Details of the Target

General Information of Target

Target ID LDTP11851
Target Name Zinc finger protein 106 (ZNF106)
Gene Name ZNF106
Gene ID 64397
Synonyms
SH3BP3; ZFP106; ZNF474; Zinc finger protein 106; Zfp-106; Zinc finger protein 474
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRRFTVTSLPPAGPARSPDPESRRHSVADPRHLPGEDVKGDGNPKESSPFINSTDTEKG
KEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRM
GTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNG
VVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAE
DASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKS
AFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFTR
NNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMT
SYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACI
EGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDG
IVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACA
VQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGA
EKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQ
LKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHL
IQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGN
PERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTT
FLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDES
RGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEG
ETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLN
EVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS
Target Bioclass
Other
Subcellular location
Nucleus, nucleolus
Function
RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism.
Uniprot ID
Q9H2Y7
Ensemble ID
ENST00000263805.8
HGNC ID
HGNC:12886

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K333(0.41)  LDD0277  [1]
AHL-Pu-1
 Probe Info  		C1238(2.59)  LDD0168  [2]
Acrolein
 Probe Info  		C1576(0.00); C1472(0.00)  LDD0222  [3]
DBIA
 Probe Info  		C1307(1.02)  LDD0078  [4]
IA-alkyne
 Probe Info  		C544(0.00); C1472(0.00); C1853(0.00)  LDD0165  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
Compound 10
 Probe Info  		N.A.  LDD2216  [7]
Compound 11
 Probe Info  		N.A.  LDD2213  [7]
IPM
 Probe Info  		C457(0.00); C1069(0.00); C510(0.00)  LDD0005  [8]
TFBX
 Probe Info  		C1238(0.00); C510(0.00); C1069(0.00)  LDD0148  [9]
VSF
 Probe Info  		C1472(0.00); C457(0.00)  LDD0007  [8]
Phosphinate-6
 Probe Info  		C432(0.00); C643(0.00); C457(0.00); C544(0.00)  LDD0018  [10]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [3]
Methacrolein
 Probe Info  		C1472(0.00); C1238(0.00)  LDD0218  [3]
AOyne
 Probe Info  		15.00  LDD0443  [11]
NAIA_5
 Probe Info  		C1661(0.00); C1653(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C1238(2.59)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1238(2.99)  LDD0169  [2]
 LDCM0214  AC1 PaTu 8988t C1472(1.48)  LDD1093  [4]
 LDCM0215  AC10 PaTu 8988t C1797(1.11)  LDD1094  [4]
 LDCM0226  AC11 PaTu 8988t C1797(1.23)  LDD1105  [4]
 LDCM0230  AC113 HEK-293T C1069(0.91)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C1069(1.00)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C1069(0.99)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C1069(0.80)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C1069(0.83)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C1069(0.90)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C1069(0.94)  LDD0834  [4]
 LDCM0237  AC12 PaTu 8988t C1797(1.56)  LDD1116  [4]
 LDCM0238  AC120 HEK-293T C1069(0.88)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C1069(0.85)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C1069(0.92)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C1069(1.06)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C1069(1.27)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C1069(1.05)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C1069(1.17)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C1069(1.22)  LDD0843  [4]
 LDCM0246  AC128 HEK-293T C1472(1.77)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C1472(1.48)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C1472(1.04)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C1472(1.31)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C1472(1.62)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C1472(1.26)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C1472(1.16)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C1472(1.41)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C1472(1.39)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C1472(1.38)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C1472(1.69)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C1472(1.58)  LDD0856  [4]
 LDCM0259  AC14 PaTu 8988t C1797(1.22)  LDD1138  [4]
 LDCM0260  AC140 HEK-293T C1472(1.56)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C1472(1.31)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C1472(1.47)  LDD0860  [4]
 LDCM0263  AC143 HEK-293T C1472(0.95)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C1472(0.99)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C1472(1.22)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C1472(1.13)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C1472(0.76)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C1472(0.75)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C1472(1.12)  LDD0867  [4]
 LDCM0270  AC15 PaTu 8988t C1797(1.23)  LDD1149  [4]
 LDCM0271  AC150 HEK-293T C1472(0.77)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C1472(1.08)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C1472(0.93)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C1472(0.93)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C1472(0.93)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C1472(1.10)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C1472(1.09)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C1472(0.83)  LDD2165  [4]
 LDCM0276  AC17 PaTu 8988t C1472(1.03); C1797(1.06)  LDD1155  [4]
 LDCM0277  AC18 PaTu 8988t C1472(1.33); C1797(1.21)  LDD1156  [4]
 LDCM0278  AC19 PaTu 8988t C1472(1.15); C1797(1.10)  LDD1157  [4]
 LDCM0279  AC2 PaTu 8988t C1472(1.26)  LDD1158  [4]
 LDCM0280  AC20 PaTu 8988t C1472(1.68); C1797(1.03)  LDD1159  [4]
 LDCM0281  AC21 PaTu 8988t C1472(1.43); C1797(1.05)  LDD1160  [4]
 LDCM0282  AC22 PaTu 8988t C1472(1.54); C1797(0.85)  LDD1161  [4]
 LDCM0283  AC23 PaTu 8988t C1472(1.67); C1797(1.35)  LDD1162  [4]
 LDCM0284  AC24 PaTu 8988t C1472(1.49); C1797(1.16)  LDD1163  [4]
 LDCM0285  AC25 PaTu 8988t C1797(1.07)  LDD1164  [4]
 LDCM0286  AC26 PaTu 8988t C1797(1.50)  LDD1165  [4]
 LDCM0287  AC27 PaTu 8988t C1797(1.36)  LDD1166  [4]
 LDCM0288  AC28 PaTu 8988t C1797(1.33)  LDD1167  [4]
 LDCM0289  AC29 PaTu 8988t C1797(1.46)  LDD1168  [4]
 LDCM0290  AC3 PaTu 8988t C1472(1.16)  LDD1169  [4]
 LDCM0291  AC30 PaTu 8988t C1797(0.96)  LDD1170  [4]
 LDCM0292  AC31 PaTu 8988t C1797(1.27)  LDD1171  [4]
 LDCM0293  AC32 PaTu 8988t C1797(1.10)  LDD1172  [4]
 LDCM0294  AC33 PaTu 8988t C1797(1.00)  LDD1173  [4]
 LDCM0295  AC34 PaTu 8988t C1797(1.10)  LDD1174  [4]
 LDCM0296  AC35 PaTu 8988t C1797(1.24)  LDD1175  [4]
 LDCM0297  AC36 PaTu 8988t C1797(1.14)  LDD1176  [4]
 LDCM0298  AC37 PaTu 8988t C1797(0.90)  LDD1177  [4]
 LDCM0299  AC38 PaTu 8988t C1797(1.10)  LDD1178  [4]
 LDCM0300  AC39 PaTu 8988t C1797(1.34)  LDD1179  [4]
 LDCM0301  AC4 PaTu 8988t C1472(1.12)  LDD1180  [4]
 LDCM0302  AC40 PaTu 8988t C1797(1.48)  LDD1181  [4]
 LDCM0303  AC41 PaTu 8988t C1797(1.12)  LDD1182  [4]
 LDCM0304  AC42 PaTu 8988t C1797(1.01)  LDD1183  [4]
 LDCM0305  AC43 PaTu 8988t C1797(1.21)  LDD1184  [4]
 LDCM0306  AC44 PaTu 8988t C1797(1.08)  LDD1185  [4]
 LDCM0307  AC45 PaTu 8988t C1797(0.95)  LDD1186  [4]
 LDCM0308  AC46 HEK-293T C1069(1.24); C1131(1.08)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C457(0.95); C1069(1.31); C1131(1.53)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C457(1.01); C1238(1.14); C1069(0.97); C1131(1.33)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C457(0.96); C1069(1.05); C1757(1.12); C1820(0.82)  LDD1550  [12]
 LDCM0312  AC5 PaTu 8988t C1472(1.27)  LDD1191  [4]
 LDCM0313  AC50 HEK-293T C457(0.90); C432(0.98)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C457(0.98); C1069(0.96); C1472(0.94); C1815(0.78)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C1307(1.23); C457(1.00); C432(1.12); C1238(1.22)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C457(1.05); C1238(0.99)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C1069(1.43); C1131(1.61)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C457(1.00); C1069(1.50); C1131(1.09)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C457(1.06); C1238(0.95); C1069(0.98); C1131(1.12)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C1069(0.99)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C1069(1.06)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C1069(1.01)  LDD0920  [4]
 LDCM0323  AC6 PaTu 8988t C1797(1.29)  LDD1202  [4]
 LDCM0324  AC60 HEK-293T C1069(1.10)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C1069(1.00)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C1069(1.05)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C1069(0.99)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C1069(1.06)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C1069(1.00)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C1069(1.07)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C1069(0.95)  LDD0929  [4]
 LDCM0332  AC68 HEK-293T C1069(0.85)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C1069(0.90)  LDD0931  [4]
 LDCM0334  AC7 PaTu 8988t C1797(1.12)  LDD1213  [4]
 LDCM0335  AC70 HEK-293T C1069(0.87)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C1069(0.90)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C1069(0.91)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C1069(0.86)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C1069(0.87)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C1069(0.88)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C1069(0.93)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C1069(0.93)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C1069(0.87)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C1069(0.91)  LDD0942  [4]
 LDCM0345  AC8 PaTu 8988t C1797(1.11)  LDD1224  [4]
 LDCM0346  AC80 HEK-293T C1069(0.96)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C1069(0.80)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C1069(0.96)  LDD0946  [4]
 LDCM0349  AC83 HEK-293T C1069(1.14)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C1069(0.96)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C1069(0.70)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C1069(1.65)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C1069(1.30)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C1069(0.72)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C1069(1.11)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C1069(0.82)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C1069(0.83)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C1069(1.20)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C1069(1.20)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C1069(0.77)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C1069(0.67)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C1069(1.03)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C1069(1.00)  LDD0962  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C1797(1.35)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C1797(1.50)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C1797(1.28)  LDD1154  [4]
 LDCM0020  ARS-1620 HCC44 C1307(1.02)  LDD0078  [4]
 LDCM0108  Chloroacetamide HeLa C1576(0.00); C1472(0.00)  LDD0222  [3]
 LDCM0367  CL1 HEK-293T C1307(1.31); C457(0.84); C432(1.07); C1238(1.23)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C1069(1.30); C1131(1.79)  LDD1572  [12]
 LDCM0369  CL100 PaTu 8988t C1472(1.17)  LDD1248  [4]
 LDCM0370  CL101 PaTu 8988t C1797(1.13)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C1797(1.11)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C1797(1.26)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C1797(1.33)  LDD1252  [4]
 LDCM0374  CL105 PaTu 8988t C1472(1.16); C1797(1.03)  LDD1253  [4]
 LDCM0375  CL106 PaTu 8988t C1472(1.10); C1797(1.23)  LDD1254  [4]
 LDCM0376  CL107 PaTu 8988t C1472(1.07); C1797(1.14)  LDD1255  [4]
 LDCM0377  CL108 PaTu 8988t C1472(0.99); C1797(1.38)  LDD1256  [4]
 LDCM0378  CL109 PaTu 8988t C1472(1.29); C1797(1.12)  LDD1257  [4]
 LDCM0379  CL11 HEK-293T C457(1.25); C1069(1.12); C1131(1.18)  LDD1583  [12]
 LDCM0380  CL110 PaTu 8988t C1472(1.49); C1797(1.26)  LDD1259  [4]
 LDCM0381  CL111 PaTu 8988t C1472(1.83); C1797(1.29)  LDD1260  [4]
 LDCM0382  CL112 PaTu 8988t C1797(1.24)  LDD1261  [4]
 LDCM0383  CL113 PaTu 8988t C1797(1.19)  LDD1262  [4]
 LDCM0384  CL114 PaTu 8988t C1797(1.07)  LDD1263  [4]
 LDCM0385  CL115 PaTu 8988t C1797(1.17)  LDD1264  [4]
 LDCM0386  CL116 PaTu 8988t C1797(1.78)  LDD1265  [4]
 LDCM0387  CL117 PaTu 8988t C1797(0.92)  LDD1266  [4]
 LDCM0388  CL118 PaTu 8988t C1797(0.97)  LDD1267  [4]
 LDCM0389  CL119 PaTu 8988t C1797(1.02)  LDD1268  [4]
 LDCM0390  CL12 HEK-293T C457(1.18); C1238(0.93); C1069(1.21); C1131(0.95)  LDD1594  [12]
 LDCM0391  CL120 PaTu 8988t C1797(1.05)  LDD1270  [4]
 LDCM0392  CL121 HEK-293T C1307(1.21); C457(0.87); C432(1.10); C1238(1.21)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C432(0.89); C1069(0.81); C1757(1.13)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C1820(0.69)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C457(1.02); C432(1.03); C1757(1.08); C1815(1.10)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C1069(1.07)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C1069(1.01)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C1069(0.96)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C1069(0.96)  LDD0997  [4]
 LDCM0400  CL13 HEK-293T C1307(1.41); C457(0.98); C432(1.11); C1238(1.29)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C432(0.75); C1069(1.05); C1757(1.04)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C1820(0.96)  LDD1606  [12]
 LDCM0403  CL16 PaTu 8988t C1472(1.18); C1797(0.90)  LDD1282  [4]
 LDCM0404  CL17 PaTu 8988t C1472(1.23); C1797(0.92)  LDD1283  [4]
 LDCM0405  CL18 PaTu 8988t C1472(1.49); C1797(1.09)  LDD1284  [4]
 LDCM0406  CL19 PaTu 8988t C1472(1.12); C1797(1.16)  LDD1285  [4]
 LDCM0407  CL2 HEK-293T C432(0.98); C1069(1.16); C1757(0.98)  LDD1611  [12]
 LDCM0408  CL20 PaTu 8988t C1472(1.19); C1797(1.18)  LDD1287  [4]
 LDCM0409  CL21 PaTu 8988t C1472(1.43); C1797(1.05)  LDD1288  [4]
 LDCM0410  CL22 PaTu 8988t C1472(1.61); C1797(1.15)  LDD1289  [4]
 LDCM0411  CL23 PaTu 8988t C1472(1.46); C1797(1.27)  LDD1290  [4]
 LDCM0412  CL24 PaTu 8988t C1472(1.36); C1797(0.95)  LDD1291  [4]
 LDCM0413  CL25 PaTu 8988t C1472(1.49); C1797(1.10)  LDD1292  [4]
 LDCM0414  CL26 PaTu 8988t C1472(1.33); C1797(1.18)  LDD1293  [4]
 LDCM0415  CL27 PaTu 8988t C1472(1.66); C1797(0.99)  LDD1294  [4]
 LDCM0416  CL28 PaTu 8988t C1472(1.24); C1797(1.17)  LDD1295  [4]
 LDCM0417  CL29 PaTu 8988t C1472(1.25); C1797(1.13)  LDD1296  [4]
 LDCM0418  CL3 HEK-293T C1820(0.80)  LDD1622  [12]
 LDCM0419  CL30 PaTu 8988t C1472(1.45); C1797(1.25)  LDD1298  [4]
 LDCM0420  CL31 HEK-293T C1472(0.95)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C1472(0.94)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C1472(0.81)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C1472(0.92)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C1472(0.90)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C1472(0.88)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C1472(1.01)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C1472(1.03)  LDD1026  [4]
 LDCM0429  CL4 HEK-293T C457(0.97); C432(1.03); C1757(0.97); C1815(1.46)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C1472(0.90)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C1472(0.92)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C1472(0.95)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C1472(0.93)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C1472(0.97)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C1472(0.89)  LDD1033  [4]
 LDCM0436  CL46 HEK-293T C1472(0.83)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C1472(0.83)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C1472(0.84)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C1472(0.86)  LDD1037  [4]
 LDCM0440  CL5 HEK-293T C457(1.13); C1069(1.28); C1757(1.03); C1820(1.11)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C1472(1.20)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C1472(0.99)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C1472(1.00)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C1472(0.82)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C1472(0.91)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C1472(0.85)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C1472(0.96)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C1472(0.99)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C1472(1.38)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C1472(1.15)  LDD1048  [4]
 LDCM0451  CL6 HEK-293T C457(1.30); C432(1.01)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C1472(0.98)  LDD1050  [4]
 LDCM0453  CL61 HEK-293T C1472(1.11)  LDD1051  [4]
 LDCM0454  CL62 HEK-293T C1472(0.99)  LDD1052  [4]
 LDCM0455  CL63 HEK-293T C1472(0.96)  LDD1053  [4]
 LDCM0456  CL64 HEK-293T C1472(1.13)  LDD1054  [4]
 LDCM0457  CL65 HEK-293T C1472(1.10)  LDD1055  [4]
 LDCM0458  CL66 HEK-293T C1472(0.98)  LDD1056  [4]
 LDCM0459  CL67 HEK-293T C1472(0.94)  LDD1057  [4]
 LDCM0460  CL68 HEK-293T C1472(1.06)  LDD1058  [4]
 LDCM0461  CL69 HEK-293T C1472(0.95)  LDD1059  [4]
 LDCM0462  CL7 HEK-293T C457(1.00); C1069(0.96); C1472(1.07); C1815(0.58)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C1472(0.92)  LDD1061  [4]
 LDCM0464  CL71 HEK-293T C1472(1.04)  LDD1062  [4]
 LDCM0465  CL72 HEK-293T C1472(0.95)  LDD1063  [4]
 LDCM0466  CL73 HEK-293T C1472(1.15)  LDD1064  [4]
 LDCM0467  CL74 HEK-293T C1472(0.98)  LDD1065  [4]
 LDCM0469  CL76 HEK-293T C1472(0.97)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C1472(1.05)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C1472(1.02)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C1472(1.09)  LDD1070  [4]
 LDCM0473  CL8 HEK-293T C1307(1.17); C457(1.37); C432(0.85); C1238(1.90)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C1472(1.24)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C1472(1.01)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C1472(0.93)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C1472(0.90)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C1472(1.33)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C1472(1.17)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C1472(1.14)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C1472(1.23)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C1472(1.32)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C1472(1.30)  LDD1081  [4]
 LDCM0484  CL9 HEK-293T C457(1.29); C1238(1.11)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C1472(1.28)  LDD1083  [4]
 LDCM0486  CL91 PaTu 8988t C1472(1.05)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C1472(0.98)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C1472(1.16)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C1472(1.12)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C1472(1.73)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C1472(1.15)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C1472(1.10)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C1472(1.34)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C1472(1.08)  LDD1373  [4]
 LDCM0495  E2913 HEK-293T C1820(0.80)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C457(1.19)  LDD1702  [13]
 LDCM0468  Fragment33 HEK-293T C1472(0.88)  LDD1066  [4]
 LDCM0427  Fragment51 HEK-293T C1472(0.91)  LDD1025  [4]
 LDCM0022  KB02 HEK-293T C432(0.98); C1472(0.90); C1238(1.00); C1131(0.99)  LDD1492  [12]
 LDCM0023  KB03 Jurkat C1238(45.89)  LDD0209  [14]
 LDCM0024  KB05 COLO792 C881(1.74); C848(2.38)  LDD3310  [15]

References

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Mass spectrometry data entry: PXD028270
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
14 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840