Details of the Target

General Information of Target

Target ID LDTP01002
Target Name Cyclin-T1 (CCNT1)
Gene Name CCNT1
Gene ID 904
Synonyms
Cyclin-T1; CycT1; Cyclin-T
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTIN
TAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPD
TRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATN
SLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHE
FLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLM
SMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGV
DHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAY
AAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEI
KMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNK
RPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSL
NFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDT
VNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPP
LPPLPK
Target Bioclass
Other
Family
Cyclin family, Cyclin C subfamily
Subcellular location
Nucleus
Function
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II.; (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes.
Uniprot ID
O60563
Ensemble ID
ENST00000261900.8
HGNC ID
HGNC:1599
ChEMBL ID
CHEMBL2108

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
769P SNV: p.V634I DBIA    Probe Info 
ABC1 SNV: p.Q18L .
HCC1395 SNV: p.I698M DBIA    Probe Info 
HT1376 SNV: p.H521Y DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.D498N DBIA    Probe Info 
MELJUSO SNV: p.K247Ter DBIA    Probe Info 
NCIH1155 SNV: p.R11Q DBIA    Probe Info 
SW756 SNV: p.K6Q DBIA    Probe Info 
TF1 Insertion: p.M66_H67insGGRVRPSQKKKKS DBIA    Probe Info 
U937 SNV: p.R254H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K395(7.88)  LDD0277  [2]
BTD
 Probe Info  		C111(1.64)  LDD1700  [3]
Johansson_61
 Probe Info  		_(20.00)  LDD1489  [4]
DBIA
 Probe Info  		C111(1.45)  LDD0531  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		C111(0.00); C261(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C111(0.00); C261(0.00)  LDD0037  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
ENE
 Probe Info  		N.A.  LDD0006  [8]
IPM
 Probe Info  		C261(0.00); C160(0.00)  LDD0147  [7]
SF
 Probe Info  		N.A.  LDD0028  [9]
Acrolein
 Probe Info  		C111(0.00); H113(0.00); H396(0.00)  LDD0217  [10]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
NAIA_5
 Probe Info  		C261(0.00); C111(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C303
 Probe Info  		5.31  LDD1972  [13]
VE-P
 Probe Info  		N.A.  LDD0396  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C111(1.55)  LDD2152  [3]
 LDCM0214  AC1 HCT 116 C111(1.45)  LDD0531  [5]
 LDCM0215  AC10 HEK-293T C111(0.93)  LDD1508  [15]
 LDCM0216  AC100 HCT 116 C111(0.97)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C111(1.02)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C111(1.00)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C111(1.00)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C111(1.08)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C111(0.97)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C111(1.08)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C111(1.05)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C111(0.97)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C111(1.12)  LDD0542  [5]
 LDCM0226  AC11 HEK-293T C111(1.01)  LDD1509  [15]
 LDCM0227  AC110 HCT 116 C111(1.11)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C111(1.08)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C111(1.07)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C111(1.06)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C111(1.08)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C111(0.91)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C111(0.93)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C111(0.94)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C111(0.93)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C111(0.87)  LDD0553  [5]
 LDCM0237  AC12 HEK-293T C111(1.01)  LDD1510  [15]
 LDCM0238  AC120 HCT 116 C111(1.18)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C111(0.93)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C111(1.10)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C111(1.01)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C111(1.01)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C111(1.08)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C111(1.19)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C111(1.06)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C111(1.19)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C111(0.96)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C111(0.96)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C111(0.98)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C111(0.94)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C111(0.95)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C111(0.89)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C111(0.97)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C111(0.92)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C111(1.01)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C111(0.89)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C111(0.97)  LDD0575  [5]
 LDCM0260  AC140 HCT 116 C111(1.00)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C111(0.95)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C111(0.98)  LDD0579  [5]
 LDCM0270  AC15 HEK-293T C111(0.92)  LDD1513  [15]
 LDCM0276  AC17 HCT 116 C111(0.94)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C111(1.26)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C111(1.12)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C111(1.08)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C111(0.77)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C111(1.10)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C111(0.94)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C111(0.99)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C111(0.88)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C111(1.05)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C111(0.87)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C111(0.78)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C111(0.74)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C111(0.57)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C111(1.46)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C111(0.66)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C111(0.67)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C111(0.59)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C111(0.86)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C111(0.82)  LDD0612  [5]
 LDCM0296  AC35 HEK-293T C111(0.98)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C111(1.05)  LDD1536  [15]
 LDCM0300  AC39 HEK-293T C111(0.93)  LDD1539  [15]
 LDCM0301  AC4 HCT 116 C111(1.51)  LDD0618  [5]
 LDCM0302  AC40 HEK-293T C630(1.07); C111(0.92)  LDD1541  [15]
 LDCM0303  AC41 HEK-293T C111(1.06)  LDD1542  [15]
 LDCM0304  AC42 HEK-293T C111(0.99)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C111(0.98)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C111(1.07)  LDD1545  [15]
 LDCM0309  AC47 HEK-293T C111(0.99)  LDD1548  [15]
 LDCM0310  AC48 HEK-293T C630(1.13); C111(0.92)  LDD1549  [15]
 LDCM0311  AC49 HEK-293T C111(1.00)  LDD1550  [15]
 LDCM0312  AC5 HCT 116 C111(1.57)  LDD0629  [5]
 LDCM0313  AC50 HEK-293T C111(0.99)  LDD1552  [15]
 LDCM0314  AC51 HEK-293T C111(0.98)  LDD1553  [15]
 LDCM0315  AC52 HEK-293T C111(1.10)  LDD1554  [15]
 LDCM0318  AC55 HEK-293T C111(0.92)  LDD1557  [15]
 LDCM0319  AC56 HEK-293T C630(1.15); C111(0.99)  LDD1558  [15]
 LDCM0320  AC57 HEK-293T C111(1.05)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C111(0.97)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C111(0.88)  LDD1561  [15]
 LDCM0324  AC60 HEK-293T C111(1.01)  LDD1563  [15]
 LDCM0327  AC63 HEK-293T C111(1.07)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C630(1.06); C111(0.93)  LDD1567  [15]
 LDCM0334  AC7 HEK-293T C111(1.01)  LDD1568  [15]
 LDCM0345  AC8 HEK-293T C630(0.95); C111(1.01)  LDD1569  [15]
 LDCM0365  AC98 HCT 116 C111(0.98)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C111(0.97)  LDD0683  [5]
 LDCM0356  AKOS034007680 HEK-293T C111(1.02)  LDD1570  [15]
 LDCM0275  AKOS034007705 HEK-293T C630(0.96); C111(0.88)  LDD1514  [15]
 LDCM0156  Aniline NCI-H1299 11.41  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C111(0.97)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C261(0.48)  LDD2227  [12]
 LDCM0367  CL1 HEK-293T C630(1.11); C111(1.08)  LDD1571  [15]
 LDCM0369  CL100 HCT 116 C111(1.39)  LDD0686  [5]
 LDCM0370  CL101 HEK-293T C630(1.18); C111(0.98)  LDD1574  [15]
 LDCM0371  CL102 HEK-293T C630(1.58); C111(0.98)  LDD1575  [15]
 LDCM0372  CL103 HEK-293T C111(0.93)  LDD1576  [15]
 LDCM0374  CL105 HCT 116 C111(1.13)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C111(1.54)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C111(1.38)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C111(1.09)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C111(0.91)  LDD0695  [5]
 LDCM0379  CL11 HEK-293T C111(1.06)  LDD1583  [15]
 LDCM0380  CL110 HCT 116 C111(1.06)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C111(0.97)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C111(0.68)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C111(0.61)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C111(0.60)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C111(0.69)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C111(0.75)  LDD0703  [5]
 LDCM0387  CL117 HEK-293T C630(1.36); C111(1.00)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C630(0.91); C111(0.88)  LDD1592  [15]
 LDCM0389  CL119 HEK-293T C111(0.90)  LDD1593  [15]
 LDCM0390  CL12 HEK-293T C630(0.99); C111(1.01)  LDD1594  [15]
 LDCM0392  CL121 HEK-293T C630(1.17); C111(1.02)  LDD1596  [15]
 LDCM0393  CL122 HEK-293T C630(1.13); C111(0.97)  LDD1597  [15]
 LDCM0394  CL123 HEK-293T C111(0.85)  LDD1598  [15]
 LDCM0396  CL125 HEK-293T C630(0.83); C111(0.91)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C630(0.89); C111(0.98)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C111(0.81)  LDD1602  [15]
 LDCM0400  CL13 HEK-293T C630(1.25); C111(0.97)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C630(0.84); C111(0.94)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C111(0.86)  LDD1606  [15]
 LDCM0404  CL17 HEK-293T C111(1.25)  LDD1608  [15]
 LDCM0405  CL18 HEK-293T C111(1.00)  LDD1609  [15]
 LDCM0406  CL19 HEK-293T C111(0.91)  LDD1610  [15]
 LDCM0407  CL2 HEK-293T C630(0.83); C111(0.91)  LDD1611  [15]
 LDCM0408  CL20 HEK-293T C111(1.13)  LDD1612  [15]
 LDCM0411  CL23 HEK-293T C111(0.98)  LDD1615  [15]
 LDCM0412  CL24 HEK-293T C630(1.28); C111(1.09)  LDD1616  [15]
 LDCM0413  CL25 HEK-293T C630(0.97); C111(1.01)  LDD1617  [15]
 LDCM0414  CL26 HEK-293T C630(1.13); C111(0.97)  LDD1618  [15]
 LDCM0415  CL27 HEK-293T C111(0.89)  LDD1619  [15]
 LDCM0417  CL29 HEK-293T C111(1.06)  LDD1621  [15]
 LDCM0418  CL3 HEK-293T C111(0.97)  LDD1622  [15]
 LDCM0419  CL30 HEK-293T C111(0.96)  LDD1623  [15]
 LDCM0420  CL31 HEK-293T C111(0.96)  LDD1624  [15]
 LDCM0421  CL32 HEK-293T C111(1.06)  LDD1625  [15]
 LDCM0424  CL35 HEK-293T C111(0.88)  LDD1628  [15]
 LDCM0425  CL36 HEK-293T C630(1.06); C111(0.96)  LDD1629  [15]
 LDCM0426  CL37 HEK-293T C630(1.06); C111(1.03)  LDD1630  [15]
 LDCM0428  CL39 HEK-293T C111(0.93)  LDD1632  [15]
 LDCM0431  CL41 HEK-293T C111(0.97)  LDD1635  [15]
 LDCM0432  CL42 HEK-293T C111(0.91)  LDD1636  [15]
 LDCM0433  CL43 HEK-293T C111(0.98)  LDD1637  [15]
 LDCM0434  CL44 HEK-293T C111(1.03)  LDD1638  [15]
 LDCM0437  CL47 HEK-293T C111(1.04)  LDD1641  [15]
 LDCM0438  CL48 HEK-293T C630(1.34); C111(1.01)  LDD1642  [15]
 LDCM0439  CL49 HEK-293T C630(1.12); C111(1.04)  LDD1643  [15]
 LDCM0440  CL5 HEK-293T C111(1.11)  LDD1644  [15]
 LDCM0441  CL50 HEK-293T C630(0.86); C111(0.91)  LDD1645  [15]
 LDCM0444  CL53 HEK-293T C111(1.20)  LDD1647  [15]
 LDCM0445  CL54 HEK-293T C111(1.05)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C111(0.91)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C111(1.07)  LDD1650  [15]
 LDCM0450  CL59 HEK-293T C111(0.95)  LDD1653  [15]
 LDCM0451  CL6 HEK-293T C111(1.04)  LDD1654  [15]
 LDCM0452  CL60 HEK-293T C630(0.97); C111(0.97)  LDD1655  [15]
 LDCM0453  CL61 HEK-293T C630(1.00); C111(0.94)  LDD1656  [15]
 LDCM0454  CL62 HEK-293T C630(1.16); C111(0.89)  LDD1657  [15]
 LDCM0455  CL63 HEK-293T C111(0.84)  LDD1658  [15]
 LDCM0457  CL65 HEK-293T C111(1.02)  LDD1660  [15]
 LDCM0458  CL66 HEK-293T C111(0.98)  LDD1661  [15]
 LDCM0459  CL67 HEK-293T C111(0.98)  LDD1662  [15]
 LDCM0460  CL68 HEK-293T C111(1.07)  LDD1663  [15]
 LDCM0462  CL7 HEK-293T C111(0.94)  LDD1665  [15]
 LDCM0464  CL71 HEK-293T C111(0.92)  LDD1667  [15]
 LDCM0465  CL72 HEK-293T C630(1.75); C111(0.92)  LDD1668  [15]
 LDCM0466  CL73 HEK-293T C630(1.24); C111(0.99)  LDD1669  [15]
 LDCM0467  CL74 HEK-293T C630(0.73); C111(0.90)  LDD1670  [15]
 LDCM0470  CL77 HEK-293T C111(0.97)  LDD1673  [15]
 LDCM0471  CL78 HEK-293T C111(0.98)  LDD1674  [15]
 LDCM0472  CL79 HEK-293T C111(1.04)  LDD1675  [15]
 LDCM0473  CL8 HEK-293T C111(0.95)  LDD1676  [15]
 LDCM0474  CL80 HEK-293T C111(0.96)  LDD1677  [15]
 LDCM0477  CL83 HEK-293T C111(0.80)  LDD1680  [15]
 LDCM0478  CL84 HEK-293T C630(0.97); C111(0.91)  LDD1681  [15]
 LDCM0479  CL85 HEK-293T C630(0.96); C111(0.88)  LDD1682  [15]
 LDCM0480  CL86 HEK-293T C630(0.68); C111(0.88)  LDD1683  [15]
 LDCM0481  CL87 HEK-293T C111(0.82)  LDD1684  [15]
 LDCM0483  CL89 HEK-293T C111(1.01)  LDD1686  [15]
 LDCM0485  CL90 HEK-293T C111(1.27)  LDD1688  [15]
 LDCM0486  CL91 HCT 116 C111(0.90)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C111(0.87)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C111(1.12)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C111(1.33)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C111(0.94)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C111(0.89)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C111(0.88)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C111(1.22)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C111(1.39)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C111(0.87)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C111(1.69); C160(1.38)  LDD1702  [3]
 LDCM0625  F8 Ramos C261(1.00); C111(1.34)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C261(2.26); C111(1.12)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C261(20.00); C111(0.59)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C261(2.82); C111(1.29)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C261(1.07)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C261(0.92); C111(1.13)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C261(2.15); C111(1.05)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C261(1.00)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C261(0.94); C111(0.97)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C261(1.03); C111(1.14)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C261(0.94); C111(0.36)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C261(1.48); C111(1.44)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C261(0.81); C111(0.99)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C261(2.20); C111(1.37)  LDD2201  [16]
 LDCM0468  Fragment33 HEK-293T C111(0.80)  LDD1671  [15]
 LDCM0596  Fragment38 Ramos C261(0.91); C111(3.00)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C261(1.18); C111(0.88)  LDD2184  [16]
 LDCM0427  Fragment51 HEK-293T C630(1.03); C111(0.91)  LDD1631  [15]
 LDCM0610  Fragment52 Ramos C261(1.39)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C261(1.22); C111(1.18)  LDD2205  [16]
 LDCM0616  Fragment61 Jurkat _(20.00)  LDD1489  [4]
 LDCM0569  Fragment7 Ramos C261(1.08); C111(1.01)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C261(2.01); C111(1.00)  LDD2188  [16]
 LDCM0022  KB02 HEK-293T C111(0.98)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C111(1.04)  LDD1497  [15]
 LDCM0024  KB05 COLO792 C111(1.65)  LDD3310  [17]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C111(1.64)  LDD1700  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-dependent kinase 9 (CDK9) CMGC Ser/Thr protein kinase family P50750
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AF4/FMR2 family member 4 (AFF4) AF4 family Q9UHB7
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein HEXIM1 (HEXIM1) HEXIM family O94992

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840