Details of the Target

General Information of Target

Target ID LDTP01961
Target Name Alpha-2-HS-glycoprotein (AHSG)
Gene Name AHSG
Gene ID 197
Synonyms
FETUA; Alpha-2-HS-glycoprotein; Alpha-2-Z-globulin; Ba-alpha-2-glycoprotein; Fetuin-A) [Cleaved into: Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKSLVLLLCLAQLWGCHSAPHGPGLIYRQPNCDDPETEEAALVAIDYINQNLPWGYKHTL
NQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPVARCSVRQLKEHAVEGDCDFQLLK
LDGKFSVVYAKCDSSPDSAEDVRKVCQDCPLLAPLNDTRVVHAAKAALAAFNAQNNGSNF
QLEEISRAQLVPLPPSTYVEFTVSGTDCVAKEATEAAKCNLLAEKQYGFCKATLSEKLGG
AEVAVTCMVFQTQPVSSQPQPEGANEAVPTPVVDPDAPPSPPLGAPGLPPAGSPPDSHVL
LAAPPGHQLHRAHYDLRHTFMGVVSLGSPSGEVSHPRKTRTVVQPSVGAAAGPVVPPCPG
RIRHFKV
Target Type
Literature-reported
Target Bioclass
Other
Family
Fetuin family
Subcellular location
Secreted
Function Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.
TTD ID
T45289
Uniprot ID
P02765
DrugMap ID
TT43L8U
Ensemble ID
ENST00000411641.7
HGNC ID
HGNC:349
ChEMBL ID
CHEMBL4295694

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C132(2.06); C230(2.64)  LDD3312  [1]
AHL-Pu-1
 Probe Info  		C132(5.75)  LDD0173  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C132(0.00); C219(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [4]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [5]
Lodoacetamide azide
 Probe Info  		C132(0.00); C219(0.00)  LDD0037  [3]
ATP probe
 Probe Info  		N.A.  LDD0035  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
WYneO
 Probe Info  		N.A.  LDD0022  [9]
IPM
 Probe Info  		N.A.  LDD0005  [9]
NPM
 Probe Info  		N.A.  LDD0016  [9]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
NAIA_5
 Probe Info  		C230(0.00); C132(0.00)  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C132(5.75)  LDD0173  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0625  F8 Ramos C132(1.30)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C132(10.04)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C132(20.00)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C132(1.83)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C132(1.38)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C132(1.20)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C132(2.43)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C132(1.35)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C132(1.56)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C132(1.31)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C132(0.72)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C132(1.71)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C132(1.60)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C132(3.39)  LDD2201  [12]
 LDCM0468  Fragment33 Ramos C132(1.60)  LDD2202  [12]
 LDCM0596  Fragment38 Ramos C132(1.18)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C132(2.07)  LDD2184  [12]
 LDCM0610  Fragment52 Ramos C132(1.74)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C132(2.86)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C132(1.77)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C132(5.29)  LDD2188  [12]
 LDCM0107  IAA HeLa N.A.  LDD0221  [10]
 LDCM0022  KB02 Ramos C132(2.14)  LDD2182  [12]
 LDCM0023  KB03 22RV1 C219(3.42); C230(3.88)  LDD2660  [1]
 LDCM0024  KB05 HMCB C132(2.06); C230(2.64)  LDD3312  [1]
 LDCM0109  NEM HeLa N.A.  LDD0223  [10]
 LDCM0131  RA190 MM1.R C219(1.69); C132(1.30)  LDD0304  [13]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Copper . DB09130
Zinc . DB01593
Zinc Acetate . DB14487
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cbx-129801 . D0N3BB

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
6 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.