Details of the Target

General Information of Target

Target ID LDTP11300
Target Name tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial (TRMT61B)
Gene Name TRMT61B
Gene ID 55006
Synonyms
tRNA; adenine(58)-N(1))-methyltransferase, mitochondrial; EC 2.1.1.220; mRNA methyladenosine-N(1)-methyltransferase; EC 2.1.1.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKVNVAKLRYMSRDDFRVLTAVEMGMKNHEIVPGSLIASIASLKHGGCNKVLRELVKHK
LIAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEEGQQF
ALKLHRLGRTSFRNLKNKRDYHKHRHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPID
YNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLANHGLIHGDFNEFNLILDESD
HITMIDFPQMVSTSHPNAEWYFDRDVKCIKDFFMKRFSYESELFPTFKDIRREDTLDVEV
SASGYTKEMQADDELLHPLGPDDKNIETKEGSEFSFSDGEVAEKAEVYGSENESERNCLE
ESEGCYCRSSGDPEQIKEDSLSEESADARSFEMTEFNQALEEIKGQVVENNSVTEFSEEK
NRTENYNRQDGQRVQGGVPAGSDEYEDECPHLIALSSLNREFRPFRDEENVGAMNQYRTR
TLSITSSGSAVSCSTIPPELVKQKVKRQLTKQQKSAVRRRLQKGEANIFTKQRRENMQNI
KSSLEAASFWGE
Target Bioclass
Enzyme
Family
Class I-like SAM-binding methyltransferase superfamily, TRM61 family
Subcellular location
Mitochondrion
Function
Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC). Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function. In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation.
Uniprot ID
Q9BVS5
Ensemble ID
ENST00000306108.10
HGNC ID
HGNC:26070

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.68  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C67(2.71)  LDD0169  [2]
DBIA
 Probe Info  		C396(1.52)  LDD0080  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		C396(0.00); C143(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C396(0.00); C143(0.00)  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
Phosphinate-6
 Probe Info  		C143(0.00); C81(0.00); C112(0.00)  LDD0018  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [8]
W1
 Probe Info  		N.A.  LDD0236  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C67(2.71)  LDD0169  [2]
 LDCM0214  AC1 HCT 116 C396(0.85)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C396(1.01); C112(1.61); C376(0.89); C81(0.94)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C396(1.01); C112(0.99); C376(0.93); C81(0.90)  LDD1509  [12]
 LDCM0230  AC113 HCT 116 C396(1.02)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C396(1.10)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C396(1.21)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C396(1.34)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C396(1.14)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C396(1.02)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C396(1.18)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C143(0.93); C396(1.06); C376(0.99); C81(0.92)  LDD1510  [12]
 LDCM0238  AC120 HCT 116 C396(1.13)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C396(1.09)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C396(1.07)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C396(0.97)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C396(1.06)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C396(1.03)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C396(1.21)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C396(1.23)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C396(1.34)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C396(0.90)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C396(1.04)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C396(0.83)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C396(1.00)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C396(1.03)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C396(1.16)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C396(1.10)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C396(1.08)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C396(1.01)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C396(0.98)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C396(1.09)  LDD0575  [3]
 LDCM0259  AC14 HEK-293T C396(1.00); C376(0.82); C81(1.13); C382(1.33)  LDD1512  [12]
 LDCM0260  AC140 HCT 116 C396(1.12)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C396(0.98)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C396(0.91)  LDD0579  [3]
 LDCM0270  AC15 HEK-293T C143(1.18); C396(0.96); C376(0.91); C81(1.13)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C143(1.07); C396(0.90); C376(0.84); C81(0.99)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C396(1.00); C112(1.46); C376(0.95); C81(0.98)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C396(0.87); C112(1.41); C376(0.97); C81(0.98)  LDD1517  [12]
 LDCM0279  AC2 HCT 116 C396(1.11)  LDD0596  [3]
 LDCM0280  AC20 HEK-293T C143(1.00); C396(1.07); C376(0.91); C81(1.10)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C143(0.99); C396(1.07); C376(0.91); C81(1.04)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C396(0.96); C376(1.00); C81(0.96); C382(0.85)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C143(1.21); C396(1.00); C376(0.99); C81(1.10)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C396(0.99); C112(0.80); C376(1.07); C81(1.19)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C376(0.94)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C376(0.90)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C376(1.25)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C376(0.94)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C376(1.07)  LDD0887  [3]
 LDCM0290  AC3 HCT 116 C396(1.09)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C376(0.93)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C376(0.95)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C376(0.94)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C376(1.09)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C376(0.95)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C376(0.71)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C376(0.63)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C376(0.67)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C376(0.91)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C376(0.71)  LDD0898  [3]
 LDCM0301  AC4 HCT 116 C396(1.01)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C376(0.84)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C376(1.00)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C376(0.91)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C376(0.76)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C376(0.88)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C376(0.78)  LDD0905  [3]
 LDCM0308  AC46 PaTu 8988t C396(1.16)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C396(1.10)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C396(1.22)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C396(1.30)  LDD1190  [3]
 LDCM0312  AC5 HCT 116 C396(1.20)  LDD0629  [3]
 LDCM0313  AC50 PaTu 8988t C396(1.54)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C396(0.36)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C396(1.20)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C396(1.79)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C396(1.68)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C396(1.35)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C396(1.57)  LDD1198  [3]
 LDCM0320  AC57 HEK-293T C143(0.90); C396(0.94); C376(0.96); C81(0.99)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C396(1.06); C112(0.97); C376(1.00); C81(1.01)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C396(0.93); C112(1.08); C376(0.97); C81(1.15)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C396(0.99); C376(1.06); C81(1.09); C382(0.81)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C143(1.12); C396(1.17); C376(0.87); C81(1.06)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C143(0.97); C396(1.03); C376(0.98); C81(0.98)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C396(0.99); C376(0.87); C81(1.15); C382(1.16)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C143(1.06); C396(0.95); C376(0.90); C81(1.13)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C396(0.98); C112(0.69); C376(0.99); C81(1.19)  LDD1567  [12]
 LDCM0332  AC68 PaTu 8988t C396(0.97)  LDD1211  [3]
 LDCM0333  AC69 PaTu 8988t C396(0.99)  LDD1212  [3]
 LDCM0334  AC7 HEK-293T C143(1.06); C396(0.96); C376(1.02); C81(1.11)  LDD1568  [12]
 LDCM0335  AC70 PaTu 8988t C396(1.09)  LDD1214  [3]
 LDCM0336  AC71 PaTu 8988t C396(1.08)  LDD1215  [3]
 LDCM0337  AC72 PaTu 8988t C396(0.93)  LDD1216  [3]
 LDCM0338  AC73 PaTu 8988t C396(0.88)  LDD1217  [3]
 LDCM0339  AC74 PaTu 8988t C396(0.99)  LDD1218  [3]
 LDCM0340  AC75 PaTu 8988t C396(1.09)  LDD1219  [3]
 LDCM0341  AC76 PaTu 8988t C396(1.01)  LDD1220  [3]
 LDCM0342  AC77 PaTu 8988t C396(1.14)  LDD1221  [3]
 LDCM0343  AC78 PaTu 8988t C396(1.08)  LDD1222  [3]
 LDCM0344  AC79 PaTu 8988t C396(1.02)  LDD1223  [3]
 LDCM0345  AC8 HEK-293T C396(1.02); C112(0.88); C376(0.93); C81(0.99)  LDD1569  [12]
 LDCM0346  AC80 PaTu 8988t C396(1.08)  LDD1225  [3]
 LDCM0347  AC81 PaTu 8988t C396(1.07)  LDD1226  [3]
 LDCM0348  AC82 PaTu 8988t C396(1.03)  LDD1227  [3]
 LDCM0248  AKOS034007472 HEK-293T C143(1.02); C396(1.04); C376(1.02); C81(1.00)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C143(1.10); C396(0.92); C376(0.93); C81(1.11)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C396(1.01); C112(0.95); C376(1.02); C81(0.82)  LDD1514  [12]
 LDCM0156  Aniline NCI-H1299 13.49  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C396(1.00); C67(0.94); C81(0.94)  LDD2171  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HEK-293T C143(0.91); C396(1.00); C81(0.96)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C396(1.17); C376(0.76); C81(1.10); C382(1.01)  LDD1572  [12]
 LDCM0369  CL100 HCT 116 C396(1.00)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C143(1.03); C396(1.05); C81(0.94)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C143(1.04); C396(0.89); C112(0.89); C376(0.86)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C143(0.94); C396(0.88); C112(0.99); C376(1.14)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C396(0.92); C376(0.97); C81(1.01)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C143(0.99); C396(1.00); C81(0.98)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C143(0.93); C396(0.97); C112(0.90); C376(0.94)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C143(0.90); C396(0.96); C112(0.96); C376(1.06)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C396(0.91); C376(1.02); C81(0.83)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C143(0.96); C396(0.93); C81(1.69)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C143(1.19); C396(1.17); C376(1.33); C81(0.93)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C143(1.09); C396(0.90); C112(1.01); C376(0.83)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C143(0.95); C396(0.94); C112(1.00); C376(1.00)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C376(1.09)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C376(0.95)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C376(0.93)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C376(0.95)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C376(0.97)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C376(0.73)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C376(1.28)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C376(1.62)  LDD0987  [3]
 LDCM0390  CL12 HEK-293T C396(1.14); C112(0.83); C376(1.22); C81(0.99)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C376(1.05)  LDD0989  [3]
 LDCM0392  CL121 PaTu 8988t C396(1.13)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C396(1.27)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C396(1.60)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C396(1.65)  LDD1274  [3]
 LDCM0396  CL125 HEK-293T C143(0.74); C396(1.02); C81(1.15)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C143(0.86); C396(0.95); C112(0.80); C376(0.81)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C143(0.81); C396(0.87); C112(0.99); C376(1.02)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C396(0.89); C376(0.89); C81(0.88)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C143(1.06); C396(1.03); C81(0.88)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C143(1.03); C396(0.78); C112(0.75); C376(0.96)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C143(0.86); C396(0.84); C112(1.04); C376(1.00)  LDD1606  [12]
 LDCM0403  CL16 PaTu 8988t C396(1.19)  LDD1282  [3]
 LDCM0404  CL17 PaTu 8988t C396(1.25)  LDD1283  [3]
 LDCM0405  CL18 PaTu 8988t C396(1.18)  LDD1284  [3]
 LDCM0406  CL19 PaTu 8988t C396(1.21)  LDD1285  [3]
 LDCM0407  CL2 HEK-293T C143(0.95); C396(0.94); C112(0.81); C376(0.99)  LDD1611  [12]
 LDCM0408  CL20 PaTu 8988t C396(1.14)  LDD1287  [3]
 LDCM0409  CL21 PaTu 8988t C396(1.32)  LDD1288  [3]
 LDCM0410  CL22 PaTu 8988t C396(1.26)  LDD1289  [3]
 LDCM0411  CL23 PaTu 8988t C396(1.18)  LDD1290  [3]
 LDCM0412  CL24 PaTu 8988t C396(1.13)  LDD1291  [3]
 LDCM0413  CL25 PaTu 8988t C396(1.31)  LDD1292  [3]
 LDCM0414  CL26 PaTu 8988t C396(1.11)  LDD1293  [3]
 LDCM0415  CL27 PaTu 8988t C396(1.26)  LDD1294  [3]
 LDCM0416  CL28 PaTu 8988t C396(1.53)  LDD1295  [3]
 LDCM0417  CL29 PaTu 8988t C396(1.08)  LDD1296  [3]
 LDCM0418  CL3 HEK-293T C143(0.93); C396(0.93); C112(1.00); C376(1.19)  LDD1622  [12]
 LDCM0419  CL30 PaTu 8988t C396(1.18)  LDD1298  [3]
 LDCM0420  CL31 HEK-293T C396(1.03); C112(1.03); C376(1.18); C81(0.79)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C143(0.57); C396(1.22); C376(1.12); C81(0.91)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C143(0.97); C396(1.06); C376(1.24); C81(0.77)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C396(1.22); C376(1.18); C81(0.99); C382(1.11)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C143(1.30); C396(1.20); C376(1.38); C81(1.01)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C396(1.25); C112(1.08); C376(1.17); C81(0.76)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C143(0.87); C396(0.97); C81(0.79)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C143(0.91); C396(0.93); C112(0.97); C376(1.11)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C396(0.95); C376(0.98); C81(0.83)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C396(0.94); C376(0.98); C81(0.80)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C143(1.32); C396(0.87); C376(0.88); C81(1.12)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C396(1.07); C112(0.69); C376(1.28); C81(0.94)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C396(1.03); C112(0.95); C376(1.02); C81(0.87)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C143(0.67); C396(1.22); C376(1.14); C81(1.15)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C143(0.99); C396(1.15); C376(1.09); C81(0.85)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C396(1.25); C376(1.36); C81(1.15); C382(1.01)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C143(1.14); C396(1.18); C376(1.11); C81(0.91)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C396(1.26); C112(1.09); C376(1.31); C81(0.85)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C143(0.92); C396(1.00); C81(1.06)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C143(0.94); C396(0.95); C376(1.01); C81(0.98)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C143(0.99); C396(0.97); C112(0.94); C376(0.93)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C396(0.87); C376(1.00); C81(0.91)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C143(1.03); C396(0.90); C376(0.76); C81(0.80)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C396(1.03); C112(1.02); C376(0.89); C81(0.80)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C396(0.94); C112(1.05); C376(1.03); C81(0.78)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C143(0.63); C396(1.34); C376(1.41); C81(1.02)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C143(1.11); C396(1.17); C376(1.35); C81(0.90)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C396(1.27); C376(1.38); C81(0.97); C382(0.94)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C143(1.33); C396(1.09); C376(1.34); C81(0.93)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C396(1.09); C112(0.84); C376(0.89); C81(0.92)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C396(1.21); C112(0.98); C376(1.18); C81(1.25)  LDD1655  [12]
 LDCM0453  CL61 HCT 116 C396(1.05)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C396(1.07)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C396(1.17)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C396(1.18)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C396(1.02)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C396(1.59)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C396(1.35)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C396(1.26)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C396(1.15)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C396(0.85); C112(0.80); C376(0.99); C81(0.99)  LDD1665  [12]
 LDCM0463  CL70 HCT 116 C396(1.22)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C396(1.21)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C396(1.04)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C396(1.19)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C396(1.15)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C376(1.20)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C376(1.60)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C376(1.88)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C376(1.42)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C143(0.58); C396(1.10); C376(0.88); C81(0.89)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C376(1.10)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C376(1.88)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C376(0.97)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C376(1.09)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C376(1.83)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C376(1.71)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C376(2.32)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C376(1.68)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C376(1.91)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C376(1.74)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C143(0.97); C396(1.14); C376(1.35); C81(0.92)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C376(1.50)  LDD1083  [3]
 LDCM0486  CL91 HCT 116 C396(1.20)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C396(0.94)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C396(0.84)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C396(0.85)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C396(1.09)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C396(1.10)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C396(1.11)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C396(1.17)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C396(1.03)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C143(0.95); C396(0.91); C112(0.84); C376(1.04)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C143(0.87)  LDD1702  [13]
 LDCM0625  F8 Ramos C143(1.93)  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C143(0.70)  LDD2189  [14]
 LDCM0573  Fragment11 Ramos C143(3.74)  LDD2190  [14]
 LDCM0574  Fragment12 Ramos C143(0.48)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C143(0.68)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C143(0.72)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C143(0.40)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C143(1.03)  LDD2195  [14]
 LDCM0578  Fragment27 Ramos C143(0.98)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C143(1.09)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C143(0.79)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C143(0.74)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C143(0.94)  LDD2201  [14]
 LDCM0468  Fragment33 HCT 116 C396(1.15)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C143(0.51)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C143(0.90)  LDD2184  [14]
 LDCM0427  Fragment51 HEK-293T C143(1.03); C396(0.88); C112(1.11); C376(0.88)  LDD1631  [12]
 LDCM0610  Fragment52 Ramos C143(0.83)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C143(0.97)  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C143(1.00)  LDD2186  [14]
 LDCM0571  Fragment9 Ramos C143(0.56)  LDD2188  [14]
 LDCM0022  KB02 HCT 116 C396(1.52)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C396(1.82)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C396(1.41)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C396(1.00); C67(0.94); C81(0.94)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon regulatory factor 7 (IRF7) IRF family Q92985
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Progranulin (GRN) Granulin family P28799

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578