Details of the Target

General Information of Target

Target ID LDTP06968
Target Name Shugoshin 1 (SGO1)
Gene Name SGO1
Gene ID 151648
Synonyms
SGOL1; Shugoshin 1; Serologically defined breast cancer antigen NY-BR-85; Shugoshin-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKERCLKKSFQDSLEDIKKRMKEKRNKNLAEIGKRRSFIAAPCQIITNTSTLLKNYQDN
NKMLVLALENEKSKVKEAQDIILQLRKECYYLTCQLYALKGKLTSQQTVEPAQNQEICSS
GMDPNSDDSSRNLFVKDLPQIPLEETELPGQGESFQIEDQIPTIPQDTLGVDFDSGEAKS
TDNVLPRTVSVRSSLKKHCNSICQFDSLDDFETSHLAGKSFEFERVGFLDPLVNMHIPEN
VQHNACQWSKDQVNLSPKLIQPGTFTKTKEDILESKSEQTKSKQRDTQERKREEKRKANR
RKSKRMSKYKENKSENKKTVPQKKMHKSVSSNDAYNFNLEEGVHLTPFRQKVSNDSNREE
NNESEVSLCESSGSGDDSDDLYLPTCKYIQNPTSNSDRPVTRPLAKRALKYTDEKETEGS
KPTKTPTTTPPETQQSPHLSLKDITNVSLYPVVKIRRLSLSPKKNKASPAVALPKRRCTA
SVNYKEPTLASKLRRGDPFTDLCFLNSPIFKQKKDLRRSKKRALEVSPAKEAIFILYYVR
EFVSRFPDCRKCKLETHICLR
Target Type
Literature-reported
Target Bioclass
Other
Family
Shugoshin family
Subcellular location
Nucleus
Function
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase.
TTD ID
T86265
Uniprot ID
Q5FBB7
DrugMap ID
TTBPKGD
Ensemble ID
ENST00000263753.8
HGNC ID
HGNC:25088

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C246(2.22)  LDD0173  [1]
DBIA
 Probe Info  		C199(1.26); C203(1.26)  LDD0078  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C503(0.00); C44(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C478(0.00); C503(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C503(0.00); C44(0.00)  LDD0037  [3]
NAIA_4
 Probe Info  		C478(0.00); C503(0.00)  LDD2226  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
Compound 11
 Probe Info  		N.A.  LDD2213  [6]
IPM
 Probe Info  		N.A.  LDD0005  [7]
VSF
 Probe Info  		N.A.  LDD0007  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C246(2.22)  LDD0173  [1]
 LDCM0214  AC1 HEK-293T C44(1.86); C478(1.86)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C199(1.04); C203(1.16); C246(1.26)  LDD0813  [2]
 LDCM0216  AC100 HEK-293T C44(1.60); C503(1.60)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C44(1.29); C503(1.29)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C44(1.37); C503(1.37)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C44(1.53); C503(1.53)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C44(1.32); C503(1.32)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C44(1.17); C503(1.17)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C44(0.76); C503(0.76)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C44(1.34); C503(1.34)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C44(1.08); C503(1.08)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C44(1.46); C503(1.46)  LDD0823  [2]
 LDCM0226  AC11 HEK-293T C199(1.02); C203(1.13); C246(1.28)  LDD0824  [2]
 LDCM0227  AC110 HEK-293T C44(1.95); C503(1.95)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C44(3.02); C503(3.02)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C44(2.05); C503(2.05)  LDD0827  [2]
 LDCM0230  AC113 HEK-293T C199(0.93)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C199(1.08)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C199(0.96)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C199(1.10)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C199(1.30)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C199(1.16)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C199(1.46)  LDD0834  [2]
 LDCM0237  AC12 HEK-293T C199(1.03); C203(1.08); C246(1.27)  LDD0835  [2]
 LDCM0238  AC120 HEK-293T C199(1.26)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C199(1.10)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C199(1.26)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C199(1.41)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C199(1.37)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C199(1.37)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C199(1.38)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C199(1.67)  LDD0843  [2]
 LDCM0246  AC128 PaTu 8988t C503(1.02)  LDD1125  [2]
 LDCM0247  AC129 PaTu 8988t C503(1.29)  LDD1126  [2]
 LDCM0249  AC130 PaTu 8988t C503(1.17)  LDD1128  [2]
 LDCM0250  AC131 PaTu 8988t C503(1.36)  LDD1129  [2]
 LDCM0251  AC132 PaTu 8988t C503(1.23)  LDD1130  [2]
 LDCM0252  AC133 PaTu 8988t C503(1.29)  LDD1131  [2]
 LDCM0253  AC134 PaTu 8988t C503(1.17)  LDD1132  [2]
 LDCM0254  AC135 PaTu 8988t C503(1.31)  LDD1133  [2]
 LDCM0255  AC136 PaTu 8988t C503(1.01)  LDD1134  [2]
 LDCM0256  AC137 PaTu 8988t C503(1.15)  LDD1135  [2]
 LDCM0257  AC138 PaTu 8988t C503(1.22)  LDD1136  [2]
 LDCM0258  AC139 PaTu 8988t C503(1.06)  LDD1137  [2]
 LDCM0259  AC14 HEK-293T C199(1.29); C203(1.25); C246(1.39)  LDD0857  [2]
 LDCM0260  AC140 PaTu 8988t C503(1.30)  LDD1139  [2]
 LDCM0261  AC141 PaTu 8988t C503(1.25)  LDD1140  [2]
 LDCM0262  AC142 PaTu 8988t C503(1.11)  LDD1141  [2]
 LDCM0263  AC143 HEK-293T C478(1.04); C503(1.07)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C478(1.62); C503(1.55)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C478(1.40); C503(1.62)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C478(1.58); C503(1.38)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C478(1.78); C503(1.75)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C478(1.68); C503(1.57)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C478(1.01); C503(1.09)  LDD0867  [2]
 LDCM0270  AC15 HEK-293T C199(1.25); C203(1.43); C246(1.54)  LDD0868  [2]
 LDCM0271  AC150 HEK-293T C478(1.57); C503(1.51)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C478(1.75); C503(1.87)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C478(1.68); C503(1.54)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C478(1.51); C503(1.73)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C478(1.10); C503(1.09)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C478(1.52); C503(1.62)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C478(1.82); C503(1.67)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C478(2.09); C503(2.21)  LDD2165  [2]
 LDCM0276  AC17 HEK-293T C203(2.01); C246(2.67); C44(3.76); C478(2.67)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C203(1.67); C246(1.47); C44(1.60); C478(1.47)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C203(1.55); C246(1.33); C44(1.47); C478(1.33)  LDD0876  [2]
 LDCM0279  AC2 HEK-293T C44(1.17); C478(1.17)  LDD0877  [2]
 LDCM0280  AC20 HEK-293T C203(2.10); C246(1.46); C44(1.93); C478(1.46)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C203(1.33); C246(1.95); C44(2.01); C478(1.95)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C203(2.03); C246(1.45); C44(1.51); C478(1.45)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C203(2.64); C246(1.88); C44(2.21); C478(1.88)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C203(2.21); C246(1.33); C44(1.42); C478(1.33)  LDD0882  [2]
 LDCM0285  AC25 HEK-293T C478(1.01)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C478(1.09)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C478(0.85)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C478(1.07)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C478(0.97)  LDD0887  [2]
 LDCM0290  AC3 HEK-293T C44(0.85); C478(0.85)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C478(0.84)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C478(0.76)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C478(0.65)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C478(0.78)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C478(0.76)  LDD0893  [2]
 LDCM0296  AC35 HEK-293T C199(1.11); C203(1.11)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C199(0.93); C203(0.93)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C199(0.95); C203(0.95)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C199(1.12); C203(1.12)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C199(1.18); C203(1.18)  LDD0898  [2]
 LDCM0301  AC4 HEK-293T C44(1.08); C478(1.08)  LDD0899  [2]
 LDCM0302  AC40 HEK-293T C199(0.95); C203(0.95)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C199(0.75); C203(0.75)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C199(0.93); C203(0.93)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C199(1.02); C203(1.02)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C199(0.94); C203(0.94)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C199(0.93); C203(0.93)  LDD0905  [2]
 LDCM0308  AC46 HEK-293T C199(0.69); C203(0.69); C246(1.27); C44(1.27)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C199(0.66); C203(0.71); C246(1.09); C44(1.09)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C199(0.73); C203(0.80); C246(1.03); C44(1.03)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C199(1.00); C203(0.96); C246(1.13); C44(1.13)  LDD0909  [2]
 LDCM0312  AC5 HEK-293T C44(1.27); C478(1.27)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C199(0.98); C203(0.96); C246(0.98); C44(0.98)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C199(0.91); C203(0.94); C246(1.02); C44(1.02)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C199(1.17); C203(1.15); C246(1.15); C44(1.15)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C199(0.86); C203(0.91); C246(1.26); C44(1.26)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C199(0.88); C203(0.99); C246(1.33); C44(1.33)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C199(1.02); C203(0.98); C246(1.67); C44(1.67)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C199(0.66); C203(0.85); C246(1.38); C44(1.38)  LDD0917  [2]
 LDCM0320  AC57 HEK-293T C203(0.81); C246(0.91); C44(1.07)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C203(0.94); C246(0.91); C44(1.29)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C203(1.08); C246(0.66); C44(0.84)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C199(1.02); C203(1.29); C246(1.05)  LDD0921  [2]
 LDCM0324  AC60 HEK-293T C203(0.79); C246(1.12); C44(1.19)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C203(1.16); C246(1.02); C44(1.32)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C203(1.01); C246(0.84); C44(1.02)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C203(0.87); C246(0.79); C44(0.91)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C203(1.03); C246(0.71); C44(1.10)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C203(1.19); C246(0.93); C44(1.22)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C203(0.91); C246(0.92); C44(1.23)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C203(1.19); C246(1.03); C44(1.22)  LDD0929  [2]
 LDCM0332  AC68 HEK-293T C203(1.07); C246(0.89)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C203(1.11); C246(0.95)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C199(0.95); C203(1.08); C246(1.22)  LDD0932  [2]
 LDCM0335  AC70 HEK-293T C203(1.37); C246(1.13)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C203(1.03); C246(0.99)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C203(0.94); C246(1.03)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C203(0.90); C246(0.90)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C203(0.93); C246(1.28)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C203(1.34); C246(1.39)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C203(1.06); C246(1.09)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C203(1.08); C246(1.16)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C203(1.02); C246(1.09)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C203(0.88); C246(1.19)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C199(1.03); C203(1.51); C246(1.57)  LDD0943  [2]
 LDCM0346  AC80 HEK-293T C203(1.42); C246(1.55)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C203(1.50); C246(1.33)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C203(2.21); C246(2.15)  LDD0946  [2]
 LDCM0349  AC83 HEK-293T C246(0.98); C44(0.81); C478(0.91); C503(0.91)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C246(1.20); C44(1.08); C478(1.19); C503(1.19)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C246(0.98); C44(0.97); C478(1.20); C503(1.20)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C246(1.24); C44(0.90); C478(1.23); C503(1.23)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C246(1.46); C44(1.39); C478(1.45); C503(1.45)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C246(1.31); C44(1.26); C478(1.30); C503(1.30)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C246(2.14); C44(1.61); C478(1.66); C503(1.66)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C246(1.00); C44(1.05); C478(1.33); C503(1.33)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C246(0.86); C44(0.95); C478(1.10); C503(1.10)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C246(0.83); C44(1.09); C478(1.02); C503(1.02)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C246(0.79); C44(1.10); C478(1.18); C503(1.18)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C246(1.27); C44(1.44); C478(1.52); C503(1.52)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C246(1.29); C44(1.17); C478(1.32); C503(1.32)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C246(1.19); C44(1.38); C478(1.32); C503(1.32)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C246(1.93); C44(2.11); C478(2.58); C503(2.58)  LDD0962  [2]
 LDCM0365  AC98 HEK-293T C44(1.32); C503(1.32)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C44(1.18); C503(1.18)  LDD0964  [2]
 LDCM0248  AKOS034007472 HEK-293T C199(1.16); C203(1.23); C246(1.45)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C199(1.24); C203(1.25); C246(1.57)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C199(1.47); C203(1.70); C246(1.62)  LDD0873  [2]
 LDCM0020  ARS-1620 HCC44 C199(1.26); C203(1.26)  LDD0078  [2]
 LDCM0632  CL-Sc Hep-G2 C44(0.47)  LDD2227  [4]
 LDCM0367  CL1 HEK-293T C246(0.82)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C246(1.49)  LDD0966  [2]
 LDCM0369  CL100 HEK-293T C44(1.20); C478(1.20)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C199(1.25); C203(1.65); C246(1.49)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C199(1.41); C203(1.51); C246(1.37)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C199(1.01); C203(1.24); C246(1.30)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C199(0.97); C203(1.39); C246(1.39)  LDD0971  [2]
 LDCM0374  CL105 HEK-293T C203(1.75); C246(1.05); C44(1.30); C478(1.05)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C203(1.51); C246(1.08); C44(1.33); C478(1.08)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C203(1.51); C246(1.66); C44(2.11); C478(1.66)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C203(1.17); C246(1.49); C44(1.73); C478(1.49)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C203(2.12); C246(1.37); C44(1.68); C478(1.37)  LDD0976  [2]
 LDCM0379  CL11 HEK-293T C246(1.28)  LDD0977  [2]
 LDCM0380  CL110 HEK-293T C203(1.77); C246(1.52); C44(1.77); C478(1.52)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C203(1.75); C246(1.78); C44(2.31); C478(1.78)  LDD0979  [2]
 LDCM0382  CL112 HEK-293T C478(0.99)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C478(0.66)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C478(1.22)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C478(0.90)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C478(1.00)  LDD0984  [2]
 LDCM0387  CL117 HEK-293T C199(1.02); C203(1.02)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C199(0.68); C203(0.68)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C199(0.72); C203(0.72)  LDD0987  [2]
 LDCM0390  CL12 HEK-293T C246(1.01)  LDD0988  [2]
 LDCM0391  CL120 HEK-293T C199(0.74); C203(0.74)  LDD0989  [2]
 LDCM0392  CL121 HEK-293T C199(1.00); C203(1.04); C246(1.29); C44(1.29)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C199(0.97); C203(0.98); C246(1.39); C44(1.39)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C199(1.29); C203(1.07); C246(1.14); C44(1.14)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C199(0.91); C203(0.93); C246(1.40); C44(1.40)  LDD0993  [2]
 LDCM0396  CL125 HEK-293T C203(0.98); C246(0.89); C44(1.21)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C203(0.88); C246(0.68); C44(0.88)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C203(0.75); C246(0.75); C44(0.90)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C203(0.86); C246(0.89); C44(1.18)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C246(1.28)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C246(1.27)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C246(1.40)  LDD1000  [2]
 LDCM0403  CL16 HEK-293T C203(1.42); C246(0.83)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C203(0.99); C246(0.79)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C203(1.25); C246(1.00)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C203(1.03); C246(1.08)  LDD1004  [2]
 LDCM0407  CL2 HEK-293T C246(1.09)  LDD1005  [2]
 LDCM0408  CL20 HEK-293T C203(1.13); C246(1.08)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C203(1.13); C246(1.13)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C203(1.01); C246(0.79)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C203(0.82); C246(0.92)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C203(0.97); C246(1.03)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C203(0.85); C246(0.95)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C203(0.89); C246(0.84)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C203(0.95); C246(1.13)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C203(0.98); C246(0.92)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C203(0.95); C246(1.18)  LDD1015  [2]
 LDCM0418  CL3 HEK-293T C246(0.94)  LDD1016  [2]
 LDCM0419  CL30 HEK-293T C203(1.06); C246(0.87)  LDD1017  [2]
 LDCM0420  CL31 HEK-293T C199(1.14); C203(1.14); C246(1.11); C44(1.22)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C199(1.05); C203(1.05); C246(1.28); C44(1.18)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C199(1.48); C203(1.48); C246(1.07); C44(1.65)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C199(1.14); C203(1.14); C246(1.10); C44(1.10)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C199(1.03); C203(1.03); C246(1.52); C44(1.15)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C199(0.90); C203(0.90); C246(1.27); C44(1.22)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C199(1.46); C203(1.46); C246(1.27); C44(1.15)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C199(1.57); C203(1.57); C246(1.79); C44(1.83)  LDD1026  [2]
 LDCM0429  CL4 HEK-293T C246(1.04)  LDD1027  [2]
 LDCM0430  CL40 HEK-293T C199(1.05); C203(1.05); C246(1.27); C44(1.22)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C199(1.58); C203(1.58); C246(1.74); C44(1.82)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C199(1.13); C203(1.13); C246(1.79); C44(1.41)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C199(1.10); C203(1.10); C246(1.40); C44(1.51)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C199(1.06); C203(1.06); C246(1.64); C44(1.25)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C199(0.99); C203(0.99); C246(1.98); C44(1.77)  LDD1033  [2]
 LDCM0436  CL46 PaTu 8988t C199(1.07); C203(1.07); C503(0.87)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C199(0.87); C203(0.87); C503(0.91)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C199(1.02); C203(1.02); C503(1.01)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C199(1.34); C203(1.34); C503(1.01)  LDD1318  [2]
 LDCM0440  CL5 HEK-293T C246(1.11)  LDD1038  [2]
 LDCM0441  CL50 PaTu 8988t C199(1.25); C203(1.25); C503(0.94)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C199(1.14); C203(1.14); C503(0.91)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C199(1.13); C203(1.13); C503(0.98)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C199(1.27); C203(1.27); C503(0.89)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C199(1.30); C203(1.30); C503(0.86)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C199(1.32); C203(1.32); C503(1.06)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C199(1.10); C203(1.10); C503(1.01)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C199(1.05); C203(1.05); C503(1.15)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C199(1.37); C203(1.37); C503(1.09)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C199(1.06); C203(1.06); C503(0.92)  LDD1329  [2]
 LDCM0451  CL6 HEK-293T C246(1.06)  LDD1049  [2]
 LDCM0452  CL60 PaTu 8988t C199(1.10); C203(1.10); C503(0.95)  LDD1331  [2]
 LDCM0453  CL61 HEK-293T C199(1.01); C203(1.31); C478(0.83); C503(0.83)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C199(0.91); C203(1.08); C478(1.15); C503(1.15)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C199(1.38); C203(1.63); C478(1.11); C503(1.11)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C199(0.89); C203(1.06); C478(1.00); C503(1.00)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C199(1.03); C203(1.07); C478(1.28); C503(1.28)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C199(0.99); C203(1.14); C478(0.84); C503(0.84)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C199(1.25); C203(1.14); C478(1.05); C503(1.05)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C199(1.03); C203(1.06); C478(1.09); C503(1.09)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C199(1.03); C203(1.07); C478(1.05); C503(1.05)  LDD1059  [2]
 LDCM0462  CL7 HEK-293T C246(1.17)  LDD1060  [2]
 LDCM0463  CL70 HEK-293T C199(1.26); C203(1.08); C478(1.06); C503(1.06)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C199(1.29); C203(1.20); C478(1.11); C503(1.11)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C199(1.24); C203(1.18); C478(1.16); C503(1.16)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C199(0.93); C203(1.00); C478(1.13); C503(1.13)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C199(1.05); C203(1.33); C478(1.55); C503(1.55)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C203(1.96)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C203(1.50)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C203(2.12)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C203(1.96)  LDD1070  [2]
 LDCM0473  CL8 HEK-293T C478(1.01); C503(0.82); C44(1.26); C246(1.64)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C203(1.82)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C203(1.65)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C203(1.41)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C203(1.14)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C203(2.29)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C203(2.46)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C203(1.58)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C203(2.54)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C203(1.44)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C203(1.49)  LDD1081  [2]
 LDCM0484  CL9 HEK-293T C478(0.98); C503(1.18); C44(1.08); C246(0.96)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C203(1.30)  LDD1083  [2]
 LDCM0486  CL91 HEK-293T C44(0.86); C478(0.86)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C44(1.09); C478(1.09)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C44(0.71); C478(0.71)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C44(1.08); C478(1.08)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C44(1.44); C478(1.44)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C44(1.21); C478(1.21)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C44(1.02); C478(1.02)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C44(1.12); C478(1.12)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C44(1.03); C478(1.03)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C478(1.00); C503(1.07); C44(1.00); C246(1.12)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C199(0.89); C203(1.23); C478(1.46); C503(1.46)  LDD1066  [2]
 LDCM0427  Fragment51 HEK-293T C199(1.44); C203(1.44); C246(1.00); C44(1.13)  LDD1025  [2]
 LDCM0022  KB02 HCT 116 C94(2.32)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C94(2.33)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C94(1.97)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C199(1.26); C203(1.26); C478(1.04)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PPP2R5A) Phosphatase 2A regulatory subunit B56 family Q15172
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA) PPP phosphatase family P67775
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Borealin (CDCA8) Borealin family Q53HL2
Cohesin subunit SA-2 (STAG2) SCC3 family Q8N3U4
Structural maintenance of chromosomes protein 1A (SMC1A) SMC family Q14683
Sororin (CDCA5) Sororin family Q96FF9
Chromobox protein homolog 1 (CBX1) . P83916
Chromobox protein homolog 5 (CBX5) . P45973

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402