Details of the Target

General Information of Target

Target ID LDTP01153
Target Name CCR4-NOT transcription complex subunit 3 (CNOT3)
Gene Name CNOT3
Gene ID 4849
Synonyms
KIAA0691; LENG2; NOT3; CCR4-NOT transcription complex subunit 3; CCR4-associated factor 3; Leukocyte receptor cluster member 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADKRKLQGEIDRCLKKVSEGVEQFEDIWQKLHNAANANQKEKYEADLKKEIKKLQRLRD
QIKTWVASNEIKDKRQLIDNRKLIETQMERFKVVERETKTKAYSKEGLGLAQKVDPAQKE
KEEVGQWLTNTIDTLNMQVDQFESEVESLSVQTRKKKGDKDKQDRIEGLKRHIEKHRYHV
RMLETILRMLDNDSILVDAIRKIKDDVEYYVDSSQDPDFEENEFLYDDLDLEDIPQALVA
TSPPSHSHMEDEIFNQSSSTPTSTTSSSPIPPSPANCTTENSEDDKKRGRSTDSEVSQSP
AKNGSKPVHSNQHPQSPAVPPTYPSGPPPAASALSTTPGNNGVPAPAAPPSALGPKASPA
PSHNSGTPAPYAQAVAPPAPSGPSTTQPRPPSVQPSGGGGGGSGGGGSSSSSNSSAGGGA
GKQNGATSYSSVVADSPAEVALSSSGGNNASSQALGPPSGPHNPPPSTSKEPSAAAPTGA
GGVAPGSGNNSGGPSLLVPLPVNPPSSPTPSFSDAKAAGALLNGPPQFSTAPEIKAPEPL
SSLKSMAERAAISSGIEDPVPTLHLTERDIILSSTSAPPASAQPPLQLSEVNIPLSLGVC
PLGPVPLTKEQLYQQAMEEAAWHHMPHPSDSERIRQYLPRNPCPTPPYHHQMPPPHSDTV
EFYQRLSTETLFFIFYYLEGTKAQYLAAKALKKQSWRFHTKYMMWFQRHEEPKTITDEFE
QGTYIYFDYEKWGQRKKEGFTFEYRYLEDRDLQ
Target Bioclass
Other
Family
CNOT2/3/5 family
Subcellular location
Cytoplasm
Function
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.
Uniprot ID
O75175
Ensemble ID
ENST00000221232.11
HGNC ID
HGNC:7879
ChEMBL ID
CHEMBL4105769

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K175(7.94); K41(5.51); K737(3.39); K92(5.78)  LDD0277  [2]
DBIA
 Probe Info  		C643(4.68)  LDD3373  [3]
BTD
 Probe Info  		C14(2.43)  LDD1700  [4]
AHL-Pu-1
 Probe Info  		C600(4.05)  LDD0169  [5]
IA-alkyne
 Probe Info  		C600(7.78)  LDD1708  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
IPM
 Probe Info  		N.A.  LDD2156  [8]
NHS
 Probe Info  		N.A.  LDD0010  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C303
 Probe Info  		6.32  LDD1972  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C14(1.05)  LDD2117  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C600(4.05)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C600(1.09); C643(0.90)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C600(1.16); C643(0.85)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C600(0.99); C643(1.01)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C600(0.95); C643(1.13)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C600(1.08); C643(1.11)  LDD1512  [13]
 LDCM0276  AC17 HEK-293T C600(1.03); C643(1.09)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C600(1.15); C643(0.81)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C600(1.20); C643(1.29)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C600(0.99); C643(1.04)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C600(1.25); C643(0.99)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C600(0.85); C643(1.11)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C600(1.12); C643(0.93)  LDD1521  [13]
 LDCM0284  AC24 HEK-293T C643(1.04)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C600(1.02); C643(1.03)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C600(1.01); C643(0.92)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C600(1.17); C643(1.26)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C600(0.89); C643(1.06)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C600(0.88); C643(1.07)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C600(1.06); C643(1.15)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C600(1.03); C643(0.96)  LDD1530  [13]
 LDCM0293  AC32 HEK-293T C643(0.95)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C600(1.11); C643(1.16)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C600(0.94); C643(0.92)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C600(1.13); C643(1.00)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C600(1.04); C643(1.02)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C600(0.87); C643(0.98)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C600(0.99); C643(1.07)  LDD1538  [13]
 LDCM0301  AC4 HEK-293T C600(0.98); C643(1.12)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C643(0.97)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C600(1.06); C643(1.06)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C600(1.04); C643(0.96)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C600(0.97); C643(0.99)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C600(1.07); C643(1.12)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C600(0.90); C643(0.96)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C600(1.06); C643(1.12)  LDD1547  [13]
 LDCM0310  AC48 HEK-293T C643(1.08)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C600(1.12); C643(0.96)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C600(0.96); C643(0.98)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C600(1.10); C643(0.89)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C600(1.16); C643(1.13)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C600(1.04); C643(1.05)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C600(0.89); C643(1.06)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C600(1.02); C643(1.14)  LDD1556  [13]
 LDCM0319  AC56 HEK-293T C643(0.96)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C600(1.08); C643(1.05)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C600(1.06); C643(0.92)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C600(1.15); C643(1.04)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C600(1.03); C643(1.03)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C600(1.10); C643(1.01)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C600(0.97); C643(1.10)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C600(1.02); C643(1.14)  LDD1565  [13]
 LDCM0328  AC64 HEK-293T C643(1.07)  LDD1567  [13]
 LDCM0345  AC8 HEK-293T C643(1.02)  LDD1569  [13]
 LDCM0520  AKOS000195272 MDA-MB-231 C14(1.00)  LDD2113  [4]
 LDCM0248  AKOS034007472 HEK-293T C600(0.98); C643(0.99)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C600(1.15); C643(1.06)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C643(0.94)  LDD1514  [13]
 LDCM0156  Aniline NCI-H1299 13.85  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C600(1.20); C643(0.96)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C600(1.04); C643(1.34)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C600(1.02); C643(0.97)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C600(1.16); C643(0.97)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C600(1.13); C643(1.00)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C600(1.03); C643(0.97)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C600(0.92); C643(0.96)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C600(1.14); C643(0.88)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C600(0.99); C643(0.99)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C600(0.98); C643(0.96)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C600(1.00); C643(0.98)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C600(1.15); C643(0.92)  LDD1582  [13]
 LDCM0380  CL110 HEK-293T C600(1.30); C643(0.91)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C600(1.12); C643(0.97)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C600(1.09); C643(0.87)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C600(1.18); C643(0.92)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C600(1.13); C643(0.97)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C600(1.10); C643(1.03)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C600(0.91); C643(1.18)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C600(1.25); C643(0.90)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C600(1.18); C643(1.01)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C600(1.00); C643(1.12)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C643(1.04)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C600(0.99); C643(1.13)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C600(1.16); C643(1.03)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C600(1.04); C643(1.10)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C600(1.40); C643(0.90)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C600(1.09); C643(1.00)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C600(1.25); C643(0.98)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C600(1.06); C643(1.01)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C600(1.09); C643(0.96)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C600(1.07); C643(0.98)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C600(1.17); C643(1.07)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C600(1.10); C643(1.05)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C600(1.16); C643(1.19)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C600(1.00); C643(0.96)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C600(1.25); C643(1.24)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C600(1.08); C643(0.97)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C600(0.94); C643(1.07)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C600(1.07); C643(1.12)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C600(0.93); C643(0.95)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C600(0.94); C643(0.78)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C600(1.10); C643(1.24)  LDD1614  [13]
 LDCM0412  CL24 HEK-293T C643(1.21)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C600(1.28); C643(1.02)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C600(1.08); C643(0.97)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C600(1.13); C643(0.91)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C600(0.97); C643(0.95)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C600(0.93); C643(0.98)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C600(1.04); C643(1.00)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C600(1.00); C643(0.92)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C600(1.12); C643(1.08)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C600(0.81); C643(0.96)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C600(1.23); C643(0.83)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C600(0.91); C643(1.04)  LDD1627  [13]
 LDCM0425  CL36 HEK-293T C643(1.04)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C600(1.17); C643(0.91)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C600(1.11); C643(0.97)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C600(1.11); C643(1.04)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C600(0.91); C643(1.01)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C600(1.06); C643(1.00)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C600(0.95); C643(0.89)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C600(0.89); C643(0.99)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C600(1.06); C643(0.92)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C600(1.13); C643(0.84)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C600(0.90); C643(1.14)  LDD1640  [13]
 LDCM0438  CL48 HEK-293T C643(1.01)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C600(0.99); C643(1.03)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C600(1.04); C643(1.08)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C600(1.11); C643(1.04)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C600(0.92); C643(1.01)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C600(1.04); C643(1.06)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C600(1.25); C643(1.11)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C600(0.98); C643(1.08)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C600(1.05); C643(0.90)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C600(1.00); C643(0.76)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C600(0.90); C643(1.08)  LDD1652  [13]
 LDCM0451  CL6 HEK-293T C600(1.13); C643(1.06)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C643(1.00)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C600(1.17); C643(0.93)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C600(1.07); C643(1.01)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C600(1.14); C643(0.92)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C600(0.98); C643(0.96)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C600(1.03); C643(0.90)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C600(1.06); C643(0.95)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C600(1.04); C643(1.18)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C600(1.20); C643(0.99)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C600(0.93); C643(0.86)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C600(1.02); C643(1.11)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C600(1.05); C643(1.06)  LDD1666  [13]
 LDCM0465  CL72 HEK-293T C643(0.95)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C600(1.28); C643(1.02)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C600(1.13); C643(1.04)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C600(0.93); C643(0.91)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C600(1.14); C643(0.97)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C600(1.03); C643(0.86)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C600(0.97); C643(1.13)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C600(1.25); C643(0.81)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C600(1.21); C643(1.03)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C600(0.81); C643(0.90)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C600(0.97); C643(1.01)  LDD1679  [13]
 LDCM0478  CL84 HEK-293T C643(0.98)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C600(1.04); C643(0.99)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C600(1.19); C643(0.95)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C600(1.12); C643(1.06)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C600(0.94); C643(0.95)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C600(1.16); C643(1.03)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C600(0.94); C643(0.86)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C600(1.80); C643(1.61)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C600(1.09); C643(1.15)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C600(1.04); C643(0.93)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C600(0.94); C643(0.97)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C600(0.99); C643(0.93)  LDD1692  [13]
 LDCM0491  CL96 HEK-293T C643(1.04)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C600(1.07); C643(0.96)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C600(1.11); C643(1.02)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C600(1.19); C643(0.97)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C600(1.47); C643(0.96)  LDD1698  [13]
 LDCM0468  Fragment33 HEK-293T C600(1.07); C643(0.89)  LDD1671  [13]
 LDCM0427  Fragment51 HEK-293T C600(1.03); C643(0.83)  LDD1631  [13]
 LDCM0022  KB02 HEK-293T C600(0.86); C643(1.06)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C600(1.00); C643(1.00)  LDD1497  [13]
 LDCM0024  KB05 OCUG-1 C643(4.68)  LDD3373  [3]
 LDCM0109  NEM HeLa N.A.  LDD0225  [10]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C14(0.91)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C14(0.30)  LDD2104  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C14(0.34)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C14(1.37)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C14(0.32)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C14(0.60)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C14(1.34)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C14(0.46)  LDD2115  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C14(3.22)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C14(0.76)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C14(0.83)  LDD2125  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C14(1.00)  LDD2129  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C14(0.51)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C14(1.40)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C14(1.06)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C14(0.90)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C14(2.43)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C14(1.16)  LDD2140  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C14(4.53)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C14(0.89)  LDD2146  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) 2-oxoacid dehydrogenase family P36957
Transitional endoplasmic reticulum ATPase (VCP) AAA ATPase family P55072
CCR4-NOT transcription complex subunit 8 (CNOT8) CAF1 family Q9UFF9
CCR4-NOT transcription complex subunit 6-like (CNOT6L) CCR4/nocturin family Q96LI5
Serine/threonine-protein kinase Nek7 (NEK7) NEK Ser/Thr protein kinase family Q8TDX7
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calreticulin (CALR) Calreticulin family P27797
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet endothelial cell adhesion molecule (PECAM1) . P16284
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein Tob1 (TOB1) BTG family P50616
CCR4-NOT transcription complex subunit 1 (CNOT1) CNOT1 family A5YKK6
CCR4-NOT transcription complex subunit 2 (CNOT2) CNOT2/3/5 family Q9NZN8
Trinucleotide repeat-containing gene 6C protein (TNRC6C) GW182 family Q9HCJ0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402