Details of the Target

General Information of Target

Target ID LDTP08093
Target Name Retinoic acid-induced protein 1 (RAI1)
Gene Name RAI1
Gene ID 10743
Synonyms
KIAA1820; Retinoic acid-induced protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQSFRERCGFHGKQQNYQQTSQETSRLENYRQPSQAGLSCDRQRLLAKDYYNPQPYPSYE
GGAGTPSGTAAAVAADKYHRGSKALPTQQGLQGRPAFPGYGVQDSSPYPGRYAGEESLQA
WGAPQPPPPQPQPLPAGVAKYDENLMKKTAVPPSRQYAEQGAQVPFRTHSLHVQQPPPPQ
QPLAYPKLQRQKLQNDIASPLPFPQGTHFPQHSQSFPTSSTYSSSVQGGGQGAHSYKSCT
APTAQPHDRPLTASSSLAPGQRVQNLHAYQSGRLSYDQQQQQQQQQQQQQQALQSRHHAQ
ETLHYQNLAKYQHYGQQGQGYCQPDAAVRTPEQYYQTFSPSSSHSPARSVGRSPSYSSTP
SPLMPNLENFPYSQQPLSTGAFPAGITDHSHFMPLLNPSPTDATSSVDTQAGNCKPLQKD
KLPENLLSDLSLQSLTALTSQVENISNTVQQLLLSKAAVPQKKGVKNLVSRTPEQHKSQH
CSPEGSGYSAEPAGTPLSEPPSSTPQSTHAEPQEADYLSGSEDPLERSFLYCNQARGSPA
RVNSNSKAKPESVSTCSVTSPDDMSTKSDDSFQSLHGSLPLDSFSKFVAGERDCPRLLLS
ALAQEDLASEILGLQEAIGEKADKAWAEAPSLVKDSSKPPFSLENHSACLDSVAKSAWPR
PGEPEALPDSLQLDKGGNAKDFSPGLFEDPSVAFATPDPKKTTGPLSFGTKPTLGVPAPD
PTTAAFDCFPDTTAASSADSANPFAWPEENLGDACPRWGLHPGELTKGLEQGGKASDGIS
KGDTHEASACLGFQEEDPPGEKVASLPGDFKQEEVGGVKEEAGGLLQCPEVAKADRWLED
SRHCCSTADFGDLPLLPPTSRKEDLEAEEEYSSLCELLGSPEQRPGMQDPLSPKAPLICT
KEEVEEVLDSKAGWGSPCHLSGESVILLGPTVGTESKVQSWFESSLSHMKPGEEGPDGER
APGDSTTSDASLAQKPNKPAVPEAPIAKKEPVPRGKSLRSRRVHRGLPEAEDSPCRAPVL
PKDLLLPESCTGPPQGQMEGAGAPGRGASEGLPRMCTRSLTALSEPRTPGPPGLTTTPAP
PDKLGGKQRAAFKSGKRVGKPSPKAASSPSNPAALPVASDSSPMGSKTKETDSPSTPGKD
QRSMILRSRTKTQEIFHSKRRRPSEGRLPNCRATKKLLDNSHLPATFKVSSSPQKEGRVS
QRARVPKPGAGSKLSDRPLHALKRKSAFMAPVPTKKRNLVLRSRSSSSSNASGNGGDGKE
ERPEGSPTLFKRMSSPKKAKPTKGNGEPATKLPPPETPDACLKLASRAAFQGAMKTKVLP
PRKGRGLKLEAIVQKITSPSLKKFACKAPGASPGNPLSPSLSDKDRGLKGAGGSPVGVEE
GLVNVGTGQKLPTSGADPLCRNPTNRSLKGKLMNSKKLSSTDCFKTEAFTSPEALQPGGT
ALAPKKRSRKGRAGAHGLSKGPLEKRPYLGPALLLTPRDRASGTQGASEDNSGGGGKKPK
MEELGLASQPPEGRPCQPQTRAQKQPGHTNYSSYSKRKRLTRGRAKNTTSSPCKGRAKRR
RQQQVLPLDPAEPEIRLKYISSCKRLRSDSRTPAFSPFVRVEKRDAFTTICTVVNSPGDA
PKPHRKPSSSASSSSSSSSFSLDAAGASLATLPGGSILQPRPSLPLSSTMHLGPVVSKAL
STSCLVCCLCQNPANFKDLGDLCGPYYPEHCLPKKKPKLKEKVRPEGTCEEASLPLERTL
KGPECAAAATAGKPPRPDGPADPAKQGPLRTSARGLSRRLQSCYCCDGREDGGEEAAPAD
KGRKHECSKEAPAEPGGEAQEHWVHEACAVWTGGVYLVAGKLFGLQEAMKVAVDMMCSSC
QEAGATIGCCHKGCLHTYHYPCASDAGCIFIEENFSLKCPKHKRLP
Target Bioclass
Transcription factor
Subcellular location
Cytoplasm
Function
Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation.
Uniprot ID
Q7Z5J4
Ensemble ID
ENST00000353383.6
HGNC ID
HGNC:9834

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 SNV: p.T221A DBIA    Probe Info 
HCT15 SNV: p.G952C DBIA    Probe Info 
HEC1B SNV: p.C1711Y .
IGR1 SNV: p.G782R DBIA    Probe Info 
IGROV1 SNV: p.R596L; p.R1325W DBIA    Probe Info 
JURKAT SNV: p.G137R; p.E1814Ter Compound 10    Probe Info 
MFE296 SNV: p.S1200G DBIA    Probe Info 
NCIH196 SNV: p.R1537G DBIA    Probe Info 
NCIH2172 SNV: p.V981L DBIA    Probe Info 
RL952 SNV: p.A1865V DBIA    Probe Info 
SNGM Deletion: p.A1865PfsTer33
SNV: p.N1180S		 DBIA    Probe Info 
SUPT1 SNV: p.K1801N DBIA    Probe Info 
SW837 SNV: p.D1643H DBIA    Probe Info 
TE4 SNV: p.A1852P DBIA    Probe Info 
UMUC3 SNV: p.E1296Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C1553(1.35)  LDD2140  [2]
AHL-Pu-1
 Probe Info  		C828(2.12)  LDD0168  [3]
HHS-475
 Probe Info  		Y311(0.71); Y17(0.84); Y334(1.55); Y78(2.67)  LDD0264  [4]
DBIA
 Probe Info  		C1423(1.24); C844(1.10); C845(1.10); C1553(1.07)  LDD0078  [5]
IA-alkyne
 Probe Info  		C1807(0.00); C649(0.00)  LDD0162  [6]
NAIA_4
 Probe Info  		C40(0.00); C322(0.00); C918(0.00); C1015(0.00)  LDD2226  [7]
TFBX
 Probe Info  		C1745(0.00); C40(0.00); C322(0.00); C1729(0.00)  LDD0027  [8]
WYneN
 Probe Info  		C1745(0.00); C556(0.00)  LDD0021  [9]
WYneO
 Probe Info  		N.A.  LDD0022  [9]
Compound 10
 Probe Info  		C1745(0.00); C322(0.00); C532(0.00)  LDD2216  [10]
Compound 11
 Probe Info  		C1745(0.00); C322(0.00); C532(0.00)  LDD2213  [10]
ENE
 Probe Info  		N.A.  LDD0006  [9]
IPM
 Probe Info  		C1423(0.00); C1553(0.00); C1729(0.00); C1745(0.00)  LDD0005  [9]
VSF
 Probe Info  		C239(0.00); C1729(0.00); C40(0.00); C1745(0.00)  LDD0007  [9]
Phosphinate-6
 Probe Info  		C918(0.00); C1423(0.00); C40(0.00); C322(0.00)  LDD0018  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C828(2.12)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C239(2.95); C1423(3.14); C1301(2.35)  LDD0169  [3]
 LDCM0214  AC1 HEK-293T C1869(1.16)  LDD0812  [5]
 LDCM0215  AC10 HCT 116 C844(0.87); C845(0.87)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C844(0.82); C845(0.82)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C844(0.91); C845(0.91)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C844(0.95); C845(0.95)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C844(1.00); C845(1.00)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C844(0.95); C845(0.95)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C844(0.95); C845(0.95)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C844(1.12); C845(1.12)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C844(0.99); C845(0.99)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C844(0.94); C845(0.94)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C844(1.01); C845(1.01)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C844(0.80); C845(0.80)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C844(1.17); C845(1.17)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C844(1.25); C845(1.25)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C844(1.35); C845(1.35)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C1400(1.07)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C1400(1.44)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C1400(1.63)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C1400(1.54)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C1400(1.35)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C1400(1.10)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C1400(1.61)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C844(0.82); C845(0.82)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C1400(1.41)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C1400(1.18)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C1400(1.45)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C1400(1.07)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C1400(0.95)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C1400(1.26)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C1400(1.79)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C1400(1.66)  LDD0562  [5]
 LDCM0246  AC128 HEK-293T C1786(0.91)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C1786(0.99)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C1786(1.01)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C1786(1.07)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C1786(1.12)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C1786(1.60)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C1786(1.26)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C1786(1.21)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C1786(1.28)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C1786(1.32)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C1786(1.62)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C1786(1.36)  LDD0856  [5]
 LDCM0259  AC14 HCT 116 C844(0.82); C845(0.82)  LDD0576  [5]
 LDCM0260  AC140 HEK-293T C1786(1.31)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C1786(1.52)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C1786(1.19)  LDD0860  [5]
 LDCM0263  AC143 HCT 116 C1703(0.82); C1711(0.82); C1400(1.27)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C1703(0.88); C1711(0.88); C1400(1.34)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C1703(1.02); C1711(1.02); C1400(1.23)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C1703(1.04); C1711(1.04); C1400(1.35)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C1703(0.82); C1711(0.82); C1400(1.61)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C1703(0.98); C1711(0.98); C1400(2.03)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C1703(0.84); C1711(0.84); C1400(1.48)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C844(0.98); C845(0.98)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C1703(0.89); C1711(0.89); C1400(1.17)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C1703(0.83); C1711(0.83); C1400(1.23)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C1703(1.10); C1711(1.10); C1400(1.49)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C1703(1.09); C1711(1.09); C1400(2.03)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C1400(1.37); C1703(0.90); C1711(0.90)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C1400(1.49); C1703(0.91); C1711(0.91)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C1400(1.26); C1703(0.84); C1711(0.84)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C1400(1.18); C1703(1.00); C1711(1.00)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C1703(0.86); C1711(0.86); C1400(1.10)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C1400(1.33); C1703(1.51); C1711(1.51)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C1703(1.17); C1711(1.17); C1400(1.30)  LDD0595  [5]
 LDCM0279  AC2 HEK-293T C1869(1.23)  LDD0877  [5]
 LDCM0280  AC20 HCT 116 C1703(1.07); C1711(1.07); C1400(1.13)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C1703(1.00); C1711(1.00); C1400(1.18)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C1703(0.72); C1711(0.72); C1400(1.08)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C1703(0.78); C1711(0.78); C1400(1.13)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C1400(1.11); C1703(1.16); C1711(1.16)  LDD0601  [5]
 LDCM0285  AC25 HEK-293T C1783(0.66); C1786(0.66)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C1783(0.82); C1786(0.82)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C1783(0.76); C1786(0.76)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C1783(0.83); C1786(0.83)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C1783(0.83); C1786(0.83)  LDD0887  [5]
 LDCM0290  AC3 HEK-293T C1869(1.33)  LDD0888  [5]
 LDCM0291  AC30 HEK-293T C1783(0.67); C1786(0.67)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C1783(0.86); C1786(0.86)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C1783(1.00); C1786(1.00)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C1783(0.82); C1786(0.82)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C1783(0.85); C1786(0.85)  LDD0893  [5]
 LDCM0296  AC35 HEK-293T C1783(1.09); C1786(1.07)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C1783(0.94); C1786(1.00)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C1783(0.92); C1786(1.06)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C1783(1.21); C1786(1.06)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C1783(1.25); C1786(1.24)  LDD0898  [5]
 LDCM0301  AC4 HEK-293T C1869(1.28)  LDD0899  [5]
 LDCM0302  AC40 HEK-293T C1783(1.15); C1786(1.17)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C1783(1.18); C1786(1.27)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C1783(1.06); C1786(1.16)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C1783(1.11); C1786(1.18)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C1783(1.16); C1786(1.19)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C1783(1.11); C1786(1.20)  LDD0905  [5]
 LDCM0308  AC46 HEK-293T C1711(1.04); C1786(1.19)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C1711(0.88); C1786(1.17)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C1711(0.78); C1786(1.29)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C1711(1.25); C1786(1.25)  LDD0909  [5]
 LDCM0312  AC5 HEK-293T C1869(1.28)  LDD0910  [5]
 LDCM0313  AC50 HEK-293T C1711(1.05); C1786(1.23)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C1711(0.95); C1786(0.65)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C1711(0.68); C1786(1.00)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C1711(0.99); C1786(1.14)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C1711(0.74); C1786(1.11)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C1711(0.73); C1786(1.34)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C1711(0.90); C1786(1.07)  LDD0917  [5]
 LDCM0320  AC57 HCT 116 C1703(0.91); C1711(0.91)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C1703(0.99); C1711(0.99)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C1703(0.74); C1711(0.74)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C844(0.71); C845(0.71)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C1703(0.80); C1711(0.80)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C1703(0.89); C1711(0.89)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C1703(0.89); C1711(0.89)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C1703(0.80); C1711(0.80)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C1703(0.98); C1711(0.98)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C1703(0.98); C1711(0.98)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C1703(1.05); C1711(1.05)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C1703(0.78); C1711(0.78)  LDD0648  [5]
 LDCM0332  AC68 HEK-293T C1783(0.67); C1786(0.97); C844(1.02); C845(1.02)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C1783(0.84); C1786(1.05); C844(0.97); C845(0.97)  LDD0931  [5]
 LDCM0334  AC7 HCT 116 C844(0.99); C845(0.99)  LDD0651  [5]
 LDCM0335  AC70 HEK-293T C1783(1.10); C1786(1.49); C844(0.90); C845(0.90)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C1783(0.95); C1786(1.11); C844(1.04); C845(1.04)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C1783(1.11); C1786(1.25); C844(1.01); C845(1.01)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C1783(0.95); C1786(1.32); C844(1.13); C845(1.13)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C1783(1.32); C1786(1.54); C844(0.95); C845(0.95)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C1783(0.86); C1786(1.20); C844(0.98); C845(0.98)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C1783(1.08); C1786(1.05); C844(1.00); C845(1.00)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C1783(0.78); C1786(1.15); C844(1.18); C845(1.18)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C1783(0.68); C1786(1.30); C844(1.05); C845(1.05)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C1783(1.39); C1786(1.06); C844(1.20); C845(1.20)  LDD0942  [5]
 LDCM0345  AC8 HCT 116 C844(0.90); C845(0.90)  LDD0662  [5]
 LDCM0346  AC80 HEK-293T C1783(0.97); C1786(1.15); C844(1.12); C845(1.12)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C1783(0.95); C1786(1.45); C844(1.30); C845(1.30)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C1783(1.06); C1786(1.42); C844(1.23); C845(1.23)  LDD0946  [5]
 LDCM0349  AC83 HCT 116 C1703(1.42); C1711(1.42); C844(1.58); C845(1.58)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C1703(1.57); C1711(1.57); C844(1.96); C845(1.96)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C844(1.23); C845(1.23); C1703(1.27); C1711(1.27)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C1703(0.72); C1711(0.72); C844(1.58); C845(1.58)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C1703(0.86); C1711(0.86); C844(1.67); C845(1.67)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C1703(1.02); C1711(1.02); C844(1.98); C845(1.98)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C1703(1.10); C1711(1.10); C844(1.41); C845(1.41)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C844(1.01); C845(1.01); C1703(1.46); C1711(1.46)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C1703(1.05); C1711(1.05); C844(2.37); C845(2.37)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C1703(0.91); C1711(0.91); C844(2.30); C845(2.30)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C1703(1.06); C1711(1.06); C844(1.47); C845(1.47)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C1703(0.91); C1711(0.91); C844(1.43); C845(1.43)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C1703(1.40); C1711(1.40); C844(1.52); C845(1.52)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C1703(0.68); C1711(0.68); C844(2.43); C845(2.43)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C1703(1.20); C1711(1.20); C844(2.24); C845(2.24)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C844(1.23); C845(1.23)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C844(0.88); C845(0.88)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C844(0.85); C845(0.85)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C844(1.10); C845(1.10)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C844(0.94); C845(0.94)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C1423(1.24); C844(1.10); C845(1.10); C1553(1.07)  LDD0078  [5]
 LDCM0632  CL-Sc Hep-G2 C828(1.35); C1745(1.10); C1745(0.55); C1516(0.50)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C1400(1.03)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C1400(1.04)  LDD0685  [5]
 LDCM0369  CL100 HEK-293T C1869(1.33)  LDD0967  [5]
 LDCM0370  CL101 HCT 116 C844(0.95); C845(0.95)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C844(1.06); C845(1.06)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C844(0.93); C845(0.93)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C844(0.77); C845(0.77)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C1703(0.91); C1711(0.91); C1400(1.06)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C1703(0.79); C1711(0.79); C1400(1.54)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C1703(0.81); C1711(0.81); C1400(1.47)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C1703(0.88); C1711(0.88); C1400(1.44)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C1703(1.07); C1711(1.07); C1400(1.22)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C1400(1.05)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C1703(0.71); C1711(0.71); C1400(1.27)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C1703(0.86); C1711(0.86); C1400(1.20)  LDD0698  [5]
 LDCM0382  CL112 HEK-293T C1783(0.84); C1786(0.84)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C1783(0.73); C1786(0.73)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C1783(0.73); C1786(0.73)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C1783(0.94); C1786(0.94)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C1783(0.74); C1786(0.74)  LDD0984  [5]
 LDCM0387  CL117 HEK-293T C1783(1.12); C1786(1.06)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C1783(0.93); C1786(1.08)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C1783(0.98); C1786(1.17)  LDD0987  [5]
 LDCM0390  CL12 HCT 116 C1400(0.91)  LDD0707  [5]
 LDCM0391  CL120 HEK-293T C1783(1.13); C1786(1.22)  LDD0989  [5]
 LDCM0392  CL121 HEK-293T C1711(0.76); C1786(1.28)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C1711(0.84); C1786(1.29)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C1711(1.64); C1786(1.63)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C1711(1.03); C1786(1.36)  LDD0993  [5]
 LDCM0396  CL125 HCT 116 C1703(1.08); C1711(1.08)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C1703(1.07); C1711(1.07)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C1703(1.24); C1711(1.24)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C1703(0.77); C1711(0.77)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C1400(0.82)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C1400(1.02)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C1400(0.80)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C1703(1.10); C1711(1.10)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C1703(1.12); C1711(1.12)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C1703(1.25); C1711(1.25)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C1703(1.12); C1711(1.12)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C1400(1.02)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C1703(1.27); C1711(1.27)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C1703(1.30); C1711(1.30)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C1703(1.66); C1711(1.66)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C1703(1.23); C1711(1.23)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C1703(1.29); C1711(1.29)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C1703(1.18); C1711(1.18)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C1703(1.30); C1711(1.30)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C1703(1.14); C1711(1.14)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C1703(1.34); C1711(1.34)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C1703(1.20); C1711(1.20)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C1400(1.07)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C1703(1.18); C1711(1.18)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C1703(1.26); C1711(1.26)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C1703(0.92); C1711(0.92)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C1703(1.11); C1711(1.11)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C1703(1.36); C1711(1.36)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C1703(1.38); C1711(1.38)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C1703(1.16); C1711(1.16)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C1703(1.16); C1711(1.16)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C1703(1.16); C1711(1.16)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C1400(1.06)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C1703(1.70); C1711(1.70)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C1703(1.03); C1711(1.03)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C1703(1.66); C1711(1.66)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C1703(1.03); C1711(1.03)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C1703(0.82); C1711(0.82)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C1703(1.75); C1711(1.75)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C1703(0.85); C1711(0.85); C844(0.89); C845(0.89)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C1703(0.96); C1711(0.96); C844(0.80); C845(0.80)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C1703(0.86); C1711(0.86); C844(1.27); C845(1.27)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C1703(0.90); C1711(0.90); C844(1.50); C845(1.50)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C1400(0.86)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C1703(0.94); C1711(0.94); C844(1.14); C845(1.14)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C1703(0.90); C1711(0.90); C844(1.27); C845(1.27)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C1703(0.85); C1711(0.85); C844(1.69); C845(1.69)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C1703(0.97); C1711(0.97); C844(1.51); C845(1.51)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C1703(1.06); C1711(1.06); C844(1.41); C845(1.41)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C1703(0.81); C1711(0.81); C844(1.59); C845(1.59)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C1703(1.06); C1711(1.06); C844(1.29); C845(1.29)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C1703(0.83); C1711(0.83); C844(1.18); C845(1.18)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C1703(0.86); C1711(0.86); C844(1.31); C845(1.31)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C1703(1.04); C1711(1.04); C844(1.33); C845(1.33)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C1400(0.85)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C1703(0.87); C1711(0.87); C844(1.25); C845(1.25)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C1703(0.81); C1711(0.81)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C1703(0.87); C1711(0.87)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C1703(1.13); C1711(1.13)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C1703(1.10); C1711(1.10)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C1703(0.88); C1711(0.88)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C1703(1.30); C1711(1.30)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C1703(1.03); C1711(1.03)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C1703(0.92); C1711(0.92)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C1703(0.89); C1711(0.89)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C1400(0.90)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C1703(1.07); C1711(1.07)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C1703(1.54); C1711(1.54)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C1703(1.07); C1711(1.07)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C1703(1.11); C1711(1.11)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C1703(1.07); C1711(1.07)  LDD0784  [5]
 LDCM0469  CL76 HEK-293T C239(0.98); C1745(1.03); C556(1.15); C40(1.19)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C239(1.06); C1745(1.00); C899(1.17); C649(0.98)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C239(0.96); C556(0.88); C899(0.97); C1301(1.01)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C239(0.97); C1729(1.10); C556(0.96); C899(0.92)  LDD1675  [14]
 LDCM0473  CL8 HCT 116 C1400(0.86)  LDD0790  [5]
 LDCM0474  CL80 HEK-293T C239(1.05); C1745(1.00); C556(0.93); C899(0.98)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C239(0.82); C1745(1.08); C556(1.07); C899(0.88)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C239(0.94); C1745(1.07); C556(0.88); C899(0.96)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C1745(1.30); C556(1.11); C899(1.01); C649(0.93)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C239(0.81); C1745(1.05); C556(1.05); C649(0.88)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C1553(0.96); C322(1.18); C239(1.02); C1745(0.81)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C239(1.02); C1745(0.91); C556(1.08); C899(0.94)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C239(0.99); C1745(0.94); C556(1.08); C649(0.88)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C239(1.18); C1745(1.08); C556(1.05); C40(1.04)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C239(1.11); C1745(1.06); C899(1.06); C649(1.08)  LDD1686  [14]
 LDCM0484  CL9 HCT 116 C1400(1.02)  LDD0801  [5]
 LDCM0485  CL90 HEK-293T C239(0.80); C556(1.00); C899(1.04); C1301(0.84)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C1869(1.22)  LDD1084  [5]
 LDCM0487  CL92 HEK-293T C1869(1.47)  LDD1085  [5]
 LDCM0488  CL93 HEK-293T C1869(1.04)  LDD1086  [5]
 LDCM0489  CL94 HEK-293T C1869(1.26)  LDD1087  [5]
 LDCM0490  CL95 HEK-293T C1869(1.17)  LDD1088  [5]
 LDCM0491  CL96 HEK-293T C1869(1.18)  LDD1089  [5]
 LDCM0492  CL97 HEK-293T C1869(1.25)  LDD1090  [5]
 LDCM0493  CL98 HEK-293T C1869(1.22)  LDD1091  [5]
 LDCM0494  CL99 HEK-293T C1869(1.45)  LDD1092  [5]
 LDCM0634  CY-0357 Hep-G2 C1015(1.91)  LDD2228  [7]
 LDCM0495  E2913 HEK-293T C239(0.87); C1745(0.95); C556(1.09); C649(1.07)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C899(1.34); C1729(1.30); C1553(0.88)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C1703(1.04); C1711(1.04)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C1703(1.43); C1711(1.43)  LDD0744  [5]
 LDCM0116  HHS-0101 DM93 Y311(0.71); Y17(0.84); Y334(1.55); Y78(2.67)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y334(0.05); Y17(0.64); Y311(0.75)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y311(0.40); Y17(1.02)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y17(0.73); Y311(1.15)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y185(0.08); Y17(0.64); Y311(1.87)  LDD0268  [4]
 LDCM0022  KB02 HCT 116 C844(3.02); C845(3.02); C322(1.36)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C844(1.94); C845(1.94); C322(1.04)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C844(2.77); C845(2.77); C322(1.35)  LDD0082  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1553(1.35)  LDD2140  [2]
 LDCM0021  THZ1 HCT 116 C1783(0.90); C1786(0.90); C1553(1.19); C322(1.14)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402