Details of the Target

General Information of Target

Target ID LDTP05757
Target Name Protein Red (IK)
Gene Name IK
Gene ID 3550
Synonyms
RED; RER; Protein Red; Cytokine IK; IK factor; Protein RER
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPERDSEPFSNPLAPDGHDVDDPHSFHQSKLTNEDFRKLLMTPRAAPTSAPPSKSRHHEM
PREYNEDEDPAARRRKKKSYYAKLRQQEIERERELAEKYRDRAKERRDGVNKDYEETELI
STTANYRAVGPTAEADKSAAEKRRQLIQESKFLGGDMEHTHLVKGLDFALLQKVRAEIAS
KEKEEEELMEKPQKETKKDEDPENKIEFKTRLGRNVYRMLFKSKAYERNELFLPGRMAYV
VDLDDEYADTDIPTTLIRSKADCPTMEAQTTLTTNDIVISKLTQILSYLRQGTRNKKLKK
KDKGKLEEKKPPEADMNIFEDIGDYVPSTTKTPRDKERERYRERERDRERDRDRDRERER
ERDRERERERDREREEEKKRHSYFEKPKVDDEPMDVDKGPGSTKELIKSINEKFAGSAGW
EGTESLKKPEDKKQLGDFFGMSNSYAECYPATMDDMAVDSDEEVDYSKMDQGNKKGPLGR
WDFDTQEEYSEYMNNKEALPKAAFQYGIKMSEGRKTRRFKETNDKAELDRQWKKISAIIE
KRKKMEADGVEVKRPKY
Target Bioclass
Cytokine and receptor
Family
RED family
Subcellular location
Nucleus
Function
Involved in pre-mRNA splicing as a component of the spliceosome. Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1.; (Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles.
Uniprot ID
Q13123
Ensemble ID
ENST00000417647.7
HGNC ID
HGNC:5958
ChEMBL ID
CHEMBL2321616

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y288(10.02)  LDD0257  [2]
STPyne
 Probe Info  		K173(0.91); K54(0.70); K541(10.00); K83(5.45)  LDD0277  [3]
Probe 1
 Probe Info  		Y64(22.56); Y114(28.33); Y126(39.18); Y506(16.59)  LDD3495  [4]
AHL-Pu-1
 Probe Info  		C263(2.18)  LDD0169  [5]
HHS-465
 Probe Info  		Y383(10.00)  LDD2237  [6]
DBIA
 Probe Info  		C263(1.48)  LDD0532  [7]
ATP probe
 Probe Info  		K137(0.00); K142(0.00); K173(0.00); K54(0.00)  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
IPM
 Probe Info  		N.A.  LDD0025  [10]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
NAIA_5
 Probe Info  		N.A.  LDD2224  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
1d-yne
 Probe Info  		N.A.  LDD0356  [12]
NHS
 Probe Info  		N.A.  LDD0010  [13]
SF
 Probe Info  		Y288(0.00); Y506(0.00); Y126(0.00)  LDD0028  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
1c-yne
 Probe Info  		K260(0.00); K331(0.00)  LDD0228  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
AOyne
 Probe Info  		15.00  LDD0443  [17]
HHS-482
 Probe Info  		Y383(0.91)  LDD2239  [6]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.56  LDD0472  [18]
FFF probe13
 Probe Info  		20.00  LDD0475  [18]
FFF probe2
 Probe Info  		18.84  LDD0463  [18]
FFF probe3
 Probe Info  		11.52  LDD0465  [18]
VE-P
 Probe Info  		N.A.  LDD0396  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C263(2.18)  LDD0169  [5]
 LDCM0214  AC1 PaTu 8988t C263(0.41)  LDD1093  [7]
 LDCM0215  AC10 HCT 116 C263(1.48)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C263(0.93)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C263(0.94)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C263(0.95)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C263(1.06)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C263(1.09)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C263(1.02)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C263(1.05)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C263(1.08)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C263(0.70)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C263(0.83)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C263(1.45)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C263(0.91)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C263(0.89)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C263(1.00)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C263(0.99)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C263(1.09)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C263(1.22)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C263(1.29)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C263(1.17)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C263(1.06)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C263(1.29)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C263(0.91)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C263(1.29)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C263(1.02)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C263(1.33)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C263(1.12)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C263(1.09)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C263(1.08)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C263(1.26)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C263(1.26)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C263(1.24)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C263(0.80)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C263(1.12)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C263(0.87)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C263(1.06)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C263(1.12)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C263(1.10)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C263(1.19)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C263(1.05)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C263(1.01)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C263(1.05)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C263(1.20)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C263(1.44)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C263(1.08)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C263(1.13)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C263(0.95)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C263(1.13)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C263(1.15)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C263(0.99)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C263(1.27)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C263(1.19)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C263(1.49)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C263(1.33)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C263(1.59)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C263(1.08)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C263(0.99)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C263(1.17)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C263(1.48)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C263(1.07)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C263(1.03)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C263(1.01)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C263(0.92)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C263(0.97)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C263(1.32)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C263(1.00)  LDD0595  [7]
 LDCM0279  AC2 PaTu 8988t C263(0.39)  LDD1158  [7]
 LDCM0280  AC20 HCT 116 C263(0.95)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C263(1.04)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C263(1.04)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C263(0.88)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C263(0.85)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C263(1.01)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C263(1.09)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C263(1.14)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C263(1.25)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C263(1.31)  LDD0606  [7]
 LDCM0290  AC3 PaTu 8988t C263(0.43)  LDD1169  [7]
 LDCM0291  AC30 HCT 116 C263(1.35)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C263(1.21)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C263(1.53)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C263(1.27)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C263(1.39)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C263(1.12)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C263(0.87)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C263(0.82)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C263(0.94)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C263(1.08)  LDD0617  [7]
 LDCM0301  AC4 PaTu 8988t C263(0.37)  LDD1180  [7]
 LDCM0302  AC40 HCT 116 C263(1.16)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C263(1.08)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C263(1.02)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C263(1.15)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C263(0.96)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C263(0.91)  LDD0624  [7]
 LDCM0308  AC46 PaTu 8988t C263(0.96)  LDD1187  [7]
 LDCM0309  AC47 PaTu 8988t C263(1.00)  LDD1188  [7]
 LDCM0310  AC48 PaTu 8988t C263(1.22)  LDD1189  [7]
 LDCM0311  AC49 PaTu 8988t C263(1.22)  LDD1190  [7]
 LDCM0312  AC5 PaTu 8988t C263(0.40)  LDD1191  [7]
 LDCM0313  AC50 PaTu 8988t C263(1.34)  LDD1192  [7]
 LDCM0314  AC51 PaTu 8988t C263(0.86)  LDD1193  [7]
 LDCM0315  AC52 PaTu 8988t C263(1.35)  LDD1194  [7]
 LDCM0316  AC53 PaTu 8988t C263(1.58)  LDD1195  [7]
 LDCM0317  AC54 PaTu 8988t C263(1.71)  LDD1196  [7]
 LDCM0318  AC55 PaTu 8988t C263(1.10)  LDD1197  [7]
 LDCM0319  AC56 PaTu 8988t C263(1.31)  LDD1198  [7]
 LDCM0320  AC57 HCT 116 C263(1.68)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C263(2.05)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C263(1.62)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C263(1.20)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C263(1.64)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C263(1.47)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C263(1.93)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C263(1.94)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C263(2.00)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C263(1.33)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C263(1.45)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C263(1.51)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C263(1.01)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C263(1.18)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C263(0.99)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C263(1.05)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C263(1.01)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C263(0.96)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C263(1.20)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C263(1.18)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C263(1.59)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C263(1.10)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C263(1.03)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C263(1.08)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C263(1.15)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C263(1.19)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C263(1.24)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C263(1.11)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C263(1.62)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C263(1.40)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C263(1.66)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C263(1.35)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C263(1.10)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C263(1.12)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C263(1.11)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C263(1.28)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C263(0.88)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C263(1.73)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C263(1.63)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C263(1.22)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C263(1.17)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C263(1.23)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C263(1.25)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C263(1.33)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C263(1.27)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C263(0.95)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C263(1.00)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C263(1.18)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C263(2.20)  LDD0592  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [16]
 LDCM0367  CL1 HEK-293T C263(0.90); C448(1.08)  LDD1571  [20]
 LDCM0368  CL10 HEK-293T C263(0.63); C448(1.00)  LDD1572  [20]
 LDCM0369  CL100 PaTu 8988t C263(0.37)  LDD1248  [7]
 LDCM0370  CL101 HCT 116 C263(1.40)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C263(1.14)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C263(0.96)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C263(0.96)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C263(1.13)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C263(1.37)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C263(1.19)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C263(1.58)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C263(1.01)  LDD0695  [7]
 LDCM0379  CL11 HEK-293T C263(0.85); C448(0.91)  LDD1583  [20]
 LDCM0380  CL110 HCT 116 C263(1.21)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C263(1.04)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C263(1.07)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C263(1.51)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C263(1.06)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C263(1.22)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C263(1.11)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C263(1.36)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C263(1.05)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C263(1.00)  LDD0706  [7]
 LDCM0390  CL12 HEK-293T C263(1.05); C448(0.87)  LDD1594  [20]
 LDCM0391  CL120 HCT 116 C263(1.13)  LDD0708  [7]
 LDCM0392  CL121 PaTu 8988t C263(1.10)  LDD1271  [7]
 LDCM0393  CL122 PaTu 8988t C263(1.08)  LDD1272  [7]
 LDCM0394  CL123 PaTu 8988t C263(1.35)  LDD1273  [7]
 LDCM0395  CL124 PaTu 8988t C263(1.17)  LDD1274  [7]
 LDCM0396  CL125 HCT 116 C263(0.98)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C263(1.17)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C263(1.00)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C263(1.78)  LDD0716  [7]
 LDCM0400  CL13 HEK-293T C263(0.98); C448(1.04)  LDD1604  [20]
 LDCM0401  CL14 HEK-293T C263(0.99); C448(1.19)  LDD1605  [20]
 LDCM0402  CL15 HEK-293T C263(0.86); C448(1.27)  LDD1606  [20]
 LDCM0403  CL16 HCT 116 C263(1.21)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C263(1.21)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C263(1.36)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C263(1.42)  LDD0723  [7]
 LDCM0407  CL2 HEK-293T C263(0.93); C448(1.06)  LDD1611  [20]
 LDCM0408  CL20 HCT 116 C263(1.68)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C263(1.60)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C263(1.80)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C263(1.60)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C263(1.83)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C263(1.55)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C263(1.46)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C263(1.49)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C263(1.72)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C263(1.73)  LDD0734  [7]
 LDCM0418  CL3 HEK-293T C263(0.96); C448(0.91)  LDD1622  [20]
 LDCM0419  CL30 HCT 116 C263(1.62)  LDD0736  [7]
 LDCM0420  CL31 HEK-293T C263(0.94); C448(0.87)  LDD1624  [20]
 LDCM0421  CL32 HEK-293T C263(1.00); C448(0.93)  LDD1625  [20]
 LDCM0422  CL33 HEK-293T C263(0.75)  LDD1626  [20]
 LDCM0423  CL34 HEK-293T C263(0.64); C448(1.00)  LDD1627  [20]
 LDCM0424  CL35 HEK-293T C263(0.80); C448(0.69)  LDD1628  [20]
 LDCM0425  CL36 HEK-293T C263(1.07); C448(0.79)  LDD1629  [20]
 LDCM0426  CL37 HEK-293T C263(0.98); C448(1.02)  LDD1630  [20]
 LDCM0428  CL39 HEK-293T C263(0.99); C448(1.24)  LDD1632  [20]
 LDCM0429  CL4 HEK-293T C263(1.11); C448(1.17)  LDD1633  [20]
 LDCM0430  CL40 HEK-293T C263(1.09); C448(1.18)  LDD1634  [20]
 LDCM0431  CL41 HEK-293T C263(0.98); C448(1.04)  LDD1635  [20]
 LDCM0432  CL42 HEK-293T C263(0.98); C448(0.96)  LDD1636  [20]
 LDCM0433  CL43 HEK-293T C263(1.03); C448(0.94)  LDD1637  [20]
 LDCM0434  CL44 HEK-293T C263(0.92); C448(1.10)  LDD1638  [20]
 LDCM0435  CL45 HEK-293T C263(0.87)  LDD1639  [20]
 LDCM0436  CL46 HCT 116 C263(1.20)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C263(1.11)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C263(1.09)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C263(1.00)  LDD0756  [7]
 LDCM0440  CL5 HEK-293T C263(1.03); C448(1.22)  LDD1644  [20]
 LDCM0441  CL50 HCT 116 C263(1.01)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C263(1.13)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C263(1.25)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C263(1.10)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C263(1.07)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C263(0.97)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C263(1.16)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C263(1.09)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C263(1.06)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C263(1.11)  LDD0767  [7]
 LDCM0451  CL6 HEK-293T C263(1.01); C448(1.00)  LDD1654  [20]
 LDCM0452  CL60 HCT 116 C263(1.08)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C263(1.09)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C263(1.10)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C263(1.34)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C263(1.53)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C263(1.18)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C263(2.10)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C263(1.67)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C263(1.45)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C263(1.15)  LDD0778  [7]
 LDCM0462  CL7 HEK-293T C263(0.92); C448(1.03)  LDD1665  [20]
 LDCM0463  CL70 HCT 116 C263(1.22)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C263(1.41)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C263(1.20)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C263(1.24)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C263(1.53)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C263(0.91)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C263(0.94)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C263(1.05)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C263(1.25)  LDD0789  [7]
 LDCM0473  CL8 HEK-293T C263(0.88); C448(0.78)  LDD1676  [20]
 LDCM0474  CL80 HCT 116 C263(0.96)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C263(1.13)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C263(1.46)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C263(1.44)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C263(1.26)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C263(1.11)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C263(0.98)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C263(1.07)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C263(1.19)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C263(1.83)  LDD0800  [7]
 LDCM0484  CL9 HEK-293T C263(0.90)  LDD1687  [20]
 LDCM0485  CL90 HCT 116 C263(0.78)  LDD0802  [7]
 LDCM0486  CL91 PaTu 8988t C263(0.22)  LDD1365  [7]
 LDCM0487  CL92 PaTu 8988t C263(0.24)  LDD1366  [7]
 LDCM0488  CL93 PaTu 8988t C263(0.28)  LDD1367  [7]
 LDCM0489  CL94 PaTu 8988t C263(0.30)  LDD1368  [7]
 LDCM0490  CL95 PaTu 8988t C263(0.25)  LDD1369  [7]
 LDCM0491  CL96 PaTu 8988t C263(0.27)  LDD1370  [7]
 LDCM0492  CL97 PaTu 8988t C263(0.28)  LDD1371  [7]
 LDCM0493  CL98 PaTu 8988t C263(0.33)  LDD1372  [7]
 LDCM0494  CL99 PaTu 8988t C263(0.33)  LDD1373  [7]
 LDCM0495  E2913 HEK-293T C263(0.93); C448(1.37)  LDD1698  [20]
 LDCM0468  Fragment33 HCT 116 C263(1.48)  LDD0785  [7]
 LDCM0427  Fragment51 HEK-293T C263(0.97); C448(1.20)  LDD1631  [20]
 LDCM0107  IAA HeLa N.A.  LDD0221  [16]
 LDCM0022  KB02 HEK-293T C263(0.95)  LDD1492  [20]
 LDCM0023  KB03 HEK-293T C263(0.95)  LDD1497  [20]
 LDCM0024  KB05 SH4 C263(2.01)  LDD3321  [21]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutamine--tRNA ligase (QARS1) Class-I aminoacyl-tRNA synthetase family P47897
Probable ATP-dependent RNA helicase DDX6 (DDX6) DEAD box helicase family P26196
Aurora kinase A (AURKA) Ser/Thr protein kinase family O14965
Transcription initiation factor IIB (GTF2B) TFIIB family Q00403
116 kDa U5 small nuclear ribonucleoprotein component (EFTUD2) Classic translation factor GTPase family Q15029
E3 ubiquitin-protein ligase RNF113A (RNF113A) . O15541
Prolyl hydroxylase EGLN3 (EGLN3) . Q9H6Z9
Protein FRA10AC1 (FRA10AC1) . Q70Z53
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Optineurin (OPTN) . Q96CV9
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein Red (IK) RED family Q13123
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pre-mRNA-splicing factor SYF1 (XAB2) Crooked-neck family Q9HCS7
Prelamin-A/C (LMNA) Intermediate filament family P02545
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
Protein Dr1 (DR1) NC2 beta/DR1 family Q01658
WD40 repeat-containing protein SMU1 (SMU1) WD repeat SMU1 family Q2TAY7
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
DnaJ homolog subfamily B member 6 (DNAJB6) . O75190
Pre-mRNA-processing factor 6 (PRPF6) . O94906
RNA-binding protein 10 (RBM10) . P98175
Smad nuclear-interacting protein 1 (SNIP1) . Q8TAD8
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Zinc finger protein 830 (ZNF830) . Q96NB3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840