRAKG
RKPCKLMLQVVKILVVTVQLILFGLSNQLAVTFREENTIAFRHLFLLGYSDGADDTFAAY
TREQLYQAIFHAVDQYLALPDVSLGRYAYVRGGGDPWTNGSGLALCQRYYHRGHVDPAND
TFDIDPMVVTDCIQVDPPERPPPPPSDDLTLLESSSSYKNLTLKFHKLVNVTIHFRLKTI
NLQSLINNEIPDCYTFSVLITFDNKAHSGRIPISLETQAHIQECKHPSVFQHGDNSFRLL
FDVVVILTCSLSFLLCARSLLRGFLLQNEFVGFMWRQRGRVISLWERLEFVNGWYILLVT
SDVLTISGTIMKIGIEAKNLASYDVCSILLGTSTLLVWVGVIRYLTFFHNYNILIATLRV
ALPSVMRFCCCVAVIYLGYCFCGWIVLGPYHVKFRSLSMVSECLFSLINGDDMFVTFAAM
QAQQGRSSLVWLFSQLYLYSFISLFIYMVLSLFIALITGAYDTIKHPGGAGAEESELQAY
IAQCQDSPTSGKFRRGSGSACSLLCCCGRDPSEEHSLLVN
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function
Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Possesses a tumor suppressing activity in glioma cells.
Uniprot ID
Q9GZU2
Ensemble ID
ENST00000326441.15
HGNC ID
HGNC:8826

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.A1465T .
AGS SNV: p.K569T .
BICR22 SNV: p.Q554Ter .
CAL148 SNV: p.A803V .
CHL1 SNV: p.A1395G .
COLO320 SNV: p.A1395G .
COLO800 SNV: p.A1395G DBIA    Probe Info 
HCT15 SNV: p.A1268S; p.D1336E .
HEC1 SNV: p.Y1153H .
HEC1B SNV: p.Y1153H .
ICC12 SNV: p.E1403K .
KPL1 Deletion: p.L434_S436del DBIA    Probe Info 
MCC13 SNV: p.R187K; p.S277F; p.S298L .
MCC26 SNV: p.E656K .
MELJUSO Insertion: p.E1403GfsTer8 .
MEWO SNV: p.E316K; p.K317Ter; p.R392K; p.E1283D .
MFE319 SNV: p.S725N .
MINO SNV: p.C507R .
NCIH1793 SNV: p.D1480E; p.V1500L .
NCIH2286 SNV: p.Q1499H .
NCIN87 SNV: p.N869K .
OCUM1 SNV: p.D178E; p.E1501D .
RKO SNV: p.G502W .
RVH421 SNV: p.P415S .
SKMEL5 SNV: p.V801L .
SNU1 SNV: p.F375Y .
SW480 SNV: p.C1284Y; p.A1394V .
SW620 SNV: p.A1394V .
U937 SNV: p.A1368T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C1542(0.00); C418(0.00); C305(0.00); C662(0.00)  LDD0241  [1]
DBIA
 Probe Info  		C1334(1.84)  LDD3343  [2]
YN-1
 Probe Info  		D347(0.00); E883(0.00)  LDD0447  [3]
W1
 Probe Info  		C685(0.00); C1542(0.00); C882(0.00); C1196(0.00)  LDD0236  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C882(1.26)  LDD2250  [2]
 LDCM0023  KB03 A204 C1133(2.85); C882(2.48); C1334(1.71); C305(2.58)  LDD2669  [2]
 LDCM0024  KB05 NCI-H1299 C1334(1.84)  LDD3343  [2]
 LDCM0112  W16 Hep-G2 C685(0.70); C535(0.83)  LDD0239  [1]
 LDCM0113  W17 Hep-G2 C685(10.91)  LDD0240  [1]

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.