Details of the Target

General Information of Target

Target ID LDTP10379
Target Name Tonsoku-like protein (TONSL)
Gene Name TONSL
Gene ID 4796
Synonyms
IKBR; NFKBIL2; Tonsoku-like protein; Inhibitor of kappa B-related protein; I-kappa-B-related protein; IkappaBR; NF-kappa-B inhibitor-like protein 2; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSPAAAAAGAGERRRPIASVRDGRGRGCGGPARAVLLGLSLVGLLLYLVPAAAALAWLTV
GATAAWWGLSREPRGSRPLSSFVRKARHRRPLSSFVRKARHRRTLFASPLAKSTANGNLL
EPRTLLEGPDPAELLLMGSYLGKPGPPQPAAAPEGQDLRDRPGRRPPARPAPRSPPPRSP
PPRSPPPSPPTHRAHHVYPSLPTPLLRPSRRPSPRDCGTLPNRFVITPRRRYPIHQAQYS
CLGVLPTVCWNGYHKKAVLSPRNSRMVCSPVTVRIAPPDRRFSRSAIPEQIISSTLSSPS
SNAPDPCAKETVLSALKEKEKKRTVEEEDQIFLDGQENKRRRHDSSGSGHSAFEPLVANG
VPASFVPKPGSLKRGLNSQSSDDHLNKRSRSSSMSSLTGAYASGIPSSSRNAITSSYSST
RGISQLWKRNGPSSSPFSSPASSRSQTPERPAKKIREEELCHHSSSSTPLAADRESQGEK
AADTTPRKKQNSNSQSTPGSSGQRKRKVQLLPSRRGEQLTLPPPPQLGYSITAEDLDLEK
KASLQWFNQALEDKSDAASNSVTETPPITQPSFTFTLPAAAPASPPTSLLAPSTNPLLES
LKKMQTPPSLPPCPESAGAATTEALSPPKTPSLLPPLGLSQSGPPGLLPSPSFDSKPPTT
LLGLIPAPSMVPATDTKAPPTLQAETATKPQATSAPSPAPKQSFLFGTQNTSPSSPAAPA
ASSAPPMFKPIFTAPPKSEKEGPTPPGPSVTATAPSSSSLPTTTSTTAPTFQPVFSSMGP
PASVPLPAPFFKQTTTPATAPTTTAPLFTGLASATSAVAPITSASPSTDSASKPAFGFGI
NSVSSSSVSTTTSTATAASQPFLFGAPQASAASFTPAMGSIFQFGKPPALPTTTTVTTFS
QSLHTAVPTATSSSAADFSGFGSTLATSAPATSSQPTLTFSNTSTPTFNIPFGSSAKSPL
PSYPGANPQPAFGAAEGQPPGAAKPALAPSFGSSFTFGNSAAPAAAPTPAPPSMIKVVPA
YVPTPIHPIFGGATHSAFGLKATASAFGAPASSQPAFGGSTAVFFGAATSSGFGATTQTA
SSGSSSSVFGSTTPSPFTFGGSAAPAGSGSFGINVATPGSSTTTGAFSFGAGQSGSTATS
TPFAGGLGQNALGTTGQSTPFAFNVSSTTESKPVFGGTATPTFGLNTPAPGVGTSGSSLS
FGASSAPAQGFVGVAPFGSAALSFSIGAGSKTPGARQRLQARRQHTRKK
Target Bioclass
Transcription factor
Family
Tonsoku family
Subcellular location
Nucleus
Function
Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication. It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs. Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination. Within the complex, TONSL acts as a histone reader, which recognizes and binds newly synthesized histones following their replacement by histone chaperones. Specifically binds histone H4 lacking methylation at 'Lys-20' (H4K20me0) and histone H3.1.
Uniprot ID
Q96HA7
Ensemble ID
ENST00000409379.8
HGNC ID
HGNC:7801

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.R426P .
HCC15 SNV: p.D650A DBIA    Probe Info 
HT1197 SNV: p.Q1356Ter .
Ishikawa (Heraklio) 02 ER SNV: p.H715R DBIA    Probe Info 
JURKAT SNV: p.A777S Compound 10    Probe Info 
LN18 SNV: p.E868K DBIA    Probe Info 
LS180 SNV: p.V948I DBIA    Probe Info 
MDAMB436 SNV: p.A449V DBIA    Probe Info 
MDAMB453 SNV: p.P760L DBIA    Probe Info 
MEWO Substitution: p.P841L DBIA    Probe Info 
MOLT4 SNV: p.S1099G IA-alkyne    Probe Info 
NCIH196 SNV: p.A1207G DBIA    Probe Info 
NUGC3 SNV: p.A331D .
SNU1 Deletion: p.L602SfsTer41 DBIA    Probe Info 
TE1 SNV: p.S756F DBIA    Probe Info 
TGBC1TKB SNV: p.A714T DBIA    Probe Info 
THP1 SNV: p.A770P .
TKKK SNV: p.Q9E DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.93  LDD0402  [1]
BTD
 Probe Info  		C420(0.81)  LDD2093  [2]
AHL-Pu-1
 Probe Info  		C830(7.62)  LDD0168  [3]
DBIA
 Probe Info  		C124(1.06)  LDD0078  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C420(0.00); C1086(0.00); C1340(0.00); C1316(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C420(0.00); C1086(0.00); C1340(0.00); C124(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C283(0.00); C420(0.00); C124(0.00); C1316(0.00)  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
Compound 10
 Probe Info  		C124(0.00); C283(0.00); C420(0.00); C762(0.00)  LDD2216  [8]
Compound 11
 Probe Info  		N.A.  LDD2213  [8]
ENE
 Probe Info  		N.A.  LDD0006  [9]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Acrolein
 Probe Info  		C124(0.00); C1365(0.00)  LDD0217  [10]
Methacrolein
 Probe Info  		C66(0.00); C124(0.00)  LDD0218  [10]
W1
 Probe Info  		C972(0.00); C420(0.00)  LDD0236  [11]
AOyne
 Probe Info  		13.10  LDD0443  [12]
NAIA_5
 Probe Info  		C283(0.00); C420(0.00); C30(0.00); C1086(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C420(0.81)  LDD2117  [2]
 LDCM0025  4SU-RNA HEK-293T C830(7.62)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C830(4.21)  LDD0169  [3]
 LDCM0214  AC1 HEK-293T C537(0.90); C1248(1.09); C283(0.96); C830(0.83)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C537(0.94); C1248(1.09); C283(0.97); C830(1.20)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C537(1.19); C283(0.85); C830(0.85); C231(1.02)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C537(0.90); C1248(1.15); C283(0.99); C830(0.88)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C537(0.84); C1340(0.99); C283(0.97); C830(0.97)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C537(1.02); C1340(1.03); C1248(1.11); C283(0.90)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C537(0.98); C1248(1.06); C283(1.00); C830(0.81)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C537(1.03); C1248(0.99); C283(1.08); C830(1.05)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C537(0.73); C283(0.89); C830(0.98); C231(1.08)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C537(1.03); C1248(0.98); C283(1.06); C830(1.24)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C537(0.93); C1248(1.16); C283(0.94); C830(1.26)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C537(1.09); C1340(1.00); C283(0.94); C830(1.14)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C537(0.91); C1340(0.96); C283(1.03); C830(0.90)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C537(1.01); C1340(0.97); C1248(1.12); C283(0.96)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C537(0.93); C1340(0.98); C283(0.82); C830(0.97)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C537(0.99); C1248(1.16); C283(1.00); C830(0.84)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C537(1.01); C1248(1.10); C283(0.91); C830(1.16)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C537(1.14); C283(0.99); C830(0.98); C231(1.03)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C537(0.89); C1248(1.14); C283(0.97); C830(0.90)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C537(0.98); C1340(0.99); C283(0.91); C830(1.04)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C537(0.97); C283(1.00); C830(0.92); C231(1.03)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C537(0.87); C1340(1.00); C283(0.96); C830(0.96)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C537(1.02); C1340(1.01); C1248(0.99); C283(0.98)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C537(0.91); C1340(1.04); C283(0.93); C830(1.10)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C537(1.00); C1248(1.10); C283(0.95); C830(0.92)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C537(1.12); C1248(1.09); C283(1.10); C830(0.94)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C537(1.15); C283(0.93); C830(0.97); C231(0.99)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C537(0.96); C1248(1.20); C283(1.03); C830(0.86)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C537(1.23); C1340(1.00); C283(0.92); C830(1.09)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C537(1.08); C1340(1.01); C283(0.96); C830(1.05)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C537(1.08); C1340(0.99); C1248(1.22); C283(0.92)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C537(0.92); C1248(1.14); C283(1.03); C830(1.21)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C537(0.91); C1340(1.12); C283(0.85); C830(0.93)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C537(0.86); C1248(1.04); C283(1.10); C830(0.91)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C537(1.01); C1248(1.15); C283(0.98); C830(0.90)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C537(1.05); C283(0.87); C830(0.99); C231(0.97)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C537(1.12); C1248(1.06); C283(1.08); C830(0.93)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C537(1.15); C1340(0.99); C283(0.95); C830(1.03)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C537(0.83); C1340(1.05); C283(0.94); C830(0.95)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C537(1.13); C1340(1.07); C1248(1.12); C283(1.02)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C537(1.00); C1340(1.08); C283(0.91); C830(1.20)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C537(0.86); C1248(0.94); C283(1.10); C830(1.20)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C537(0.92); C1340(0.89); C283(0.93); C830(1.08)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C537(1.06); C1248(1.12); C283(0.99); C830(0.98)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C537(1.24); C283(0.97); C830(1.39); C231(1.11)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C537(0.93); C1248(1.12); C283(1.00); C830(1.31)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C537(0.96); C1340(0.99); C283(1.08); C830(1.14)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C537(0.88); C1340(1.00); C283(1.02); C830(0.96)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C537(1.03); C1340(1.04); C1248(1.10); C283(0.91)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C537(0.98); C1340(1.07); C283(0.96); C830(1.17)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C537(0.93); C1248(0.98); C283(1.02); C830(0.70)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C537(1.01); C1248(0.97); C283(1.07); C830(1.14)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C537(1.19); C283(0.97); C830(0.92); C231(1.03)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C537(0.86); C1340(0.99); C283(0.98); C830(0.97)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C537(1.00); C1248(1.07); C283(0.93); C830(0.93)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C537(0.93); C1340(1.05); C283(0.94); C830(1.00)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C537(0.75); C1340(1.09); C283(0.96); C830(0.96)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C537(1.01); C1340(1.02); C1248(1.09); C283(0.92)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C537(0.87); C1340(1.06); C283(0.94); C830(1.10)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C537(1.03); C1340(1.07); C1248(1.16); C283(0.93)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C537(0.86); C1340(1.05); C283(0.87); C830(1.07)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C537(1.09); C1340(0.94); C283(0.96); C830(1.05)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C537(0.86); C1248(1.03); C283(0.98); C830(0.73)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C537(0.85); C1340(1.06); C283(0.93); C830(1.13)  LDD1514  [13]
 LDCM0020  ARS-1620 HCC44 C124(1.06)  LDD0078  [4]
 LDCM0630  CCW28-3 231MFP C1291(1.25)  LDD2214  [14]
 LDCM0108  Chloroacetamide HeLa C124(0.00); C66(0.00); C30(0.00)  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C283(0.52)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C124(1.13); C537(0.90); C1340(0.94); C1248(1.16)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C537(0.78); C1340(1.22); C283(0.85); C830(0.91)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C537(1.11); C283(1.03); C830(0.82); C231(1.02)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C124(1.29); C537(0.81); C1340(1.01); C1248(0.97)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C124(0.93); C1340(1.08); C283(0.98); C830(0.89)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C537(1.10); C1340(1.04); C283(0.95); C830(0.91)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C537(1.03); C283(0.94); C830(0.85); C231(1.01)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C124(1.01); C537(0.85); C1340(1.03); C1248(1.15)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C124(1.02); C1340(1.04); C283(1.04); C830(1.07)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C537(0.99); C1340(1.05); C283(1.02); C830(0.93)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C537(1.08); C283(0.93); C830(0.80); C231(0.98)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C124(1.01); C537(0.82); C1340(1.03); C1248(1.27)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C537(0.91); C1340(1.06); C1248(1.14); C283(0.90)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C124(0.98); C1340(1.15); C283(0.94); C830(0.89)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C537(1.00); C1340(1.01); C283(0.97); C830(1.05)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C537(0.97); C283(0.94); C830(0.85); C231(1.05)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C124(0.95); C537(0.93); C1340(0.95); C1248(1.23)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C124(0.98); C1340(1.13); C283(1.07); C830(0.94)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C537(1.11); C1340(0.97); C283(0.92); C830(1.03)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C537(1.04); C283(1.04); C830(0.84); C231(1.01)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C124(1.16); C537(0.83); C1340(1.03); C1248(1.08)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C124(1.08); C1340(1.01); C283(0.96); C830(1.03)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C537(1.05); C1340(0.98); C283(0.93); C830(1.05)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C537(0.79); C1340(1.04); C283(0.88); C830(1.09)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C537(1.08); C283(0.97); C830(0.99); C231(0.96)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C124(1.17); C537(0.89); C1340(0.97); C1248(0.91)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C124(1.11); C1340(1.06); C283(0.99); C830(1.07)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C537(0.92); C1340(0.95); C283(1.02); C830(0.84)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C537(1.07); C283(1.00); C830(0.87); C231(0.99)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C124(1.23); C537(0.88); C1340(1.00); C1248(0.81)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C124(1.16); C1340(1.06); C283(0.98); C830(1.01)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C537(1.08); C1340(1.16); C283(0.98); C830(1.00)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C537(1.04); C283(1.10); C830(1.13); C231(0.97)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C124(1.27); C537(1.02); C1340(1.09); C1248(0.89)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C124(1.12); C1340(1.07); C283(1.05); C830(1.22)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C537(1.00); C1340(1.03); C283(0.99); C830(1.08)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C537(1.11); C283(0.94); C830(1.00); C231(0.96)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C537(0.82); C1248(1.28); C283(1.03); C830(0.86)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C537(1.10); C1248(1.06); C283(1.02); C830(1.21)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C537(1.12); C283(0.94); C830(0.83); C231(1.02)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C124(1.09); C1340(1.12); C283(1.02); C830(1.15)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C537(0.92); C1248(1.02); C283(1.02); C830(0.87)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C537(0.93); C1340(1.17); C283(0.92); C830(1.18)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C537(0.90); C1340(1.08); C283(0.95); C830(0.94)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C537(0.89); C1340(1.01); C1248(1.17); C283(0.96)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C537(0.80); C1340(1.02); C283(0.92); C830(1.34)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C124(1.40); C537(0.91); C1340(1.06); C1248(1.12)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C124(1.05); C1340(0.98); C283(1.04); C830(0.93)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C537(1.07); C1340(1.02); C283(0.98); C830(1.10)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C537(1.05); C283(1.02); C830(0.92); C231(0.98)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C537(1.00); C1248(0.97); C283(0.94); C830(0.98)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C537(1.02); C1340(1.12); C283(1.05); C830(0.80)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C537(1.22); C1248(1.01); C283(0.99); C830(1.15)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C537(1.04); C283(0.83); C830(0.84); C231(0.97)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C537(1.03); C1248(0.96); C283(0.99); C830(0.79)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C537(0.84); C1340(1.60); C283(0.91); C830(0.83)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C537(1.01); C1340(1.07); C283(0.90); C830(0.99)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C537(1.06); C1340(0.99); C1248(1.04); C283(0.85)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C537(0.75); C1340(1.02); C283(0.80); C830(1.08)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C124(1.07); C537(1.01); C1340(1.02); C1248(1.08)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C537(1.02); C1340(0.98); C283(0.92); C830(1.03)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C537(1.07); C283(1.04); C830(0.87); C231(1.02)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C537(1.05); C283(0.96); C830(0.89); C231(1.16)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C537(0.96); C1248(1.19); C283(1.00); C830(0.64)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C537(1.31); C1248(0.88); C283(1.00); C830(1.10)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C537(1.34); C283(0.89); C830(1.17); C231(1.14)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C537(0.86); C1248(1.01); C283(0.97); C830(1.05)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C537(1.00); C1340(1.22); C283(0.99); C830(0.83)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C537(0.93); C1340(1.09); C283(0.91); C830(0.87)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C537(0.96); C1340(1.10); C1248(0.93); C283(0.85)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C537(0.87); C1340(0.97); C283(0.79); C830(1.05)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C124(1.05); C537(1.08); C1340(0.96); C1248(0.90)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C537(0.88); C1248(0.92); C283(1.02); C830(0.87)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C124(1.03); C1340(1.08); C283(0.98); C830(1.08)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C537(1.26); C283(0.94); C830(0.97); C231(1.07)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C537(0.92); C1248(1.41); C283(1.01); C830(0.82)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C537(0.90); C1248(1.20); C283(0.95); C830(1.18)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C537(1.06); C283(0.83); C830(1.13); C231(1.07)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C537(0.81); C1248(1.00); C283(0.97); C830(1.10)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C537(0.80); C1340(1.25); C283(0.87); C830(0.86)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C537(1.07); C1340(1.09); C283(1.06); C830(0.93)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C537(0.92); C1340(1.00); C1248(1.01); C283(0.84)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C537(0.94); C1248(1.17); C283(1.03); C830(1.22)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C537(0.76); C1340(1.03); C283(0.78); C830(1.15)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C124(1.19); C537(0.87); C1340(0.95); C1248(0.98)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C124(1.15); C1340(1.03); C283(1.04); C830(1.16)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C537(1.13); C1340(1.13); C283(0.97); C830(1.06)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C537(1.00); C283(0.97); C830(0.79); C231(0.90)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C537(1.06); C1248(1.07); C283(0.96); C830(0.84)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C537(1.03); C1248(1.13); C283(1.03); C830(1.14)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C537(1.09); C283(0.86); C830(0.89); C231(1.02)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C537(0.93); C1248(1.03); C283(1.01); C830(0.75)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C537(1.05); C1340(1.13); C283(0.86); C830(1.00)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C537(1.00); C283(0.94); C830(1.13); C231(1.00)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C537(0.95); C1340(1.12); C283(0.89); C830(0.98)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C537(0.94); C1340(1.08); C1248(0.98); C283(0.88)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C537(0.83); C1340(1.08); C283(0.89); C830(1.19)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C124(0.99); C537(0.86); C1340(1.04); C1248(0.99)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C124(1.02); C1340(1.03); C283(1.10); C830(1.07)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C537(0.94); C283(1.06); C830(0.85); C231(1.02)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C537(0.83); C1248(1.13); C283(0.98); C830(0.65)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C537(0.96); C1248(1.06); C283(1.07); C830(1.04)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C537(0.92); C283(0.86); C830(1.20); C231(1.00)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C537(0.59); C1248(1.36); C283(0.95); C830(0.77)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C537(1.03); C1248(0.90); C283(0.95); C830(1.00)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C537(1.05); C1340(1.08); C283(0.97); C830(1.02)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C537(1.04); C1340(0.77); C283(0.94); C830(0.98)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C537(0.90); C1340(1.02); C1248(1.03); C283(0.94)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C537(0.72); C1340(1.06); C283(0.83); C830(1.08)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C124(1.07); C537(0.75); C1340(0.98); C1248(0.88)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C124(1.08); C1340(1.04); C283(1.09); C830(1.00)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C537(1.06); C1340(0.96); C283(0.99); C830(1.10)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C537(1.42); C283(1.04); C830(0.89); C231(1.09)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C537(1.03); C1248(0.80); C283(0.89); C830(0.65)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C537(1.14); C1340(1.11); C283(0.96); C830(1.00)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C537(0.77); C1248(1.24); C283(1.00); C830(0.86)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C537(1.17); C283(0.84); C830(0.72); C231(1.14)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C537(0.88); C1248(1.06); C283(0.93); C830(0.75)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C537(0.90); C1340(1.16); C283(0.89); C830(1.05)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C537(0.87); C1340(1.02); C283(0.85); C830(0.97)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C537(0.67); C1340(1.49); C1248(1.28); C283(0.82)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C537(0.76); C1340(1.09); C283(0.75); C830(0.92)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C124(1.31); C537(0.80); C1340(0.97); C1248(0.95)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C124(1.00); C1340(1.02); C283(1.02); C830(1.06)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C537(1.02); C1340(0.97); C283(0.98); C830(1.30)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C537(1.20); C1340(1.16); C283(0.91); C830(0.90)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C124(2.44); C762(1.52); C66(1.16)  LDD1702  [2]
 LDCM0625  F8 Ramos C762(0.98); C420(1.41); C283(0.57)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C762(1.29); C420(0.43); C30(0.47)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C762(7.36); C420(0.77); C283(0.83); C30(6.05)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C762(0.79); C420(0.50)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C762(0.83); C420(0.65)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C762(1.03); C420(0.65); C283(0.96)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C420(0.85)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C762(0.93); C420(0.61); C30(0.66)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C762(0.74); C420(0.58)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C762(0.80); C420(0.84)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C420(0.74); C283(1.66); C30(0.65)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C762(0.94); C420(0.77); C30(0.58)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C762(0.65); C420(0.68); C30(0.91)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C762(1.34); C420(0.45); C30(0.44)  LDD2201  [15]
 LDCM0468  Fragment33 HEK-293T C537(1.11); C1340(1.06); C283(1.00); C830(1.06)  LDD1671  [13]
 LDCM0596  Fragment38 Ramos C762(0.88); C420(0.83)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C762(1.01); C420(0.82); C30(0.87)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C124(1.09); C1340(1.12); C283(1.04); C830(0.71)  LDD1631  [13]
 LDCM0610  Fragment52 Ramos C762(1.61); C420(1.04)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C762(2.42); C420(1.51)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C420(0.85); C30(2.00)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C762(1.14); C420(0.82)  LDD2188  [15]
 LDCM0022  KB02 HEK-293T C231(0.94); C1365(1.17); C66(0.89); C1340(0.94)  LDD1492  [13]
 LDCM0023  KB03 Jurkat C66(78.60); C537(400.13); C231(161.20); C224(9.30)  LDD0209  [16]
 LDCM0024  KB05 G361 C283(2.46); C537(1.82)  LDD3311  [17]
 LDCM0109  NEM HeLa H436(0.00); H438(0.00)  LDD0223  [10]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C420(0.81)  LDD2093  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C420(0.64)  LDD2099  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C420(0.72)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C66(1.10)  LDD2111  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C420(0.68)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C420(1.40); C66(1.14)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C231(1.05)  LDD2129  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C420(1.09)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C420(0.93)  LDD2137  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C66(0.94)  LDD2140  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C66(0.71)  LDD2148  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein MMS22-like (MMS22L) MMS22 family Q6ZRQ5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840