Details of the Target

General Information of Target

Target ID LDTP06185
Target Name Disco-interacting protein 2 homolog A (DIP2A)
Gene Name DIP2A
Gene ID 23181
Synonyms
C21orf106; DIP2; KIAA0184; Disco-interacting protein 2 homolog A; DIP2 homolog A; EC 6.2.1.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADRGCPLEAAPLPAEVRESLAELELELSEGDITQKGYEKKRAKLLARYIPLIQGIDPSL
QAENRIPGPSQTTAAAPKQQKSRPTASRDERFRSDVHTEAVQAALAKYKERKMPMPSKRR
SVLVHSSVETYTPPDTSSASEDEGSLRRPGRLTSTPLQSHSSVEPWLDRVIQGSSTSSSA
SSTSSHPGGRPTTAPSAAATPGAAATTALAGLEAHTHIDLHSAPPDVTTGLVEHSYFERP
QVASVRSVPRGCSGSMLETADGVPVNSRVSSKIQQLLNTLKRPKRPPLKEFFVDDFEELL
EVQQPDPNQPKPEGSETSVLRGEPLTAGVPRPPSLLATLQRWGTTQPKSPCLTALDTTGK
AVYTLTYGKLWSRSLKLAYTLLNKLTSKNEPLLKPGDRVALVFPNSDPVMFMVAFYGCLL
AELVPVPIEVPLTRKDAGSQQVGFLLGSCGVFLALTTDACQKGLPKAQTGEVAAFKGWPP
LSWLVIDGKHLAKPPKDWHPLAQDTGTGTAYIEYKTSKEGSTVGVTVSHASLLAQCRALT
QACGYSEAETLTNVLDFKRDAGLWHGVLTSVMNRMHVVSVPYALMKANPLSWIQKVCFYK
ARAALVKSRDMHWSLLAQRGQRDVSLSSLRMLIVADGANPWSISSCDAFLNVFQSRGLRP
EVICPCASSPEALTVAIRRPPDLGGPPPRKAVLSMNGLSYGVIRVDTEEKLSVLTVQDVG
QVMPGANVCVVKLEGTPYLCKTDEVGEICVSSSATGTAYYGLLGITKNVFEAVPVTTGGA
PIFDRPFTRTGLLGFIGPDNLVFIVGKLDGLMVTGVRRHNADDVVATALAVEPMKFVYRG
RIAVFSVTVLHDDRIVLVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTL
PKAPLGGIHISETKQRFLEGTLHPCNVLMCPHTCVTNLPKPRQKQPEVGPASMIVGNLVA
GKRIAQASGRELAHLEDSDQARKFLFLADVLQWRAHTTPDHPLFLLLNAKGTVTSTATCV
QLHKRAERVAAALMEKGRLSVGDHVALVYPPGVDLIAAFYGCLYCGCVPVTVRPPHPQNL
GTTLPTVKMIVEVSKSACVLTTQAVTRLLRSKEAAAAVDIRTWPTILDTDDIPKKKIASV
FRPPSPDVLAYLDFSVSTTGILAGVKMSHAATSALCRSIKLQCELYPSRQIAICLDPYCG
LGFALWCLCSVYSGHQSVLVPPLELESNVSLWLSAVSQYKARVTFCSYSVMEMCTKGLGA
QTGVLRMKGVNLSCVRTCMVVAEERPRIALTQSFSKLFKDLGLPARAVSTTFGCRVNVAI
CLQGTAGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVKVIIAHTETKGP
LGDSHLGEIWVSSPHNATGYYTVYGEEALHADHFSARLSFGDTQTIWARTGYLGFLRRTE
LTDASGGRHDALYVVGSLDETLELRGMRYHPIDIETSVIRAHRSIAECAVFTWTNLLVVV
VELDGLEQDALDLVALVTNVVLEEHYLVVGVVVIVDPGVIPINSRGEKQRMHLRDGFLAD
QLDPIYVAYNM
Target Bioclass
Enzyme
Family
DIP2 family
Subcellular location
Cell membrane
Function
Catalyzes the de novo synthesis of acetyl-CoA in vitro. Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission. Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes.
Uniprot ID
Q14689
Ensemble ID
ENST00000400274.5
HGNC ID
HGNC:17217

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.P901S DBIA    Probe Info 
COLO320 SNV: p.T827N DBIA    Probe Info 
DAOY SNV: p.G920W DBIA    Probe Info 
EFO21 SNV: p.G438D DBIA    Probe Info 
HEC1 Deletion: p.G37DfsTer20
SNV: p.I1540V		 DBIA    Probe Info 
HEC1B Deletion: p.G37DfsTer20 .
HS936T SNV: p.A510S DBIA    Probe Info 
IM95 SNV: p.E313D .
JURKAT SNV: p.H1354Y .
KASUMI2 SNV: p.T1018P .
MDAMB231 SNV: p.L918V .
MFE319 SNV: p.T34A; p.L792P .
NCIH2172 SNV: p.D294Y .
NCIH2291 SNV: p.K586N .
NCIH358 Deletion: p.G1456_L1462del DBIA    Probe Info 
PF382 SNV: p.V1091A .
RAMOS SNV: p.R373Q .
SNGM SNV: p.A583V; p.W1206L DBIA    Probe Info 
SUPT1 SNV: p.G150R .
TC71 SNV: p.R1341C DBIA    Probe Info 
TE11 SNV: p.P395H .
TOV21G SNV: p.A638S; p.L1231M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K1036(8.33); K281(10.00)  LDD0277  [1]
AHL-Pu-1
 Probe Info  		C6(2.04)  LDD0173  [2]
DBIA
 Probe Info  		C252(0.75)  LDD0531  [3]
IA-alkyne
 Probe Info  		C1098(0.00); C351(0.00); C891(0.00)  LDD0162  [4]
IPM
 Probe Info  		N.A.  LDD0025  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
VSF
 Probe Info  		N.A.  LDD0007  [6]
W1
 Probe Info  		N.A.  LDD0236  [7]
m-APA
 Probe Info  		N.A.  LDD0404  [8]
NAIA_5
 Probe Info  		C536(0.00); C1019(0.00); C891(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C6(2.04)  LDD0173  [2]
 LDCM0214  AC1 HCT 116 C252(0.75)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C1183(0.85)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C930(0.89); C934(0.89)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C930(0.93); C934(0.93)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C930(0.92); C934(0.92)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C930(0.94); C934(0.94)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C930(1.00); C934(1.00)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C930(0.98); C934(0.98)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C930(1.10); C934(1.10)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C930(0.97); C934(0.97)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C930(0.90); C934(0.90)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C930(0.98); C934(0.98)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C1183(0.91)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C930(0.96); C934(0.96)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C930(1.32); C934(1.32)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C930(1.28); C934(1.28)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C1183(0.91); C252(0.97); C930(0.97); C934(0.97)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C1183(0.98); C252(1.01); C930(0.97); C934(0.91)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C1183(0.99); C252(0.98); C930(1.15); C934(1.12)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C1183(1.02); C252(1.15); C930(1.08); C934(1.06)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C1183(0.85); C252(0.95); C930(0.97); C934(0.91)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C1183(1.30); C252(0.92); C930(1.12); C934(1.03)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C1183(1.00); C252(1.05); C930(1.02); C934(0.90)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C1183(1.01)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C1183(0.84); C252(1.13); C930(1.16); C934(0.95)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C1183(1.05); C252(1.07); C930(0.99); C934(0.96)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C1183(0.86); C252(1.21); C930(1.07); C934(0.99)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C1183(0.76); C252(0.93); C930(1.06); C934(1.04)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C1183(0.96); C252(1.01); C930(1.01); C934(0.89)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C1183(0.89); C252(1.34); C930(1.22); C934(0.95)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C1183(1.04); C252(1.09); C930(1.20); C934(0.97)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C1183(0.92); C252(1.06); C930(1.20); C934(1.00)  LDD0562  [3]
 LDCM0246  AC128 HEK-293T C543(1.06); C666(0.82)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C543(0.71); C666(0.58)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C543(0.64); C666(0.84)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C543(1.04); C666(1.02)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C543(0.79); C666(1.09)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C543(0.39); C666(0.67)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C543(0.58); C666(0.71)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C543(0.54); C666(0.71)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C543(0.55); C666(0.83)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C543(0.21); C666(0.75)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C543(0.12); C666(0.80)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C543(0.22); C666(0.83)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C1183(1.06)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C543(0.44); C666(0.82)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C543(0.24); C666(0.71)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C543(0.36); C666(0.78)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C666(0.98)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C666(0.91)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C666(1.09)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C666(0.96)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C666(1.10)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C666(1.21)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C666(0.87)  LDD0867  [3]
 LDCM0270  AC15 HCT 116 C1183(0.72)  LDD0587  [3]
 LDCM0271  AC150 HEK-293T C666(0.84)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C666(0.80)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C666(0.89)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C666(0.90)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C666(1.00)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C666(0.80)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C666(0.99)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C666(1.05)  LDD2165  [3]
 LDCM0276  AC17 HCT 116 C1183(0.82)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C1183(0.72)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C1183(0.69)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C252(0.86)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C1183(0.93)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C1183(0.97)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C1183(1.15)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C1183(0.89)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C1183(0.83)  LDD0601  [3]
 LDCM0285  AC25 PaTu 8988t C543(0.81); C252(0.72)  LDD1164  [3]
 LDCM0286  AC26 PaTu 8988t C543(0.59); C252(0.92)  LDD1165  [3]
 LDCM0287  AC27 PaTu 8988t C543(0.64); C252(1.13)  LDD1166  [3]
 LDCM0288  AC28 PaTu 8988t C543(0.55); C252(1.05)  LDD1167  [3]
 LDCM0289  AC29 PaTu 8988t C543(0.53); C252(1.04)  LDD1168  [3]
 LDCM0290  AC3 HCT 116 C252(0.74)  LDD0607  [3]
 LDCM0291  AC30 PaTu 8988t C543(0.69); C252(0.98)  LDD1170  [3]
 LDCM0292  AC31 PaTu 8988t C543(0.81); C252(0.69)  LDD1171  [3]
 LDCM0293  AC32 PaTu 8988t C543(0.68); C252(0.88)  LDD1172  [3]
 LDCM0294  AC33 PaTu 8988t C543(0.54); C252(0.99)  LDD1173  [3]
 LDCM0295  AC34 PaTu 8988t C543(0.73); C252(1.42)  LDD1174  [3]
 LDCM0296  AC35 HCT 116 C1183(0.99)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C1183(0.82)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C1183(0.76)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C1183(0.72)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C1183(0.80)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C252(0.75)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C1183(1.07)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C1183(1.11)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C1183(0.84)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C1183(0.86)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C1183(0.96)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C1183(0.82)  LDD0624  [3]
 LDCM0308  AC46 HEK-293T C666(1.04)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C666(0.98)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C666(0.96)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C666(0.92)  LDD0909  [3]
 LDCM0312  AC5 HCT 116 C252(0.73)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C666(0.96)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C666(0.86)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C666(1.03)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C666(1.00)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C666(0.91)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C666(0.97)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C666(1.05)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C1183(1.25)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C1183(1.29)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C1183(1.61)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C1183(0.85)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C1183(1.32)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C1183(2.14)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C1183(1.71)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C1183(1.35)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C1183(1.59)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C1183(1.36)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C1183(1.24)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C1183(2.24)  LDD0648  [3]
 LDCM0332  AC68 PaTu 8988t C252(0.65)  LDD1211  [3]
 LDCM0333  AC69 PaTu 8988t C252(0.90)  LDD1212  [3]
 LDCM0334  AC7 HCT 116 C1183(0.87)  LDD0651  [3]
 LDCM0335  AC70 PaTu 8988t C252(0.72)  LDD1214  [3]
 LDCM0336  AC71 PaTu 8988t C252(0.72)  LDD1215  [3]
 LDCM0337  AC72 PaTu 8988t C252(0.72)  LDD1216  [3]
 LDCM0338  AC73 PaTu 8988t C252(0.69)  LDD1217  [3]
 LDCM0339  AC74 PaTu 8988t C252(0.71)  LDD1218  [3]
 LDCM0340  AC75 PaTu 8988t C252(0.77)  LDD1219  [3]
 LDCM0341  AC76 PaTu 8988t C252(0.73)  LDD1220  [3]
 LDCM0342  AC77 PaTu 8988t C252(0.68)  LDD1221  [3]
 LDCM0343  AC78 PaTu 8988t C252(0.77)  LDD1222  [3]
 LDCM0344  AC79 PaTu 8988t C252(0.77)  LDD1223  [3]
 LDCM0345  AC8 HCT 116 C1183(0.90)  LDD0662  [3]
 LDCM0346  AC80 PaTu 8988t C252(0.58)  LDD1225  [3]
 LDCM0347  AC81 PaTu 8988t C252(0.67)  LDD1226  [3]
 LDCM0348  AC82 PaTu 8988t C252(0.60)  LDD1227  [3]
 LDCM0349  AC83 HEK-293T C543(1.00)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C543(0.59)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C543(0.78)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C543(0.93)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C543(0.67)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C543(0.64)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C543(0.51)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C543(0.51)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C543(0.78)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C543(0.73)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C543(0.76)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C543(0.48)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C543(0.66)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C543(0.76)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C543(0.09)  LDD0962  [3]
 LDCM0365  AC98 HCT 116 C930(1.04); C934(1.04)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C930(0.97); C934(0.97)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C1183(1.09)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C1183(0.91)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C1183(0.89)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [8]
 LDCM0632  CL-Sc Hep-G2 C6(0.47)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C252(0.82); C6(1.20)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C252(1.26); C6(0.72)  LDD1572  [10]
 LDCM0369  CL100 HCT 116 C252(0.70)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C1183(0.84)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C1183(1.19)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C1183(0.78)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C1183(0.63)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C1183(0.89)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C1183(0.88)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C1183(1.03)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C1183(0.86)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C1183(0.90)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C252(0.94); C6(0.75)  LDD1583  [10]
 LDCM0380  CL110 HCT 116 C1183(1.12)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C1183(0.84)  LDD0698  [3]
 LDCM0382  CL112 PaTu 8988t C543(0.85); C252(1.17)  LDD1261  [3]
 LDCM0383  CL113 PaTu 8988t C543(0.73); C252(0.83)  LDD1262  [3]
 LDCM0384  CL114 PaTu 8988t C543(0.62); C252(0.95)  LDD1263  [3]
 LDCM0385  CL115 PaTu 8988t C543(0.71); C252(0.94)  LDD1264  [3]
 LDCM0386  CL116 PaTu 8988t C543(0.56); C252(0.81)  LDD1265  [3]
 LDCM0387  CL117 HCT 116 C1183(1.57)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C1183(1.16)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C1183(0.77)  LDD0706  [3]
 LDCM0390  CL12 HEK-293T C252(1.18); C6(0.64)  LDD1594  [10]
 LDCM0391  CL120 HCT 116 C1183(0.74)  LDD0708  [3]
 LDCM0392  CL121 HEK-293T C666(1.05)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C666(0.98)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C666(1.61)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C666(0.99)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C1183(1.34)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C1183(0.84)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C1183(1.23)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C1183(2.08)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C252(1.12); C6(1.11)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C252(1.09); C6(1.15)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C252(1.11); C6(1.02)  LDD1606  [10]
 LDCM0403  CL16 PaTu 8988t C543(0.91)  LDD1282  [3]
 LDCM0404  CL17 HCT 116 C1183(0.87)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C1183(1.13)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C1183(0.78)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C252(0.98); C6(1.07)  LDD1611  [10]
 LDCM0408  CL20 HCT 116 C1183(0.82)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C1183(0.96)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C1183(0.65)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C1183(0.85)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C1183(0.91)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C1183(1.01)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C1183(0.98)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C1183(0.79)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C1183(0.94)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C1183(0.78)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C252(1.12); C6(0.93)  LDD1622  [10]
 LDCM0419  CL30 HCT 116 C1183(0.98)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C1183(0.69); C252(1.07)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C252(0.85)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C252(1.25)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C252(1.08)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C252(0.97)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C252(0.79)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C252(0.80)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C252(0.74)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C252(1.06); C6(0.96)  LDD1633  [10]
 LDCM0430  CL40 HCT 116 C252(0.75)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C252(0.83)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C252(0.95)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C252(0.89)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C252(1.04)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C252(0.79)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C666(1.00)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C666(0.95)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C666(0.99)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C666(0.88)  LDD1037  [3]
 LDCM0440  CL5 HEK-293T C252(1.21); C6(1.00)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C666(1.06)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C666(1.00)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C666(1.02)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C666(1.03)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C666(1.09)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C666(1.02)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C666(1.11)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C666(1.28)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C666(1.14)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C666(0.93)  LDD1048  [3]
 LDCM0451  CL6 HEK-293T C252(0.89); C6(1.09)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C666(1.17)  LDD1050  [3]
 LDCM0453  CL61 HCT 116 C930(0.87); C934(0.87)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C930(0.94); C934(0.94)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C930(1.12); C934(1.12)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C930(0.89); C934(0.89)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C930(0.79); C934(0.79)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C930(0.90); C934(0.90)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C930(0.76); C934(0.76)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C930(0.80); C934(0.80)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C930(1.02); C934(1.02)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C252(0.94); C6(0.93)  LDD1665  [10]
 LDCM0463  CL70 HCT 116 C930(1.12); C934(1.12)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C930(1.03); C934(1.03)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C930(0.95); C934(0.95)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C930(0.97); C934(0.97)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C930(0.93); C934(0.93)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C252(0.89); C930(0.77); C934(0.77)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C252(0.68); C930(0.66); C934(0.66)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C252(1.07); C930(0.79); C934(0.79)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C252(0.89); C930(1.03); C934(1.03)  LDD0789  [3]
 LDCM0473  CL8 HEK-293T C252(0.84); C6(1.56)  LDD1676  [10]
 LDCM0474  CL80 HCT 116 C252(0.85); C930(1.18); C934(1.18)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C252(1.23); C930(1.21); C934(1.21)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C252(0.86); C930(1.02); C934(1.02)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C252(0.87); C930(1.00); C934(1.00)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C252(1.11); C930(1.06); C934(1.06)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C252(1.67); C930(1.16); C934(1.16)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C252(1.03); C930(1.02); C934(1.02)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C252(0.97); C930(0.86); C934(0.86)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C252(0.86); C930(0.73); C934(0.73)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C252(0.74); C930(0.87); C934(0.87)  LDD0800  [3]
 LDCM0484  CL9 HEK-293T C252(0.74); C6(1.05)  LDD1687  [10]
 LDCM0485  CL90 HCT 116 C252(1.18); C930(0.99); C934(0.99)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C252(0.86)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C252(0.94)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C252(0.88)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C252(0.75)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C252(0.98)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C252(0.75)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C252(0.87)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C252(1.04)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C252(0.91)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C252(1.13); C6(1.27)  LDD1698  [10]
 LDCM0468  Fragment33 HCT 116 C930(1.04); C934(1.04)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C252(0.83)  LDD0744  [3]
 LDCM0022  KB02 HEK-293T C1176(0.72); C252(1.07); C6(0.94)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C1176(1.00); C252(1.09); C6(1.01)  LDD1497  [10]
 LDCM0024  KB05 COLO792 C1274(2.26)  LDD3310  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) Protein-tyrosine phosphatase family P26045
E3 ubiquitin-protein ligase TRIM39 (TRIM39) TRIM/RBCC family Q9HCM9
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 43 (ZBTB43) Krueppel C2H2-type zinc-finger protein family O43298
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transforming growth factor beta-1 proprotein (TGFB1) TGF-beta family P01137
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-10 (ATXN10) Ataxin-10 family Q9UBB4
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Proteasome activator complex subunit 3 (PSME3) PA28 family P61289
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Centrosomal protein of 44 kDa (CEP44) . Q9C0F1
Follistatin (FST) . P19883
Follistatin-related protein 1 (FSTL1) . Q12841
G patch domain-containing protein 2-like (GPATCH2L) . Q9NWQ4
IQ motif and ubiquitin-like domain-containing protein (IQUB) . Q8NA54
SH3 and cysteine-rich domain-containing protein 3 (STAC3) . Q96MF2
Vinexin (SORBS3) . O60504

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840