Details of the Target

General Information of Target

Target ID LDTP04210
Target Name Casein kinase I isoform delta (CSNK1D)
Gene Name CSNK1D
Gene ID 1453
Synonyms
HCKID; Casein kinase I isoform delta; CKI-delta; CKId; EC 2.7.11.1; Tau-protein kinase CSNK1D; EC 2.7.11.26
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQ
GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRA
ADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPV
SGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
Target Type
Preclinical
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily
Subcellular location
Cytoplasm
Function
Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.
TTD ID
T87109
Uniprot ID
P48730
DrugMap ID
TTH30UI
Ensemble ID
ENST00000314028.11
HGNC ID
HGNC:2452
ChEMBL ID
CHEMBL2828

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL33 SNV: p.R160S .
CAL72 SNV: p.G336V .
HCT15 SNV: p.A36V .
HT SNV: p.L252P .
MCC13 Substitution: p.S283F .
MFE319 SNV: p.G12D .
MOLT4 SNV: p.E339K IA-alkyne    Probe Info 
NCIH1993 SNV: p.A300P ATP probe    Probe Info 
SNU1 SNV: p.N123S .
TC71 SNV: p.R367L .
UACC257 SNV: p.A304V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C241(0.81)  LDD2109  [2]
AHL-Pu-1
 Probe Info  		C241(6.41)  LDD0172  [3]
DBIA
 Probe Info  		C255(0.81)  LDD0531  [4]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C255(0.00); C241(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
ATP probe
 Probe Info  		N.A.  LDD0035  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C241(6.41)  LDD0172  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C241(4.40)  LDD0173  [3]
 LDCM0214  AC1 HCT 116 C255(0.81)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C255(0.97)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C255(0.59)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C255(0.54)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C255(0.69)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C255(0.65)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C255(0.72)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C255(0.60)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C255(0.60)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C255(0.60)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C255(0.75)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C255(0.86)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C255(0.76)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C255(0.67)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C255(0.71)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C255(0.68)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C255(1.04)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C255(0.90)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C255(0.94)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C255(0.99)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C255(1.13)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C255(0.97)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C255(0.87)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C255(0.81)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C255(1.02)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C255(1.14)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C255(1.02)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C255(1.19)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C255(1.02)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C255(0.98)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C255(1.00)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C255(1.01)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C255(1.13)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C255(1.01)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C255(0.71)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C255(1.52)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C255(0.55)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C255(0.59)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C255(0.71)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C255(0.59)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C255(0.56)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C255(0.66)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C255(0.94)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C255(0.53)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C255(1.25)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C255(0.49)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C255(0.59)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C255(0.61)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C255(1.25)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C255(1.00)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C255(1.09)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C255(1.00)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C255(1.07)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C255(0.56)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C255(0.77)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C255(0.84)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C255(1.07)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C255(0.94)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C255(0.86)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C255(0.58)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C255(1.04)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C255(1.05)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C255(1.30)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C255(1.42)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C255(0.85)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C255(1.18)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C255(0.99)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C255(0.82)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C255(0.97)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C255(1.26)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C255(1.01)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C255(1.06)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C255(1.21)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C255(0.83)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C255(0.82)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C255(0.77)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C255(0.75)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C255(0.64)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C255(0.75)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C255(0.78)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C255(0.73)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C255(0.61)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C255(0.89)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C255(0.83)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C255(0.71)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C255(0.68)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C255(0.76)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C255(1.00)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C255(1.05)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C255(0.74)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C255(1.25)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C255(0.83)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C255(1.35)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C255(0.97)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C255(1.20)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C255(1.12)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C255(0.56)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C255(0.62)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C255(0.71)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C255(0.96)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C255(0.67)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C255(0.62)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C255(0.78)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C255(0.96)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C255(1.14)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C255(0.68)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C255(1.16)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C255(0.87)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C255(0.72)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C255(1.10)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C255(0.74)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C255(0.89)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C255(0.75)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C255(0.64)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C255(0.65)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C255(0.74)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C255(0.64)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C255(0.52)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C255(0.79)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C255(0.51)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C255(0.92)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C255(0.99)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C255(0.86)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C255(0.43)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C255(0.83)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C255(0.76)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C255(0.42)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C255(0.65)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C255(0.52)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C255(0.69)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C255(0.81)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C255(0.74)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C255(0.77)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C255(0.82)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C255(0.67)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C255(0.90)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C255(0.45)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C255(0.51)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C255(0.60)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C255(0.58)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C255(0.74)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C255(0.74)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C255(0.79)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C255(0.78)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C255(0.77)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C255(0.55)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C255(0.53)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C255(0.76)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C255(0.76)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C255(0.79)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C255(0.68)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C255(0.58)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C255(0.36)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C255(0.72)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C255(0.73)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C255(0.77)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C255(0.61)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 13.76  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C255(0.81)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C255(0.47)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C255(0.67)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C255(1.14)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C255(1.19)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C255(1.11)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C255(1.03)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C255(0.98)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C255(1.26)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C255(1.15)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C255(0.87)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C255(1.24)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C255(0.40)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C255(0.80)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C255(0.81)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C255(0.81)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C255(0.72)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C255(0.67)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C255(0.72)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C255(0.75)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C255(1.28)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C255(0.75)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C255(0.63)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C255(0.34)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C255(0.83)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C255(0.88)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C255(0.83)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C255(0.69)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C255(0.73)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C255(0.65)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C255(1.29)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C255(0.98)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C255(0.74)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C255(0.94)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C255(0.89)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C255(0.78)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C255(0.92)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C255(0.83)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C255(0.86)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C255(0.73)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C255(0.87)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C255(0.75)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C255(0.66)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C255(0.74)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C255(1.49)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C255(0.65)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C255(0.63)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C255(0.95)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C255(0.69)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C255(0.75)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C255(0.76)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C255(0.81)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C255(1.09)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C255(0.99)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C255(1.10)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C255(0.96)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C255(0.71)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C255(1.13)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C255(0.80)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C255(0.77)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C255(0.83)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C255(0.83)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C255(0.77)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C255(1.17)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C255(0.55)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C255(0.87)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C255(1.03)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C255(0.93)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C255(0.78)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C255(0.84)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C255(0.99)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C255(0.86)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C255(0.92)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C255(1.08)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C255(0.76)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C255(0.76)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C255(1.42)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C255(1.09)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C255(1.12)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C255(1.34)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C255(1.26)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C255(1.42)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C255(1.16)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C255(0.70)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C255(0.78)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C255(0.71)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C255(0.78)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C255(0.81)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C255(0.79)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C255(1.01)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C255(0.71)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C255(1.14)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C255(0.99)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C255(0.87)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C255(0.42)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C255(0.65)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C255(0.81)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C255(0.93)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C255(1.27)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C255(1.15)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C255(0.79)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C255(1.52)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C255(0.63)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C255(0.66)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C255(0.93)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C255(0.86)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C255(0.66)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C255(0.37)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C255(0.49)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C255(0.30)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C255(0.65)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C255(0.69)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C255(0.50)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C255(0.50)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C255(0.20)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C255(0.78)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C255(0.58)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C255(0.65)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C255(0.74)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C255(0.99)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C255(0.80)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C255(0.63)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C255(0.71)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C255(0.79)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C255(0.63)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C255(0.72)  LDD0811  [4]
 LDCM0468  Fragment33 HCT 116 C255(0.81)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C255(0.75)  LDD0744  [4]
 LDCM0022  KB02 Hs 936.T C255(2.02)  LDD2363  [10]
 LDCM0023  KB03 Hs 936.T C255(5.23)  LDD2780  [10]
 LDCM0024  KB05 COLO792 C255(2.89)  LDD3310  [10]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C241(0.81)  LDD2109  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C241(1.10)  LDD2127  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C241(1.24)  LDD2136  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Superoxide dismutase [Cu-Zn] (SOD1) Cu-Zn superoxide dismutase family P00441
Palmitoyltransferase ZDHHC17 (ZDHHC17) DHHC palmitoyltransferase family Q8IUH5
E3 ubiquitin-protein ligase Mdm2 (MDM2) MDM2/MDM4 family Q00987
Phospholipid phosphatase 1 (PLPP1) PA-phosphatase related phosphoesterase family O14494
Transmembrane protease serine 4 (TMPRSS4) Peptidase S1 family Q9NRS4
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) AGC Ser/Thr protein kinase family P17612
Beta-adrenergic receptor kinase 1 (GRK2) AGC Ser/Thr protein kinase family P25098
MAP/microtubule affinity-regulating kinase 4 (MARK4) CAMK Ser/Thr protein kinase family Q96L34
Mitogen-activated protein kinase 14 (MAPK14) CMGC Ser/Thr protein kinase family Q16539
Serine/threonine-protein kinase PAK 5 (PAK5) STE Ser/Thr protein kinase family Q9P286
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
TGF-beta receptor type-2 (TGFBR2) TKL Ser/Thr protein kinase family P37173
Transcription initiation factor IIB (GTF2B) TFIIB family Q00403
E3 ubiquitin-protein ligase TRIM9 (TRIM9) TRIM/RBCC family Q9C026
Tripartite motif-containing protein 3 (TRIM3) TRIM/RBCC family O75382
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Calcium homeostasis modulator protein 1 (CALHM1) CALHM family Q8IU99
Caveolin-1 (CAV1) Caveolin family Q03135
Scavenger receptor class B member 1 (SCARB1) CD36 family Q8WTV0
Gap junction alpha-1 protein (GJA1) Connexin family P17302
Huntingtin (HTT) Huntingtin family P42858
Protein S100-B (S100B) S-100 family P04271
Alpha-synuclein (SNCA) Synuclein family P37840
Prosaposin (PSAP) . P07602
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mothers against decapentaplegic homolog 3 (SMAD3) Dwarfin/SMAD family P84022
Zinc finger protein Eos (IKZF4) Ikaros C2H2-type zinc-finger protein family Q9H2S9
Zinc finger protein 618 (ZNF618) Krueppel C2H2-type zinc-finger protein family Q5T7W0
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Brevican core protein (BCAN) Aggrecan/versican proteoglycan family Q96GW7
Other
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Protein Dr1 (DR1) NC2 beta/DR1 family Q01658
UV excision repair protein RAD23 homolog A (RAD23A) RAD23 family P54725
RNA-binding protein FUS (FUS) RRM TET family P35637
Corticoliberin (CRH) Sauvagine/corticotropin-releasing factor/urotensin I family P06850
Serpin H1 (SERPINH1) Serpin family P50454
U3 small nucleolar RNA-associated protein 14 homolog A (UTP14A) UTP14 family Q9BVJ6
Amyloid protein-binding protein 2 (APPBP2) . Q92624
Aspartate-rich protein 1 (DRICH1) . Q6PGQ1
Chromobox protein homolog 5 (CBX5) . P45973
Ecotropic viral integration site 5 protein homolog (EVI5) . O60447
Endoplasmic reticulum resident protein 44 (ERP44) . Q9BS26
General transcription factor 3C polypeptide 3 (GTF3C3) . Q9Y5Q9
Leucine rich adaptor protein 1 (LURAP1) . Q96LR2
PAX-interacting protein 1 (PAXIP1) . Q6ZW49
Period circadian protein homolog 2 (PER2) . O15055
TAR DNA-binding protein 43 (TARDBP) . Q13148

The Drug(s) Related To This Target

Preclinical
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
D-4476 Small molecular drug D00JGL
Ic261 Small molecular drug D0UN8H
Pf-4800567 Small molecular drug D06QYR
Pf-670462 Small molecular drug DZK7E0
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid24900428c14 Small molecular drug D0H4VB

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840