Details of the Target

General Information of Target

Target ID LDTP13360
Target Name Methyl-CpG-binding domain protein 1 (MBD1)
Gene Name MBD1
Gene ID 4152
Synonyms
CXXC3; PCM1; Methyl-CpG-binding domain protein 1; CXXC-type zinc finger protein 3; Methyl-CpG-binding protein MBD1; Protein containing methyl-CpG-binding domain 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVDFPGYNLSGAVASFLFILLTMKQSEDFRVIGPAHPILAGVGEDALLTCQLLPKRTTMH
VEVRWYRSEPSTPVFVHRDGVEVTEMQMEEYRGWVEWIENGIAKGNVALKIHNIQPSDNG
QYWCHFQDGNYCGETSLLLKVAGLGSAPSIHMEGPGESGVQLVCTARGWFPEPQVYWEDI
RGEKLLAVSEHRIQDKDGLFYAEATLVVRNASAESVSCLVHNPVLTEEKGSVISLPEKLQ
TELASLKVNGPSQPILVRVGEDIQLTCYLSPKANAQSMEVRWDRSHRYPAVHVYMDGDHV
AGEQMAEYRGRTVLVSDAIDEGRLTLQILSARPSDDGQYRCLFEKDDVYQEASLDLKVVS
LGSSPLITVEGQEDGEMQPMCSSDGWFPQPHVPWRDMEGKTIPSSSQALTQGSHGLFHVQ
TLLRVTNISAVDVTCSISIPFLGEEKIATFSLSESRMTFLWKTLLVWGLLLAVAVGLPRK
RS
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
Uniprot ID
Q9UIS9
Ensemble ID
ENST00000269468.10
HGNC ID
HGNC:6916

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.K359E .
HT115 SNV: p.D358N .
HUPT3 SNV: p.H77L DBIA    Probe Info 
ICC8 SNV: p.V219M DBIA    Probe Info 
IGROV1 SNV: p.R373H DBIA    Probe Info 
LN229 SNV: p.R51Ter DBIA    Probe Info 
MV411 SNV: p.D531H DBIA    Probe Info 
NUGC3 SNV: p.A56V .
OVTOKO SNV: p.G363R DBIA    Probe Info 
OZ SNV: p.A556P DBIA    Probe Info 
PF382 SNV: p.R384Q DBIA    Probe Info 
RPMI8226 SNV: p.K172E DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C274(0.00); C28(0.00)  LDD0241  [1]
DBIA
 Probe Info  		C70(1.30); C57(1.54)  LDD3310  [2]
BTD
 Probe Info  		C28(0.29)  LDD2123  [3]
AHL-Pu-1
 Probe Info  		C57(2.20); C525(2.41); C486(17.57)  LDD0169  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C70(0.00); C28(0.00); C57(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C274(0.00); C28(0.00); C70(0.00); C57(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C274(0.00); C28(0.00); C70(0.00); C57(0.00)  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
TFBX
 Probe Info  		C57(0.00); C28(0.00)  LDD0148  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C28(0.91)  LDD2142  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C57(2.20); C525(2.41); C486(17.57)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C70(0.94); C57(0.97)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C70(1.03); C57(0.99)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C70(1.03); C57(0.96); C377(0.89)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C70(1.18); C57(1.01)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C28(1.08); C57(1.00)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C70(1.28); C525(1.01); C57(1.02); C208(1.05)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C70(0.95); C57(0.97)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C70(1.08); C57(1.03)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C70(1.14); C57(1.00); C377(0.92)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C70(1.06); C57(0.97)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C70(1.12); C57(1.02)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C28(1.03); C525(1.02); C57(1.16)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C28(1.02); C57(1.02)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C70(1.15); C525(0.89); C57(1.02); C208(0.95)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C28(1.00); C70(0.94); C57(1.01); C377(1.09)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C70(1.07); C57(1.01)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C70(1.20); C57(0.91)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C70(0.86); C57(0.96); C377(0.98)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C70(1.02); C57(1.01)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C28(0.99); C525(0.95); C57(1.04)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C70(1.01); C57(1.04); C377(1.16)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C28(1.07); C57(1.08)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C70(1.16); C525(1.02); C57(0.96); C208(1.16)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C28(1.04); C70(1.09); C57(1.18); C377(0.99)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C70(1.06); C57(1.04)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C70(1.25); C57(0.96)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C70(1.08); C57(0.98); C377(0.98)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C70(1.10); C57(1.07)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C28(0.98); C525(1.03); C57(1.25)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C28(1.13); C57(1.01)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C70(1.10); C525(0.90); C57(1.07); C208(0.97)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C70(1.04); C57(1.07)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C28(1.01); C70(1.06); C57(1.06); C377(1.14)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C70(0.98); C57(0.96)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C70(1.08); C57(0.98)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C70(1.07); C57(1.03); C377(1.18)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C70(1.08); C57(1.10)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C28(0.98); C525(0.95); C57(0.99)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C28(1.13); C57(1.01)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C70(1.05); C525(1.01); C57(1.07); C208(0.92)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C28(1.04); C70(1.05); C57(1.08); C377(1.32)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C70(0.98); C57(1.07)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C28(1.00); C525(1.00); C57(1.06)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C70(1.10); C57(1.06)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C70(1.10); C57(0.95); C377(0.93)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C70(1.17); C57(1.05)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C28(0.95); C525(1.06); C57(1.08)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C28(1.08); C57(1.06)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C70(1.23); C525(1.06); C57(0.96); C208(1.12)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C28(1.09); C70(1.18); C57(1.02); C377(1.18)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C70(1.05); C57(0.97)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C70(1.19); C57(1.06)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C70(1.06); C57(1.06); C377(0.90)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C28(1.02); C57(1.06)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C70(1.08); C57(1.02)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C28(1.00); C525(1.09); C57(1.06)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C28(1.05); C57(1.00)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C70(1.17); C525(1.02); C57(1.01); C208(1.06)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C28(1.00); C70(1.10); C57(0.97); C377(0.93)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C70(1.12); C525(0.95); C57(1.01); C208(1.08)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C28(1.03); C70(1.19); C57(1.00); C377(1.11)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C28(0.95); C525(0.99); C57(1.09)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C70(1.00); C57(1.01)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C28(1.09); C70(1.17); C57(1.04); C377(1.07)  LDD1514  [8]
 LDCM0367  CL1 HEK-293T C28(0.90); C70(1.07); C57(0.98); C208(0.92)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C28(0.82); C57(0.91)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C70(1.12); C525(0.87); C57(1.12)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C28(0.99); C70(1.09); C57(1.00); C208(0.78)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C525(1.01); C57(0.90); C208(0.86)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C70(1.16); C57(0.97)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C70(1.12); C525(1.05); C57(0.99)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C28(0.97); C70(1.06); C57(1.01); C208(0.95)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C525(0.94); C57(0.94); C208(0.81)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C70(1.12); C57(1.04)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C70(1.10); C525(1.03); C57(1.03)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C28(0.93); C70(1.03); C57(0.97); C208(0.91)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C70(0.97); C525(1.15); C57(0.96); C208(1.18)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C525(0.92); C57(0.92); C208(0.77)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C70(1.14); C57(0.99)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C70(0.98); C525(1.00); C57(1.07)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C28(1.02); C70(1.01); C57(1.05); C208(0.97)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C525(0.92); C57(0.95); C208(0.83)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C70(1.11); C57(0.99)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C70(1.17); C525(1.03); C57(1.10)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C28(0.97); C70(1.07); C57(1.12); C208(1.03)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C525(1.04); C57(0.96); C208(0.90)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C70(1.22); C57(1.05)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C28(0.91); C70(0.91); C57(1.26); C377(1.36)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C70(1.14); C525(0.99); C57(0.99)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C28(0.97); C70(1.07); C57(1.01); C208(1.05)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C525(1.02); C57(0.94); C208(0.85)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C70(1.04); C57(0.90)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C70(1.06); C525(1.09); C57(1.03)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C28(0.94); C70(1.14); C57(0.98); C208(1.05)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C525(0.97); C57(0.93); C208(0.90)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C70(1.02); C57(1.01)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C70(1.02); C525(1.07); C57(1.02)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C28(0.96); C70(1.20); C57(1.05); C208(1.07)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C525(1.02); C57(1.11); C208(1.07)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C70(1.14); C57(0.91)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C70(1.17); C525(1.11); C57(1.08)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C70(1.01); C57(0.55)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C70(1.27); C57(1.04)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C70(1.06); C57(1.02); C377(1.05)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C525(0.96); C57(1.06); C208(1.01)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C70(1.17); C57(1.13)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C28(0.85); C525(1.08); C57(0.93)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C28(0.98); C57(1.07)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C70(0.97); C525(1.19); C57(1.00); C208(1.00)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C28(1.06); C70(0.91); C57(1.07); C377(1.32)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C28(0.92); C70(1.13); C57(0.97); C208(0.78)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C525(0.96); C57(1.02); C208(0.79)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C70(1.22); C57(1.08)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C70(1.24); C525(1.01); C57(1.14)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C70(1.00); C57(1.03)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C70(1.11); C57(1.03)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C70(1.17); C57(1.07)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C70(0.95); C57(1.05); C377(0.88)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C70(1.17); C57(0.98)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C28(0.90); C525(0.97); C57(0.86)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C28(1.02); C57(0.99)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C70(0.98); C525(0.89); C57(0.96); C208(0.94)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C28(1.04); C70(0.87); C57(1.19); C377(1.07)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C28(0.96); C70(1.16); C57(1.17); C208(0.88)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C70(1.07); C57(0.97)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C70(1.17); C525(0.96); C57(1.08)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C70(1.18); C525(1.04); C57(0.99)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C70(0.85); C57(0.90)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C70(0.97); C57(0.93)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C70(1.05); C57(1.02); C377(1.02)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C70(1.13); C57(0.97)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C28(0.95); C525(0.80); C57(0.94)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C28(1.06); C57(1.01)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C70(0.81); C525(1.15); C57(1.02); C208(1.01)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C28(1.02); C70(0.91); C57(1.23); C377(1.10)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C28(1.00); C70(1.11); C57(1.12); C208(0.95)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C70(1.07); C57(1.02)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C525(1.03); C57(1.01); C208(1.09)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C70(1.08); C525(0.98); C57(1.13)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C70(0.99); C57(0.94)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C70(1.08); C57(0.96)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C70(0.98); C57(1.08); C377(1.13)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C70(1.09); C57(1.04)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C28(0.96); C525(1.07); C57(1.06)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C28(1.10); C57(0.93)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C70(0.85); C525(1.03); C57(1.07); C208(1.09)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C70(1.06); C57(1.00)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C28(1.06); C70(0.84); C57(1.31); C377(1.31)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C28(1.05); C70(1.25); C57(1.11); C208(1.06)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C525(0.95); C57(1.04); C208(0.93)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C70(1.21); C57(1.07)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C70(1.08); C525(0.91); C57(1.15)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C70(1.10); C57(1.01)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C70(1.20); C57(1.05)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C70(1.03); C57(1.05); C377(1.03)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C70(1.09); C57(1.00)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C28(1.01); C525(1.07); C57(1.07)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C70(1.00); C57(1.03); C377(1.05)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C28(1.11); C57(1.08)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C70(0.91); C525(0.99); C57(0.95); C208(1.19)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C28(1.15); C70(0.90); C57(1.17); C377(1.20)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C28(0.96); C70(1.06); C57(0.95); C208(0.87)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C525(0.99); C57(0.99); C208(0.84)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C70(1.19); C525(1.19); C57(1.12)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C70(1.00); C57(0.55)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C70(1.24); C57(1.03)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C70(1.09); C57(1.04); C377(0.90)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C70(0.90); C57(0.80)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C70(1.10); C57(1.05)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C28(1.02); C525(1.12); C57(1.13)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C28(1.04); C57(1.14)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C70(1.04); C525(0.90); C57(0.94); C208(0.92)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C28(1.02); C70(0.84); C57(1.16); C377(0.92)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C28(0.95); C70(1.11); C57(1.12); C208(0.99)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C525(1.19); C57(0.99); C208(1.11)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C70(1.15); C57(1.08)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C70(1.18); C525(0.97); C57(1.03)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C70(1.03); C57(1.05)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C28(0.92); C525(1.11); C57(1.09)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C70(0.99); C57(0.90)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C70(1.13); C57(1.04); C377(1.16)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C70(1.10); C57(0.97)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C28(0.96); C525(0.96); C57(1.06)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C28(1.08); C57(1.04)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C70(1.16); C525(1.12); C57(0.82); C208(0.88)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C28(1.03); C70(0.77); C57(1.22); C377(1.00)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C28(0.93); C70(1.03); C57(0.92); C208(0.92)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C525(0.97); C57(0.99); C208(0.84)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C70(0.97); C57(1.02)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C70(1.20); C57(0.98)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C28(1.09)  LDD1702  [3]
 LDCM0468  Fragment33 HEK-293T C70(1.16); C57(1.05)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C525(0.87); C57(0.98); C208(0.94)  LDD1631  [8]
 LDCM0022  KB02 HEK-293T C70(1.02); C525(0.92); C208(1.18)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C70(1.24); C525(1.08); C208(1.02)  LDD1497  [8]
 LDCM0024  KB05 COLO792 C70(1.30); C57(1.54)  LDD3310  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C28(0.29)  LDD2123  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C28(0.34)  LDD2137  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase SETDB1 (SETDB1) Histone-lysine methyltransferase family Q15047
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) Histone-lysine methyltransferase family O43463
Histone deacetylase 1 (HDAC1) Histone deacetylase family Q13547
Histone deacetylase 2 (HDAC2) Histone deacetylase family Q92769
Histone deacetylase 3 (HDAC3) Histone deacetylase family O15379
E3 SUMO-protein ligase PIAS1 (PIAS1) PIAS family O75925
E3 SUMO-protein ligase PIAS3 (PIAS3) PIAS family Q9Y6X2
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chromatin assembly factor 1 subunit A (CHAF1A) CHAF1A family Q13111
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165
Chromobox protein homolog 5 (CBX5) . P45973
Protein kinase C-binding protein NELL2 (NELL2) . Q99435

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402