Details of the Target

General Information of Target

Target ID LDTP08713
Target Name WD repeat and FYVE domain-containing protein 3 (WDFY3)
Gene Name WDFY3
Gene ID 23001
Synonyms
KIAA0993; WD repeat and FYVE domain-containing protein 3; Autophagy-linked FYVE protein; Alfy
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNMVKRIMGRPRQEECSPQDNALGLMHLRRLFTELCHPPRHMTQKEQEEKLYMMLPVFNR
VFGNAPPNTMTEKFSDLLQFTTQVSRLMVTEIRRRASNKSTEAASRAIVQFLEINQSEEA
SRGWMLLTTINLLASSGQKTVDCMTTMSVPSTLVKCLYLFFDLPHVPEAVGGAQNELPLA
ERRGLLQKVFVQILVKLCSFVSPAEELAQKDDLQLLFSAITSWCPPYNLPWRKSAGEVLM
TISRHGLSVNVVKYIHEKECLSTCVQNMQQSDDLSPLEIVEMFAGLSCFLKDSSDVSQTL
LDDFRIWQGYNFLCDLLLRLEQAKEAESKDALKDLVNLITSLTTYGVSELKPAGITTGAP
FLLPGFAVPQPAGKGHSVRNVQAFAVLQNAFLKAKTSFLAQIILDAITNIYMADNANYFI
LESQHTLSQFAEKISKLPEVQNKYFEMLEFVVFSLNYIPCKELISVSILLKSSSSYHCSI
IAMKTLLKFTRHDYIFKDVFREVGLLEVMVNLLHKYAALLKDPTQALNEQGDSRNNSSVE
DQKHLALLVMETLTVLLQGSNTNAGIFREFGGARCAHNIVKYPQCRQHALMTIQQLVLSP
NGDDDMGTLLGLMHSAPPTELQLKTDILRALLSVLRESHRSRTVFRKVGGFVYITSLLVA
MERSLSCPPKNGWEKVNQNQVFELLHTVFCTLTAAMRYEPANSHFFKTEIQYEKLADAVR
FLGCFSDLRKISAMNVFPSNTQPFQRLLEEDVISIESVSPTLRHCSKLFIYLYKVATDSF
DSRAEQIPPCLTSESSLPSPWGTPALSRKRHAYHSVSTPPVYPPKNVADLKLHVTTSSLQ
SSDAVIIHPGAMLAMLDLLASVGSVTQPEHALDLQLAVANILQSLVHTERNQQVMCEAGL
HARLLQRCSAALADEDHSLHPPLQRMFERLASQALEPMVLREFLRLASPLNCGAWDKKLL
KQYRVHKPSSLSYEPEMRSSMITSLEGLGTDNVFSLHEDNHYRISKSLVKSAEGSTVPLT
RVKCLVSMTTPHDIRLHGSSVTPAFVEFDTSLEGFGCLFLPSLAPHNAPTNNTVTTGLID
GAVVSGIGSGERFFPPPSGLSYSSWFCIEHFSSPPNNHPVRLLTVVRRANSSEQHYVCLA
IVLSAKDRSLIVSTKEELLQNYVDDFSEESSFYEILPCCARFRCGELIIEGQWHHLVLVM
SKGMLKNSTAALYIDGQLVNTVKLHYVHSTPGGSGSANPPVVSTVYAYIGTPPAQRQIAS
LVWRLGPTHFLEEVLPSSNVTTIYELGPNYVGSFQAVCMPCKDAKSEGVVPSPVSLVPEE
KVSFGLYALSVSSLTVARIRKVYNKLDSKAIAKQLGISSHENATPVKLIHNSAGHLNGSA
RTIGAALIGYLGVRTFVPKPVATTLQYVGGAAAILGLVAMASDVEGLYAAVKALVCVVKS
NPLASKEMERIKGYQLLAMLLKKKRSLLNSHILHLTFSLVGTVDSGHETSIIPNSTAFQD
LLCDFEVWLHAPYELHLSLFEHFIELLTESSEASKNAKLMREFQLIPKLLLTLRDMSLSQ
PTIAAISNVLSFLLQGFPSSNDLLRFGQFISSTLPTFAVCEKFVVMEINNEEKLDTGTEE
EFGGLVSANLILLRNRLLDILLKLIYTSKEKTSINLQACEELVKTLGFDWIMMFMEEHLH
STTVTAAMRILVVLLSNQSILIKFKEGLSGGGWLEQTDSVLTNKIGTVLGFNVGRSAGGR
STVREINRDACHFPGFPVLQSFLPKHTNVPALYFLLMALFLQQPVSELPENLQVSVPVIS
CRSKQGCQFDLDSIWTFIFGVPASSGTVVSSIHNVCTEAVFLLLGMLRSMLTSPWQSEEE
GSWLREYPVTLMQFFRYLYHNVPDLASMWMSPDFLCALAATVFPFNIRPYSEMVTDLDDE
VGSPAEEFKAFAADTGMNRSQSEYCNVGTKTYLTNHPAKKFVFDFMRVLIIDNLCLTPAS
KQTPLIDLLLEASPERSTRTQQKEFQTYILDSVMDHLLAADVLLGEDASLPITSGGSYQV
LVNNVFYFTQRVVDKLWQGMFNKESKLLIDFIIQLIAQSKRRSQGLSLDAVYHCLNRTIL
YQFSRAHKTVPQQVALLDSLRVLTVNRNLILGPGNHDQEFISCLAHCLINLHVGSNVDGF
GLEAEARMTTWHIMIPSDIEPDGSYSQDISEGRQLLIKAVNRVWTELIHSKKQVLEELFK
VTLPVNERGHVDIATARPLIEEAALKCWQNHLAHEKKCISRGEALAPTTQSKLSRVSSGF
GLSKLTGSRRNRKESGLNKHSLSTQEISQWMFTHIAVVRDLVDTQYKEYQERQQNALKYV
TEEWCQIECELLRERGLWGPPIGSHLDKWMLEMTEGPCRMRKKMVRNDMFYNHYPYVPET
EQETNVASEIPSKQPETPDDIPQKKPARYRRAVSYDSKEYYMRLASGNPAIVQDAIVESS
EGEAAQQEPEHGEDTIAKVKGLVKPPLKRSRSAPDGGDEENQEQLQDQIAEGSSIEEEEK
TDNATLLRLLEEGEKIQHMYRCARVQGLDTSEGLLLFGKEHFYVIDGFTMTATREIRDIE
TLPPNMHEPIIPRGARQGPSQLKRTCSIFAYEDIKEVHKRRYLLQPIAVEVFSGDGRNYL
LAFQKGIRNKVYQRFLAVVPSLTDSSESVSGQRPNTSVEQGSGLLSTLVGEKSVTQRWER
GEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEEVDLTNPKTFRNLAKPMGAQT
DERLAQYKKRYKDWEDPNGETPAYHYGTHYSSAMIVASYLVRMEPFTQIFLRLQGGHFDL
ADRMFHSVREAWYSASKHNMADVKELIPEFFYLPEFLFNSNNFDLGCKQNGTKLGDVILP
PWAKGDPREFIRVHREALECDYVSAHLHEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQV
DIYNINDPLKETATIGFINNFGQIPKQLFKKPHPPKRVRSRLNGDNAGISVLPGSTSDKI
FFHHLDNLRPSLTPVKELKEPVGQIVCTDKGILAVEQNKVLIPPTWNKTFAWGYADLSCR
LGTYESDKAMTVYECLSEWGQILCAICPNPKLVITGGTSTVVCVWEMGTSKEKAKTVTLK
QALLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFLTQLRGHRAPVSALCINEL
TGDIVSCAGTYIHVWSINGNPIVSVNTFTGRSQQIICCCMSEMNEWDTQNVIVTGHSDGV
VRFWRMEFLQVPETPAPEPAEVLEMQEDCPEAQIGQEAQDEDSSDSEADEQSISQDPKDT
PSQPSSTSHRPRAASCRATAAWCTDSGSDDSRRWSDQLSLDEKDGFIFVNYSEGQTRAHL
QGPLSHPHPNPIEVRNYSRLKPGYRWERQLVFRSKLTMHTAFDRKDNAHPAEVTALGISK
DHSRILVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCG
QLFCQKCSRFQSEIKRLKISSPVRVCQNCYYNLQHERGSEDGPRNC
Target Bioclass
Other
Subcellular location
Nucleus membrane
Function
Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3. Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus. Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1. Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development. May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway. After cytokinetic abscission, involved in midbody remnant degradation. In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P).
Uniprot ID
Q8IZQ1
Ensemble ID
ENST00000295888.9
HGNC ID
HGNC:20751

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.R568Ter DBIA    Probe Info 
A3KAW SNV: p.F2863V .
CAL148 SNV: p.Q1805R DBIA    Probe Info 
CAL33 SNV: p.E422Q DBIA    Probe Info 
CCK81 SNV: p.L185P DBIA    Probe Info 
CHL1 SNV: p.A1380S DBIA    Probe Info 
COLO320 SNV: p.D914G .
COLO792 Substitution: p.P800F DBIA    Probe Info 
DU145 SNV: p.R2544L; p.G3480A .
EFO27 Deletion: p.F453LfsTer3 .
G361 SNV: p.Q2963H DBIA    Probe Info 
HEC1 SNV: p.V3434D DBIA    Probe Info 
HT115 SNV: p.I464V; p.D3282N .
Ishikawa (Heraklio) 02 ER SNV: p.K2918E DBIA    Probe Info 
KMS27 SNV: p.N1071S .
KNS42 SNV: p.R2770Q DBIA    Probe Info 
LS180 SNV: p.F651L .
MCC13 SNV: p.H37Q; p.G2875R DBIA    Probe Info 
MDST8 SNV: p.K2383Ter DBIA    Probe Info 
MEWO SNV: p.P1994S DBIA    Probe Info 
NALM6 SNV: p.N2861K .
NCIH1993 SNV: p.E2372K .
NCIH2286 SNV: p.S1531I .
PF382 SNV: p.G1416C .
RH41 Substitution: p.A3401V DBIA    Probe Info 
SJSA1 SNV: p.S2184G .
SKMEL5 SNV: p.F80L DBIA    Probe Info 
SNU1 SNV: p.A2657V; p.R3489H DBIA    Probe Info 
SW1271 SNV: p.K1705Ter .
SW1783 SNV: p.S3221L .
SW403 SNV: p.E986V DBIA    Probe Info 
VMRCRCW SNV: p.G246A DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K2971(10.00)  LDD0277  [1]
NAIA_5
 Probe Info  		C1600(20.00); C1975(0.58)  LDD2227  [2]
AHL-Pu-1
 Probe Info  		C1600(2.78)  LDD0172  [3]
DBIA
 Probe Info  		C3460(1.40); C3463(1.40); C1945(0.90)  LDD0078  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
NAIA_4
 Probe Info  		C908(0.00); C3103(0.00); C3323(0.00)  LDD2226  [2]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
AOyne
 Probe Info  		7.70  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C1600(2.78)  LDD0172  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1600(5.40)  LDD0173  [3]
 LDCM0214  AC1 HCT 116 C1945(1.33); C2247(1.18); C724(0.94)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C1945(1.05); C2247(1.35); C724(1.04); C952(0.92)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C2247(0.92); C724(0.66)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C2247(0.97); C724(0.73)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C2247(0.91); C724(0.69)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C2247(1.05); C724(0.73)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C2247(0.96); C724(0.74)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C2247(1.07); C724(0.83)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C2247(1.10); C724(0.73)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C2247(1.48); C724(0.69)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C2247(0.99); C724(0.73)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C2247(0.97); C724(0.70)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C1945(1.20); C2247(1.30); C724(1.00); C952(0.85)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C2247(0.93); C724(0.74)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C2247(1.00); C724(0.69)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C2247(1.18); C724(0.80)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C2247(0.94); C724(0.84)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C2247(1.11); C724(0.97)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C2247(1.15); C724(0.95)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C2247(1.03); C724(0.88)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C2247(0.97); C724(0.96)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C2247(1.12); C724(1.13)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C2247(1.01); C724(1.11)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C1945(0.88); C2247(1.01); C724(0.96); C952(0.89)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C2247(0.86); C724(1.05)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C2247(0.95); C724(1.04)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C2247(1.14); C724(0.88)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C2247(0.97); C724(0.97)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C2247(0.91); C724(0.86)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C2247(0.97); C724(1.07)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C2247(1.02); C724(1.03)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C2247(1.06); C724(1.00)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C2247(1.43); C724(1.35)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C2247(1.10); C724(1.00)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C2247(1.39); C724(1.11)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C2247(1.14); C724(1.02)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C2247(1.26); C724(1.26)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C2247(1.36); C724(1.27)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C2247(1.43); C724(1.25)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C2247(1.54); C724(1.27)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C2247(1.20); C724(1.17)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C2247(1.18); C724(1.00)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C2247(1.47); C724(1.15)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C2247(1.48); C724(1.34)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C1945(1.07); C2247(1.25); C724(1.00); C952(0.85)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C2247(1.49); C724(1.21)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C2247(1.40); C724(1.30)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C2247(1.14); C724(1.09)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C724(0.85); C2247(1.20)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C724(0.94); C2247(1.01)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C724(0.86); C2247(1.10)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C724(0.83); C2247(1.18)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C724(1.01); C2247(1.11)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C724(0.93); C2247(1.00)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C724(0.85); C2247(0.99)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C952(0.89); C724(1.07); C1945(1.31); C2247(1.35)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C724(0.88); C2247(0.93)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C724(0.85); C2247(1.03)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C2247(0.85); C724(0.89)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C2247(0.79); C724(0.88)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C2247(0.87); C724(0.83)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C2247(0.92); C724(0.72)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C2247(1.01); C724(0.87)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C2247(1.05); C724(0.81)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C724(0.88); C2247(0.98); C1945(1.14)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C724(0.80); C2247(1.16); C1945(1.71)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C2247(0.97); C724(1.01); C1945(1.21)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C724(1.10); C2247(1.21); C1945(1.27)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C724(0.84); C2247(1.06); C1945(1.15)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C724(0.88); C2247(1.00); C1945(1.29)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C724(0.84); C2247(0.98); C1945(1.11)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C724(0.87); C2247(1.05); C1945(1.16)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C2247(0.93); C724(1.04); C1945(1.07)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C724(0.95); C952(0.95); C2247(1.10); C3059(1.29)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C3460(0.86); C3463(0.86); C952(0.93); C724(1.09)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C952(0.91); C724(1.01); C3059(1.04); C2247(1.24)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C952(1.06); C3059(1.07); C724(1.10); C2247(1.11)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C3460(0.84); C3463(0.84); C952(0.91); C724(0.97)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C724(1.18); C2247(1.26); C1945(1.29)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C952(0.81); C724(1.00); C3460(1.08); C3463(1.08)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C952(0.84); C724(0.97); C3460(1.03); C3463(1.03)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C952(0.85); C3460(0.91); C3463(0.91); C724(1.18)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C952(0.92); C724(0.96); C3460(0.99); C3463(0.99)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C3460(0.62); C3463(0.62); C952(0.84); C724(0.91)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C3059(0.68); C2247(0.80); C724(0.96); C952(1.08)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C2247(0.88); C3059(0.89); C952(0.90); C724(0.99)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C2247(0.89); C724(1.01); C952(1.16); C3059(1.25)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C2247(0.88); C724(0.99); C952(1.03); C3059(1.20)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C3059(0.81); C952(0.94); C2247(1.01); C724(1.10)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C724(1.10); C2247(1.35); C1945(1.59)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C3059(0.78); C952(0.94); C724(0.97); C2247(1.06)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C3059(0.72); C2247(0.92); C724(0.92); C952(0.94)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C952(0.92); C2247(0.99); C724(1.01); C3059(1.02)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C3059(0.68); C952(0.93); C2247(1.02); C724(1.03)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C3059(0.63); C724(1.00); C952(1.06); C2247(1.10)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C724(0.99); C952(1.00); C3059(1.02); C2247(1.07)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C2247(1.02); C724(1.03); C3059(1.27)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C3059(0.82); C724(1.05); C2247(1.09)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C724(1.12); C2247(1.15); C3059(1.40)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C3059(0.72); C724(1.09); C2247(1.36)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C724(1.06); C2247(1.48); C1945(1.64)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C3059(0.75); C724(0.99); C2247(1.32)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C2247(0.87); C724(0.88); C3059(1.28)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C3059(0.93); C724(0.93); C2247(1.03)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C3059(0.81); C724(0.97); C2247(1.21)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C3059(0.72); C724(0.99); C2247(1.04)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C3059(0.75); C724(1.11); C2247(1.41)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C3059(0.88); C724(1.21); C2247(1.59)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C3059(0.84); C952(0.97); C724(1.10); C2247(1.22)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C3059(0.70); C724(0.97); C952(0.98); C2247(1.29)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C3059(0.62); C724(0.91); C952(0.96); C2247(1.29)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C952(0.97); C724(1.01); C1945(1.14); C2247(1.43)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C3059(0.85); C724(0.94); C952(1.04); C2247(1.23)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C3059(0.87); C952(1.05); C724(1.16); C2247(1.21)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C3059(0.68); C952(0.93); C724(1.08); C2247(1.36)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C3059(0.69); C952(0.99); C724(1.03); C2247(1.29)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C3059(0.70); C952(1.02); C724(1.10); C2247(1.21)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C3059(0.84); C952(0.98); C724(1.20); C2247(1.40)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C3059(0.84); C952(1.06); C724(1.15); C2247(1.41)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C3059(0.60); C952(0.99); C724(1.28); C2247(1.36)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C3059(0.70); C724(1.04); C2247(1.07); C1945(1.28)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C3059(0.70); C724(1.08); C2247(1.14); C1945(1.22)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C952(0.95); C1945(0.99); C724(0.99); C2247(1.25)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C3059(0.49); C724(1.10); C2247(1.28); C1945(1.32)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C2247(1.12); C3059(1.14); C724(1.16); C1945(1.34)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C3059(0.75); C724(1.16); C1945(1.18); C2247(1.23)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C3059(0.71); C724(1.10); C2247(1.55); C1945(1.87)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C3059(0.76); C724(1.25); C2247(1.53); C1945(1.99)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C3059(0.80); C724(1.22); C2247(1.66); C1945(1.88)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C3059(0.68); C724(1.14); C2247(1.28); C1945(1.52)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C3059(0.76); C724(1.01); C2247(1.21); C1945(1.36)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C724(1.00); C2247(1.07); C3059(1.10); C1945(1.24)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C3059(0.80); C724(1.03); C2247(1.20); C1945(1.25)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C952(0.96); C724(0.97); C2247(1.17); C1945(1.28)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C3059(0.71); C724(1.12); C2247(1.19); C1945(1.21)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C3059(0.96); C724(1.12); C2247(1.14); C1945(1.17)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C3059(0.79); C724(1.21); C2247(1.66); C1945(2.60)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C3059(0.74); C1945(0.96); C724(1.06); C2247(1.64)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C1945(0.85); C3059(0.88); C724(0.97); C2247(1.51)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C3059(0.86); C1945(0.92); C724(1.00); C2247(1.14)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C724(1.02); C1945(1.06); C3059(1.08); C2247(1.17)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C1945(0.88); C3059(0.99); C724(1.01); C2247(1.03)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C3059(0.93); C724(0.95); C1945(0.96); C2247(1.07)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C3059(0.97); C1945(0.99); C724(1.02); C2247(1.53)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C1945(0.87); C2247(1.09); C724(1.18); C3059(2.85)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C3059(0.81); C1945(0.85); C724(1.00); C2247(1.77)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C3059(0.61); C1945(0.86); C724(1.01); C2247(1.65)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C724(0.96); C2247(1.04); C3059(1.05); C1945(1.06)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C3059(0.87); C724(0.98); C2247(1.04); C1945(1.45)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C724(0.93); C2247(1.06); C1945(1.14); C3059(1.90)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C3059(0.85); C724(1.03); C1945(1.05); C2247(1.34)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C3059(0.61); C1945(0.99); C724(1.00); C2247(1.29)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C724(0.79); C2247(1.27)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C724(0.81); C2247(0.95)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C1945(1.15); C2247(1.19); C724(1.04); C952(0.95)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C952(0.90); C724(0.96); C1945(1.10); C2247(1.24)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C952(0.85); C724(1.12); C1945(1.58); C2247(1.68)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C3460(1.40); C3463(1.40); C1945(0.90)  LDD0078  [4]
 LDCM0632  CL-Sc Hep-G2 C1600(20.00); C1975(0.58)  LDD2227  [2]
 LDCM0367  CL1 HCT 116 C2247(0.79); C724(1.01); C1945(1.15)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C1945(1.09); C724(1.19); C2247(1.25)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C724(1.08); C2247(1.27); C1945(1.44)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C952(0.86); C724(1.03); C2247(1.35); C1945(1.38)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C952(0.90); C1945(0.97); C724(1.00); C2247(1.27)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C952(0.93); C724(0.98); C2247(1.16); C1945(1.22)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C724(0.91); C952(1.04); C1945(1.08); C2247(1.18)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C724(0.88); C2247(1.18); C1945(1.34)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C724(1.02); C2247(1.55); C1945(1.77)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C724(1.04); C2247(1.35); C1945(1.59)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C724(0.97); C2247(1.26); C1945(1.70)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C724(0.87); C2247(1.06); C1945(1.28)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C1945(1.00); C724(1.20); C2247(1.31)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C724(0.90); C2247(1.25); C1945(1.59)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C724(0.81); C2247(0.99); C1945(1.39)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C952(0.91); C3059(0.99); C2247(1.00); C724(1.02)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C3460(0.84); C3463(0.84); C952(0.89); C3059(1.04)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C3460(0.76); C3463(0.76); C952(0.82); C724(0.90)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C3460(0.71); C3463(0.71); C952(0.87); C724(0.97)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C952(0.92); C3059(0.93); C724(1.03); C2247(1.27)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C3059(0.81); C952(1.07); C724(1.15); C2247(1.41)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C3059(0.93); C952(0.95); C2247(1.00); C724(1.06)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C3059(0.90); C2247(0.93); C952(0.99); C724(1.05)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C1945(1.20); C724(1.35); C2247(1.57)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C2247(0.97); C724(1.01); C952(1.03); C3059(1.29)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C3059(0.66); C2247(0.78); C724(0.89)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C3059(0.96); C724(1.00); C2247(1.23)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C3059(0.70); C724(1.06); C2247(1.20)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C3059(0.72); C724(1.12); C2247(1.32)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C2247(0.78); C724(0.90); C3059(1.00); C952(1.21)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C952(0.93); C724(0.95); C3059(1.03); C2247(1.25)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C3059(0.79); C952(0.93); C724(0.97); C2247(0.98)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C3059(0.65); C952(1.07); C724(1.17); C2247(1.37)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C1945(1.14); C724(1.15); C2247(1.22)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C1945(1.03); C2247(1.08); C724(1.09)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C724(1.10); C1945(1.14); C2247(1.23)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C724(0.76); C3059(0.87); C952(0.89); C3460(0.94)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C3059(0.89); C724(0.91); C952(0.93); C2247(1.07)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C952(0.77); C724(0.82); C3059(0.89); C1945(1.04)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C952(0.85); C3059(0.85); C724(0.94); C1945(1.12)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C2247(0.84); C724(1.05); C1945(1.15)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C3059(0.66); C952(0.82); C724(0.84); C1945(1.19)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C3059(0.59); C952(0.83); C724(0.86); C1945(1.36)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C3059(0.65); C952(1.05); C724(1.11); C1945(1.49)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C3059(0.71); C952(0.89); C724(0.98); C1945(1.11)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C1945(1.19); C2247(1.41); C3059(0.49); C724(1.08)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C1945(1.21); C2247(1.24); C3059(0.53); C724(0.84)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C1945(0.97); C2247(1.12); C3059(0.82); C724(0.79)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C1945(1.09); C2247(1.36); C3059(0.79); C724(0.80)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C1945(1.16); C2247(1.15); C3059(0.62); C724(0.85)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C1945(1.07); C2247(1.38); C3059(0.77); C724(0.85)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C1945(0.96); C2247(0.87); C724(1.00)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C1945(0.99); C2247(1.06); C3059(0.81); C724(0.76)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C1945(1.09); C724(0.90); C952(0.92)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C1945(1.20); C3460(0.78); C3463(0.78); C724(0.87)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C1945(1.25); C3460(1.07); C3463(1.07); C724(0.86)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C1945(1.61); C3460(1.15); C3463(1.15); C724(0.95)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C1945(1.18); C3460(1.05); C3463(1.05); C724(0.83)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C1945(1.24); C3460(0.91); C3463(0.91); C724(0.84)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C1945(1.52); C3460(1.16); C3463(1.16); C724(1.00)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C1945(1.56); C3460(0.89); C3463(0.89); C724(0.95)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C1945(1.50); C2247(0.93); C724(1.04)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C1945(1.25); C3460(0.86); C3463(0.86); C724(0.80)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C1945(1.23); C3460(0.95); C3463(0.95); C724(0.89)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C1945(1.91); C3460(0.79); C3463(0.79); C724(1.07)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C1945(1.36); C3460(0.98); C3463(0.98); C724(0.99)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C1945(1.54); C3460(0.98); C3463(0.98); C724(0.99)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C1945(1.73); C3460(1.11); C3463(1.11); C724(0.89)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C2247(0.90); C3460(0.96); C3463(0.96); C724(1.02)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C2247(0.91); C3460(0.82); C3463(0.82); C724(0.95)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C2247(0.79); C3460(0.85); C3463(0.85); C724(0.93)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C2247(0.91); C3460(0.99); C3463(0.99); C724(1.01)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C1945(1.12); C2247(1.09); C724(1.13)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C2247(0.94); C3460(1.05); C3463(1.05); C724(0.97)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C2247(0.94); C3460(1.01); C3463(1.01); C724(0.97)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C2247(0.85); C3460(1.03); C3463(1.03); C724(0.99)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C2247(0.90); C3460(0.84); C3463(0.84); C724(0.95)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C2247(0.72); C3460(0.80); C3463(0.80); C724(0.96)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C2247(0.75); C3460(0.80); C3463(0.80); C724(0.94)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C2247(0.84); C3460(0.94); C3463(0.94); C724(0.93)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C2247(0.82); C3460(1.09); C3463(1.09); C724(0.87)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C2247(0.76); C3460(1.10); C3463(1.10); C724(0.92)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C2247(0.80); C3460(1.14); C3463(1.14); C724(0.92)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C1945(1.05); C2247(1.09); C724(1.08)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C2247(0.78); C3460(0.94); C3463(0.94); C724(0.94)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C2247(1.01); C3059(1.06); C3460(0.84); C3463(0.84)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C2247(1.10); C3059(0.95); C3460(0.64); C3463(0.64)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C2247(0.92); C3059(1.00); C3460(0.60); C3463(0.60)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C2247(1.03); C3059(0.81); C3460(0.99); C3463(0.99)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C2247(1.01); C3059(1.00); C3460(0.74); C3463(0.74)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C2247(1.01); C3059(0.72); C3460(0.78); C3463(0.78)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C2247(0.90); C3059(0.83); C3460(0.65); C3463(0.65)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C2247(0.86); C3059(0.98); C3460(0.57); C3463(0.57)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C2247(0.89); C3059(1.15); C3460(0.58); C3463(0.58)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C1945(1.07); C2247(1.28); C724(1.20)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C2247(0.84); C3059(0.95); C3460(0.64); C3463(0.64)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C2247(0.90); C3059(0.86); C3460(0.56); C3463(0.56)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C2247(0.90); C3059(0.97); C3460(0.85); C3463(0.85)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C2247(0.79); C3059(0.82); C3460(0.66); C3463(0.66)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C2247(0.91); C3059(0.92); C3460(0.91); C3463(0.91)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C2247(1.13); C3460(1.05); C3463(1.05); C724(1.01)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C2247(1.05); C3460(1.21); C3463(1.21); C724(1.10)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C2247(1.10); C3460(1.08); C3463(1.08); C724(0.94)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C2247(1.28); C3460(1.18); C3463(1.18); C724(1.09)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C1945(1.19); C2247(1.48); C724(1.17)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C2247(1.08); C3460(1.17); C3463(1.17); C724(1.02)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C2247(1.19); C3460(1.25); C3463(1.25); C724(1.03)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C2247(1.47); C3460(1.17); C3463(1.17); C724(1.25)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C2247(1.41); C3460(1.16); C3463(1.16); C724(1.24)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C2247(1.56); C3460(0.90); C3463(0.90); C724(1.21)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C2247(1.17); C3460(0.97); C3463(0.97); C724(1.10)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C2247(1.12); C3460(1.02); C3463(1.02); C724(1.04)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C2247(1.20); C3460(1.05); C3463(1.05); C724(1.16)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C2247(1.28); C3460(1.00); C3463(1.00); C724(1.23)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C2247(1.64); C3460(1.33); C3463(1.33); C724(1.60)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C1945(1.31); C2247(1.09); C724(1.13)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C2247(0.93); C3460(0.83); C3463(0.83); C724(1.06)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C1945(1.27); C2247(1.20); C724(1.07)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C1945(1.30); C2247(1.10); C724(0.61)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C1945(1.12); C2247(1.16); C724(1.05)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C1945(1.54); C2247(1.41); C724(1.17)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C1945(1.56); C2247(1.36); C724(1.04)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C1945(1.32); C2247(1.12); C724(1.13)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C1945(1.42); C2247(1.22); C724(1.00)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C1945(1.42); C2247(1.46); C724(1.04)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C1945(1.52); C2247(1.27); C724(1.02)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C575(1.07); C3027(0.91); C16(0.87); C724(0.97)  LDD1698  [9]
 LDCM0468  Fragment33 HCT 116 C2247(0.90); C3059(0.81); C3460(0.86); C3463(0.86)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C1945(1.76); C3460(0.97); C3463(0.97); C724(1.02)  LDD0744  [4]
 LDCM0022  KB02 HCT 116 C3460(1.61); C3463(1.61); C3506(1.06); C3509(1.06)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C3460(1.81); C3463(1.81); C3506(1.12); C3509(1.12)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C3460(1.92); C3463(1.92); C3506(1.04); C3509(1.04)  LDD0082  [4]
 LDCM0021  THZ1 HCT 116 C3460(1.21); C3463(1.21)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase TRIM39 (TRIM39) TRIM/RBCC family Q9HCM9
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Optineurin (OPTN) . Q96CV9
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 44 (ZBTB44) . Q8NCP5
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Autophagy protein 5 (ATG5) ATG5 family Q9H1Y0
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) ATG8 family Q9H0R8
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ATG8 family Q9GZQ8
Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C) ATG8 family Q9BXW4
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) PI3K p85 subunit family Q92569
Sequestosome-1 (SQSTM1) . Q13501

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402