Details of the Target

General Information of Target

Target ID LDTP12518
Target Name Bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
Gene Name BAZ1A
Gene ID 11177
Synonyms
ACF1; WCRF180; Bromodomain adjacent to zinc finger domain protein 1A; ATP-dependent chromatin-remodeling protein; ATP-utilizing chromatin assembly and remodeling factor 1; hACF1; CHRAC subunit ACF1; Williams syndrome transcription factor-related chromatin-remodeling factor 180; WCRF180; hWALp1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRGPPAWPLRLLEPPSPAEPGRLLPVACVWAAASRVPGSLSPFTGLRPARLWGAGPALLW
GVGAARRWRSGCRGGGPGASRGVLGLARLLGLWARGPGSCRCGAFAGPGAPRLPRARFPG
GPAAAAWAGDEAWRRGPAAPPGDKGRLRPAAAGLPEARKLLGLAYPERRRLAAAVGFLTM
SSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSG
QRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQA
SVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGN
VRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLL
MGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEG
VILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLL
LRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTA
EEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEA
TSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLS
KPNGIYRKLMNKQSFISA
Target Bioclass
Other
Family
WAL family
Subcellular location
Nucleus
Function
Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner. The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex. Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex. Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase. May have a role in nuclear receptor-mediated transcription repression.
Uniprot ID
Q9NRL2
Ensemble ID
ENST00000358716.8
HGNC ID
HGNC:960
ChEMBL ID
CHEMBL4105737

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.P1193S DBIA    Probe Info 
HCT15 SNV: p.A1124D DBIA    Probe Info 
HT115 SNV: p.R1480C DBIA    Probe Info 
IPC298 SNV: p.P271L DBIA    Probe Info 
JURKAT SNV: p.L1052P Compound 10    Probe Info 
LNCaP clone FGC SNV: p.A508D DBIA    Probe Info 
MCC13 SNV: p.E791K DBIA    Probe Info 
MELHO SNV: p.T1184A .
MIAPACA2 SNV: p.E1037D DBIA    Probe Info 
PF382 SNV: p.Y606H DBIA    Probe Info 
REH SNV: p.V1076M DBIA    Probe Info 
SKMEL2 SNV: p.V1258I DBIA    Probe Info 
SNU1196 Deletion: p.S1339TfsTer14; p.H1340LfsTer52 DBIA    Probe Info 
UACC62 SNV: p.V238A DBIA    Probe Info 
WM1552C SNV: p.Q483R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y1466(9.77)  LDD0257  [1]
BTD
 Probe Info  		C621(3.68); C1486(1.01)  LDD1700  [2]
AHL-Pu-1
 Probe Info  		C970(2.13); C930(9.57)  LDD0169  [3]
DBIA
 Probe Info  		C547(1.43); C1166(1.40); C1169(1.40); C27(1.09)  LDD0078  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C930(0.00); C799(0.00); C105(0.00); C537(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C893(0.00); C970(0.00); C537(0.00)  LDD0032  [6]
Lodoacetamide azide
 Probe Info  		C930(0.00); C799(0.00); C105(0.00); C764(0.00)  LDD0037  [5]
WYneN
 Probe Info  		C970(0.00); C764(0.00)  LDD0021  [7]
WYneO
 Probe Info  		N.A.  LDD0022  [7]
Compound 10
 Probe Info  		C537(0.00); C764(0.00); C799(0.00)  LDD2216  [8]
Compound 11
 Probe Info  		C537(0.00); C764(0.00)  LDD2213  [8]
ENE
 Probe Info  		C930(0.00); C970(0.00)  LDD0006  [7]
IPM
 Probe Info  		C970(0.00); C764(0.00)  LDD0005  [7]
SF
 Probe Info  		N.A.  LDD0028  [9]
TFBX
 Probe Info  		C799(0.00); C930(0.00); C621(0.00)  LDD0148  [10]
VSF
 Probe Info  		N.A.  LDD0007  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
Acrolein
 Probe Info  		C970(0.00); C799(0.00); C105(0.00); H284(0.00)  LDD0217  [12]
W1
 Probe Info  		C764(0.00); C799(0.00); C232(0.00)  LDD0236  [13]
NAIA_5
 Probe Info  		C537(0.00); C1486(0.00); C1177(0.00); C799(0.00)  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		6.28  LDD0475  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C1486(0.78)  LDD2142  [2]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1486(1.06)  LDD2112  [2]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1486(0.91)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C621(1.77); C1486(1.12)  LDD2152  [2]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1486(0.93)  LDD2103  [2]
 LDCM0025  4SU-RNA DM93 C1177(3.20)  LDD0170  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C970(2.13); C930(9.57)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C1166(1.01); C1169(1.01); C232(1.08); C27(1.03)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C1166(1.10); C1169(1.10); C47(0.93); C54(0.93)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C1166(1.14); C1169(1.14); C1192(0.68); C1195(0.68)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C1166(1.25); C1169(1.25); C1192(0.61); C1195(0.61)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C1166(1.05); C1169(1.05); C1192(0.65); C1195(0.65)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C1166(1.10); C1169(1.10); C1192(0.67); C1195(0.67)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C1166(1.14); C1169(1.14); C1192(0.71); C1195(0.71)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C1166(1.06); C1169(1.06); C1192(0.62); C1195(0.62)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C1166(1.18); C1169(1.18); C1192(0.67); C1195(0.67)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C1166(1.34); C1169(1.34); C1192(0.69); C1195(0.69)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C1166(1.23); C1169(1.23); C1192(0.61); C1195(0.61)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C1166(0.93); C1169(0.93); C1192(0.66); C1195(0.66)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C1166(1.04); C1169(1.04); C47(1.26); C54(1.26)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C1166(1.10); C1169(1.10); C1192(0.73); C1195(0.73)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C1166(1.38); C1169(1.38); C1192(0.69); C1195(0.69)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C1166(1.14); C1169(1.14); C1192(0.65); C1195(0.65)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C1166(0.96); C1169(0.96); C1192(1.06); C1195(1.06)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C1166(0.91); C1169(0.96); C1192(0.85); C1195(0.76)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C1166(1.06); C1169(1.07); C1192(0.95); C1195(0.98)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C1166(0.88); C1169(0.88); C1192(0.99); C1195(0.93)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C1166(0.88); C1169(0.86); C1192(0.91); C1195(0.75)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C1166(0.90); C1169(0.89); C1192(0.92); C1195(0.77)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C1166(1.02); C1169(1.03); C1192(0.92); C1195(0.81)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C1166(1.06); C1169(1.06); C47(0.90); C54(0.90)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C1166(0.93); C1169(0.96); C1192(0.81); C1195(0.75)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C1166(1.06); C1169(0.99); C1192(0.88); C1195(0.78)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C1166(0.94); C1169(0.95); C1192(0.79); C1195(0.86)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C1166(0.83); C1169(0.89); C1192(1.27); C1195(0.77)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C1166(0.98); C1169(0.93); C1192(1.02); C1195(0.73)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C1166(0.77); C1169(0.80); C1192(0.84); C1195(0.79)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C1166(0.88); C1169(0.95); C1192(1.02); C1195(0.85)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C1166(0.98); C1169(0.98); C1192(0.83); C1195(0.83)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C1166(1.00); C1169(1.00); C1192(0.69); C1195(0.69)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C1166(0.66); C1169(0.66); C1192(0.42); C1195(0.42)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C1166(0.87); C1169(0.87); C1192(0.38); C1195(0.38)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C1166(1.14); C1169(1.14); C1192(0.55); C1195(0.55)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C1166(0.90); C1169(0.90); C1192(0.37); C1195(0.37)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C1166(0.81); C1169(0.81); C1192(0.37); C1195(0.37)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C1166(0.71); C1169(0.71); C1192(0.37); C1195(0.37)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C1166(0.89); C1169(0.89); C1192(0.50); C1195(0.50)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C1166(0.88); C1169(0.88); C1192(0.46); C1195(0.46)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C1166(0.77); C1169(0.77); C1192(0.51); C1195(0.51)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C1166(0.63); C1169(0.63); C1192(0.40); C1195(0.40)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C1166(0.65); C1169(0.65); C1192(0.40); C1195(0.40)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C1166(1.17); C1169(1.17); C47(1.70); C54(1.70)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C1166(0.75); C1169(0.75); C1192(0.38); C1195(0.38)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C1166(0.79); C1169(0.79); C1192(0.35); C1195(0.35)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C1166(0.82); C1169(0.82); C1192(0.52); C1195(0.52)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C1166(1.04); C1169(1.04); C1192(0.95); C1195(0.95)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C232(0.78); C27(0.84); C930(0.94); C586(1.03)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C47(0.72); C54(0.72); C232(0.74); C27(0.81)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C47(0.85); C54(0.85); C1192(0.85); C1195(0.85)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C232(0.87); C1192(0.91); C1195(0.91); C27(0.92)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C27(0.82); C47(0.97); C54(0.97); C930(1.00)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C47(0.75); C54(0.75); C232(0.92); C27(0.95)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C586(0.78); C1166(0.86); C1169(0.86); C764(0.98)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C47(0.76); C54(0.76); C232(0.78); C1166(0.98)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C232(0.77); C930(0.84); C586(0.94); C27(0.97)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C232(0.81); C47(0.93); C54(0.93); C27(0.96)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C27(0.73); C930(1.06); C232(1.10); C547(1.13)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C1166(1.13); C1169(1.13); C1192(1.29); C1195(1.29)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C1166(1.26); C1169(1.26); C1192(1.14); C1195(1.14)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C1166(1.25); C1169(1.25); C1192(1.39); C1195(1.39)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C1166(1.38); C1169(1.38); C1192(1.39); C1195(1.39)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C586(0.68); C1166(0.79); C1169(0.79); C621(0.82)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C27(0.60); C1166(0.69); C1169(0.69); C799(0.82)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C27(0.63); C586(0.80); C799(0.92); C970(0.94)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C586(0.72); C799(0.79); C1166(0.83); C1169(0.83)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C621(0.77); C586(0.78); C1166(1.01); C1169(1.01)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C27(0.79); C586(0.86); C1166(0.86); C1169(0.86)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C586(0.77); C621(0.86); C27(0.88); C930(0.92)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C1166(0.70); C1169(0.70); C586(0.74); C930(0.83)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C1166(0.78); C1169(0.78); C27(0.82); C621(0.83)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C27(0.68); C930(0.76); C621(0.81); C586(0.84)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C930(0.74); C621(0.76); C27(0.80); C1166(0.81)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C27(0.58); C930(0.68); C621(0.76); C1166(0.83)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C930(0.66); C27(0.67); C621(0.77); C1166(0.81)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C621(0.57); C27(0.67); C930(0.84); C586(0.87)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C586(0.76); C970(0.79); C1166(0.85); C1169(0.85)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C621(0.57); C27(0.69); C930(0.71); C586(0.79)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C621(0.66); C27(0.84); C799(0.84); C764(0.85)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C621(0.56); C1166(0.79); C1169(0.79); C54(0.82)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C27(0.66); C621(0.73); C586(0.87); C54(0.94)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C27(0.44); C621(0.73); C930(0.76); C1166(0.79)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C930(0.79); C764(0.81); C547(0.86); C232(0.87)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C764(0.67); C930(0.74); C547(0.84); C27(0.90)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C764(0.77); C930(0.81); C547(0.81); C232(0.86)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C764(0.75); C930(0.85); C621(0.89); C27(0.91)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C621(0.81); C232(0.88); C27(0.90); C930(0.90)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C970(0.76); C1166(0.83); C1169(0.83); C764(0.93)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C930(0.87); C621(0.88); C27(0.93); C1166(0.99)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C621(0.82); C764(0.85); C27(0.85); C930(0.91)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C621(0.78); C27(0.85); C1166(0.92); C1169(0.92)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C621(0.93); C930(0.96); C764(0.97); C1166(1.01)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C27(0.94); C586(1.02); C764(1.03); C621(1.06)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C27(0.91); C930(0.91); C621(0.92); C232(1.00)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C1192(0.65); C1195(0.65); C1166(0.81); C1169(0.81)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C1192(0.87); C1195(0.87); C1166(0.89); C1169(0.89)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C1192(0.73); C1195(0.73); C621(0.91); C27(0.94)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C1192(0.69); C1195(0.69); C621(0.69); C799(0.87)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C970(0.72); C586(0.91); C1166(0.92); C1169(0.92)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C1192(0.74); C1195(0.74); C621(0.74); C232(0.96)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C621(0.77); C1192(0.77); C1195(0.77); C547(0.93)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C1192(0.70); C1195(0.70); C621(0.76); C1166(0.85)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C621(0.82); C1192(0.87); C1195(0.87); C27(0.94)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C621(0.81); C1192(0.83); C1195(0.83); C764(1.01)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C799(0.81); C27(0.92); C1166(1.14); C1169(1.14)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C621(0.77); C1192(0.79); C1195(0.79); C27(0.95)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C586(0.72); C1166(0.78); C1169(0.78); C47(0.82)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C1166(0.89); C1169(0.89); C586(0.90); C47(0.91)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C1166(0.72); C1169(0.72); C586(0.93); C930(0.96)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C586(0.83); C799(0.89); C47(0.97); C54(0.97)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C930(0.83); C586(0.92); C1166(0.96); C1169(0.96)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C586(0.83); C47(0.91); C54(0.91); C1166(1.03)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C1166(0.60); C1169(0.60); C586(0.77); C47(1.02)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C1166(0.75); C1169(0.75); C47(0.88); C54(0.88)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C586(0.85); C1166(0.88); C1169(0.88); C47(0.97)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C586(0.69); C1192(0.71); C1195(0.71); C1166(0.80)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C586(0.75); C1166(0.86); C1169(0.86); C47(0.91)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C1166(0.70); C1169(0.70); C586(0.73); C1192(0.73)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C621(0.82); C1166(1.01); C1169(1.01); C1192(1.07)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C621(0.96); C1166(1.03); C1169(1.03); C1192(1.05)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C586(0.81); C799(0.88); C1166(0.92); C1169(0.92)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C1192(0.71); C1195(0.71); C621(0.98); C1166(1.03)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C621(0.86); C1166(0.87); C1169(0.87); C1192(0.96)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C621(0.86); C1166(0.89); C1169(0.89); C1192(1.13)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C621(0.85); C799(1.00); C1166(1.02); C1169(1.02)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C621(0.86); C1166(1.03); C1169(1.03); C1192(1.21)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C621(0.84); C799(1.10); C1192(1.22); C1195(1.22)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C621(0.95); C1192(0.99); C1195(0.99); C1166(0.99)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C621(0.73); C799(0.96); C1166(0.96); C1169(0.96)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C621(0.76); C1166(0.90); C1169(0.90); C764(0.96)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C621(0.81); C1166(0.92); C1169(0.92); C1192(0.95)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C47(0.80); C54(0.80); C586(0.81); C930(0.83)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C621(0.84); C799(0.87); C1166(0.90); C1169(0.90)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C621(0.89); C1166(0.97); C1169(0.97); C47(1.10)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C1192(0.83); C1195(0.83); C621(0.85); C1166(1.11)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C799(0.76); C547(0.80); C1192(0.81); C1195(0.81)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C1192(0.77); C1195(0.77); C799(0.80); C1166(0.91)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C799(0.63); C1192(0.71); C1195(0.71); C1166(0.85)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C1192(0.81); C1195(0.81); C799(0.84); C54(0.85)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C1192(0.76); C1195(0.76); C54(0.89); C27(0.94)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C799(0.82); C1192(0.84); C1195(0.84); C54(0.87)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C1166(0.81); C1169(0.81); C1192(0.81); C1195(0.81)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C1192(0.72); C1195(0.72); C27(0.82); C799(0.84)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C799(0.78); C547(0.84); C1192(0.91); C1195(0.91)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C799(0.79); C1192(0.87); C1195(0.87); C547(0.91)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C799(0.78); C547(0.90); C1192(0.92); C1195(0.92)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C799(0.64); C547(0.86); C1192(0.90); C1195(0.90)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C27(0.92); C547(0.93); C1166(0.99); C1169(0.99)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C799(0.71); C547(0.82); C54(0.86); C1166(0.87)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C799(0.71); C1192(0.85); C1195(0.85); C547(0.91)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C1192(0.61); C1195(0.61); C586(0.66); C54(0.91)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C586(0.55); C1192(0.65); C1195(0.65); C47(0.75)  LDD0683  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C621(1.19)  LDD2113  [2]
 LDCM0248  AKOS034007472 HCT 116 C1166(1.16); C1169(1.16); C47(1.25); C54(1.25)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C799(0.82); C586(0.85); C547(0.98); C47(1.04)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C764(0.93); C1166(0.98); C1169(0.98); C799(1.04)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C547(1.43); C1166(1.40); C1169(1.40); C27(1.09)  LDD0078  [4]
 LDCM0108  Chloroacetamide HeLa C799(0.00); C970(0.00); C105(0.00)  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C537(3.06); C799(0.97)  LDD2227  [14]
 LDCM0367  CL1 HCT 116 C1192(0.69); C1195(0.69); C799(0.80); C27(0.85)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C799(0.77); C1192(0.96); C1195(0.96); C547(1.02)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C586(0.83); C970(0.87); C799(0.88); C764(0.92)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C586(0.78); C764(0.89); C970(1.11); C547(1.12)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C586(0.77); C547(0.89); C764(0.93); C970(1.01)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C47(0.72); C54(0.72); C586(0.78); C547(0.86)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C586(0.80); C47(0.81); C54(0.81); C764(0.85)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C586(0.65); C1166(0.84); C1169(0.84); C930(0.94)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C586(0.83); C799(0.83); C1166(0.91); C1169(0.91)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C586(0.77); C799(0.84); C1166(0.89); C1169(0.89)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C586(0.86); C27(0.88); C1166(0.89); C1169(0.89)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C586(0.79); C799(0.80); C27(0.89); C930(0.90)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C1192(0.67); C1195(0.67); C799(0.80); C621(0.97)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C1166(0.75); C1169(0.75); C27(0.77); C586(0.77)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C27(0.68); C586(0.72); C1166(0.73); C1169(0.73)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C586(0.75); C621(0.77); C764(0.78); C1166(0.82)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C621(0.56); C27(0.74); C47(0.74); C930(0.75)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C621(0.51); C27(0.70); C1166(0.74); C1169(0.74)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C621(0.57); C27(0.65); C1166(0.84); C1169(0.84)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C27(0.55); C621(0.74); C1166(0.84); C1169(0.84)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C232(0.87); C27(0.94); C930(0.95); C621(1.01)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C232(0.94); C586(0.94); C970(0.98); C621(0.98)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C621(0.88); C232(0.94); C27(0.98); C930(1.02)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C799(0.84); C547(0.98); C1192(1.05); C1195(1.05)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C621(0.94); C970(0.96); C764(0.97); C1166(0.99)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C970(0.71); C232(0.84); C586(0.84); C621(0.89)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C621(0.83); C27(0.93); C1166(0.95); C1169(0.95)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C1192(0.69); C1195(0.69); C764(0.70); C621(0.82)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C621(0.77); C1192(0.79); C1195(0.79); C1166(0.85)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C586(0.76); C1166(0.77); C1169(0.77); C930(0.80)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C47(0.68); C54(0.68); C586(0.72); C1166(0.80)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C1166(0.72); C1169(0.72); C586(0.74); C930(0.85)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C1166(0.76); C1169(0.76); C586(0.91); C47(0.97)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C1192(0.85); C1195(0.85); C799(0.97); C27(0.99)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C1192(0.83); C1195(0.83); C799(0.84); C27(0.89)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C1192(0.78); C1195(0.78); C27(0.90); C547(0.99)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C1192(0.63); C1195(0.63); C799(0.74); C547(0.99)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C799(0.58); C621(0.86); C547(0.87); C27(0.89)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C799(0.77); C970(0.86); C621(0.86); C547(0.94)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C799(0.73); C621(0.82); C27(0.94); C547(0.96)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C799(0.89); C27(0.91); C621(0.92); C1192(0.93)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C799(0.64); C621(0.74); C970(1.02); C232(1.04)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C799(0.65); C621(0.83); C547(0.90); C232(1.02)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C621(0.86); C799(0.89); C970(0.96); C547(1.10)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C799(0.73); C547(0.81); C621(0.83); C232(1.00)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C799(0.84); C970(0.90); C621(0.91); C232(0.96)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C1166(1.30); C1169(1.30); C232(0.89); C27(1.20)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C1166(1.19); C1169(1.19); C232(1.29); C27(1.04)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C1166(1.21); C1169(1.21); C232(0.98); C27(1.06)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C1166(1.16); C1169(1.16); C232(1.08); C27(1.13)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C1166(1.27); C1169(1.27); C232(1.12); C27(1.11)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C1166(1.02); C1169(1.02); C1192(0.88); C1195(0.88)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C1166(1.23); C1169(1.23); C232(1.02); C27(1.05)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C1166(0.85); C1169(0.85); C27(1.00); C547(1.10)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C1166(1.03); C1169(1.03); C1192(0.58); C1195(0.58)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C1166(0.70); C1169(0.70); C1192(0.68); C1195(0.68)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C1166(0.91); C1169(0.91); C1192(0.69); C1195(0.69)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C1166(0.86); C1169(0.86); C1192(0.56); C1195(0.56)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C1166(0.87); C1169(0.87); C1192(0.50); C1195(0.50)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C1166(0.83); C1169(0.83); C1192(0.55); C1195(0.55)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C1166(0.78); C1169(0.78); C1192(0.61); C1195(0.61)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C1166(1.30); C1169(1.30); C1192(0.95); C1195(0.95)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C1166(0.73); C1169(0.73); C1192(0.52); C1195(0.52)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C1166(0.81); C1169(0.81); C1192(0.65); C1195(0.65)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C1166(0.81); C1169(0.81); C1192(0.75); C1195(0.75)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C1166(0.96); C1169(0.96); C1192(0.64); C1195(0.64)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C1166(0.75); C1169(0.75); C1192(0.51); C1195(0.51)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C1166(1.00); C1169(1.00); C1192(0.59); C1195(0.59)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C27(0.95); C547(0.81); C586(1.11); C764(1.46)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C27(0.88); C547(0.87); C586(1.02); C764(0.94)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C27(0.95); C547(0.83); C586(1.00); C764(1.13)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C27(0.93); C547(0.91); C586(0.97); C764(1.41)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C1166(1.06); C1169(1.06); C1192(0.86); C1195(0.86)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C27(0.88); C547(0.85); C586(1.08); C764(1.16)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C27(0.86); C547(0.84); C586(1.03); C764(0.81)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C27(0.84); C547(0.90); C586(1.11); C764(0.74)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C27(0.78); C547(0.95); C586(1.05); C764(0.83)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C27(0.88); C547(0.88); C586(1.04); C764(0.55)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C27(0.86); C547(0.83); C586(1.42); C764(0.76)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C27(0.95); C547(1.01); C586(1.13); C764(0.69)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C27(0.84); C547(0.88); C586(1.02); C764(1.23)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C27(0.92); C547(0.84); C586(1.20); C764(0.66)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C27(0.92); C547(0.94); C586(1.22); C764(0.71)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C1166(1.25); C1169(1.25); C1192(0.92); C1195(0.92)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C27(0.89); C547(0.93); C586(1.22); C764(0.90)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C1166(0.80); C1169(0.80); C27(1.06); C547(0.91)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C1166(0.84); C1169(0.84); C27(1.19); C547(0.86)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C1166(0.85); C1169(0.85); C27(1.09); C547(0.90)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C1166(0.87); C1169(0.87); C27(1.22); C547(0.90)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C1166(0.77); C1169(0.77); C27(1.17); C547(0.85)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C1166(0.90); C1169(0.90); C27(1.72); C547(1.34)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C1166(0.86); C1169(0.86); C27(1.38); C547(1.02)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C1166(0.88); C1169(0.88); C27(1.13); C547(0.93)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C1166(1.08); C1169(1.08); C27(0.99); C547(1.07)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C1166(1.22); C1169(1.22); C1192(0.69); C1195(0.69)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C1166(0.84); C1169(0.84); C27(1.11); C547(0.69)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C1166(0.83); C1169(0.83); C27(1.19); C547(0.93)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C1166(0.84); C1169(0.84); C27(1.19); C547(0.92)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C1166(0.75); C1169(0.75); C27(1.21); C547(1.05)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C1166(0.85); C1169(0.85); C27(1.17); C547(1.00)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C1166(0.87); C1169(0.87); C1192(0.89); C1195(0.89)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C1166(0.81); C1169(0.81); C1192(0.42); C1195(0.42)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C1166(0.94); C1169(0.94); C1192(0.46); C1195(0.46)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C1166(0.79); C1169(0.79); C1192(1.00); C1195(1.00)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C1166(1.20); C1169(1.20); C1192(0.54); C1195(0.54)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C1166(1.08); C1169(1.08); C1192(0.77); C1195(0.77)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C1166(0.67); C1169(0.67); C1192(0.68); C1195(0.68)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C1166(0.95); C1169(0.95); C1192(0.77); C1195(0.77)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C1166(0.77); C1169(0.77); C1192(1.26); C1195(1.26)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C1166(0.92); C1169(0.92); C1192(0.62); C1195(0.62)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C1166(0.85); C1169(0.85); C1192(0.98); C1195(0.98)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C1166(0.66); C1169(0.66); C1192(0.65); C1195(0.65)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C1166(0.77); C1169(0.77); C1192(0.50); C1195(0.50)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C1166(1.02); C1169(1.02); C1192(0.66); C1195(0.66)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C1166(1.10); C1169(1.10); C1192(0.64); C1195(0.64)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C1166(1.04); C1169(1.04); C1192(0.88); C1195(0.88)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C1166(0.59); C1169(0.59); C1192(0.42); C1195(0.42)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C1166(0.87); C1169(0.87); C232(1.04); C27(0.99)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C1166(0.81); C1169(0.81); C232(1.08); C27(0.94)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C1166(0.99); C1169(0.99); C232(1.17); C27(0.87)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C1166(0.97); C1169(0.97); C232(1.08); C27(1.05)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C1166(0.84); C1169(0.84); C232(0.94); C27(0.87)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C1166(0.96); C1169(0.96); C232(1.06); C27(1.02)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C1166(0.97); C1169(0.97); C232(0.89); C27(0.97)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C1166(0.91); C1169(0.91); C232(1.00); C27(1.00)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C1166(0.86); C1169(0.86); C232(0.95); C27(1.06)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C764(0.97); C404(1.03); C970(0.95); C930(0.79)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C537(3.23); C105(1.83); C764(1.01)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C1166(0.78); C1169(0.78); C27(1.13); C547(0.92)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C1166(1.15); C1169(1.15); C1192(0.67); C1195(0.67)  LDD0744  [4]
 LDCM0022  KB02 HCT 116 C586(2.10); C970(3.09); C1166(1.27); C1169(1.27)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C586(4.62); C970(2.10); C1166(1.71); C1169(1.71)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C586(2.90); C970(2.43); C1166(1.58); C1169(1.58)  LDD0082  [4]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C1486(1.05)  LDD2102  [2]
 LDCM0109  NEM HeLa N.A.  LDD0225  [12]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C1486(1.25); C764(2.32)  LDD2090  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1486(0.92)  LDD2092  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C621(1.07); C1486(0.77)  LDD2093  [2]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C1486(1.12)  LDD2094  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1486(1.12)  LDD2098  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1486(0.75); C930(1.69)  LDD2099  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1486(1.02)  LDD2100  [2]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C621(1.00)  LDD2101  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C1486(0.82)  LDD2104  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1486(0.94); C930(1.04)  LDD2107  [2]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1486(0.82)  LDD2108  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C621(0.66); C1486(0.72); C930(0.81)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C621(1.48); C930(1.08)  LDD2111  [2]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1486(0.94)  LDD2114  [2]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C1486(0.85)  LDD2116  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1486(2.12)  LDD2119  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C621(0.57)  LDD2120  [2]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C621(0.10)  LDD2122  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C621(1.06); C1486(0.74)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1486(0.72); C930(1.12); C764(0.94)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1486(0.82)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C621(1.26); C1486(0.86)  LDD2129  [2]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C621(0.72)  LDD2133  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C621(0.44)  LDD2134  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C621(1.61); C1486(0.98)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1486(1.15)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C621(0.94); C1486(0.85)  LDD2137  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C621(3.68); C1486(1.01)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C621(0.56); C1486(0.59)  LDD2140  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1486(0.64); C764(0.85)  LDD2141  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C621(0.66)  LDD2143  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C621(1.75); C1486(2.62); C930(2.05)  LDD2144  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C621(1.22); C1486(0.73)  LDD2146  [2]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C621(1.11)  LDD2147  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C1486(1.62)  LDD2153  [2]
 LDCM0021  THZ1 HCT 116 C1192(1.24); C1195(1.24); C970(0.95); C764(1.08)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) SNF2/RAD54 helicase family O60264
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 7A (ZBTB7A) . O95365

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402