Details of the Target

General Information of Target

Target ID LDTP07049
Target Name Histone H2B type 2-F (H2BC18)
Gene Name H2BC18
Gene ID 440689
Synonyms
HIST2H2BF; Histone H2B type 2-F; H2B-clustered histone 18
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPDPAKSAPAPKKGSKKAVTKVQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSSK
Target Bioclass
Other
Family
Histone H2B family
Subcellular location
Nucleus
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Uniprot ID
Q5QNW6
Ensemble ID
ENST00000369167.3
HGNC ID
HGNC:24700
ChEMBL ID
CHEMBL4295850

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		2.60  LDD0066  [1]
ONAyne
 Probe Info  		N.A.  LDD0273  [2]
DBIA
 Probe Info  		C84(1.21)  LDD2408  [3]
HHS-475
 Probe Info  		Y84(1.13)  LDD0264  [4]
HHS-465
 Probe Info  		Y84(2.95)  LDD2237  [5]
Alkyne tyramide
 Probe Info  		K117(0.00); K121(0.00); K47(0.00); K86(0.00)  LDD0003  [6]
ATP probe
 Probe Info  		K86(0.00); K35(0.00)  LDD0035  [7]
NHS
 Probe Info  		K35(0.00); K109(0.00); K6(0.00); K117(0.00)  LDD0010  [6]
STPyne
 Probe Info  		K35(0.00); K109(0.00)  LDD0009  [6]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [8]
STS-2
 Probe Info  		N.A.  LDD0138  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y84(1.13)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y84(1.00)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y84(1.27)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y84(1.26)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y84(1.74)  LDD0268  [4]
 LDCM0022  KB02 JM-1 C84(1.21)  LDD2408  [3]
 LDCM0024  KB05 JM-1 C84(1.77)  LDD3242  [3]

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
8 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.