Details of the Target

General Information of Target

Target ID LDTP07959
Target Name Protein MCM10 homolog (MCM10)
Gene Name MCM10
Gene ID 55388
Synonyms
Protein MCM10 homolog; HsMCM10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDEEEDNLSLLTALLEENESALDCNSEENNFLTRENGEPDAFDELFDADGDGESYTEEAD
DGETGETRDEKENLATLFGDMEDLTDEEEVPASQSTENRVLPAPAPRREKTNEELQEELR
NLQEQMKALQEQLKVTTIKQTASPARLQKSPVEKSPRPPLKERRVQRIQESTCFSAELDV
PALPRTKRVARTPKASPPDPKSSSSRMTSAPSQPLQTISRNKPSGITRGQIVGTPGSSGE
TTQPICVEAFSGLRLRRPRVSSTEMNKKMTGRKLIRLSQIKEKMAREKLEEIDWVTFGVI
LKKVTPQSVNSGKTFSIWKLNDLRDLTQCVSLFLFGEVHKALWKTEQGTVVGILNANPMK
PKDGSEEVCLSIDHPQKVLIMGEALDLGTCKAKKKNGEPCTQTVNLRDCEYCQYHVQAQY
KKLSAKRADLQSTFSGGRIPKKFARRGTSLKERLCQDGFYYGGVSSASYAASIAAAVAPK
KKIQTTLSNLVVKGTNLIIQETRQKLGIPQKSLSCSEEFKELMDLPTCGARNLKQHLAKA
TASGIMGSPKPAIKSISASALLKQQKQRMLEMRRRKSEEIQKRFLQSSSEVESPAVPSSS
RQPPAQPPRTGSEFPRLEGAPATMTPKLGRGVLEGDDVLFYDESPPPRPKLSALAEAKKL
AAITKLRAKGQVLTKTNPNSIKKKQKDPQDILEVKERVEKNTMFSSQAEDELEPARKKRR
EQLAYLESEEFQKILKAKSKHTGILKEAEAEMQERYFEPLVKKEQMEEKMRNIREVKCRV
VTCKTCAYTHFKLLETCVSEQHEYHWHDGVKRFFKCPCGNRSISLDRLPNKHCSNCGLYK
WERDGMLKEKTGPKIGGETLLPRGEEHAKFLNSLK
Target Bioclass
Other
Family
MCM10 family
Subcellular location
Nucleus
Function
Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38.
Uniprot ID
Q7L590
Ensemble ID
ENST00000378714.8
HGNC ID
HGNC:18043

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C246(2.68)  LDD0173  [1]
DBIA
 Probe Info  		C515(0.74); C528(0.99)  LDD0533  [2]
IA-alkyne
 Probe Info  		C246(0.00); C786(0.00)  LDD0036  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]
VSF
 Probe Info  		N.A.  LDD0007  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C246(2.68)  LDD0173  [1]
 LDCM0214  AC1 HEK-293T C786(0.98); C515(0.94); C246(1.01); C528(1.04)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C786(0.95); C515(0.91); C246(1.28); C528(0.95)  LDD1508  [8]
 LDCM0216  AC100 HCT 116 C515(0.74); C528(0.99)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C515(0.76); C528(1.05)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C515(0.79); C528(1.00)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C515(1.00); C528(1.11)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C515(1.02); C528(0.86)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C515(1.20); C528(1.16)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C515(0.75); C528(1.06)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C515(0.86); C528(0.98)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C515(0.83); C528(0.99)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C515(0.70); C528(0.93)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C786(0.99); C515(0.98); C246(1.05); C528(0.99)  LDD1509  [8]
 LDCM0227  AC110 HCT 116 C515(0.71); C528(1.05)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C515(0.85); C528(0.98)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C515(0.87); C528(0.95)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C528(0.80)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C528(0.96)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C528(0.95)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C528(1.37)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C528(1.61)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C528(1.22)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C528(1.26)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C786(0.93); C515(0.99); C246(0.97); C528(0.92)  LDD1510  [8]
 LDCM0238  AC120 HCT 116 C528(1.22)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C528(1.68)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C528(1.30)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C528(1.14)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C528(1.73)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C528(1.13)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C528(0.90)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C528(1.17)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C528(0.53)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C528(0.72)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C528(0.79)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C528(0.70)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C528(0.74)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C528(0.77)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C528(0.81)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C528(0.83)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C528(0.82)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C528(0.79)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C528(0.82)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C528(0.88)  LDD0575  [2]
 LDCM0259  AC14 HEK-293T C515(1.01); C246(1.02); C329(0.94); C390(1.17)  LDD1512  [8]
 LDCM0260  AC140 HCT 116 C528(0.94)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C528(0.88)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C528(0.76)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C528(0.95); C515(0.96)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C528(0.95); C515(1.24)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C515(1.01); C528(1.05)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C528(1.08); C515(1.74)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C528(0.72); C515(1.19)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C528(0.97); C515(1.42)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C528(1.10); C515(1.72)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C786(0.98); C515(1.12); C246(1.04); C528(1.03)  LDD1513  [8]
 LDCM0271  AC150 HCT 116 C528(0.87); C515(1.19)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C528(0.92); C515(0.93)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C515(0.88); C528(1.08)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C528(1.16); C515(1.31)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C515(1.65); C528(1.14)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C515(1.25); C528(1.20)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C515(1.27); C528(1.11)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C515(1.01); C528(1.12)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C528(0.79); C515(0.87)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C528(0.99); C515(1.11)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C515(0.91); C528(0.99)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C786(1.04); C515(0.92); C246(1.02); C528(0.96)  LDD1518  [8]
 LDCM0280  AC20 HCT 116 C515(0.89); C528(0.91)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C528(1.05); C515(1.09)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C528(0.73); C515(1.40)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C528(0.87); C515(0.92)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C528(0.94); C515(1.04)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C786(0.96); C515(0.99); C246(1.02); C528(1.03)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C786(1.00); C515(0.97); C246(0.96); C528(0.93)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C786(0.95); C515(0.99); C246(1.02); C528(1.04)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C786(0.95); C515(1.01); C246(1.11); C528(1.03)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C786(0.86); C515(0.95); C246(1.03); C528(1.02)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C786(1.07); C515(1.00); C246(1.03); C528(0.90)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C515(1.11); C246(0.92); C329(0.86); C390(0.87)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C786(1.05); C515(1.06); C246(1.22); C528(0.97)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C786(0.82); C515(0.91); C246(1.00); C528(0.93)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C786(0.94); C515(0.91); C246(1.03); C528(1.01)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C786(0.99); C515(0.96); C246(1.09); C528(0.92)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C786(1.01); C515(1.04); C246(0.93); C528(1.20)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C786(0.98); C515(1.01); C246(1.01); C528(0.91)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C786(1.28); C515(1.03); C246(0.96); C528(0.90)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C515(1.14); C246(0.91); C329(0.85); C390(0.95)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C786(1.02); C515(1.13); C246(1.16); C528(1.05)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C786(1.04); C515(0.97); C246(0.94); C528(0.96)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C786(0.97); C515(0.98); C246(1.08); C528(1.05)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C786(0.93); C515(1.00); C246(1.07); C528(1.03)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C786(0.95); C515(1.02); C246(1.16); C528(1.05)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C786(1.02); C515(0.93); C246(0.97); C528(1.08)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C786(0.95); C515(0.95); C246(0.88); C528(0.91)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C786(0.87); C515(1.08); C246(0.97); C528(1.02)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C515(1.06); C246(1.01); C329(0.89); C390(0.81)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C786(1.00); C515(0.97); C246(1.10); C528(0.99)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C786(0.92); C515(0.85); C246(1.05); C528(0.99)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C786(0.88); C515(0.97); C246(1.00); C528(0.97)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C786(1.06); C515(1.04); C246(1.05); C528(0.92)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C786(0.97); C515(0.93); C246(1.03); C528(0.92)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C786(1.01); C515(0.92); C246(0.93); C528(0.98)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C786(0.99); C515(0.97); C246(0.90); C528(0.94)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C786(0.70); C515(0.99); C246(1.06); C528(1.01)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C515(1.00); C246(1.00); C329(0.86); C390(0.83)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C786(0.98); C515(0.93); C246(1.25); C528(1.01)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C786(0.90); C515(0.86); C246(1.04); C528(0.97)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C786(0.90); C515(0.97); C246(0.99); C528(1.04)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C786(0.94); C515(0.98); C246(1.12); C528(0.89)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C786(1.03); C515(0.98); C246(0.95); C528(0.94)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C515(1.10); C246(1.06); C329(0.91); C390(0.88)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C786(1.01); C515(0.98); C246(1.04); C528(0.97)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C786(0.81); C515(1.04); C246(0.97); C528(0.91)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C515(1.04); C246(0.92); C329(0.88); C390(0.91)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C786(1.00); C515(1.11); C246(1.12); C528(1.02)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C786(0.92); C515(0.93); C246(0.95); C528(0.95)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C786(1.08); C515(1.00); C246(1.20); C528(0.92)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C786(0.91); C515(1.09); C246(0.94); C528(1.07)  LDD1569  [8]
 LDCM0349  AC83 HCT 116 C515(0.73); C528(0.81)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C515(0.92); C528(1.06)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C515(0.73); C528(1.23)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C515(0.73); C528(1.18)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C515(0.81); C528(1.14)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C515(0.97); C528(1.42)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C515(0.60); C528(1.18)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C515(0.72); C528(1.31)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C515(0.73); C528(1.23)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C515(0.91); C528(1.16)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C515(0.58); C528(1.09)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C515(0.64); C528(1.12)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C515(0.78); C528(1.25)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C515(0.80); C528(1.00)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C515(0.84); C528(1.29)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C515(0.40); C528(0.89)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C515(0.74); C528(0.94)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C786(0.71); C515(1.06); C246(1.15); C528(0.98)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C786(0.94); C515(0.95); C246(1.05); C528(1.03)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C786(1.02); C515(0.84); C246(1.04); C528(1.06)  LDD1514  [8]
 LDCM0367  CL1 HCT 116 C528(0.68)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C528(1.03)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C786(0.94); C515(0.89); C246(1.04); C528(1.01)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C786(0.97); C515(0.89); C246(0.92); C528(0.99)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C786(0.97); C515(1.08); C246(1.06); C528(1.03)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C786(0.92); C515(0.87); C246(0.94); C528(0.94)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C786(0.87); C515(0.96); C246(1.02); C528(1.02)  LDD1577  [8]
 LDCM0374  CL105 HCT 116 C528(0.63); C515(0.90)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C528(0.80); C515(1.47)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C528(0.85); C515(0.99)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C528(0.68); C515(1.24)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C528(0.77); C515(0.96)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C528(0.93)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C528(0.79); C515(1.39)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C528(0.92); C515(0.92)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C786(0.86); C515(0.89); C246(1.13); C528(1.08)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C786(0.97); C515(0.90); C246(0.81); C528(0.94)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C786(0.97); C515(1.09); C246(0.99); C528(1.13)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C786(0.96); C515(0.90); C246(1.04); C528(0.92)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C786(0.90); C515(0.95); C246(0.90); C528(1.05)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C786(0.98); C515(0.89); C246(0.96); C528(1.01)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C786(0.92); C515(1.11); C246(1.03); C528(1.02)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C786(1.00); C515(0.95); C246(1.01); C528(0.95)  LDD1593  [8]
 LDCM0390  CL12 HCT 116 C528(0.96)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C786(0.90); C515(0.94); C246(1.15); C528(1.14)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C786(1.00); C515(0.85); C246(0.94); C528(1.09)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C786(0.95); C515(1.08); C246(1.00); C528(1.05)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C786(0.92); C515(0.88); C246(1.05); C528(0.98)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C786(0.76); C515(0.89); C246(0.98); C528(0.98)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C786(1.07); C515(0.90); C246(0.91); C528(0.86)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C786(0.98); C515(1.05); C246(1.07); C528(1.06)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C786(1.00); C515(0.98); C246(1.01); C528(0.92)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C786(0.92); C515(0.97); C246(1.08); C528(0.93)  LDD1603  [8]
 LDCM0400  CL13 HCT 116 C528(0.82)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C528(0.88)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C528(1.06)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C528(0.63)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C528(0.90)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C528(0.93)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C528(0.90)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C528(0.87)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C528(0.93)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C528(0.86)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C528(0.86)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C528(0.94)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C528(0.98)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C528(0.84)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C528(1.01)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C528(0.88)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C528(0.97)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C528(0.90)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C528(0.97)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C528(1.05)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C786(1.00); C515(0.96); C246(0.80); C528(1.24)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C786(0.96); C515(1.07); C246(0.94); C528(0.93)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C786(0.90); C515(1.19); C246(0.97); C528(1.20)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C515(1.22); C246(0.79); C329(0.96); C390(0.80)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C786(1.22); C515(1.12); C246(0.86); C528(1.00)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C786(1.41); C515(0.98); C246(1.01); C528(1.11)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C786(1.00); C515(1.00); C246(0.82); C528(0.86)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C786(0.92); C515(0.91); C246(0.95); C528(0.99)  LDD1632  [8]
 LDCM0429  CL4 HCT 116 C528(0.76)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C786(0.91); C515(1.01); C246(1.00); C528(1.17)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C786(0.94); C515(1.05); C246(0.94); C528(1.14)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C786(0.97); C515(0.99); C246(0.86); C528(1.18)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C786(1.06); C515(0.98); C246(0.84); C528(1.07)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C786(1.05); C515(1.04); C246(0.94); C528(0.88)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C786(0.83); C515(1.09); C246(1.12); C528(1.01)  LDD1639  [8]
 LDCM0436  CL46 HCT 116 C515(0.46)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C515(0.97)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C515(0.84)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C515(1.07)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C528(0.95)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C515(0.98)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C515(1.08)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C515(1.08)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C515(0.97)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C515(0.97)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C515(0.87)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C515(0.78)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C515(0.94)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C515(0.93)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C515(1.09)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C528(0.95)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C515(0.99)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C528(0.91)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C528(1.11)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C528(1.01)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C528(1.00)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C528(0.98)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C528(1.04)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C528(0.95)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C528(0.84)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C528(1.16)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C528(0.91)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C528(0.99)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C528(1.19)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C528(0.96)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C528(0.77)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C528(1.02)  LDD0784  [2]
 LDCM0469  CL76 HEK-293T C786(0.87); C515(1.00); C246(0.91); C528(1.02)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C786(0.92); C515(1.02); C246(1.07); C528(0.97)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C786(1.03); C515(0.97); C246(1.02); C528(0.97)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C786(1.06); C515(1.04); C246(0.86); C528(1.08)  LDD1675  [8]
 LDCM0473  CL8 HCT 116 C528(1.38)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C786(0.99); C515(1.03); C246(0.96); C528(0.90)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C786(0.81); C515(1.19); C246(1.08); C528(1.01)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C515(1.02); C246(0.88); C329(1.03); C390(1.00)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C786(1.07); C515(1.22); C246(1.10); C528(1.01)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C786(1.07); C515(0.99); C246(0.84); C528(1.02)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C786(0.99); C515(0.98); C246(0.84); C528(1.03)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C786(1.04); C515(0.98); C246(0.97); C528(0.98)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C786(0.93); C515(0.94); C246(1.07); C528(0.81)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C786(0.96); C515(1.02); C246(1.04); C528(0.95)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C786(0.96); C515(1.02); C246(1.02); C528(1.03)  LDD1686  [8]
 LDCM0484  CL9 HCT 116 C528(1.00)  LDD0801  [2]
 LDCM0485  CL90 HEK-293T C786(0.79); C515(1.06); C246(1.08); C528(1.38)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C786(1.11); C515(1.00); C246(0.92); C528(1.11)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C786(0.95); C515(0.99); C246(1.00); C528(0.89)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C786(0.73); C515(1.07); C246(0.84); C528(1.13)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C515(1.11); C246(1.04); C329(0.90); C390(0.88)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C786(0.97); C515(1.06); C246(1.14); C528(1.37)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C786(1.11); C515(1.09); C246(0.98); C528(1.07)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C786(1.02); C515(1.01); C246(0.92); C528(1.08)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C786(0.97); C515(1.04); C246(0.99); C528(1.09)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C786(1.00); C515(0.97); C246(1.10); C528(0.87)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C786(0.90); C515(0.87); C246(1.08); C528(0.84)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C528(0.85)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C786(1.05); C515(1.05); C246(1.00); C528(1.00)  LDD1631  [8]
 LDCM0022  KB02 HEK-293T C786(1.06); C369(0.96); C528(0.95); C246(1.02)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C786(1.12); C369(0.97); C528(0.93); C246(0.95)  LDD1497  [8]
 LDCM0024  KB05 SNU-478 C246(2.37)  LDD3444  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA replication licensing factor MCM6 (MCM6) MCM family Q14566
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Kelch-like protein 40 (KLHL40) KLHL40 family Q2TBA0
Protein MCM10 homolog (MCM10) MCM10 family Q7L590
Origin recognition complex subunit 2 (ORC2) ORC2 family Q13416
PRKCA-binding protein (PICK1) . Q9NRD5
Ubiquitin-associated domain-containing protein 1 (UBAC1) . Q9BSL1

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840