Details of the Target
General Information of Target
| Target ID | LDTP06979 | |||||
|---|---|---|---|---|---|---|
| Target Name | BCL-6 corepressor-like protein 1 (BCORL1) | |||||
| Gene Name | BCORL1 | |||||
| Gene ID | 63035 | |||||
| Synonyms |
BCL-6 corepressor-like protein 1; BCoR-L1; BCoR-like protein 1 |
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| 3D Structure | ||||||
| Sequence |
MISTAPLYSGVHNWTSSDRIRMCGINEERRAPLSDEESTTGDCQHFGSQEFCVSSSFSKV
ELTAVGSGSNARGADPDGSATEKLGHKSEDKPDDPQPKMDYAGNVAEAEGLLVPLSSPGD GLKLPASDSAEASNSRADCSWTPLNTQMSKQVDCSPAGVKALDSRQGVGEKNTFILATLG TGVPVEGTLPLVTTNFSPLPAPICPPAPGSASVPHSVPDAFQVPLSVPAPVPHSGLVPVQ VATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLSVSASVLVPVPASAPPSGPVPLSAP APAPLSVPVSAPPLALIQAPVPPSAPTLVLAPVPTPVLAPMPASTPPAAPAPPSVPMPTP TPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAIPTSAPIPASFSLSRV CFPAAQAPAMQKVPLSFQPGTVLTPSQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPV LPSYLQDRCLPGVLASPELRSYPYAFSVARPLTSDSKLVSLEVNRLPCTSPSGSTTTQPA PDGVPGPLADTSLVTASAKVLPTPQPLLPAPSGSSAPPHPAKMPSGTEQQTEGTSVTFSP LKSPPQLEREMASPPECSEMPLDLSSKSNRQKLPLPNQRKTPPMPVLTPVHTSSKALLST VLSRSQRTTQAAGGNVTSCLGSTSSPFVIFPEIVRNGDPSTWVKNSTALISTIPGTYVGV ANPVPASLLLNKDPNLGLNRDPRHLPKQEPISIIDQGEPKGTGATCGKKGSQAGAEGQPS TVKRYTPARIAPGLPGCQTKELSLWKPTGPANIYPRCSVNGKPTSTQVLPVGWSPYHQAS LLSIGISSAGQLTPSQGAPIRPTSVVSEFSGVPSLSSSEAVHGLPEGQPRPGGSFVPEQD PVTKNKTCRIAAKPYEEQVNPVLLTLSPQTGTLALSVQPSGGDIRMNQGPEESESHLCSD STPKMEGPQGACGLKLAGDTKPKNQVLATYMSHELVLATPQNLPKMPELPLLPHDSHPKE LILDVVPSSRRGSSTERPQLGSQVDLGRVKMEKVDGDVVFNLATCFRADGLPVAPQRGQA EVRAKAGQARVKQESVGVFACKNKWQPDDVTESLPPKKMKCGKEKDSEEQQLQPQAKAVV RSSHRPKCRKLPSDPQESTKKSPRGASDSGKEHNGVRGKHKHRKPTKPESQSPGKRADSH EEGSLEKKAKSSFRDFIPVVLSTRTRSQSGSICSSFAGMADSDMGSQEVFPTEEEEEVTP TPAKRRKVRKTQRDTQYRSHHAQDKSLLSQGRRHLWRAREMPWRTEAARQMWDTNEEEEE EEEEGLLKRKKRRRQKSRKYQTGEYLTEQEDEQRRKGRADLKARKQKTSSSQSLEHRLRN RNLLLPNKVQGISDSPNGFLPNNLEEPACLENSEKPSGKRKCKTKHMATVSEEAKGKGRW SQQKTRSPKSPTPVKPTEPCTPSKSRSASSEEASESPTARQIPPEARRLIVNKNAGETLL QRAARLGYKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSA QDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDTMKRFLSDHLSDLQ GRAEGDPGVSWDFYSSSVLEEKDGFACDLLHNPPGSSDQEGDDPMEEDDFMFELSDKPLL PCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLL TPAERPGGLDDRSPPGSSETVELVRYEPDLLRLLGSEVEFQSCNS |
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| Target Bioclass |
Other
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| Family |
BCOR family
|
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| Subcellular location |
Nucleus
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| Function |
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C1694(1.29) | LDD3312 | [1] | |
|
AHL-Pu-1 Probe Info |
 |
C679(7.30) | LDD0172 | [2] | |
|
IA-alkyne Probe Info |
 |
N.A. | LDD0165 | [3] | |
|
IPM Probe Info |
 |
N.A. | LDD0005 | [4] | |
|
NPM Probe Info |
 |
N.A. | LDD0016 | [4] | |
|
TFBX Probe Info |
 |
N.A. | LDD0148 | [5] | |
|
VSF Probe Info |
 |
N.A. | LDD0007 | [4] | |
|
Phosphinate-6 Probe Info |
 |
C1460(0.00); C766(0.00); C797(0.00) | LDD0018 | [6] | |
|
m-APA Probe Info |
 |
N.A. | LDD0404 | [7] | |
|
AOyne Probe Info |
 |
15.00 | LDD0443 | [8] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0025 | 4SU-RNA | HEK-293T | C679(7.30) | LDD0172 | [2] |
| LDCM0026 | 4SU-RNA+native RNA | HEK-293T | C679(3.94) | LDD0173 | [2] |
| LDCM0156 | Aniline | NCI-H1299 | N.A. | LDD0404 | [7] |
| LDCM0213 | Electrophilic fragment 2 | MDA-MB-231 | C766(1.59) | LDD1702 | [9] |
| LDCM0022 | KB02 | 22RV1 | C1694(1.44) | LDD2243 | [1] |
| LDCM0023 | KB03 | MDA-MB-231 | C766(2.40) | LDD1701 | [9] |
| LDCM0024 | KB05 | HMCB | C1694(1.29) | LDD3312 | [1] |
References