Details of the Target

General Information of Target

Target ID LDTP09490
Target Name DDB1- and CUL4-associated factor 11 (DCAF11)
Gene Name DCAF11
Gene ID 80344
Synonyms
WDR23; DDB1- and CUL4-associated factor 11; WD repeat-containing protein 23
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQVLAYLLRRGQVRLVQG
GGAANLQFIQALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQL
GLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIY
SKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD
YIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRT
LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITF
IDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKL
KLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLT
NHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSST
PFSSPQ
Target Bioclass
Enzyme
Function May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Uniprot ID
Q8TEB1
Ensemble ID
ENST00000396936.5
HGNC ID
HGNC:20258

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.D344A .
AN3CA Deletion: p.A416PfsTer5 DBIA    Probe Info 
HT115 SNV: p.R386H .
MOLT4 SNV: p.R337Ter .
OVCAR8 SNV: p.K346Q .
RL952 SNV: p.Y457F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y91(10.97); Y407(12.89)  LDD3495  [1]
DBIA
 Probe Info  		C77(2.44)  LDD3332  [2]
Johansson_61
 Probe Info  		_(11.86)  LDD1485  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C288(0.00); C460(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
AOyne
 Probe Info  		8.90  LDD0443  [6]
NAIA_5
 Probe Info  		C143(0.00); C460(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C191(0.93)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C191(1.00)  LDD1512  [7]
 LDCM0280  AC20 HEK-293T C191(1.03)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C191(1.13)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C191(1.15)  LDD1521  [7]
 LDCM0284  AC24 HEK-293T C191(1.04)  LDD1523  [7]
 LDCM0288  AC28 HEK-293T C191(1.07)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C191(0.90)  LDD1528  [7]
 LDCM0291  AC30 HEK-293T C191(1.03)  LDD1530  [7]
 LDCM0293  AC32 HEK-293T C191(1.01)  LDD1532  [7]
 LDCM0297  AC36 HEK-293T C191(1.06)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C191(0.99)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C191(1.00)  LDD1538  [7]
 LDCM0301  AC4 HEK-293T C191(1.01)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C191(1.01)  LDD1541  [7]
 LDCM0306  AC44 HEK-293T C191(1.03)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C191(0.99)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C191(1.02)  LDD1547  [7]
 LDCM0310  AC48 HEK-293T C191(1.11)  LDD1549  [7]
 LDCM0312  AC5 HEK-293T C191(0.94)  LDD1551  [7]
 LDCM0315  AC52 HEK-293T C191(1.22)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C191(1.02)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C191(1.10)  LDD1556  [7]
 LDCM0319  AC56 HEK-293T C191(1.07)  LDD1558  [7]
 LDCM0323  AC6 HEK-293T C191(1.07)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C191(1.07)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C191(0.94)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C191(1.19)  LDD1565  [7]
 LDCM0328  AC64 HEK-293T C191(1.05)  LDD1567  [7]
 LDCM0345  AC8 HEK-293T C191(1.03)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C191(0.98)  LDD1511  [7]
 LDCM0275  AKOS034007705 HEK-293T C191(0.95)  LDD1514  [7]
 LDCM0367  CL1 HEK-293T C191(1.09)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C191(1.30)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C191(0.85)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C191(1.04)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C191(1.08)  LDD1575  [7]
 LDCM0373  CL104 HEK-293T C191(1.25)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C191(1.01)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C191(1.04)  LDD1579  [7]
 LDCM0377  CL108 HEK-293T C191(1.17)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C191(0.86)  LDD1582  [7]
 LDCM0380  CL110 HEK-293T C191(1.23)  LDD1584  [7]
 LDCM0382  CL112 HEK-293T C191(0.74)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C191(1.06)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C191(0.84)  LDD1588  [7]
 LDCM0386  CL116 HEK-293T C191(1.00)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C191(1.19)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C191(1.64)  LDD1592  [7]
 LDCM0390  CL12 HEK-293T C191(0.90)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C191(1.03)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C191(1.05)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C191(0.88)  LDD1597  [7]
 LDCM0395  CL124 HEK-293T C191(0.73)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C191(1.21)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C191(0.85)  LDD1601  [7]
 LDCM0399  CL128 HEK-293T C191(0.85)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C191(1.19)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C191(1.00)  LDD1605  [7]
 LDCM0403  CL16 HEK-293T C191(0.96)  LDD1607  [7]
 LDCM0407  CL2 HEK-293T C191(1.00)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C191(1.18)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C191(1.07)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C191(1.22)  LDD1614  [7]
 LDCM0412  CL24 HEK-293T C191(1.04)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C191(1.01)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C191(0.84)  LDD1618  [7]
 LDCM0416  CL28 HEK-293T C191(0.98)  LDD1620  [7]
 LDCM0421  CL32 HEK-293T C191(0.81)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C191(1.28)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C191(1.08)  LDD1627  [7]
 LDCM0425  CL36 HEK-293T C191(0.91)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C191(1.04)  LDD1630  [7]
 LDCM0429  CL4 HEK-293T C191(1.06)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C191(0.83)  LDD1634  [7]
 LDCM0434  CL44 HEK-293T C191(1.03)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C191(1.13)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C191(1.34)  LDD1640  [7]
 LDCM0438  CL48 HEK-293T C191(0.97)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C191(1.07)  LDD1643  [7]
 LDCM0441  CL50 HEK-293T C191(0.86)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C191(0.72)  LDD1646  [7]
 LDCM0447  CL56 HEK-293T C191(1.04)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C191(1.16)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C191(1.25)  LDD1652  [7]
 LDCM0452  CL60 HEK-293T C191(0.96)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C191(1.11)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C191(1.03)  LDD1657  [7]
 LDCM0456  CL64 HEK-293T C191(0.88)  LDD1659  [7]
 LDCM0460  CL68 HEK-293T C191(1.12)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C191(1.07)  LDD1664  [7]
 LDCM0463  CL70 HEK-293T C191(1.22)  LDD1666  [7]
 LDCM0465  CL72 HEK-293T C191(1.04)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C191(1.19)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C191(0.83)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C191(1.33)  LDD1672  [7]
 LDCM0473  CL8 HEK-293T C191(1.51)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C191(1.08)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C191(0.92)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C191(1.15)  LDD1679  [7]
 LDCM0478  CL84 HEK-293T C191(0.83)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C191(1.11)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C191(0.83)  LDD1683  [7]
 LDCM0482  CL88 HEK-293T C191(1.06)  LDD1685  [7]
 LDCM0484  CL9 HEK-293T C191(0.88)  LDD1687  [7]
 LDCM0487  CL92 HEK-293T C191(1.08)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C191(0.87)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C191(1.10)  LDD1692  [7]
 LDCM0491  CL96 HEK-293T C191(0.99)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C191(0.99)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C191(1.38)  LDD1696  [7]
 LDCM0427  Fragment51 HEK-293T C191(0.79)  LDD1631  [7]
 LDCM0569  Fragment7 Jurkat _(11.86)  LDD1485  [3]
 LDCM0022  KB02 HEK-293T C191(0.87)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C191(1.02)  LDD1497  [7]
 LDCM0024  KB05 MKN45 C77(2.44)  LDD3332  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Reticulocalbin-1 (RCN1) CREC family Q15293
DNA damage-binding protein 1 (DDB1) DDB1 family Q16531
Troponin I, fast skeletal muscle (TNNI2) Troponin I family P48788
Troponin I, slow skeletal muscle (TNNI1) Troponin I family P19237

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402