Details of the Target

General Information of Target

Target ID LDTP04339
Target Name Type-2 angiotensin II receptor (AGTR2)
Gene Name AGTR2
Gene ID 186
Synonyms
Type-2 angiotensin II receptor; Angiotensin II type-2 receptor; AT2 receptor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFL
VNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMET
FVS
Target Type
Successful
Target Bioclass
GPCR
Family
G-protein coupled receptor 1 family
Subcellular location
Cell membrane
Function
Receptor for angiotensin II, a vasoconstricting peptide. Signals primarily via a non-canonical G-protein- and beta-arrestin independent pathways. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
TTD ID
T09909
Uniprot ID
P50052
DrugMap ID
TTQVOEI
Ensemble ID
ENST00000371906.5
HGNC ID
HGNC:338
ChEMBL ID
CHEMBL4607

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C195(3.79)  LDD0173  [1]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C195(3.79)  LDD0173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Metalloproteinase inhibitor 3 (TIMP3) Protease inhibitor I35 (TIMP) family P35625

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Angiotensin Ii Small molecular drug D0G6SE
Saralasin Small molecular drug D0K0AT
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ema-401 Small molecular drug D0O0JP
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Mp-157 . D03VWB
Investigative
Click To Hide/Show 14 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Angiotensin Iii Small molecular drug D0D9AS
L-159093 Small molecular drug D04SVT
L-162313 Small molecular drug D0A4NO
Pd123177 Small molecular drug D09FRL
Pmid22802221c21 Small molecular drug D0K2EX
Sar-arg-val-tyr-ile-his-pro-ala Small molecular drug D0K7DW
Sar-arg-val-tyr-ile-his-pro-ile Small molecular drug D00UWL
Sc-52892 Small molecular drug D0O0SH
Sc-55634 Small molecular drug D0MH1K
Tasosartan Small molecular drug DB01349
[125i]Cgp42112 Small molecular drug D04UJZ
Cyt006-angqb . DB05739
Olodanrigan . DB16266
Sar-arg-val-tyr-ile-his-pro-phe-oh . D0OF3M
Patented
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1-(Biphenyl-4-yl-methyl)-1h-imidazole Derivative 1 Small molecular drug D0U6AW
Phenylpyridine Derivative 3 Small molecular drug D0NF8V
Pmid25416646-compound-figure5-e Small molecular drug D0LA6O
Discontinued
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
L-158282 Small molecular drug D0A9BX
L-158809 Small molecular drug D0GS7N
L-159689 Small molecular drug D00UBK
L-162234 Small molecular drug D09TED
Pd-123319 Small molecular drug D0F5VB
Sc-50560 Small molecular drug D0RG2P
Sc-51895 Small molecular drug D04AOA
Fonsartan . D08CKJ
Tak-591 . D0A8EG

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264