Details of the Target

General Information of Target

Target ID LDTP15517
Target Name Cytosolic endo-beta-N-acetylglucosaminidase (ENGASE)
Gene Name ENGASE
Gene ID 64772
Synonyms
Cytosolic endo-beta-N-acetylglucosaminidase; ENGase; EC 3.2.1.96
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRGVSCLQVLLLLVLGAAGTQGRKSAACGQPRMSSRIVGGRDGRDGEWPWQASIQHRGAH
VCGGSLIAPQWVLTAAHCFPRRALPAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSE
DGARGDLALLQLRRPVPLSARVQPVCLPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRPL
QGVRVPLLDSRTCDGLYHVGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQS
GSWVLVGVVSWGKGCALPNRPGVYTSVATYSPWIQARVSF
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 85 family
Subcellular location
Cytoplasm, cytosol
Function
Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol.
Uniprot ID
Q8NFI3
Ensemble ID
ENST00000311595.14
HGNC ID
HGNC:24622
ChEMBL ID
CHEMBL5172

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EGI1 SNV: p.H183Y DBIA    Probe Info 
NALM6 SNV: p.G445D .
NCIH1993 SNV: p.R411L .
NCIH2286 Deletion: p.R555PfsTer6 .
RL952 SNV: p.P123H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y304(20.00)  LDD0257  [1]
AHL-Pu-1
 Probe Info  		C414(2.12)  LDD0173  [2]
DBIA
 Probe Info  		C113(1.46)  LDD0080  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C202(0.00); C113(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C113(0.00); C202(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C202(0.00); C113(0.00); C665(0.00); C297(0.00)  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
Phosphinate-6
 Probe Info  		C556(0.00); C453(0.00); C454(0.00)  LDD0018  [6]
W1
 Probe Info  		N.A.  LDD0236  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C414(2.12)  LDD0173  [2]
 LDCM0214  AC1 HCT 116 C113(0.99)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C369(1.07); C113(0.95); C576(1.18); C454(1.01)  LDD1508  [8]
 LDCM0216  AC100 HCT 116 C113(0.86)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C113(0.92)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C113(0.92)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C113(1.08)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C113(1.04)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C113(0.96)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C113(0.85)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C113(0.98)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C113(0.85)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C113(0.97)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C369(1.02); C113(0.95); C576(0.68)  LDD1509  [8]
 LDCM0227  AC110 HCT 116 C113(1.06)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C113(1.12)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C113(1.01)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C113(1.01)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C113(0.86)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C113(0.98)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C113(0.86)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C113(0.78)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C113(0.91)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C113(0.87)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C369(1.02); C113(0.99); C568(0.92); C576(0.88)  LDD1510  [8]
 LDCM0238  AC120 HCT 116 C113(1.04)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C113(0.85)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C113(0.75)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C113(0.87)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C113(0.77)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C113(0.99)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C113(0.79)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C113(0.77)  LDD0562  [3]
 LDCM0259  AC14 HEK-293T C369(1.11); C576(0.98); C454(1.20)  LDD1512  [8]
 LDCM0263  AC143 HCT 116 C113(0.75)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C113(1.44)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C113(0.86)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C113(0.96)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C113(1.32)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C113(0.95)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C113(1.30)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C369(0.97); C113(0.82); C576(0.88); C454(1.07)  LDD1513  [8]
 LDCM0271  AC150 HCT 116 C113(1.09)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C113(0.88)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C113(0.90)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C113(1.48)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C113(0.95)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C113(1.15)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C113(1.07)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C113(0.87)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C113(1.01)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C113(0.85)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C113(1.02)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C113(1.11)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C113(0.76)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C113(0.92)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C113(0.83)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C113(1.18)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C113(1.11)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C369(1.03); C113(1.00); C576(1.03); C405(1.08)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C369(0.95); C113(1.16); C576(1.11); C454(0.87)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C369(0.81); C113(0.96); C576(0.71)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C369(0.94); C113(1.20); C568(0.93); C576(0.66)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C369(0.93); C113(1.09); C576(0.93); C454(0.95)  LDD1528  [8]
 LDCM0290  AC3 HCT 116 C113(1.02)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C369(1.08); C576(1.14); C454(0.96)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C369(0.99); C113(1.11); C576(0.99); C454(1.04)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C369(1.01); C113(1.13); C568(0.94); C454(1.02)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C369(0.99); C113(0.98); C576(1.01); C405(0.87)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C369(1.00); C113(1.05); C576(1.30); C454(0.94)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C369(0.96); C113(0.98); C576(0.76)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C369(1.08); C113(1.01); C568(0.94); C576(0.92)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C369(1.09); C113(1.12); C576(0.89); C454(0.93)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C369(0.97); C576(0.82); C454(0.86)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C369(1.02); C113(1.17); C576(0.95); C454(1.03)  LDD1539  [8]
 LDCM0301  AC4 HCT 116 C113(1.21)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C369(1.08); C113(0.99); C568(0.91); C454(1.11)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C369(0.96); C113(1.00); C576(1.22); C405(0.97)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C369(0.97); C113(0.93); C576(0.79); C454(1.08)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C369(1.15); C113(1.10); C576(1.04)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C369(0.93); C113(0.94); C568(0.97); C576(0.79)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C369(0.99); C113(1.00); C576(1.16); C454(0.86)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C369(1.03); C576(0.89); C454(0.86)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C369(1.07); C113(1.03); C576(0.86); C454(0.90)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C369(1.01); C113(1.13); C568(0.92); C454(0.97)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C369(0.91); C113(1.01); C576(1.03); C405(1.32)  LDD1550  [8]
 LDCM0312  AC5 HCT 116 C113(1.43)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C369(1.02); C113(0.98); C576(1.20); C454(0.88)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C369(1.20); C113(0.93); C576(0.72)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C369(1.00); C113(1.19); C568(0.98); C576(0.92)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C369(0.99); C113(1.21); C576(1.05); C454(1.08)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C369(0.99); C576(0.92); C454(0.84)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C369(1.00); C113(0.95); C576(1.17); C454(1.02)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C369(0.96); C113(1.26); C568(1.05); C454(1.00)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C369(0.97); C113(0.96); C576(1.58); C405(0.90)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C369(0.91); C113(0.94); C576(0.97); C454(0.87)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C369(1.07); C113(0.99); C576(1.59)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C369(0.97); C576(0.71); C454(1.09)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C369(1.05); C113(0.97); C568(0.97); C576(0.91)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C369(0.97); C113(1.22); C576(1.05); C454(0.89)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C369(1.01); C576(0.97); C454(0.84)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C369(0.94); C113(0.98); C576(1.08); C454(0.95)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C369(0.93); C113(1.35); C568(1.03); C454(0.97)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C369(1.10); C113(1.11); C576(1.13); C454(1.01)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C369(1.09); C113(1.18); C568(0.85); C454(1.03)  LDD1569  [8]
 LDCM0365  AC98 HCT 116 C113(0.95)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C113(0.83)  LDD0683  [3]
 LDCM0248  AKOS034007472 HEK-293T C369(1.06); C113(1.17); C576(1.14); C454(1.14)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C369(1.00); C113(0.95); C576(1.02); C405(0.90)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C369(1.04); C113(1.60); C568(0.97); C454(1.05)  LDD1514  [8]
 LDCM0367  CL1 HEK-293T C369(1.13); C113(1.20); C576(0.72); C454(1.02)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C369(1.34); C576(0.86); C454(1.64)  LDD1572  [8]
 LDCM0369  CL100 HCT 116 C113(0.89)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C369(1.03); C113(1.23); C576(0.65); C454(0.84)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C113(1.29); C576(0.86); C454(0.88)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C369(0.99); C113(1.05); C202(0.93); C576(1.05)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C369(0.94); C113(1.00); C297(0.67); C576(1.20)  LDD1577  [8]
 LDCM0374  CL105 HCT 116 C113(0.85)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C113(1.04)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C113(0.81)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C113(0.96)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C113(1.27)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C369(1.05); C113(0.97); C576(1.08); C454(1.53)  LDD1583  [8]
 LDCM0380  CL110 HCT 116 C113(0.94)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C113(0.72)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C369(1.01); C113(1.08); C297(0.97); C576(0.68)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C369(1.10); C113(1.26); C576(0.94); C454(1.04)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C113(0.89); C576(1.01); C454(0.94)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C369(0.95); C113(1.18); C202(1.02); C576(1.02)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C369(0.96); C113(1.09); C297(0.89); C576(0.91)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C369(1.09); C113(1.14); C576(0.83); C454(0.97)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C113(1.19); C576(1.05); C454(0.90)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C369(1.11); C113(0.99); C202(1.04); C576(1.03)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C369(1.37); C113(0.94); C568(0.97); C454(1.37)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C369(1.11); C113(1.06); C297(0.77); C576(0.74)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C369(1.06); C113(1.19); C576(0.78); C454(0.99)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C113(1.12); C576(1.03); C454(0.89)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C369(0.96); C113(1.02); C202(1.30); C576(0.95)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C369(1.22); C113(0.99); C297(0.78); C576(0.85)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C369(0.83); C113(1.27); C576(0.92); C454(0.72)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C113(1.11); C576(1.01); C454(0.88)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C369(1.03); C113(1.14); C202(1.02); C576(1.29)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C369(0.99); C113(1.26); C297(0.90); C576(1.30)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C369(1.12); C113(1.04); C576(0.71); C454(0.83)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C113(1.10); C576(0.83); C454(0.88)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C369(1.05); C113(1.11); C202(1.20); C576(1.12)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C369(0.97); C113(0.93); C297(0.70); C576(1.51)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C369(0.89); C113(0.92); C576(0.96); C405(0.44)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C369(0.87); C113(1.02); C576(1.18); C454(1.17)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C369(1.15); C113(1.30); C576(1.21)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C113(0.94); C576(1.11); C454(0.93)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C369(0.92); C113(0.99); C568(0.90); C576(1.06)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C369(0.33); C113(0.97); C576(0.86); C454(1.11)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C369(1.12); C576(0.92); C454(1.07)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C369(1.03); C113(0.90); C576(1.33); C454(1.40)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C369(1.06); C113(1.56); C568(1.06); C454(1.33)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C369(1.03); C113(1.10); C576(0.56); C454(0.89)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C113(1.06); C576(0.87); C454(0.96)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C369(1.01); C113(1.26); C202(1.04); C576(1.02)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C369(1.19); C113(0.89); C297(0.53); C576(0.79)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C369(0.88); C113(0.85); C576(1.13); C405(0.88)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C369(1.09); C113(1.12); C202(1.18); C576(0.92)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C369(0.95); C113(0.92); C576(0.95); C454(1.15)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C369(1.16); C113(1.09); C576(0.64)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C369(0.96); C113(0.86); C568(0.96); C576(0.97)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C369(1.14); C113(0.96); C576(0.71); C454(1.02)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C369(0.93); C576(0.90); C454(1.10)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C369(0.99); C113(0.94); C576(0.94); C454(1.15)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C369(1.02); C113(0.99); C568(0.93); C454(1.34)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C369(1.03); C113(1.16); C576(0.71); C454(0.84)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C369(1.13); C113(1.17); C202(1.03); C576(0.89)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C369(0.98); C113(1.01); C297(0.71); C576(0.85)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C369(0.94); C113(1.00); C297(0.67); C576(0.59)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C369(1.13); C113(0.89); C576(1.00); C405(0.96)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C369(0.95); C113(0.94); C576(1.05); C454(0.88)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C369(1.00); C113(0.95); C576(0.93)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C369(1.00); C113(1.18); C568(1.04); C576(0.56)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C369(1.25); C113(0.95); C576(0.77); C454(1.44)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C369(1.10); C576(0.90); C454(1.11)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C369(1.12); C113(0.80); C576(1.18); C454(1.28)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C369(1.09); C113(0.98); C568(0.96); C454(1.29)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C369(1.14); C113(1.23); C576(0.97); C454(0.87)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C369(0.95); C113(0.94); C576(0.82); C405(0.91)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C113(1.03); C576(1.07); C454(0.87)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C369(0.96); C113(0.93); C297(0.72); C576(0.84)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C369(0.95); C113(0.86); C576(0.86); C405(0.80)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C369(0.85); C113(0.80); C576(0.82); C454(0.96)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C369(1.07); C113(0.99); C576(0.74)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C369(1.04); C113(0.82); C568(0.96); C576(0.87)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C369(0.91); C113(1.21); C576(0.87); C454(1.19)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C369(1.01); C576(0.95); C454(1.19)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C369(1.05); C113(0.91); C576(0.99); C454(1.23)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C369(0.97); C113(1.06); C576(0.97); C454(1.01)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C369(1.17); C113(1.04); C568(0.94); C454(1.28)  LDD1655  [8]
 LDCM0453  CL61 HCT 116 C113(1.36)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C113(1.22)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C113(1.47)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C113(1.50)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C113(1.26)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C113(1.99)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C113(1.57)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C113(1.54)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C113(1.23)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C369(0.92); C113(0.98); C576(0.75)  LDD1665  [8]
 LDCM0463  CL70 HCT 116 C113(1.29)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C113(1.36)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C113(1.38)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C113(1.34)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C113(1.63)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C369(1.02); C113(0.93); C297(0.67); C576(1.15)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C369(0.86); C113(0.92); C576(1.15); C405(0.85)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C369(0.99); C113(0.99); C576(1.21); C454(1.06)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C369(0.92); C113(0.90); C576(0.67)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C369(1.05); C113(0.88); C568(0.92); C576(0.80)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C369(1.02); C113(1.09); C568(1.02); C576(0.67)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C369(0.99); C113(1.03); C576(0.85); C454(1.08)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C369(1.08); C576(0.95); C454(0.96)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C369(1.06); C113(0.85); C576(0.91); C454(1.28)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C369(1.03); C113(0.95); C568(0.96); C454(1.18)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C369(1.01); C113(1.30); C576(0.92); C454(0.75)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C113(1.06); C576(1.23); C454(0.77)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C369(1.28); C113(1.09); C202(1.13); C576(0.84)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C369(1.05); C113(1.24); C297(0.81); C576(1.35)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C369(1.00); C113(1.10); C576(1.21); C405(0.90)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C369(1.03); C113(1.00); C576(0.98); C454(1.11)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C369(1.02); C113(0.82); C576(0.93); C454(1.01)  LDD1688  [8]
 LDCM0486  CL91 HCT 116 C113(0.93)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C113(1.20)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C113(1.14)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C113(1.27)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C113(1.16)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C113(1.13)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C113(1.28)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C113(0.94)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C113(0.91)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C369(1.09); C113(1.14); C202(1.06); C576(1.00)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C113(1.63)  LDD0785  [3]
 LDCM0427  Fragment51 HEK-293T C113(1.32); C576(1.01); C454(0.97)  LDD1631  [8]
 LDCM0022  KB02 HCT 116 C113(1.46)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C113(1.39)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C113(2.02)  LDD0082  [3]

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402