Details of the Target

General Information of Target

Target ID LDTP16241
Target Name Transmembrane and coiled-coil domain protein 3 (TMCC3)
Gene Name TMCC3
Gene ID 57458
Synonyms
KIAA1145; Transmembrane and coiled-coil domain protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNGSNMANTSPSVKSKEDQGLSGHDEKENPFAEYMWMENEEDFNRQVEEELQEQDFLDRC
FQEMLDEEDQDWFIPSRDLPQAMGQLQQQLNGLSVSEGHDSEDILSKSNLNPDAKEFIPG
EKY
Target Bioclass
Transporter and channel
Family
TEX28 family
Subcellular location
Endoplasmic reticulum membrane
Uniprot ID
Q9ULS5
Ensemble ID
ENST00000261226.9
HGNC ID
HGNC:29199

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C180(1.31)  LDD3312  [2]
AHL-Pu-1
 Probe Info  		C180(2.37)  LDD0173  [3]
IPM
 Probe Info  		C180(1.69)  LDD1702  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C180(2.37)  LDD0173  [3]
 LDCM0237  AC12 HEK-293T C180(1.03)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C180(1.06)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C180(1.00)  LDD1513  [5]
 LDCM0280  AC20 HEK-293T C180(1.08)  LDD1519  [5]
 LDCM0282  AC22 HEK-293T C180(1.05)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C180(0.89)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C180(0.99)  LDD1523  [5]
 LDCM0288  AC28 HEK-293T C180(1.13)  LDD1527  [5]
 LDCM0291  AC30 HEK-293T C180(1.04)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C180(0.96)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C180(1.03)  LDD1532  [5]
 LDCM0297  AC36 HEK-293T C180(1.06)  LDD1536  [5]
 LDCM0299  AC38 HEK-293T C180(0.93)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C180(1.01)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C180(0.95)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C180(1.00)  LDD1541  [5]
 LDCM0306  AC44 HEK-293T C180(1.10)  LDD1545  [5]
 LDCM0308  AC46 HEK-293T C180(1.05)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C180(0.99)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C180(1.02)  LDD1549  [5]
 LDCM0315  AC52 HEK-293T C180(1.01)  LDD1554  [5]
 LDCM0317  AC54 HEK-293T C180(0.98)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C180(0.93)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C180(0.90)  LDD1558  [5]
 LDCM0323  AC6 HEK-293T C180(0.95)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C180(1.09)  LDD1563  [5]
 LDCM0326  AC62 HEK-293T C180(1.02)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C180(0.99)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C180(1.06)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C180(0.97)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C180(1.13)  LDD1569  [5]
 LDCM0275  AKOS034007705 HEK-293T C180(0.89)  LDD1514  [5]
 LDCM0156  Aniline NCI-H1299 11.99  LDD0403  [1]
 LDCM0368  CL10 HEK-293T C180(1.21)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C180(0.93)  LDD1573  [5]
 LDCM0373  CL104 HEK-293T C180(0.96)  LDD1577  [5]
 LDCM0377  CL108 HEK-293T C180(0.99)  LDD1581  [5]
 LDCM0379  CL11 HEK-293T C180(0.93)  LDD1583  [5]
 LDCM0382  CL112 HEK-293T C180(1.20)  LDD1586  [5]
 LDCM0386  CL116 HEK-293T C180(1.06)  LDD1590  [5]
 LDCM0390  CL12 HEK-293T C180(0.89)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C180(0.97)  LDD1595  [5]
 LDCM0395  CL124 HEK-293T C180(0.96)  LDD1599  [5]
 LDCM0399  CL128 HEK-293T C180(0.98)  LDD1603  [5]
 LDCM0403  CL16 HEK-293T C180(0.91)  LDD1607  [5]
 LDCM0408  CL20 HEK-293T C180(1.07)  LDD1612  [5]
 LDCM0410  CL22 HEK-293T C180(1.04)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C180(0.88)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C180(0.87)  LDD1616  [5]
 LDCM0416  CL28 HEK-293T C180(0.94)  LDD1620  [5]
 LDCM0421  CL32 HEK-293T C180(0.98)  LDD1625  [5]
 LDCM0423  CL34 HEK-293T C180(0.88)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C180(0.90)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C180(0.89)  LDD1629  [5]
 LDCM0429  CL4 HEK-293T C180(0.98)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C180(0.89)  LDD1634  [5]
 LDCM0434  CL44 HEK-293T C180(1.15)  LDD1638  [5]
 LDCM0436  CL46 HEK-293T C180(1.00)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C180(0.92)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C180(0.85)  LDD1642  [5]
 LDCM0443  CL52 HEK-293T C180(0.96)  LDD1646  [5]
 LDCM0447  CL56 HEK-293T C180(1.10)  LDD1650  [5]
 LDCM0449  CL58 HEK-293T C180(0.88)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C180(0.96)  LDD1653  [5]
 LDCM0452  CL60 HEK-293T C180(0.96)  LDD1655  [5]
 LDCM0456  CL64 HEK-293T C180(0.94)  LDD1659  [5]
 LDCM0460  CL68 HEK-293T C180(0.96)  LDD1663  [5]
 LDCM0463  CL70 HEK-293T C180(0.87)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C180(0.85)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C180(1.17)  LDD1668  [5]
 LDCM0469  CL76 HEK-293T C180(0.92)  LDD1672  [5]
 LDCM0473  CL8 HEK-293T C180(1.09)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C180(1.03)  LDD1677  [5]
 LDCM0476  CL82 HEK-293T C180(0.99)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C180(0.91)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C180(0.85)  LDD1681  [5]
 LDCM0482  CL88 HEK-293T C180(0.99)  LDD1685  [5]
 LDCM0487  CL92 HEK-293T C180(1.05)  LDD1690  [5]
 LDCM0489  CL94 HEK-293T C180(1.06)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C180(1.01)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C180(0.86)  LDD1694  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C180(1.69)  LDD1702  [4]
 LDCM0022  KB02 22RV1 C180(2.51)  LDD2243  [2]
 LDCM0023  KB03 22RV1 C180(3.27)  LDD2660  [2]
 LDCM0024  KB05 HMCB C180(1.31)  LDD3312  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Testis-specific protein TEX28 (TEX28; TEX28P1; TEX28P2) TEX28 family O15482

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402