Details of the Target

General Information of Target

Target ID LDTP11054
Target Name Zinc phosphodiesterase ELAC protein 2 (ELAC2)
Gene Name ELAC2
Gene ID 60528
Synonyms
HPC2; Zinc phosphodiesterase ELAC protein 2; EC 3.1.26.11; ElaC homolog protein 2; Heredity prostate cancer protein 2; Ribonuclease Z 2; RNase Z 2; tRNA 3 endonuclease 2; tRNase Z 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIFLLLMLSLELQLHQIAALFTVTVPKELYIIEHGSNVTLECNFDTGSHVNLGAITASLQ
KVENDTSPHRERATLLEEQLPLGKASFHIPQVQVRDEGQYQCIIIYGVAWDYKYLTLKVK
ASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVL
RLKPPPGRNFSCVFWNTHVRELTLASIDLQSQMEPRTHPTWLLHIFIPFCIIAFIFIATV
IALRKQLCQKLYSSKDTTKRPVTTTKREVNSAI
Target Bioclass
Enzyme
Family
RNase Z family
Subcellular location
Mitochondrion
Function
Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.
Uniprot ID
Q9BQ52
Ensemble ID
ENST00000338034.9
HGNC ID
HGNC:14198

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MEWO SNV: p.C421G DBIA    Probe Info 
SKMEL24 SNV: p.S70L DBIA    Probe Info 
SNGM SNV: p.L148F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.39  LDD0402  [1]
Alkylaryl probe 3
 Probe Info  		17.57  LDD0381  [2]
TH211
 Probe Info  		Y463(7.54)  LDD0257  [3]
STPyne
 Probe Info  		K811(7.69)  LDD0277  [4]
BTD
 Probe Info  		C670(1.10)  LDD2089  [5]
AHL-Pu-1
 Probe Info  		C753(2.08); C670(2.03); C640(2.02); C441(2.28)  LDD0168  [6]
DBIA
 Probe Info  		C51(1.14); C670(1.00)  LDD0078  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
ATP probe
 Probe Info  		K811(0.00); K99(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C609(0.00); C136(0.00); C441(0.00); C245(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C374(0.00); C609(0.00); C670(0.00); C87(0.00)  LDD0032  [11]
Lodoacetamide azide
 Probe Info  		C609(0.00); C136(0.00); C441(0.00); C421(0.00)  LDD0037  [10]
JW-RF-010
 Probe Info  		C753(0.00); C136(0.00)  LDD0026  [12]
NAIA_4
 Probe Info  		C51(0.00); C421(0.00); C441(0.00); C670(0.00)  LDD2226  [13]
TFBX
 Probe Info  		C87(0.00); C753(0.00); C609(0.00)  LDD0027  [12]
1d-yne
 Probe Info  		N.A.  LDD0356  [14]
Compound 10
 Probe Info  		C136(0.00); C374(0.00); C51(0.00); C87(0.00)  LDD2216  [15]
Compound 11
 Probe Info  		C136(0.00); C374(0.00); C51(0.00); C753(0.00)  LDD2213  [15]
IPM
 Probe Info  		C51(0.00); C670(0.00)  LDD0005  [16]
NPM
 Probe Info  		N.A.  LDD0016  [16]
VSF
 Probe Info  		C609(0.00); C51(0.00)  LDD0007  [16]
Phosphinate-6
 Probe Info  		C136(0.00); C51(0.00); C670(0.00); C405(0.00)  LDD0018  [17]
1c-yne
 Probe Info  		N.A.  LDD0228  [14]
Acrolein
 Probe Info  		C670(0.00); C87(0.00); C609(0.00); C640(0.00)  LDD0217  [18]
Crotonaldehyde
 Probe Info  		C87(0.00); C640(0.00)  LDD0219  [18]
Methacrolein
 Probe Info  		C374(0.00); C87(0.00); C670(0.00); C640(0.00)  LDD0218  [18]
W1
 Probe Info  		N.A.  LDD0236  [19]
AOyne
 Probe Info  		5.50  LDD0443  [20]
NAIA_5
 Probe Info  		C595(0.00); C609(0.00); C136(0.00); C441(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe2
 Probe Info  		12.09  LDD0463  [21]
FFF probe3
 Probe Info  		7.52  LDD0464  [21]
STS-2
 Probe Info  		N.A.  LDD0139  [22]
VE-P
 Probe Info  		N.A.  LDD0396  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C670(0.66)  LDD2112  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C670(0.92); C87(1.02)  LDD2117  [5]
 LDCM0025  4SU-RNA HEK-293T C753(2.08); C670(2.03); C640(2.02); C441(2.28)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C87(2.50); C670(2.68); C516(2.16); C441(3.69)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C136(1.24); C51(0.90); C516(0.67); C525(0.67)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C51(1.00); C609(1.05); C632(1.04); C640(1.04)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C136(0.49); C421(0.81); C51(1.12); C516(0.68)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C136(0.56); C421(0.83); C51(1.18); C516(0.80)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C136(0.66); C421(0.83); C51(1.09); C516(0.61)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C136(0.47); C421(0.71); C51(1.02); C516(0.76)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C136(0.81); C421(1.06); C51(0.96); C516(0.75)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C136(0.57); C421(0.76); C51(1.08); C516(0.88)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C136(0.44); C421(0.79); C51(1.31); C516(0.74)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C136(0.52); C421(0.77); C51(1.12); C516(0.76)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C136(0.43); C421(0.78); C51(1.10); C516(1.01)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C136(0.92); C421(1.12); C51(1.08); C516(0.95)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C51(0.98); C609(1.12); C632(1.06); C640(1.05)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C136(0.45); C421(0.76); C51(1.25); C516(0.77)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C136(0.46); C421(0.76); C51(1.25); C516(0.78)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C136(0.44); C421(0.68); C51(1.23); C516(0.61)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C136(1.07); C421(1.16); C51(1.09); C609(1.16)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C136(0.98); C421(1.35); C51(1.10); C609(1.00)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C136(0.94); C421(0.97); C51(0.99); C609(0.90)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C136(0.99); C421(1.01); C51(1.11); C609(1.04)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C136(1.00); C421(1.18); C51(0.91); C609(1.18)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C136(1.13); C421(1.16); C51(1.01); C609(1.02)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C136(1.04); C421(1.00); C51(1.06); C609(1.07)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C51(0.94); C609(0.97); C632(1.17); C640(1.10)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C136(1.05); C421(1.23); C51(1.29); C609(0.91)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C136(1.14); C421(1.04); C51(1.03); C609(1.10)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C136(1.15); C421(1.07); C51(1.16); C609(1.10)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C136(1.22); C421(1.35); C51(1.06); C609(0.93)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C136(1.13); C421(1.18); C51(0.91); C609(1.10)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C136(1.16); C421(1.12); C51(1.04); C609(1.11)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C136(1.16); C421(1.16); C51(1.02); C609(0.95)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C136(1.26); C421(1.28); C51(0.97); C609(0.93)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C136(1.68); C51(1.18); C632(1.35); C640(1.35)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C136(1.39); C51(1.06); C632(1.28); C640(1.28)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C136(1.49); C51(1.22); C632(1.50); C640(1.50)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C136(1.09); C51(0.93); C632(1.14); C640(1.14)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C136(1.00); C51(1.31); C632(1.00); C640(1.00)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C136(1.25); C51(0.99); C632(1.29); C640(1.29)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C136(0.91); C51(1.42); C632(0.78); C640(0.78)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C136(0.90); C51(0.81); C632(0.91); C640(0.91)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C136(0.86); C51(1.11); C632(0.88); C640(0.88)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C136(0.91); C51(0.86); C632(0.80); C640(0.80)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C136(0.63); C51(1.37); C632(0.48); C640(0.48)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C136(0.63); C51(1.12); C632(0.59); C640(0.59)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C51(1.11); C609(1.04); C632(1.13); C640(1.06)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C136(0.57); C51(1.29); C632(0.51); C640(0.51)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C136(0.60); C51(1.31); C632(0.49); C640(0.49)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C136(0.78); C51(0.98); C632(0.76); C640(0.76)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C136(1.38); C51(1.15); C516(1.05); C525(1.05)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C516(0.85); C525(0.85); C87(0.93); C51(0.97)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C136(0.84); C516(0.84); C525(0.84); C51(0.92)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C516(0.70); C525(0.70); C632(0.94); C136(0.94)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C136(0.86); C87(0.92); C516(0.93); C525(0.93)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C516(0.79); C525(0.79); C632(0.91); C87(1.07)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C516(0.74); C525(0.74); C632(0.92); C136(0.95)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C609(0.90); C51(1.05); C640(1.12); C753(1.13)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C516(0.72); C525(0.72); C136(0.89); C51(1.01)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C136(0.82); C516(0.91); C525(0.91); C51(0.99)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C516(0.65); C525(0.65); C136(0.90); C640(0.94)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C516(0.67); C525(0.67); C632(0.92); C640(1.06)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C136(1.01); C51(0.91); C516(0.78); C525(0.78)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C136(1.13); C51(0.88); C516(0.87); C525(0.87)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C136(1.12); C51(0.95); C516(0.85); C525(0.85)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C136(0.92); C51(0.85); C516(1.28); C525(1.28)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C640(1.09); C753(1.11); C670(1.11); C632(1.14)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C753(0.95); C136(1.00); C640(1.03); C632(1.05)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C640(0.96); C632(1.01); C609(1.05); C670(1.10)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C87(0.84); C51(0.86); C753(0.90); C516(0.93)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C640(0.88); C632(0.93); C87(0.98); C609(1.03)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C640(1.02); C136(1.04); C753(1.07); C87(1.08)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C640(0.94); C87(0.99); C632(1.03); C51(1.07)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C640(0.84); C632(0.87); C87(0.94); C753(0.96)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C640(1.03); C87(1.04); C632(1.04); C753(1.05)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C421(0.61); C640(0.88); C51(0.97); C632(0.98)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C640(0.78); C87(0.82); C51(0.83); C632(0.92)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C87(0.79); C421(0.82); C136(0.92); C640(0.93)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C87(0.79); C640(0.82); C136(0.85); C753(0.87)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C87(0.52); C136(0.71); C753(0.79); C640(0.80)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C51(0.80); C516(0.91); C525(0.91); C87(0.96)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C87(0.53); C421(0.68); C136(0.69); C753(0.84)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C87(0.63); C753(0.78); C421(0.84); C640(0.88)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C87(0.56); C421(0.76); C753(0.79); C640(0.81)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C136(0.82); C753(0.88); C421(0.92); C640(0.96)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C421(0.42); C136(0.83); C640(0.85); C753(0.86)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C670(0.85); C651(0.92); C51(0.95); C640(1.02)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C651(0.88); C136(0.89); C670(0.92); C51(1.01)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C651(0.92); C51(0.96); C670(0.97); C87(1.01)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C87(0.81); C51(0.85); C136(0.87); C670(0.95)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C51(0.76); C136(0.94); C87(0.97); C651(1.07)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C51(0.75); C516(0.77); C525(0.77); C753(1.01)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C87(0.81); C651(0.85); C753(0.88); C136(0.91)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C87(0.63); C136(0.71); C753(0.80); C651(0.89)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C136(0.76); C651(0.81); C87(0.84); C753(0.88)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C136(0.60); C87(0.72); C753(0.80); C51(0.86)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C87(0.56); C753(0.79); C651(0.79); C51(0.97)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C87(0.60); C651(0.66); C753(0.80); C51(0.89)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C632(0.49); C87(0.65); C640(0.71); C136(0.72)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C632(0.53); C640(0.74); C753(0.77); C87(0.78)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C632(0.49); C87(0.63); C753(0.68); C640(0.74)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C632(0.40); C87(0.64); C136(0.71); C640(0.74)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C516(0.69); C525(0.69); C51(0.79); C753(0.97)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C632(0.37); C87(0.67); C136(0.72); C753(0.76)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C632(0.36); C87(0.68); C136(0.74); C609(0.93)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C632(0.37); C640(0.69); C87(0.72); C136(0.76)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C632(0.66); C753(0.69); C640(0.76); C87(0.85)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C632(0.46); C640(0.65); C87(0.79); C136(0.80)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C753(0.74); C136(0.84); C640(0.90); C87(0.93)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C632(0.41); C640(0.56); C753(0.60); C87(0.62)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C516(0.59); C525(0.59); C753(0.92); C632(0.96)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C516(0.67); C525(0.67); C609(0.83); C640(0.89)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C516(0.73); C525(0.73); C136(0.79); C753(0.87)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C87(0.92); C753(1.01); C609(1.03); C632(1.05)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C516(0.53); C525(0.53); C136(0.67); C753(0.71)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C516(0.48); C525(0.48); C753(0.77); C640(0.82)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C516(0.76); C525(0.76); C136(0.83); C753(0.85)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C516(0.58); C525(0.58); C753(0.82); C136(0.86)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C516(0.58); C525(0.58); C136(0.79); C753(0.80)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C516(0.73); C525(0.73); C136(0.84); C753(0.89)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C516(0.62); C525(0.62); C753(0.88); C136(0.93)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C516(0.34); C525(0.34); C136(0.61); C753(0.63)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C136(0.62); C87(0.80); C640(0.86); C51(0.89)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C136(0.62); C640(0.80); C609(0.87); C632(0.89)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C632(0.97); C609(0.98); C640(0.99); C670(1.03)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C136(0.65); C609(0.77); C640(0.81); C753(0.86)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C136(0.67); C51(0.88); C609(0.89); C640(0.91)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C136(0.60); C609(0.80); C640(0.81); C632(0.90)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C136(0.65); C640(0.75); C609(0.83); C632(0.85)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C640(0.71); C136(0.71); C632(0.76); C753(0.87)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C136(0.66); C640(0.82); C753(0.89); C632(0.94)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C136(0.73); C609(0.93); C640(0.95); C753(1.00)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C136(0.61); C609(0.73); C640(0.87); C87(0.90)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C136(0.66); C609(0.81); C640(0.84); C632(0.96)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C136(0.57); C609(0.73); C640(0.91); C87(0.99)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C640(0.97); C632(0.97); C753(0.99); C87(1.01)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C136(0.66); C640(0.79); C609(0.86); C632(0.89)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C136(0.54); C640(0.88); C51(0.92); C609(0.97)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C640(0.55); C632(0.61); C136(0.67); C753(0.74)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C516(0.61); C525(0.61); C640(0.85); C632(0.88)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C516(0.58); C525(0.58); C640(0.78); C632(0.81)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C516(0.58); C525(0.58); C640(0.87); C753(0.94)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C136(0.76); C632(0.80); C640(0.82); C516(0.82)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C136(0.67); C632(0.87); C51(0.87); C640(0.89)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C136(0.68); C640(0.71); C632(0.73); C516(0.73)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C516(0.70); C525(0.70); C136(0.76); C753(0.90)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C136(0.62); C632(0.80); C640(0.83); C516(0.87)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C516(0.72); C525(0.72); C640(0.94); C753(1.01)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C516(0.84); C525(0.84); C640(0.96); C632(1.01)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C516(0.87); C525(0.87); C136(0.87); C640(0.87)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C516(0.68); C525(0.68); C753(1.05); C51(1.13)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C136(0.64); C640(0.79); C632(0.79); C516(0.81)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C516(0.76); C525(0.76); C753(0.91); C640(0.93)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C136(0.59); C516(0.60); C525(0.60); C640(0.69)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C516(0.31); C525(0.31); C651(0.41); C136(0.44)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C136(0.55); C651(0.71); C640(0.75); C632(0.76)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C51(0.99); C609(1.11); C632(1.10); C640(1.06)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C640(1.07); C670(1.08); C632(1.10); C753(1.12)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C632(0.87); C609(0.87); C87(0.90); C640(0.91)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C51(1.14); C670(1.00)  LDD0078  [7]
 LDCM0498  BS-3668 MDA-MB-231 C670(0.84)  LDD2091  [5]
 LDCM0108  Chloroacetamide HeLa C374(0.00); C670(0.00); C87(0.00); C609(0.00)  LDD0222  [18]
 LDCM0632  CL-Sc Hep-G2 C421(0.86)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C753(0.65); C516(0.67); C525(0.67); C609(0.74)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C516(0.52); C525(0.52); C753(0.63); C632(0.77)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C516(0.64); C525(0.64); C753(0.91); C87(0.92)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C753(0.92); C632(0.93); C640(0.93); C609(0.99)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C670(1.08); C640(1.12); C609(1.13); C753(1.16)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C640(0.94); C632(0.94); C609(1.04); C670(1.06)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C640(0.95); C632(0.97); C753(1.02); C609(1.07)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C640(0.89); C753(0.94); C632(0.95); C87(1.08)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C753(0.88); C640(0.92); C632(0.99); C609(1.07)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C136(0.99); C753(1.02); C640(1.04); C87(1.13)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C753(0.98); C640(1.13); C632(1.15); C87(1.15)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C640(0.88); C753(0.89); C87(0.96); C632(0.96)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C516(0.52); C525(0.52); C753(0.65); C640(0.69)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C753(0.82); C640(0.95); C87(0.95); C632(0.97)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C87(0.78); C753(0.86); C640(0.89); C136(0.89)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C609(0.71); C421(0.76); C753(0.84); C87(0.87)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C87(0.56); C640(0.68); C136(0.76); C632(0.78)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C87(0.54); C136(0.65); C640(0.70); C753(0.70)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C87(0.63); C640(0.78); C136(0.82); C753(0.83)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C640(0.78); C632(0.83); C87(0.84); C421(0.85)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C87(0.73); C632(0.77); C640(0.81); C753(0.86)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C651(0.82); C136(0.83); C87(0.91); C753(0.92)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C136(0.78); C753(0.87); C87(0.90); C51(0.95)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C753(0.70); C640(0.86); C632(0.90); C516(0.91)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C136(0.72); C87(0.86); C753(0.92); C51(1.00)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C632(0.53); C87(0.60); C640(0.64); C136(0.68)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C632(0.49); C87(0.61); C753(0.62); C136(0.71)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C632(0.57); C640(0.62); C87(0.66); C753(0.78)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C632(0.40); C640(0.56); C87(0.63); C136(0.72)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C516(0.87); C525(0.87); C609(0.90); C51(0.93)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C516(0.76); C525(0.76); C632(0.88); C609(0.88)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C516(0.73); C525(0.73); C136(0.88); C51(0.90)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C516(0.92); C525(0.92); C51(0.93); C609(0.96)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C516(0.55); C525(0.55); C753(0.63); C632(0.71)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C753(0.70); C609(0.89); C51(0.91); C640(0.93)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C753(0.65); C516(0.71); C525(0.71); C632(0.74)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C87(0.63); C136(0.67); C609(0.74); C753(0.77)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C516(0.66); C525(0.66); C753(0.81); C632(0.85)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C516(0.55); C525(0.55); C753(0.69); C632(0.87)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C753(0.78); C609(0.93); C632(0.93); C640(0.93)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C753(0.69); C87(0.76); C609(0.77); C136(0.82)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C516(0.74); C525(0.74); C753(0.83); C87(0.89)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C753(0.76); C516(0.78); C525(0.78); C632(0.90)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C516(0.62); C525(0.62); C753(0.76); C87(0.87)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C136(0.78); C753(0.81); C516(0.85); C525(0.85)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C136(0.72); C753(0.77); C516(0.95); C525(0.95)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C136(0.69); C51(1.19); C516(0.86); C525(0.86)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C136(0.61); C51(1.17); C516(0.87); C525(0.87)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C136(0.99); C51(1.06); C516(1.16); C525(1.16)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C136(0.72); C51(1.10); C516(0.53); C525(0.53)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C136(0.93); C51(1.07); C516(0.76); C525(0.76)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C136(0.93); C51(0.86); C516(0.75); C525(0.75)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C136(1.04); C51(1.02); C516(0.68); C525(0.68)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C136(0.78); C51(1.13); C609(1.08); C632(1.01)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C136(0.71); C421(0.76); C51(1.10); C609(0.80)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C136(0.86); C421(1.12); C51(2.13); C609(1.02)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C136(0.77); C421(0.96); C51(1.27); C609(1.04)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C136(0.79); C421(1.10); C51(1.28); C609(1.05)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C136(0.80); C421(0.96); C51(1.53); C609(0.84)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C136(0.87); C421(1.04); C51(1.62); C609(1.41)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C136(0.81); C421(0.99); C51(1.68); C609(1.04)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C136(0.96); C51(1.13); C516(0.65); C525(0.65)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C136(0.76); C421(0.95); C51(1.48); C609(1.01)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C136(0.74); C421(0.93); C51(1.52); C609(1.05)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C136(0.81); C421(0.99); C51(1.98); C609(1.07)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C136(0.73); C421(0.87); C51(2.09); C609(1.01)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C136(0.84); C421(1.01); C51(1.33); C609(0.81)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C136(0.88); C421(1.08); C51(1.24); C609(0.85)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C136(0.94); C51(1.12); C516(1.41); C525(1.41)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C136(0.93); C51(1.00); C516(1.22); C525(1.22)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C136(1.02); C51(0.99); C516(1.46); C525(1.46)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C136(1.07); C51(1.23); C516(1.48); C525(1.48)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C136(0.98); C51(1.17); C516(0.88); C525(0.88)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C136(1.04); C51(1.06); C516(1.42); C525(1.42)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C136(1.09); C51(0.97); C516(1.54); C525(1.54)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C136(0.96); C51(0.99); C516(1.76); C525(1.76)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C136(0.83); C51(1.34); C516(1.62); C525(1.62)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C136(0.83); C51(1.22); C516(1.32); C525(1.32)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C136(0.82); C51(1.15); C516(2.05); C525(2.05)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C136(0.86); C51(1.13); C516(1.08); C525(1.08)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C136(0.85); C51(1.19); C516(1.34); C525(1.34)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C136(1.09); C51(1.27); C516(1.42); C525(1.42)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C136(0.98); C51(0.96); C516(1.33); C525(1.33)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C136(0.95); C51(1.18); C516(0.57); C525(0.57)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C136(1.01); C51(1.05); C516(1.11); C525(1.11)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C136(0.96); C51(0.71); C516(0.99); C525(0.99)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C136(0.86); C51(0.79); C516(0.65); C525(0.65)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C136(0.94); C51(1.04); C516(0.65); C525(0.65)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C136(1.10); C51(0.92); C516(0.48); C525(0.48)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C136(1.08); C51(0.72); C516(0.85); C525(0.85)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C136(1.27); C51(1.01); C516(0.43); C525(0.43)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C136(1.22); C51(1.03); C516(0.50); C525(0.50)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C136(1.20); C51(0.94); C516(0.46); C525(0.46)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C136(0.85); C51(1.49); C516(0.47); C525(0.47)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C136(0.91); C51(0.77); C516(0.58); C525(0.58)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C136(1.00); C51(0.77); C516(0.49); C525(0.49)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C136(1.09); C51(1.24); C516(0.49); C525(0.49)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C136(1.17); C51(1.08); C516(1.14); C525(1.14)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C136(1.34); C51(1.53); C516(0.61); C525(0.61)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C136(1.12); C51(1.38); C516(0.56); C525(0.56)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C136(0.69); C51(1.05); C516(0.72); C525(0.72)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C136(0.73); C51(1.16); C516(0.83); C525(0.83)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C136(0.85); C51(1.09); C516(1.84); C525(1.84)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C136(0.95); C51(1.26); C516(0.73); C525(0.73)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C136(0.94); C51(1.85); C516(0.60); C525(0.60)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C136(0.89); C51(0.97); C516(0.71); C525(0.71)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C136(0.94); C51(1.05); C516(0.56); C525(0.56)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C136(0.81); C51(1.42); C516(0.63); C525(0.63)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C136(0.77); C51(1.16); C516(0.62); C525(0.62)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C136(0.71); C51(1.26); C516(0.52); C525(0.52)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C136(0.81); C51(1.10); C516(0.63); C525(0.63)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C136(0.87); C51(0.93); C516(0.84); C525(0.84)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C136(0.88); C51(1.16); C516(0.80); C525(0.80)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C136(0.85); C51(1.07); C516(0.85); C525(0.85)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C136(0.72); C51(1.15); C516(0.36); C525(0.36)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C136(0.83); C51(0.91); C516(0.90); C525(0.90)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C136(0.80); C51(1.31); C516(0.97); C525(0.97)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C136(0.78); C51(0.98); C516(0.78); C525(0.78)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C136(0.88); C51(1.04); C516(0.62); C525(0.62)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C136(1.19); C51(1.18); C516(0.69); C525(0.69)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C136(1.14); C51(1.26); C516(0.82); C525(0.82)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C136(1.19); C51(1.01); C516(0.73); C525(0.73)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C136(0.93); C51(0.81); C516(0.67); C525(0.67)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C136(0.87); C51(1.12); C516(0.91); C525(0.91)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C136(0.94); C51(0.94); C516(0.68); C525(0.68)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C136(1.14); C51(0.88); C516(0.72); C525(0.72)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C51(0.97); C374(1.09); C670(0.99); C136(0.93)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C136(0.62)  LDD1702  [5]
 LDCM0625  F8 Ramos C87(0.72); C670(1.15); C51(4.02)  LDD2187  [25]
 LDCM0572  Fragment10 Ramos C87(0.62); C670(0.53)  LDD2189  [25]
 LDCM0573  Fragment11 Ramos C87(2.70); C670(0.44); C51(2.28)  LDD2190  [25]
 LDCM0574  Fragment12 Ramos C87(0.57); C670(0.67)  LDD2191  [25]
 LDCM0575  Fragment13 Ramos C87(0.72); C670(0.79)  LDD2192  [25]
 LDCM0576  Fragment14 Ramos C670(0.57); C51(0.70)  LDD2193  [25]
 LDCM0579  Fragment20 Ramos C87(0.50); C670(0.47)  LDD2194  [25]
 LDCM0580  Fragment21 Ramos C87(0.92); C670(0.76)  LDD2195  [25]
 LDCM0582  Fragment23 Ramos C87(0.96); C670(0.83)  LDD2196  [25]
 LDCM0578  Fragment27 Ramos C87(0.98); C670(0.91)  LDD2197  [25]
 LDCM0586  Fragment28 Ramos C87(0.66)  LDD2198  [25]
 LDCM0588  Fragment30 Ramos C87(0.85); C670(0.99)  LDD2199  [25]
 LDCM0589  Fragment31 Ramos C87(0.93); C670(0.76)  LDD2200  [25]
 LDCM0590  Fragment32 Ramos C87(0.57); C670(1.20)  LDD2201  [25]
 LDCM0468  Fragment33 HCT 116 C136(1.39); C51(0.83); C516(0.52); C525(0.52)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C87(0.55); C670(0.66)  LDD2203  [25]
 LDCM0566  Fragment4 Ramos C87(0.62); C670(0.66); C51(1.25)  LDD2184  [25]
 LDCM0427  Fragment51 HCT 116 C136(0.83); C421(1.17); C51(1.33); C609(0.95)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C87(1.03)  LDD2204  [25]
 LDCM0614  Fragment56 Ramos C87(0.86); C670(0.90)  LDD2205  [25]
 LDCM0569  Fragment7 Ramos C87(0.56); C670(0.50); C51(0.40)  LDD2186  [25]
 LDCM0571  Fragment9 Ramos C87(0.62); C670(0.54)  LDD2188  [25]
 LDCM0107  IAA HeLa C374(0.00); C87(0.00); C640(0.00)  LDD0221  [18]
 LDCM0022  KB02 HCT 116 C670(0.99)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C670(1.06)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C670(0.97)  LDD0082  [7]
 LDCM0109  NEM HeLa C87(0.00); H814(0.00); H702(0.00); C640(0.00)  LDD0224  [18]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C670(1.10)  LDD2089  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C87(0.51)  LDD2109  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C670(0.96)  LDD2114  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C87(0.94)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C87(0.93)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C87(1.03)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C87(1.17)  LDD2126  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C670(1.09); C87(1.79); C753(1.37)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C87(1.00)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C136(1.01); C753(1.00)  LDD2140  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C87(1.17)  LDD2146  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C609(1.65)  LDD2206  [26]
 LDCM0628  OTUB2-COV-1 HEK-293T C609(0.80)  LDD2207  [26]
 LDCM0131  RA190 MM1.R C51(0.88); C670(0.84)  LDD0304  [27]
 LDCM0021  THZ1 HCT 116 C51(1.26); C753(1.09); C670(0.99)  LDD2173  [7]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
23 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
27 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.