Details of the Target

General Information of Target

Target ID LDTP05714
Target Name GATOR1 complex protein NPRL3 (NPRL3)
Gene Name NPRL3
Gene ID 8131
Synonyms
C16orf35; CGTHBA; MARE; GATOR1 complex protein NPRL3; -14 gene protein; Alpha-globin regulatory element-containing gene protein; Nitrogen permease regulator 3-like protein; Protein CGTHBA
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRDNTSPISVILVSSGSRGNKLLFRYPFQRSQEHPASQTSKPRSRYAASNTGDHADEQDG
DSRFSDVILATILATKSEMCGQKFELKIDNVRFVGHPTLLQHALGQISKTDPSPKREAPT
MILFNVVFALRANADPSVINCLHNLSRRIATVLQHEERRCQYLTREAKLILALQDEVSAM
ADGNEGPQSPFHHILPKCKLARDLKEAYDSLCTSGVVRLHINSWLEVSFCLPHKIHYAAS
SLIPPEAIERSLKAIRPYHALLLLSDEKSLLGELPIDCSPALVRVIKTTSAVKNLQQLAQ
DADLALLQVFQLAAHLVYWGKAIIIYPLCENNVYMLSPNASVCLYSPLAEQFSHQFPSHD
LPSVLAKFSLPVSLSEFRNPLAPAVQETQLIQMVVWMLQRRLLIQLHTYVCLMASPSEEE
PRPREDDVPFTARVGGRSLSTPNALSFGSPTSSDDMTLTSPSMDNSSAELLPSGDSPLNQ
RMTENLLASLSEHERAAILSVPAAQNPEDLRMFARLLHYFRGRHHLEEIMYNENTRRSQL
LMLFDKFRSVLVVTTHEDPVIAVFQALLP
Target Bioclass
Other
Family
NPR3 family
Subcellular location
Lysosome membrane
Function
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway. In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway.
Uniprot ID
Q12980
Ensemble ID
ENST00000611875.5
HGNC ID
HGNC:14124

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K21(7.69)  LDD0277  [1]
Johansson_61
 Probe Info  		_(20.00)  LDD1485  [2]
NAIA_5
 Probe Info  		C278(0.84)  LDD2227  [3]
DBIA
 Probe Info  		C80(5.65)  LDD0080  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
IPM
 Probe Info  		N.A.  LDD0147  [5]
AOyne
 Probe Info  		13.50  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C80(1.04)  LDD0531  [4]
 LDCM0215  AC10 PaTu 8988t C278(1.36)  LDD1094  [4]
 LDCM0216  AC100 HCT 116 C212(0.61)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C212(1.03)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C212(1.18)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C212(1.09)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C212(0.97)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C212(0.89)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C212(0.84)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C212(0.89)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C212(0.90)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C212(0.61)  LDD0542  [4]
 LDCM0226  AC11 PaTu 8988t C278(1.21)  LDD1105  [4]
 LDCM0227  AC110 HCT 116 C212(1.01)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C212(1.18)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C212(0.96)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C80(0.98)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C80(0.87)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C80(0.83)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C80(0.84)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C80(1.18)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C80(0.98)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C80(1.06)  LDD0553  [4]
 LDCM0237  AC12 PaTu 8988t C278(1.08)  LDD1116  [4]
 LDCM0238  AC120 HCT 116 C80(0.77)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C80(1.00)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C80(1.23)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C80(1.16)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C80(0.91)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C80(0.95)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C80(0.94)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C80(0.94)  LDD0562  [4]
 LDCM0246  AC128 HEK-293T C141(0.93)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C141(0.92)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C141(0.97)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C141(0.88)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C141(0.94)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C141(0.97)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C141(0.98)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C141(1.03)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C141(1.18)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C141(1.14)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C141(1.28)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C141(1.11)  LDD0856  [4]
 LDCM0259  AC14 PaTu 8988t C278(1.28)  LDD1138  [4]
 LDCM0260  AC140 HEK-293T C141(0.99)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C141(1.11)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C141(1.15)  LDD0860  [4]
 LDCM0270  AC15 PaTu 8988t C278(1.20)  LDD1149  [4]
 LDCM0276  AC17 HCT 116 C212(1.13); C80(1.22)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C80(1.44); C212(1.78)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C80(0.91); C212(1.20)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C80(1.01)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C212(0.98); C80(1.19)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C212(1.11); C80(2.83)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C80(0.86); C212(1.01)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C80(0.54); C212(1.43)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C80(0.93); C212(1.49)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C212(0.95)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C212(1.16)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C212(1.17)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C212(1.43)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C212(1.05)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C80(1.07)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C212(0.97)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C212(0.80)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C212(1.05)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C212(1.19)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C212(1.11)  LDD0612  [4]
 LDCM0296  AC35 PaTu 8988t C278(0.97)  LDD1175  [4]
 LDCM0297  AC36 PaTu 8988t C278(1.03)  LDD1176  [4]
 LDCM0298  AC37 PaTu 8988t C278(0.92)  LDD1177  [4]
 LDCM0299  AC38 PaTu 8988t C278(0.62)  LDD1178  [4]
 LDCM0300  AC39 PaTu 8988t C278(1.06)  LDD1179  [4]
 LDCM0301  AC4 HCT 116 C80(1.09)  LDD0618  [4]
 LDCM0302  AC40 PaTu 8988t C278(1.01)  LDD1181  [4]
 LDCM0303  AC41 PaTu 8988t C278(1.10)  LDD1182  [4]
 LDCM0304  AC42 PaTu 8988t C278(0.96)  LDD1183  [4]
 LDCM0305  AC43 PaTu 8988t C278(1.03)  LDD1184  [4]
 LDCM0306  AC44 PaTu 8988t C278(1.01)  LDD1185  [4]
 LDCM0307  AC45 PaTu 8988t C278(0.82)  LDD1186  [4]
 LDCM0308  AC46 HEK-293T C212(0.99); C278(1.07)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C212(1.14); C278(0.97)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C212(0.91); C278(0.85)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C212(0.98); C278(1.06)  LDD1550  [7]
 LDCM0312  AC5 HCT 116 C80(1.04)  LDD0629  [4]
 LDCM0313  AC50 HEK-293T C212(0.91); C278(1.03)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C212(0.99); C278(0.95)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C212(0.98)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C212(1.11)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C212(1.17); C278(1.28)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C212(1.21); C278(0.93)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C212(1.17); C278(0.99)  LDD1558  [7]
 LDCM0320  AC57 HCT 116 C212(0.99); C80(1.05)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C80(1.01); C212(1.32)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C212(1.00); C80(1.86)  LDD0639  [4]
 LDCM0323  AC6 PaTu 8988t C278(0.95)  LDD1202  [4]
 LDCM0324  AC60 HCT 116 C212(1.00); C80(1.06)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C212(1.09); C80(1.11)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C80(1.02); C212(1.26)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C212(0.98); C80(1.31)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C80(1.18); C212(1.25)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C80(1.18); C212(1.48)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C80(1.06); C212(1.20)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C80(1.00); C212(1.31)  LDD0648  [4]
 LDCM0332  AC68 HEK-293T C141(1.08)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C141(0.90)  LDD0931  [4]
 LDCM0334  AC7 PaTu 8988t C278(1.14)  LDD1213  [4]
 LDCM0335  AC70 HEK-293T C141(1.18)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C141(0.92)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C141(1.08)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C141(1.02)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C141(1.00)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C141(0.73)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C141(0.98)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C141(1.24)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C141(1.10)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C141(0.89)  LDD0942  [4]
 LDCM0345  AC8 PaTu 8988t C278(1.12)  LDD1224  [4]
 LDCM0346  AC80 HEK-293T C141(1.17)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C141(1.05)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C141(1.40)  LDD0946  [4]
 LDCM0349  AC83 HEK-293T C141(1.06)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C141(1.13)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C141(0.52)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C141(1.10)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C141(1.04)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C141(1.16)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C141(1.35)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C141(1.18)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C141(1.11)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C141(1.28)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C141(1.39)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C141(1.23)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C141(1.10)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C141(1.31)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C141(1.75)  LDD0962  [4]
 LDCM0365  AC98 HCT 116 C212(0.82)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C212(0.99)  LDD0683  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C278(1.54)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C278(1.09)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C278(1.26)  LDD1154  [4]
 LDCM0632  CL-Sc Hep-G2 C278(0.84)  LDD2227  [3]
 LDCM0367  CL1 HEK-293T C212(1.02); C278(1.09); C141(0.96)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C212(0.89); C278(1.18)  LDD1572  [7]
 LDCM0369  CL100 HCT 116 C80(1.23)  LDD0686  [4]
 LDCM0370  CL101 PaTu 8988t C278(1.16)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C278(1.12)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C278(1.56)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C278(1.26)  LDD1252  [4]
 LDCM0374  CL105 HCT 116 C80(1.23); C212(1.38)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C80(0.97); C212(2.23)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C80(1.01); C212(1.79)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C80(1.49); C212(1.52)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C80(0.82); C212(1.17)  LDD0695  [4]
 LDCM0379  CL11 HEK-293T C212(1.30); C278(0.93)  LDD1583  [7]
 LDCM0380  CL110 HCT 116 C80(0.97); C212(1.84)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C80(0.97); C212(1.52)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C212(1.11)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C212(1.19)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C212(1.22)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C212(0.91)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C212(1.02)  LDD0703  [4]
 LDCM0387  CL117 PaTu 8988t C278(0.95)  LDD1266  [4]
 LDCM0388  CL118 PaTu 8988t C278(0.85)  LDD1267  [4]
 LDCM0389  CL119 PaTu 8988t C278(0.93)  LDD1268  [4]
 LDCM0390  CL12 HEK-293T C212(1.04); C278(1.17)  LDD1594  [7]
 LDCM0391  CL120 PaTu 8988t C278(1.12)  LDD1270  [4]
 LDCM0392  CL121 HEK-293T C212(0.73); C278(0.96); C141(1.02)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C212(0.78); C278(0.99)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C212(0.99); C278(0.97)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C212(0.78); C278(0.84)  LDD1599  [7]
 LDCM0396  CL125 HCT 116 C212(0.88); C80(1.03)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C212(0.95); C80(1.00)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C212(1.00); C80(1.27)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C80(0.87); C212(1.05)  LDD0716  [4]
 LDCM0400  CL13 HEK-293T C212(0.80); C278(1.02); C141(0.96)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C212(1.09); C278(0.89)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C212(1.09); C278(0.95)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C141(1.02)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C141(0.78)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C141(1.01)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C141(1.01)  LDD1004  [4]
 LDCM0407  CL2 HEK-293T C212(1.13); C278(0.90)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C141(0.89)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C141(0.99)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C141(1.08)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C141(0.89)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C141(0.91)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C141(0.93)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C141(1.15)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C141(0.90)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C141(0.92)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C141(1.01)  LDD1015  [4]
 LDCM0418  CL3 HEK-293T C212(1.20); C278(0.96)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C141(1.02)  LDD1017  [4]
 LDCM0420  CL31 HEK-293T C141(0.88)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C141(1.24)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C141(0.96)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C141(1.04)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C141(1.01)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C141(0.93)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C141(1.07)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C141(1.57)  LDD1026  [4]
 LDCM0429  CL4 HEK-293T C212(1.40); C278(0.87)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C141(1.15)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C141(1.32)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C141(1.13)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C141(1.35)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C141(1.12)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C141(1.25)  LDD1033  [4]
 LDCM0436  CL46 HCT 116 C212(0.72)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C212(0.60)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C212(0.79)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C212(0.60)  LDD0756  [4]
 LDCM0440  CL5 HEK-293T C212(1.28); C278(0.96)  LDD1644  [7]
 LDCM0441  CL50 HCT 116 C212(0.94)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C212(0.83)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C212(1.29)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C212(0.60)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C212(0.68)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C212(0.70)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C212(1.07)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C212(1.58)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C212(0.54)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C212(0.66)  LDD0767  [4]
 LDCM0451  CL6 HEK-293T C212(0.95); C278(0.98)  LDD1654  [7]
 LDCM0452  CL60 HCT 116 C212(0.76)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C212(0.95)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C212(1.37)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C212(1.68)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C212(1.15)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C212(1.39)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C212(1.37)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C212(1.50)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C212(1.72)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C212(1.10)  LDD0778  [4]
 LDCM0462  CL7 HEK-293T C212(0.91); C278(0.98)  LDD1665  [7]
 LDCM0463  CL70 HCT 116 C212(2.07)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C212(0.63)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C212(0.89)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C212(1.20)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C212(2.61)  LDD0784  [4]
 LDCM0469  CL76 HEK-293T C141(1.03)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C141(1.14)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C141(1.38)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C141(1.19)  LDD1070  [4]
 LDCM0473  CL8 HEK-293T C212(0.76)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C141(1.27)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C141(1.24)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C141(0.93)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C141(1.03)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C141(1.38)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C141(1.33)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C141(1.59)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C141(1.22)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C141(1.09)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C141(1.13)  LDD1081  [4]
 LDCM0484  CL9 HEK-293T C212(0.92)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C141(0.91)  LDD1083  [4]
 LDCM0486  CL91 HCT 116 C80(1.62)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C80(0.92)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C80(1.07)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C80(0.81)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C80(1.73)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C80(1.20)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C80(1.23)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C80(1.67)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C80(1.14)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C212(1.19); C278(0.98)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C212(0.77)  LDD0785  [4]
 LDCM0427  Fragment51 HEK-293T C141(1.15)  LDD1025  [4]
 LDCM0569  Fragment7 Jurkat _(20.00)  LDD1485  [2]
 LDCM0022  KB02 HCT 116 C80(5.65)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C80(2.04)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C80(3.55)  LDD0082  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GATOR1 complex protein NPRL2 (NPRL2) NPR2 family Q8WTW4
KICSTOR complex protein SZT2 (SZT2) . Q5T011

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402