Details of the Target

General Information of Target

Target ID LDTP15414
Target Name Ligand-dependent nuclear receptor corepressor-like protein (LCORL)
Gene Name LCORL
Gene ID 254251
Synonyms
Ligand-dependent nuclear receptor corepressor-like protein; LCoR-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKKSRAVPGRRPILQLSPPGPRGSTPGRDPEPEPDTEPDSTAAVPSQPAPSAATTTTTA
VTAAAASDDSPSEDEQEAVQEVPRVVQNPPKPVMTTRPTAVKATGGLCLLGAYADSDDDD
NDVSEKLAQSKETNGNQSTDIDSTLANFLAEIDAITAPQPAAPVGASAPPPTPPRPEPKE
AATSTLSSSTSNGTDSTQTSGWQYDTQCSLAGVGIEMGDWQEVWDENTGCYYYWNTQTNE
VTWELPQYLATQVQGLQHYQPSSVPGAETSFVVNTDIYSKEKTISVSSSKSGPVIAKREV
KKEVNEGIQALSNSEEEKKGVAASLLAPLLPEGIKEEEERWRRKVICKEEPVSEVKETST
TVEEATTIVKPQEIMLDNIEDPSQEDLCSVVQSGESEEEEEQDTLELELVLERKKAELRA
LEEGDGSVSGSSPRSDISQPASQDGMRRLMSKRGKWKMFVRATSPESTSRSSSKTGRDTP
ENGETAIGAENSEKIDENSDKEMEVEESPEKIKVQTTPKVEEEQDLKFQIGELANTLTSK
FEFLGINRQSISNFHVLLLQTETRIADWREGALNGNYLKRKLQDAAEQLKQYEINATPKG
WSCHWDRDHRRYFYVNEQSGESQWEFPDGEEEEEESQAQENRDETLAKQTLKDKTGTDSN
STESSETSTGSLCKESFSGQVSSSSLMPLTPFWTLLQSNVPVLQPPLPLEMPPPPPPPPE
SPPPPPPPPPPAEDGEIQEVEMEDEGSEEPPAPGTEEDTPLKPSAQTTVVTSQSSVDSTI
SSSSSTKGIKRKATEISTAVVQRSATIGSSPVLYSQSAIATGHQAAGIGNQATGIGHQTI
PVSLPAAGMGHQARGMSLQSNYLGLAAAPAIMSYAECSVPIGVTAPSLQPVQARGAVPTA
TIIEPPPPPPPPPPPPPPAPKMPPPEKTKKGRKDKAKKSKTKMPSLVKKWQSIQRELDEE
DNSSSSEEDRESTAQKRIEEWKQQQLVSGMAERNANFEALPEDWRARLKRRKMAPNT
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis.
Uniprot ID
Q8N3X6
Ensemble ID
ENST00000326877.8
HGNC ID
HGNC:30776

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C130(3.03)  LDD0172  [1]
IA-alkyne
 Probe Info  		C24(0.80)  LDD2207  [2]
DBIA
 Probe Info  		C89(1.39); C92(1.39)  LDD0531  [3]
NAIA_5
 Probe Info  		N.A.  LDD2225  [4]
Compound 10
 Probe Info  		N.A.  LDD2216  [5]
Compound 11
 Probe Info  		N.A.  LDD2213  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C130(3.03)  LDD0172  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C130(2.93)  LDD0173  [1]
 LDCM0214  AC1 HCT 116 C89(1.39); C92(1.39)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C50(0.89); C193(1.00)  LDD1508  [8]
 LDCM0216  AC100 HCT 116 C89(1.14); C92(1.14)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C89(1.23); C92(1.23)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C89(0.97); C92(0.97)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C89(1.22); C92(1.22)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C89(1.08); C92(1.08)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C89(1.43); C92(1.43)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C89(1.34); C92(1.34)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C89(1.15); C92(1.24)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C89(1.18); C92(1.18)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C89(0.95); C92(0.93)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C50(1.11); C343(1.12)  LDD1509  [8]
 LDCM0227  AC110 HCT 116 C89(1.14); C92(1.13)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C89(1.03); C92(1.11)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C89(1.14); C92(1.24)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C89(0.76); C92(0.76)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C89(0.89); C92(0.82)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C89(0.99); C92(0.97)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C89(0.86); C92(1.08)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C89(0.96); C92(0.70)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C89(0.63); C92(0.62)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C89(0.88); C92(0.74)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C50(0.81); C92(0.93)  LDD1510  [8]
 LDCM0238  AC120 HCT 116 C89(0.75); C92(0.64)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C89(1.19); C92(0.76)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C89(0.88); C92(0.82)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C89(0.65); C92(0.98)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C89(1.03); C92(0.72)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C89(0.88); C92(0.74)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C89(0.94); C92(0.86)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C89(0.69); C92(0.69)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C89(0.53); C92(0.53)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C89(0.56); C92(0.56)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C89(0.61); C92(0.61)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C89(0.50); C92(0.50)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C89(0.57); C92(0.57)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C89(0.62); C92(0.62)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C89(0.71); C92(0.71)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C89(0.74); C92(0.74)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C89(0.77); C92(0.77)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C89(0.66); C92(0.66)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C89(0.85); C92(0.85)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C89(0.87); C92(0.87)  LDD0575  [3]
 LDCM0259  AC14 HEK-293T C50(1.19); C130(0.90)  LDD1512  [8]
 LDCM0260  AC140 HCT 116 C89(0.84); C92(0.84)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C89(0.78); C92(0.78)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C89(0.75); C92(0.75)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C89(1.01); C92(1.01)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C89(2.04); C92(2.04)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C89(1.11); C92(1.11)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C89(1.03); C92(1.03)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C89(1.63); C92(1.63)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C89(2.32); C92(2.32)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C89(1.67); C92(1.67)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C50(1.12); C24(0.99)  LDD1513  [8]
 LDCM0271  AC150 HCT 116 C89(1.51); C92(1.51)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C89(0.98); C92(0.98)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C89(1.27); C92(1.27)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C89(2.69); C92(2.69)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C89(1.41); C92(1.41)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C89(1.20); C92(1.20)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C89(0.86); C92(0.86)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C89(0.97); C92(0.97)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C89(0.64); C92(0.64)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C89(0.72); C92(0.72)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C89(0.60); C92(0.60)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C89(1.28); C92(1.28)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C89(0.59); C92(0.59)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C89(0.64); C92(0.64)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C89(0.59); C92(0.59)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C89(0.53); C92(0.53)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C89(0.48); C92(0.48)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C89(0.56); C92(0.56)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C89(0.92); C92(0.92)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C89(0.92); C92(0.92)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C89(0.75); C92(0.75)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C89(0.57); C92(0.57)  LDD0887  [3]
 LDCM0290  AC3 HCT 116 C89(1.14); C92(1.14)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C89(1.10); C92(1.10)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C89(0.76); C92(0.76)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C89(0.56); C92(0.56)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C89(0.85); C92(0.85)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C89(0.95); C92(0.95)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C50(1.14); C343(1.19)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C50(1.05); C92(0.97)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C50(1.13)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C50(1.12); C130(0.89)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C50(1.09); C24(0.99)  LDD1539  [8]
 LDCM0301  AC4 HCT 116 C89(1.45); C92(1.45)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C50(0.92)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C50(1.30)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C50(1.18); C193(1.34)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C50(1.13); C343(1.05)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C50(1.03); C92(1.07)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C50(0.98)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C50(1.08); C130(0.87)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C50(1.35); C24(1.05)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C50(0.82)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C50(1.20)  LDD1550  [8]
 LDCM0312  AC5 HCT 116 C89(1.56); C92(1.56)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C50(1.10); C193(1.17)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C50(0.98); C343(1.07)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C50(1.05); C92(1.13)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C50(1.12)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C50(1.13); C130(0.94)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C50(1.18); C24(0.97)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C50(0.99)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C50(1.15)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C50(1.11); C193(1.10)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C50(0.97); C343(1.08)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C50(1.11); C130(1.00)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C50(0.98); C92(0.98)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C50(1.13)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C50(1.12); C130(0.99)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C50(1.18); C24(0.82)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C50(0.98)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C50(0.98); C24(0.84)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C50(0.90)  LDD1569  [8]
 LDCM0349  AC83 HCT 116 C89(1.07); C92(1.07)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C89(0.82); C92(0.82)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C89(0.59); C92(0.59)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C89(1.02); C92(1.02)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C89(1.23); C92(1.23)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C89(0.90); C92(0.90)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C89(0.72); C92(0.72)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C89(0.71); C92(0.71)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C89(1.11); C92(1.11)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C89(1.21); C92(1.21)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C89(0.88); C92(0.88)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C89(0.57); C92(0.57)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C89(0.84); C92(0.84)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C89(0.81); C92(0.81)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C89(1.13); C92(1.13)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C89(1.55); C92(1.55)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C89(0.99); C92(0.99)  LDD0683  [3]
 LDCM0248  AKOS034007472 HEK-293T C50(1.04)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C50(1.07)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C50(0.94)  LDD1514  [8]
 LDCM0367  CL1 HEK-293T C50(1.02)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C50(1.46); C130(1.00)  LDD1572  [8]
 LDCM0369  CL100 HCT 116 C89(1.35); C92(1.35)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C50(0.84)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C130(0.95)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C50(0.98); C343(1.10)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C50(0.99)  LDD1577  [8]
 LDCM0374  CL105 HCT 116 C89(0.62); C92(0.62)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C89(0.56); C92(0.56)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C89(0.70); C92(0.70)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C89(0.61); C92(0.61)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C89(0.91); C92(0.91)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C50(1.13); C24(1.08)  LDD1583  [8]
 LDCM0380  CL110 HCT 116 C89(0.64); C92(0.64)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C89(0.66); C92(0.66)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C89(0.64); C92(0.64)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C89(1.41); C92(1.41)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C89(0.72); C92(0.72)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C89(0.85); C92(0.85)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C89(0.52); C92(0.52)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C50(1.20)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C130(1.05)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C50(0.92); C343(0.98)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C50(0.92)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C50(1.03)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C50(0.98)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C130(1.09)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C50(0.88); C343(1.40)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C50(0.91)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C50(1.01)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C130(1.17)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C50(1.04); C343(1.05)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C50(0.94)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C50(1.01)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C130(1.06)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C50(1.01); C343(1.38)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C50(1.02)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C50(1.36)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C50(0.77); C193(0.97)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C50(1.21); C343(1.06)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C130(0.97)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C50(0.98); C92(0.87)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C50(1.22)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C50(1.04); C130(1.10)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C50(1.03); C24(0.85)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C50(0.90)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C50(0.83)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C130(0.95)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C50(0.91); C343(0.97)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C50(0.90)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C50(0.77)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C50(1.04); C343(0.94)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C50(0.96); C193(0.99)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C50(0.97); C343(1.13)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C50(0.86); C92(1.01)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C50(0.24)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C50(1.12); C130(1.00)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C50(0.80); C24(1.00)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C50(0.76)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C50(1.00)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C50(1.02); C343(1.04)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C50(1.06)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C50(1.05)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C50(0.94)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C50(0.86); C193(1.03)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C50(0.91); C343(1.12)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C50(1.00); C92(0.96)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C50(1.01)  LDD1639  [8]
 LDCM0436  CL46 HCT 116 C89(0.78); C92(0.78)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C89(0.89); C92(0.89)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C89(1.32); C92(1.32)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C89(1.21); C92(1.21)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C50(1.07)  LDD1644  [8]
 LDCM0441  CL50 HCT 116 C89(0.70); C92(0.70)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C89(0.91); C92(0.91)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C89(1.14); C92(1.14)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C89(1.08); C92(1.08)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C89(0.94); C92(0.94)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C89(1.18); C92(1.18)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C89(1.05); C92(1.05)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C89(1.12); C92(1.12)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C89(0.88); C92(0.88)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C89(0.88); C92(0.88)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C50(1.16); C193(0.91)  LDD1654  [8]
 LDCM0452  CL60 HCT 116 C89(1.05); C92(1.05)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C50(0.89)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C130(0.96)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C50(0.97); C343(1.03)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C50(1.02)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C50(1.23)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C50(0.89); C193(1.08)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C50(1.04); C343(1.07)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C50(1.00); C92(1.00)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C50(0.75)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C50(0.95); C343(0.94)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C50(0.99); C130(1.06)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C50(1.06); C24(0.94)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C50(0.98)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C50(0.93)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C130(0.96)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C50(1.05)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C50(1.27)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C50(0.90); C193(1.07)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C50(0.90); C343(0.88)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C50(1.12); C92(1.02)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C50(0.90); C92(0.93)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C50(0.92)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C50(1.01); C130(1.10)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C50(1.13); C24(1.01)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C50(0.96)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C50(1.03)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C130(0.95)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C50(0.93); C343(1.15)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C50(1.06)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C50(1.28)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C50(0.92)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C50(1.00); C193(1.06)  LDD1688  [8]
 LDCM0486  CL91 HCT 116 C89(1.12); C92(1.12)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C89(0.93); C92(0.93)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C89(1.09); C92(1.09)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C89(1.38); C92(1.38)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C89(1.19); C92(1.19)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C89(1.49); C92(1.49)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C89(1.78); C92(1.78)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C89(1.10); C92(1.10)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C89(1.21); C92(1.21)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C50(1.08); C343(1.13)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C50(1.10); C343(0.81)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C130(0.90)  LDD1631  [8]
 LDCM0022  KB02 CC-LP-1 C193(1.89)  LDD2298  [9]
 LDCM0023  KB03 CC-SW-1 C193(1.91)  LDD2716  [9]
 LDCM0024  KB05 SG231 C193(7.73)  LDD3418  [9]
 LDCM0628  OTUB2-COV-1 HEK-293T C24(0.80)  LDD2207  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-terminal-binding protein 1 (CTBP1) D-isomer specific 2-hydroxyacid dehydrogenase family Q13363
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Melanoma-associated antigen 6 (MAGEA6) . P43360

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840