Details of the Target

General Information of Target

Target ID LDTP04317
Target Name NADH dehydrogenase flavoprotein 1, mitochondrial (NDUFV1)
Gene Name NDUFV1
Gene ID 4723
Synonyms
UQOR1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NDUFV1; EC 7.1.1.2; Complex I-51kD; CI-51kD; NADH dehydrogenase flavoprotein 1; NADH-ubiquinone oxidoreductase 51 kDa subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLATRRLLGWSLPARVSVRFSGDTTAPKKTSFGSLKDEDRIFTNLYGRHDWRLKGSLSRG
DWYKTKEILLKGPDWILGEIKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEG
EPGTCKDREILRHDPHKLLEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYEAG
LIGKNACGSGYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPT
TVANVETVAVSPTICRRGGTWFAGFGRERNSGTKLFNISGHVNHPCTVEEEMSVPLKELI
EKHAGGVTGGWDNLLAVIPGGSSTPLIPKSVCETVLMDFDALVQAQTGLGTAAVIVMDRS
TDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVRGDARPAEIDSLWEISKQIE
GHTICALGDGAAWPVQGLIRHFRPELEERMQRFAQQHQARQAAS
Target Bioclass
Enzyme
Family
Complex I 51 kDa subunit family
Subcellular location
Mitochondrion inner membrane
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Part of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone. Contains FMN, which is the initial electron acceptor as well as one iron-sulfur cluster.
Uniprot ID
P49821
Ensemble ID
ENST00000322776.11
HGNC ID
HGNC:7716
ChEMBL ID
CHEMBL2363065

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.A462V .
JEKO1 SNV: p.V435M DBIA    Probe Info 
MFE319 Deletion: p.G146AfsTer36 DBIA    Probe Info 
MOLT4 Insertion: p.D403GfsTer27 IA-alkyne    Probe Info 
SG231 SNV: p.Y163H DBIA    Probe Info 
SUPT1 Insertion: p.F229LfsTer73 DBIA    Probe Info 
SW403 SNV: p.R159Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K54(6.90)  LDD0277  [1]
IPM
 Probe Info  		C379(0.00); C125(0.00); C142(0.00); C286(0.00)  LDD0241  [2]
Probe 1
 Probe Info  		Y46(9.25); Y163(11.40)  LDD3495  [3]
BTD
 Probe Info  		C385(0.91); C382(1.01); C379(0.87)  LDD2092  [4]
AHL-Pu-1
 Probe Info  		C206(11.55)  LDD0168  [5]
DBIA
 Probe Info  		C142(11.27)  LDD0209  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C206(0.00); C142(0.00); C187(0.00); C425(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C142(0.00); C425(0.00); C206(0.00); C286(0.00)  LDD0032  [9]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [10]
Lodoacetamide azide
 Probe Info  		C206(0.00); C142(0.00); C187(0.00); C425(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		C125(0.00); C206(0.00)  LDD2226  [11]
Compound 10
 Probe Info  		C125(0.00); C425(0.00)  LDD2216  [12]
Compound 11
 Probe Info  		C125(0.00); C286(0.00); C425(0.00)  LDD2213  [12]
TFBX
 Probe Info  		N.A.  LDD0148  [13]
Phosphinate-6
 Probe Info  		C385(0.00); C238(0.00)  LDD0018  [14]
1c-yne
 Probe Info  		K71(0.00); K302(0.00)  LDD0228  [15]
Acrolein
 Probe Info  		C206(0.00); C142(0.00); C125(0.00); C286(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		C142(0.00); C125(0.00)  LDD0219  [16]
Methacrolein
 Probe Info  		C125(0.00); C142(0.00)  LDD0218  [16]
AOyne
 Probe Info  		4.90  LDD0443  [17]
NAIA_5
 Probe Info  		C142(0.00); C206(0.00); C286(0.00); C255(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		12.54  LDD0471  [18]
FFF probe13
 Probe Info  		5.85  LDD0476  [18]
STS-1
 Probe Info  		N.A.  LDD0136  [19]
STS-2
 Probe Info  		N.A.  LDD0138  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C142(0.37)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C142(0.62); C385(0.91); C382(0.97); C379(0.72)  LDD2112  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C142(0.96)  LDD2152  [4]
 LDCM0025  4SU-RNA HEK-293T C206(11.55)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C238(3.09)  LDD0173  [5]
 LDCM0214  AC1 HCT 116 C238(0.64); C255(0.64)  LDD0531  [20]
 LDCM0215  AC10 HEK-293T C255(0.63)  LDD0813  [20]
 LDCM0216  AC100 HCT 116 C238(2.65); C255(2.65)  LDD0533  [20]
 LDCM0217  AC101 HCT 116 C238(1.10); C255(1.10)  LDD0534  [20]
 LDCM0218  AC102 HCT 116 C238(0.84); C255(0.84)  LDD0535  [20]
 LDCM0219  AC103 HCT 116 C238(0.53); C255(0.53)  LDD0536  [20]
 LDCM0220  AC104 HCT 116 C238(0.72); C255(0.72)  LDD0537  [20]
 LDCM0221  AC105 HCT 116 C238(0.80); C255(0.80)  LDD0538  [20]
 LDCM0222  AC106 HCT 116 C238(0.61); C255(0.61)  LDD0539  [20]
 LDCM0223  AC107 HCT 116 C238(0.52); C255(0.41)  LDD0540  [20]
 LDCM0224  AC108 HCT 116 C238(0.46); C255(0.57)  LDD0541  [20]
 LDCM0225  AC109 HCT 116 C238(1.02); C255(1.14)  LDD0542  [20]
 LDCM0226  AC11 HEK-293T C255(0.83)  LDD0824  [20]
 LDCM0227  AC110 HCT 116 C238(0.68); C255(0.76)  LDD0544  [20]
 LDCM0228  AC111 HCT 116 C238(0.56); C255(0.70)  LDD0545  [20]
 LDCM0229  AC112 HCT 116 C238(0.43); C255(0.45)  LDD0546  [20]
 LDCM0230  AC113 HCT 116 C238(0.86); C255(0.86)  LDD0547  [20]
 LDCM0231  AC114 HCT 116 C238(1.12); C255(1.12)  LDD0548  [20]
 LDCM0232  AC115 HCT 116 C238(0.85); C255(0.85)  LDD0549  [20]
 LDCM0233  AC116 HCT 116 C238(0.70); C255(0.70)  LDD0550  [20]
 LDCM0234  AC117 HCT 116 C238(0.90); C255(0.90)  LDD0551  [20]
 LDCM0235  AC118 HCT 116 C238(0.93); C255(0.93)  LDD0552  [20]
 LDCM0236  AC119 HCT 116 C238(1.08); C255(1.08)  LDD0553  [20]
 LDCM0237  AC12 HEK-293T C255(1.06)  LDD0835  [20]
 LDCM0238  AC120 HCT 116 C238(0.79); C255(0.79)  LDD0555  [20]
 LDCM0239  AC121 HCT 116 C238(0.81); C255(0.81)  LDD0556  [20]
 LDCM0240  AC122 HCT 116 C238(0.85); C255(0.85)  LDD0557  [20]
 LDCM0241  AC123 HCT 116 C238(0.93); C255(0.93)  LDD0558  [20]
 LDCM0242  AC124 HCT 116 C238(1.01); C255(1.01)  LDD0559  [20]
 LDCM0243  AC125 HCT 116 C238(0.98); C255(0.98)  LDD0560  [20]
 LDCM0244  AC126 HCT 116 C238(1.05); C255(1.05)  LDD0561  [20]
 LDCM0245  AC127 HCT 116 C238(1.07); C255(1.07)  LDD0562  [20]
 LDCM0246  AC128 HCT 116 C142(1.09)  LDD0563  [20]
 LDCM0247  AC129 HCT 116 C142(0.93)  LDD0564  [20]
 LDCM0249  AC130 HCT 116 C142(0.97)  LDD0566  [20]
 LDCM0250  AC131 HCT 116 C142(0.96)  LDD0567  [20]
 LDCM0251  AC132 HCT 116 C142(1.59)  LDD0568  [20]
 LDCM0252  AC133 HCT 116 C142(0.92)  LDD0569  [20]
 LDCM0253  AC134 HCT 116 C142(1.60)  LDD0570  [20]
 LDCM0254  AC135 HCT 116 C142(1.04)  LDD0571  [20]
 LDCM0255  AC136 HCT 116 C142(1.06)  LDD0572  [20]
 LDCM0256  AC137 HCT 116 C142(1.04)  LDD0573  [20]
 LDCM0257  AC138 HCT 116 C142(1.21)  LDD0574  [20]
 LDCM0258  AC139 HCT 116 C142(1.17)  LDD0575  [20]
 LDCM0259  AC14 HEK-293T C255(0.74)  LDD0857  [20]
 LDCM0260  AC140 HCT 116 C142(1.26)  LDD0577  [20]
 LDCM0261  AC141 HCT 116 C142(1.09)  LDD0578  [20]
 LDCM0262  AC142 HCT 116 C142(1.10)  LDD0579  [20]
 LDCM0263  AC143 HEK-293T C187(1.03); C238(1.25)  LDD0861  [20]
 LDCM0264  AC144 HEK-293T C187(1.18); C238(1.71)  LDD0862  [20]
 LDCM0265  AC145 HEK-293T C187(1.19); C238(1.56)  LDD0863  [20]
 LDCM0266  AC146 HEK-293T C187(1.38); C238(1.63)  LDD0864  [20]
 LDCM0267  AC147 HEK-293T C187(1.22); C238(1.86)  LDD0865  [20]
 LDCM0268  AC148 HEK-293T C187(1.41); C238(1.68)  LDD0866  [20]
 LDCM0269  AC149 HEK-293T C187(0.70); C238(1.13)  LDD0867  [20]
 LDCM0270  AC15 HEK-293T C255(1.27)  LDD0868  [20]
 LDCM0271  AC150 HEK-293T C187(0.90); C238(1.28)  LDD0869  [20]
 LDCM0272  AC151 HEK-293T C187(1.33); C238(1.38)  LDD0870  [20]
 LDCM0273  AC152 HEK-293T C187(1.21); C238(1.39)  LDD0871  [20]
 LDCM0274  AC153 HEK-293T C187(0.97); C238(1.35)  LDD0872  [20]
 LDCM0621  AC154 HEK-293T C187(0.59); C238(1.24)  LDD2162  [20]
 LDCM0622  AC155 HEK-293T C187(1.00); C238(1.30)  LDD2163  [20]
 LDCM0623  AC156 HEK-293T C187(1.52); C238(1.63)  LDD2164  [20]
 LDCM0624  AC157 HEK-293T C187(1.46); C238(2.05)  LDD2165  [20]
 LDCM0276  AC17 HCT 116 C238(0.71); C255(0.71)  LDD0593  [20]
 LDCM0277  AC18 HCT 116 C238(0.70); C255(0.70)  LDD0594  [20]
 LDCM0278  AC19 HCT 116 C238(1.40); C255(1.40)  LDD0595  [20]
 LDCM0279  AC2 HCT 116 C238(0.72); C255(0.72)  LDD0596  [20]
 LDCM0280  AC20 HCT 116 C238(1.19); C255(1.19)  LDD0597  [20]
 LDCM0281  AC21 HCT 116 C238(1.66); C255(1.66)  LDD0598  [20]
 LDCM0282  AC22 HCT 116 C238(1.36); C255(1.36)  LDD0599  [20]
 LDCM0283  AC23 HCT 116 C238(1.59); C255(1.59)  LDD0600  [20]
 LDCM0284  AC24 HCT 116 C238(1.18); C255(1.18)  LDD0601  [20]
 LDCM0285  AC25 HCT 116 C238(0.88); C255(0.88)  LDD0602  [20]
 LDCM0286  AC26 HCT 116 C238(0.59); C255(0.59)  LDD0603  [20]
 LDCM0287  AC27 HCT 116 C238(0.69); C255(0.69)  LDD0604  [20]
 LDCM0288  AC28 HCT 116 C238(0.64); C255(0.64)  LDD0605  [20]
 LDCM0289  AC29 HCT 116 C238(0.76); C255(0.76)  LDD0606  [20]
 LDCM0290  AC3 HCT 116 C238(0.90); C255(0.90)  LDD0607  [20]
 LDCM0291  AC30 HCT 116 C238(0.65); C255(0.65)  LDD0608  [20]
 LDCM0292  AC31 HCT 116 C238(0.77); C255(0.77)  LDD0609  [20]
 LDCM0293  AC32 HCT 116 C238(0.57); C255(0.57)  LDD0610  [20]
 LDCM0294  AC33 HCT 116 C238(0.68); C255(0.68)  LDD0611  [20]
 LDCM0295  AC34 HCT 116 C238(0.67); C255(0.67)  LDD0612  [20]
 LDCM0296  AC35 HCT 116 C142(0.93); C238(1.22); C255(1.22)  LDD0613  [20]
 LDCM0297  AC36 HCT 116 C142(0.98); C238(1.02); C255(1.02)  LDD0614  [20]
 LDCM0298  AC37 HCT 116 C238(0.91); C255(0.91); C142(1.04)  LDD0615  [20]
 LDCM0299  AC38 HCT 116 C142(1.21); C238(1.31); C255(1.31)  LDD0616  [20]
 LDCM0300  AC39 HCT 116 C238(0.72); C255(0.72); C142(1.00)  LDD0617  [20]
 LDCM0301  AC4 HCT 116 C238(0.57); C255(0.57)  LDD0618  [20]
 LDCM0302  AC40 HCT 116 C238(0.55); C255(0.55); C142(0.93)  LDD0619  [20]
 LDCM0303  AC41 HCT 116 C238(0.76); C255(0.76); C142(1.13)  LDD0620  [20]
 LDCM0304  AC42 HCT 116 C238(0.74); C255(0.74); C142(1.18)  LDD0621  [20]
 LDCM0305  AC43 HCT 116 C238(0.64); C255(0.64); C142(1.23)  LDD0622  [20]
 LDCM0306  AC44 HCT 116 C238(0.66); C255(0.66); C142(1.02)  LDD0623  [20]
 LDCM0307  AC45 HCT 116 C238(0.52); C255(0.52); C142(1.10)  LDD0624  [20]
 LDCM0308  AC46 HCT 116 C238(1.17); C255(1.17)  LDD0625  [20]
 LDCM0309  AC47 HCT 116 C238(1.03); C255(1.03)  LDD0626  [20]
 LDCM0310  AC48 HCT 116 C238(0.86); C255(0.86)  LDD0627  [20]
 LDCM0311  AC49 HCT 116 C238(0.52); C255(0.52)  LDD0628  [20]
 LDCM0312  AC5 HCT 116 C238(0.32); C255(0.32)  LDD0629  [20]
 LDCM0313  AC50 HCT 116 C238(0.66); C255(0.66)  LDD0630  [20]
 LDCM0314  AC51 HCT 116 C238(1.62); C255(1.62)  LDD0631  [20]
 LDCM0315  AC52 HCT 116 C238(1.69); C255(1.69)  LDD0632  [20]
 LDCM0316  AC53 HCT 116 C238(0.98); C255(0.98)  LDD0633  [20]
 LDCM0317  AC54 HCT 116 C238(0.80); C255(0.80)  LDD0634  [20]
 LDCM0318  AC55 HCT 116 C238(0.59); C255(0.59)  LDD0635  [20]
 LDCM0319  AC56 HCT 116 C238(0.19); C255(0.19)  LDD0636  [20]
 LDCM0320  AC57 HCT 116 C238(0.69); C255(0.69)  LDD0637  [20]
 LDCM0321  AC58 HCT 116 C238(0.79); C255(0.79)  LDD0638  [20]
 LDCM0322  AC59 HCT 116 C238(0.59); C255(0.59)  LDD0639  [20]
 LDCM0323  AC6 HEK-293T C255(0.55)  LDD0921  [20]
 LDCM0324  AC60 HCT 116 C238(0.86); C255(0.86)  LDD0641  [20]
 LDCM0325  AC61 HCT 116 C238(0.73); C255(0.73)  LDD0642  [20]
 LDCM0326  AC62 HCT 116 C238(0.61); C255(0.61)  LDD0643  [20]
 LDCM0327  AC63 HCT 116 C238(0.76); C255(0.76)  LDD0644  [20]
 LDCM0328  AC64 HCT 116 C238(0.57); C255(0.57)  LDD0645  [20]
 LDCM0329  AC65 HCT 116 C238(0.56); C255(0.56)  LDD0646  [20]
 LDCM0330  AC66 HCT 116 C238(0.64); C255(0.64)  LDD0647  [20]
 LDCM0331  AC67 HCT 116 C238(0.16); C255(0.16)  LDD0648  [20]
 LDCM0332  AC68 HCT 116 C238(0.66); C255(0.66); C142(1.10)  LDD0649  [20]
 LDCM0333  AC69 HCT 116 C238(0.62); C255(0.62); C142(0.75)  LDD0650  [20]
 LDCM0334  AC7 HEK-293T C255(1.13)  LDD0932  [20]
 LDCM0335  AC70 HCT 116 C238(0.36); C255(0.36); C142(0.54)  LDD0652  [20]
 LDCM0336  AC71 HCT 116 C238(0.72); C255(0.72); C142(0.99)  LDD0653  [20]
 LDCM0337  AC72 HCT 116 C238(0.69); C255(0.69); C142(0.92)  LDD0654  [20]
 LDCM0338  AC73 HCT 116 C238(0.21); C255(0.21); C142(0.30)  LDD0655  [20]
 LDCM0339  AC74 HCT 116 C238(0.24); C255(0.24); C142(0.37)  LDD0656  [20]
 LDCM0340  AC75 HCT 116 C238(0.09); C255(0.09); C142(0.15)  LDD0657  [20]
 LDCM0341  AC76 HCT 116 C238(0.49); C255(0.49); C142(0.65)  LDD0658  [20]
 LDCM0342  AC77 HCT 116 C238(0.51); C255(0.51); C142(0.65)  LDD0659  [20]
 LDCM0343  AC78 HCT 116 C238(0.79); C255(0.79); C142(1.00)  LDD0660  [20]
 LDCM0344  AC79 HCT 116 C238(0.88); C255(0.88); C142(1.01)  LDD0661  [20]
 LDCM0345  AC8 HEK-293T C255(1.05)  LDD0943  [20]
 LDCM0346  AC80 HCT 116 C238(0.60); C255(0.60); C142(0.92)  LDD0663  [20]
 LDCM0347  AC81 HCT 116 C238(0.67); C255(0.67); C142(0.71)  LDD0664  [20]
 LDCM0348  AC82 HCT 116 C238(0.08); C255(0.08); C142(0.16)  LDD0665  [20]
 LDCM0349  AC83 HCT 116 C238(0.55); C255(0.55); C142(0.64)  LDD0666  [20]
 LDCM0350  AC84 HCT 116 C238(0.66); C255(0.66); C142(0.83)  LDD0667  [20]
 LDCM0351  AC85 HCT 116 C238(0.87); C255(0.87); C142(1.15)  LDD0668  [20]
 LDCM0352  AC86 HCT 116 C238(0.84); C255(0.84); C142(1.14)  LDD0669  [20]
 LDCM0353  AC87 HCT 116 C238(1.03); C255(1.03); C142(1.79)  LDD0670  [20]
 LDCM0354  AC88 HCT 116 C238(1.06); C255(1.06); C142(1.12)  LDD0671  [20]
 LDCM0355  AC89 HCT 116 C142(0.70); C238(0.98); C255(0.98)  LDD0672  [20]
 LDCM0357  AC90 HCT 116 C238(1.31); C255(1.31); C142(1.32)  LDD0674  [20]
 LDCM0358  AC91 HCT 116 C238(0.52); C255(0.52); C142(0.68)  LDD0675  [20]
 LDCM0359  AC92 HCT 116 C238(0.72); C255(0.72); C142(1.07)  LDD0676  [20]
 LDCM0360  AC93 HCT 116 C142(0.81); C238(1.24); C255(1.24)  LDD0677  [20]
 LDCM0361  AC94 HCT 116 C238(1.05); C255(1.05); C142(1.65)  LDD0678  [20]
 LDCM0362  AC95 HCT 116 C238(1.05); C255(1.05); C142(1.60)  LDD0679  [20]
 LDCM0363  AC96 HCT 116 C142(0.87); C238(0.95); C255(0.95)  LDD0680  [20]
 LDCM0364  AC97 HCT 116 C142(0.75); C238(0.90); C255(0.90)  LDD0681  [20]
 LDCM0365  AC98 HCT 116 C238(0.04); C255(0.04)  LDD0682  [20]
 LDCM0366  AC99 HCT 116 C238(0.67); C255(0.67)  LDD0683  [20]
 LDCM0520  AKOS000195272 MDA-MB-231 C385(0.71); C379(0.77)  LDD2113  [4]
 LDCM0248  AKOS034007472 HEK-293T C255(0.98)  LDD0846  [20]
 LDCM0356  AKOS034007680 HEK-293T C255(0.76)  LDD0954  [20]
 LDCM0275  AKOS034007705 HEK-293T C255(0.88)  LDD0873  [20]
 LDCM0020  ARS-1620 HCC44 C187(1.00); C142(0.95)  LDD2171  [20]
 LDCM0108  Chloroacetamide HeLa C286(0.00); C142(0.00); C125(0.00); H376(0.00)  LDD0222  [16]
 LDCM0367  CL1 HCT 116 C142(0.87); C238(1.04); C255(1.04)  LDD0684  [20]
 LDCM0368  CL10 HCT 116 C238(0.83); C255(0.83); C142(1.11)  LDD0685  [20]
 LDCM0369  CL100 HCT 116 C238(0.54); C255(0.54)  LDD0686  [20]
 LDCM0370  CL101 HEK-293T C255(0.78)  LDD0968  [20]
 LDCM0371  CL102 HEK-293T C255(0.91)  LDD0969  [20]
 LDCM0372  CL103 HEK-293T C255(0.79)  LDD0970  [20]
 LDCM0373  CL104 HEK-293T C255(0.39)  LDD0971  [20]
 LDCM0374  CL105 HCT 116 C238(0.66); C255(0.66)  LDD0691  [20]
 LDCM0375  CL106 HCT 116 C238(0.54); C255(0.54)  LDD0692  [20]
 LDCM0376  CL107 HCT 116 C238(0.56); C255(0.56)  LDD0693  [20]
 LDCM0377  CL108 HCT 116 C238(0.47); C255(0.47)  LDD0694  [20]
 LDCM0378  CL109 HCT 116 C238(1.04); C255(1.04)  LDD0695  [20]
 LDCM0379  CL11 HCT 116 C238(0.47); C255(0.47); C142(0.78)  LDD0696  [20]
 LDCM0380  CL110 HCT 116 C238(0.90); C255(0.90)  LDD0697  [20]
 LDCM0381  CL111 HCT 116 C238(0.73); C255(0.73)  LDD0698  [20]
 LDCM0382  CL112 HCT 116 C238(0.58); C255(0.58)  LDD0699  [20]
 LDCM0383  CL113 HCT 116 C238(0.86); C255(0.86)  LDD0700  [20]
 LDCM0384  CL114 HCT 116 C238(0.50); C255(0.50)  LDD0701  [20]
 LDCM0385  CL115 HCT 116 C238(0.72); C255(0.72)  LDD0702  [20]
 LDCM0386  CL116 HCT 116 C238(0.54); C255(0.54)  LDD0703  [20]
 LDCM0387  CL117 HCT 116 C238(0.23); C255(0.23); C142(0.85)  LDD0704  [20]
 LDCM0388  CL118 HCT 116 C238(0.84); C255(0.84); C142(1.09)  LDD0705  [20]
 LDCM0389  CL119 HCT 116 C238(0.62); C255(0.62); C142(1.20)  LDD0706  [20]
 LDCM0390  CL12 HCT 116 C238(0.46); C255(0.46); C142(1.02)  LDD0707  [20]
 LDCM0391  CL120 HCT 116 C238(0.75); C255(0.75); C142(0.97)  LDD0708  [20]
 LDCM0392  CL121 HCT 116 C238(0.79); C255(0.79)  LDD0709  [20]
 LDCM0393  CL122 HCT 116 C238(0.76); C255(0.76)  LDD0710  [20]
 LDCM0394  CL123 HCT 116 C238(0.79); C255(0.79)  LDD0711  [20]
 LDCM0395  CL124 HCT 116 C238(0.58); C255(0.58)  LDD0712  [20]
 LDCM0396  CL125 HCT 116 C238(0.72); C255(0.72)  LDD0713  [20]
 LDCM0397  CL126 HCT 116 C238(1.00); C255(1.00)  LDD0714  [20]
 LDCM0398  CL127 HCT 116 C238(0.87); C255(0.87)  LDD0715  [20]
 LDCM0399  CL128 HCT 116 C238(1.00); C255(1.00)  LDD0716  [20]
 LDCM0400  CL13 HCT 116 C238(0.94); C255(0.94); C142(1.08)  LDD0717  [20]
 LDCM0401  CL14 HCT 116 C142(0.98); C238(1.21); C255(1.21)  LDD0718  [20]
 LDCM0402  CL15 HCT 116 C142(0.77); C238(0.91); C255(0.91)  LDD0719  [20]
 LDCM0403  CL16 HCT 116 C238(1.13); C255(1.13)  LDD0720  [20]
 LDCM0404  CL17 HCT 116 C238(0.82); C255(0.82)  LDD0721  [20]
 LDCM0405  CL18 HCT 116 C238(0.80); C255(0.80)  LDD0722  [20]
 LDCM0406  CL19 HCT 116 C238(1.02); C255(1.02)  LDD0723  [20]
 LDCM0407  CL2 HCT 116 C142(0.82); C238(1.39); C255(1.39)  LDD0724  [20]
 LDCM0408  CL20 HCT 116 C238(0.65); C255(0.65)  LDD0725  [20]
 LDCM0409  CL21 HCT 116 C238(0.36); C255(0.36)  LDD0726  [20]
 LDCM0410  CL22 HCT 116 C238(0.13); C255(0.13)  LDD0727  [20]
 LDCM0411  CL23 HCT 116 C238(1.12); C255(1.12)  LDD0728  [20]
 LDCM0412  CL24 HCT 116 C238(0.58); C255(0.58)  LDD0729  [20]
 LDCM0413  CL25 HCT 116 C238(0.56); C255(0.56)  LDD0730  [20]
 LDCM0414  CL26 HCT 116 C238(1.06); C255(1.06)  LDD0731  [20]
 LDCM0415  CL27 HCT 116 C238(0.74); C255(0.74)  LDD0732  [20]
 LDCM0416  CL28 HCT 116 C238(0.61); C255(0.61)  LDD0733  [20]
 LDCM0417  CL29 HCT 116 C238(0.75); C255(0.75)  LDD0734  [20]
 LDCM0418  CL3 HCT 116 C142(1.00); C238(1.03); C255(1.03)  LDD0735  [20]
 LDCM0419  CL30 HCT 116 C238(0.83); C255(0.83)  LDD0736  [20]
 LDCM0420  CL31 HCT 116 C142(0.87)  LDD0737  [20]
 LDCM0421  CL32 HCT 116 C142(1.06)  LDD0738  [20]
 LDCM0422  CL33 HCT 116 C142(0.76)  LDD0739  [20]
 LDCM0423  CL34 HCT 116 C142(0.66)  LDD0740  [20]
 LDCM0424  CL35 HCT 116 C142(0.62)  LDD0741  [20]
 LDCM0425  CL36 HCT 116 C142(0.72)  LDD0742  [20]
 LDCM0426  CL37 HCT 116 C142(0.66)  LDD0743  [20]
 LDCM0428  CL39 HCT 116 C142(0.64)  LDD0745  [20]
 LDCM0429  CL4 HCT 116 C142(0.85); C238(1.21); C255(1.21)  LDD0746  [20]
 LDCM0430  CL40 HCT 116 C142(0.68)  LDD0747  [20]
 LDCM0431  CL41 HCT 116 C142(0.75)  LDD0748  [20]
 LDCM0432  CL42 HCT 116 C142(0.39)  LDD0749  [20]
 LDCM0433  CL43 HCT 116 C142(0.56)  LDD0750  [20]
 LDCM0434  CL44 HCT 116 C142(0.79)  LDD0751  [20]
 LDCM0435  CL45 HCT 116 C142(0.80)  LDD0752  [20]
 LDCM0436  CL46 HEK-293T C206(1.04)  LDD1034  [20]
 LDCM0437  CL47 HEK-293T C206(0.99)  LDD1035  [20]
 LDCM0438  CL48 HEK-293T C206(1.15)  LDD1036  [20]
 LDCM0439  CL49 HEK-293T C206(0.97)  LDD1037  [20]
 LDCM0440  CL5 HCT 116 C142(1.04); C238(1.50); C255(1.50)  LDD0757  [20]
 LDCM0441  CL50 HEK-293T C206(1.39)  LDD1039  [20]
 LDCM0442  CL51 HEK-293T C206(1.16)  LDD1040  [20]
 LDCM0443  CL52 HEK-293T C206(0.88)  LDD1041  [20]
 LDCM0444  CL53 HEK-293T C206(0.95)  LDD1042  [20]
 LDCM0445  CL54 HEK-293T C206(1.21)  LDD1043  [20]
 LDCM0446  CL55 HEK-293T C206(1.23)  LDD1044  [20]
 LDCM0447  CL56 HEK-293T C206(1.19)  LDD1045  [20]
 LDCM0448  CL57 HEK-293T C206(1.16)  LDD1046  [20]
 LDCM0449  CL58 HEK-293T C206(1.05)  LDD1047  [20]
 LDCM0450  CL59 HEK-293T C206(1.42)  LDD1048  [20]
 LDCM0451  CL6 HCT 116 C142(1.03); C238(1.01); C255(1.01)  LDD0768  [20]
 LDCM0452  CL60 HEK-293T C206(1.36)  LDD1050  [20]
 LDCM0453  CL61 HCT 116 C238(1.31); C255(1.31)  LDD0770  [20]
 LDCM0454  CL62 HCT 116 C238(1.54); C255(1.54)  LDD0771  [20]
 LDCM0455  CL63 HCT 116 C238(1.44); C255(1.44)  LDD0772  [20]
 LDCM0456  CL64 HCT 116 C238(1.26); C255(1.26)  LDD0773  [20]
 LDCM0457  CL65 HCT 116 C238(1.31); C255(1.31)  LDD0774  [20]
 LDCM0458  CL66 HCT 116 C238(0.57); C255(0.57)  LDD0775  [20]
 LDCM0459  CL67 HCT 116 C238(0.93); C255(0.93)  LDD0776  [20]
 LDCM0460  CL68 HCT 116 C238(0.63); C255(0.63)  LDD0777  [20]
 LDCM0461  CL69 HCT 116 C238(0.94); C255(0.94)  LDD0778  [20]
 LDCM0462  CL7 HCT 116 C142(1.00); C238(0.69); C255(0.69)  LDD0779  [20]
 LDCM0463  CL70 HCT 116 C238(1.00); C255(1.00)  LDD0780  [20]
 LDCM0464  CL71 HCT 116 C238(0.69); C255(0.69)  LDD0781  [20]
 LDCM0465  CL72 HCT 116 C238(0.90); C255(0.90)  LDD0782  [20]
 LDCM0466  CL73 HCT 116 C238(1.34); C255(1.34)  LDD0783  [20]
 LDCM0467  CL74 HCT 116 C238(1.21); C255(1.21)  LDD0784  [20]
 LDCM0469  CL76 HCT 116 C238(1.33); C255(1.33)  LDD0786  [20]
 LDCM0470  CL77 HCT 116 C238(1.97); C255(1.97)  LDD0787  [20]
 LDCM0471  CL78 HCT 116 C238(1.04); C255(1.04)  LDD0788  [20]
 LDCM0472  CL79 HCT 116 C238(0.82); C255(0.82)  LDD0789  [20]
 LDCM0473  CL8 HCT 116 C142(1.03); C238(0.44); C255(0.44)  LDD0790  [20]
 LDCM0474  CL80 HCT 116 C238(1.20); C255(1.20)  LDD0791  [20]
 LDCM0475  CL81 HCT 116 C238(0.83); C255(0.83)  LDD0792  [20]
 LDCM0476  CL82 HCT 116 C238(0.57); C255(0.57)  LDD0793  [20]
 LDCM0477  CL83 HCT 116 C238(0.64); C255(0.64)  LDD0794  [20]
 LDCM0478  CL84 HCT 116 C238(0.26); C255(0.26)  LDD0795  [20]
 LDCM0479  CL85 HCT 116 C238(0.90); C255(0.90)  LDD0796  [20]
 LDCM0480  CL86 HCT 116 C238(1.02); C255(1.02)  LDD0797  [20]
 LDCM0481  CL87 HCT 116 C238(1.10); C255(1.10)  LDD0798  [20]
 LDCM0482  CL88 HCT 116 C238(0.67); C255(0.67)  LDD0799  [20]
 LDCM0483  CL89 HCT 116 C238(0.18); C255(0.18)  LDD0800  [20]
 LDCM0484  CL9 HCT 116 C142(0.89); C238(1.12); C255(1.12)  LDD0801  [20]
 LDCM0485  CL90 HCT 116 C238(1.03); C255(1.03)  LDD0802  [20]
 LDCM0486  CL91 HCT 116 C238(0.43); C255(0.43)  LDD0803  [20]
 LDCM0487  CL92 HCT 116 C238(0.58); C255(0.58)  LDD0804  [20]
 LDCM0488  CL93 HCT 116 C238(0.44); C255(0.44)  LDD0805  [20]
 LDCM0489  CL94 HCT 116 C238(0.36); C255(0.36)  LDD0806  [20]
 LDCM0490  CL95 HCT 116 C238(0.46); C255(0.46)  LDD0807  [20]
 LDCM0491  CL96 HCT 116 C238(0.57); C255(0.57)  LDD0808  [20]
 LDCM0492  CL97 HCT 116 C238(0.41); C255(0.41)  LDD0809  [20]
 LDCM0493  CL98 HCT 116 C238(0.44); C255(0.44)  LDD0810  [20]
 LDCM0494  CL99 HCT 116 C238(0.37); C255(0.37)  LDD0811  [20]
 LDCM0495  E2913 HEK-293T C125(0.98); C142(0.91); C187(1.04); C286(1.11)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C382(2.93); C125(1.32)  LDD1702  [4]
 LDCM0625  F8 Ramos C125(1.51)  LDD2187  [22]
 LDCM0572  Fragment10 Ramos C125(0.61)  LDD2189  [22]
 LDCM0574  Fragment12 Ramos C125(0.87)  LDD2191  [22]
 LDCM0575  Fragment13 Ramos C125(2.00)  LDD2192  [22]
 LDCM0579  Fragment20 Ramos C125(0.66)  LDD2194  [22]
 LDCM0580  Fragment21 Ramos C125(1.00)  LDD2195  [22]
 LDCM0582  Fragment23 Ramos C125(0.88)  LDD2196  [22]
 LDCM0578  Fragment27 Ramos C125(1.24)  LDD2197  [22]
 LDCM0586  Fragment28 Ramos C125(0.53)  LDD2198  [22]
 LDCM0588  Fragment30 Ramos C125(0.85)  LDD2199  [22]
 LDCM0589  Fragment31 Ramos C125(0.75)  LDD2200  [22]
 LDCM0590  Fragment32 Ramos C125(0.65)  LDD2201  [22]
 LDCM0468  Fragment33 HCT 116 C238(1.07); C255(1.07)  LDD0785  [20]
 LDCM0596  Fragment38 Ramos C125(2.43)  LDD2203  [22]
 LDCM0566  Fragment4 Ramos C125(1.02)  LDD2184  [22]
 LDCM0427  Fragment51 HCT 116 C142(0.54)  LDD0744  [20]
 LDCM0614  Fragment56 Ramos C125(2.92)  LDD2205  [22]
 LDCM0569  Fragment7 Ramos C125(1.25)  LDD2186  [22]
 LDCM0571  Fragment9 Ramos C125(0.72)  LDD2188  [22]
 LDCM0107  IAA HeLa C142(0.00); H376(0.00); C125(0.00); C286(0.00)  LDD0221  [16]
 LDCM0022  KB02 HEK-293T C125(1.02); C142(1.23); C187(0.93); C425(0.93)  LDD1492  [21]
 LDCM0023  KB03 Jurkat C142(11.27)  LDD0209  [6]
 LDCM0024  KB05 COLO792 C425(1.02); C125(1.33)  LDD3310  [23]
 LDCM0109  NEM HeLa C125(0.00); C142(0.00)  LDD0223  [16]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C385(0.91); C382(1.01); C379(0.87)  LDD2092  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C385(1.52); C379(1.02)  LDD2094  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C385(1.13)  LDD2097  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C379(1.04)  LDD2098  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C142(0.32); C385(1.31); C382(1.01); C379(0.82)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C385(0.86); C382(1.37)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C385(1.16); C382(0.93); C379(0.67)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C385(1.89); C382(1.52); C379(1.49)  LDD2105  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C142(0.55); C385(1.05)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C142(0.63)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C142(0.55)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C142(0.99); C385(0.44)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C385(0.89); C382(0.85); C379(0.61)  LDD2114  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C142(1.14)  LDD2119  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C142(0.76)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C385(0.43)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C142(0.98); C385(0.28)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C385(0.66)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C385(0.81); C379(0.73)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C142(1.29)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C142(0.78)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C142(0.65)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C142(0.91)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C142(0.50); C385(0.99); C382(0.79); C379(0.84)  LDD2141  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C142(1.66)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C142(0.67)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C385(0.86)  LDD2146  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C379(0.57)  LDD2148  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C385(1.68)  LDD2153  [4]
 LDCM0021  THZ1 HCT 116 C187(1.00); C142(0.95)  LDD2173  [20]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase flavoprotein 3, mitochondrial (NDUFV3) Complex I NDUFV3 subunit family P56181
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
26S proteasome non-ATPase regulatory subunit 5 (PSMD5) Proteasome subunit S5B/HSM3 family Q16401
Protein kinase C alpha type (PRKCA) AGC Ser/Thr protein kinase family P17252
E3 ubiquitin-protein transferase RMND5A (RMND5A) . Q9H871
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Voltage-dependent anion-selective channel protein 2 (VDAC2) Eukaryotic mitochondrial porin family P45880
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myeloid cell nuclear differentiation antigen (MNDA) . P41218
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
COP9 signalosome complex subunit 2 (COPS2) CSN2 family P61201
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
WD40 repeat-containing protein SMU1 (SMU1) WD repeat SMU1 family Q2TAY7
ADP-ribosylation factor GTPase-activating protein 3 (ARFGAP3) . Q9NP61
F-box only protein 42 (FBXO42) . Q6P3S6
F-box/WD repeat-containing protein 1A (BTRC) . Q9Y297

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
20 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840