Details of the Target

General Information of Target

Target ID LDTP14291
Target Name Mitogen-activated protein kinase kinase kinase 4 (MAP3K4)
Gene Name MAP3K4
Gene ID 4216
Synonyms
KIAA0213; MAPKKK4; MEKK4; MTK1; Mitogen-activated protein kinase kinase kinase 4; EC 2.7.11.25; MAP three kinase 1; MAPK/ERK kinase kinase 4; MEK kinase 4; MEKK 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEDEAVLDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRRHKRKTGHKEKKEKERI
SENYSDKSDIENADESSSSILKPLISPAAERIRFILGEEDDSPAPPQLFTELDELLAVDG
QEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGSIMLDREASSLP
QLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKKSNLRSLADIGKTVSSASRMFTN
PDNGSPAMTHRNLTSSSLNDISDKPEKDQLKNKFMKKLPRDAEASNVLVGEVDFLDTPFI
AFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKA
KDRHDLIAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTP
HDGGHGGGGHGDCEELQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLAT
VTNAITFGGLLGDATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLF
NFSKDNNFDYLEFRLWIGLWSAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDA
FKKMIKLADYYPINSNFKVGYNTLFSCTCVPPDPANISISNDTTLAPEYLPTMSSTDMYH
NTTFDWAFLSKKECSKYGGNLVGNNCNFVPDITLMSFILFLGTYTSSMALKKFKTSPYFP
TTARKLISDFAIILSILIFCVIDALVGVDTPKLIVPSEFKPTSPNRGWFVPPFGENPWWV
CLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPW
YVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFI
PMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLC
LALLWILKSTVAAIIFPVMILALVAVRKGMDYLFSQHDLSFLDDVIPEKDKKKKEDEKKK
KKKKGSLDSDNDDSDCPYSEKVPSIKIPMDIMEQQPFLSDSKPSDRERSPTFLERHTSC
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
Subcellular location
Cytoplasm, perinuclear region
Function Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.
TTD ID
T78492
Uniprot ID
Q9Y6R4
DrugMap ID
TT1RSX7
Ensemble ID
ENST00000366919.6
HGNC ID
HGNC:6856
ChEMBL ID
CHEMBL4853

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.M863V .
A3KAW SNV: p.R110Q .
AN3CA Insertion: p.S178IfsTer9 .
CHL1 SNV: p.A1510V .
COLO792 SNV: p.A1201P .
HCT15 SNV: p.I484V; p.K814R .
HT115 SNV: p.E262K .
ICC3 SNV: p.R909G .
JEKO1 Deletion: p.I474SfsTer5 .
JHH1 SNV: p.S178L .
JURKAT SNV: p.E1172V .
MDAMB157 SNV: p.G538R .
MDAMB436 SNV: p.K563T .
MFE296 Deletion: p.K177NfsTer30 .
MFE319 Insertion: p.N160KfsTer27 .
MKN45 Deletion: p.L395GfsTer2 DBIA    Probe Info 
ONS76 SNV: p.S111F .
P31FUJ Deletion: p.N160MfsTer8 .
PF382 SNV: p.C655R .
RL SNV: p.C655R .
SBC5 SNV: p.I206L .
SKMEL30 SNV: p.W506Ter .
SNGM SNV: p.K1385E .
SUPT1 SNV: p.G1366R .
TOV21G SNV: p.L646F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y739(15.62)  LDD0260  [1]
Johansson_61
 Probe Info  		_(20.00)  LDD1485  [2]
DBIA
 Probe Info  		C326(1.16); C596(0.91)  LDD0078  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C596(0.00); C1484(0.00); C1322(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C596(0.00); C521(0.00)  LDD0036  [5]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [6]
Lodoacetamide azide
 Probe Info  		C752(0.00); C998(0.00)  LDD0037  [5]
IPM
 Probe Info  		C1484(0.00); C326(0.00)  LDD0005  [7]
W1
 Probe Info  		N.A.  LDD0236  [8]
AOyne
 Probe Info  		12.70  LDD0443  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C169
 Probe Info  		23.10  LDD1849  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1484(0.73); C193(0.69)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C326(1.18); C521(0.47)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C326(0.89)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C326(0.95)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C326(0.95)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C326(1.15)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C326(1.14)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C326(1.07)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C326(1.24)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C326(0.81)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C326(1.16)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C326(1.68)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C326(1.15); C521(0.40)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C326(1.45)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C326(1.28)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C326(0.83)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C1484(0.90); C326(0.87); C521(0.88)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C1484(0.96); C326(0.90); C521(1.05)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C1484(0.89); C326(1.02); C521(1.11)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C1484(0.95); C326(1.01); C521(1.10)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C1484(0.86); C326(1.26); C521(0.95)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C1484(0.95); C326(0.97); C521(0.98)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C1484(0.88); C326(1.02); C521(1.03)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C326(0.98); C521(0.61)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C1484(0.80); C326(0.97); C521(0.99)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C1484(0.64); C326(0.94); C521(1.09)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C1484(0.81); C326(0.96); C521(1.08)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C1484(0.64); C326(0.88); C521(1.34)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C1484(0.66); C326(0.87); C521(1.00)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C1484(0.66); C326(0.85); C521(0.98)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C1484(0.75); C326(1.02); C521(1.01)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C1484(0.79); C326(1.06); C521(0.99)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C326(0.97); C521(1.22)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C326(1.13); C521(1.12)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C326(1.28); C521(0.99)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C326(0.93); C521(1.27)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C326(1.27); C521(1.10)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C326(1.33); C521(1.11)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C326(1.69); C521(1.22)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C326(1.21); C521(1.05)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C326(1.40); C521(1.13)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C326(1.39); C521(1.06)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C326(1.93); C521(1.35)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C326(1.28); C521(1.14)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C326(1.04); C521(0.80)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C326(2.15); C521(1.27)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C326(1.59); C521(1.30)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C326(1.45); C521(1.16)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C326(1.12)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C326(1.14)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C326(0.97)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C326(1.03)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C326(0.93)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C326(1.20)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C326(1.20)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C521(0.94); C326(1.20)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C326(1.05)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C326(1.02)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C326(1.08)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C326(1.25)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C326(1.20)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C326(1.21)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C326(1.10)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C326(1.13)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C1484(0.98); C326(1.04); C521(1.10)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C521(0.95); C1484(0.96); C326(1.25)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C521(0.83); C1484(0.86); C326(1.10)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C193(0.91); C1484(0.97)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C521(0.97); C326(1.00); C1484(1.03)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C1484(0.75); C326(1.08); C521(1.09)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C1484(0.84); C326(1.07); C521(1.09)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C1484(0.75); C521(0.88); C326(1.09)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C326(1.00); C1484(1.07); C521(1.15)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C326(0.72); C193(1.26)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C326(0.65); C193(1.08)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C326(0.85); C193(1.14)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C326(0.77); C193(1.32)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C326(0.91); C193(2.73)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C193(0.84); C1484(0.97)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C326(0.81); C193(1.00)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C326(0.80); C193(1.32)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C326(0.67); C193(0.99)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C326(0.79); C193(2.21)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C326(0.94); C193(1.39)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C326(1.02); C218(1.34)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C326(1.10); C218(1.34)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C218(0.89); C326(1.10)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C326(1.13); C218(1.18)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C218(1.18); C326(1.28)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C193(0.82); C1484(1.03)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C218(1.16); C326(1.39)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C218(1.13); C326(1.28)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C326(1.17); C218(1.51)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C326(1.27); C218(1.88)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C218(1.16); C326(1.40)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C218(0.83); C326(1.23)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C521(0.89); C326(1.03); C1484(1.16)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C521(0.69); C326(0.99); C1484(1.02)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C326(0.95); C1484(0.96); C521(1.07)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C1484(1.12); C521(1.13); C326(1.19)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C193(0.69); C1484(1.04)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C1484(0.95); C521(0.98); C326(1.21)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C1484(0.91); C326(0.97); C521(0.99)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C326(0.96); C1484(0.99); C521(1.05)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C521(0.83); C1484(0.96); C326(1.19)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C1484(0.88); C521(1.02); C326(1.21)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C521(0.65); C326(1.21); C1484(1.30)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C521(0.87); C1484(1.12); C326(1.34)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C218(1.10); C326(1.17); C1322(1.33)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C218(1.12); C1322(1.14); C326(1.22)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C218(0.92); C1322(1.20); C326(1.34)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C521(0.96); C326(1.19)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C218(1.14); C1322(1.22); C326(1.28)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C218(0.98); C326(1.14); C1322(1.16)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C218(1.05); C326(1.25); C1322(1.26)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C1322(1.15); C218(1.15); C326(1.48)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C1322(1.17); C218(1.26); C326(1.44)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C218(0.93); C326(1.31); C1322(1.35)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C1322(1.08); C218(1.22); C326(1.29)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C1322(1.13); C218(1.23); C326(1.57)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C1484(0.85); C193(0.90); C521(1.30)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C193(0.78); C1484(0.92); C521(1.10)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C521(0.72); C326(1.11)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C193(0.89); C521(1.15); C1484(1.27)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C193(0.79); C1484(0.90); C521(1.12)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C193(0.84); C1484(1.24); C521(1.24)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C193(0.95); C521(1.22); C1484(1.24)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C193(0.88); C1484(1.08); C521(1.31)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C193(1.01); C521(1.04); C1484(1.24)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C521(1.00); C193(1.01); C1484(1.32)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C1484(0.80); C193(0.93); C521(1.32)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C193(0.81); C1484(0.97); C521(1.12)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C193(0.83); C1484(0.95); C521(1.24)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C521(0.98); C326(1.20)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C193(0.87); C521(1.06); C1484(1.53)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C193(0.93); C1484(1.21); C521(1.22)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C193(1.07); C521(1.12); C1484(1.15)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C1484(1.34); C521(1.89)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C1484(1.13); C521(1.87)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C1484(1.05); C521(1.51)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C1484(0.97); C521(1.31)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C1484(0.94); C521(1.15)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C1484(1.18); C521(1.25)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C1484(1.10); C521(1.29)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C1484(1.05); C521(1.08)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C1484(0.87); C521(1.82)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C1484(1.16); C521(1.62)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C1484(1.16); C521(1.43)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C1484(0.92); C521(1.38)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C1484(0.97); C521(1.10)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C1484(1.02); C521(1.41)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C1484(1.04); C521(1.65)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C326(1.77)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C326(1.02)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C326(1.10); C521(0.57)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C521(0.68); C326(1.06)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C521(1.11); C326(1.78)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C326(1.16); C596(0.91)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C326(0.77); C1322(0.96)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C1322(1.02); C326(1.07)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C193(0.87); C1484(1.05)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C521(0.80); C326(1.49)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C521(0.78); C326(0.96)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C521(0.54); C326(1.28)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C521(0.81); C326(1.29)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C1484(0.85); C521(1.10); C326(1.17)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C1484(0.63); C521(1.18); C326(1.35)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C1484(0.71); C521(1.20); C326(1.28)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C1484(0.95); C521(1.32); C326(1.33)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C1484(0.82); C521(1.13); C326(1.19)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C326(0.98); C1322(1.00)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C521(1.07); C1484(1.11); C326(1.38)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C1484(0.95); C521(1.08); C326(1.29)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C193(0.69); C326(1.05)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C326(0.91); C193(1.20)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C326(0.88); C193(0.88)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C326(0.90); C193(0.97)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C326(1.10); C193(1.12)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C218(1.49); C326(1.62)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C326(1.04); C218(1.40)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C326(1.04); C218(1.29)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C1322(1.00); C326(1.30)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C326(1.07); C218(1.24)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C326(0.88); C521(1.08); C1484(1.11)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C1484(1.02); C326(1.08); C521(1.14)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C521(0.84); C1484(0.97); C326(1.15)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C521(1.04); C1484(1.16); C326(1.34)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C218(1.07); C326(1.10); C1322(1.12)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C218(1.05); C1322(1.10); C326(1.23)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C218(1.10); C326(1.19); C1322(1.23)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C218(1.14); C1322(1.19); C326(1.31)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C1322(0.98); C326(1.07)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C1322(0.99); C326(1.12)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C1322(1.06); C326(1.12)  LDD0719  [3]
 LDCM0403  CL16 PaTu 8988t C326(1.27)  LDD1282  [3]
 LDCM0404  CL17 HCT 116 C1322(0.79)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C1322(0.98)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C1322(1.05)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C326(0.74); C1322(0.99)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C1322(0.96)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C1322(0.90)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C1322(0.92)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C1322(0.97)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C1322(0.91)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C1322(1.06)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C1322(0.91)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C1322(0.93)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C1322(0.93)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C1322(0.93)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C1322(0.88); C326(0.75)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C1322(1.00)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C1322(0.90); C1484(1.01); C193(1.17); C326(0.94)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C1322(1.09); C1484(1.12); C193(1.10); C326(0.86)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C1322(1.05); C1484(1.06); C193(1.12); C326(0.95)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C1322(0.89); C1484(1.54); C193(1.08); C326(1.01)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C1322(0.99); C1484(0.97); C193(1.18); C326(0.98)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C1322(1.03); C1484(1.29); C193(1.42); C326(1.05)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C1322(1.04); C1484(1.42); C193(1.22); C326(1.05)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C1322(1.06); C1484(0.87); C193(1.13); C326(1.01)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C1322(0.76); C326(1.03)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C1322(0.95); C1484(1.55); C193(1.43); C326(1.24)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C1322(1.02); C1484(1.04); C193(1.24); C326(1.01)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C1322(0.96); C1484(1.48); C193(1.03); C326(0.94)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C1322(1.05); C1484(1.06); C193(1.55); C326(1.07)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C1322(0.87); C1484(1.16); C193(1.18); C326(1.01)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C1322(0.93); C1484(1.17); C193(1.38); C326(1.11)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C1484(1.33); C193(1.03); C521(0.70)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C1484(1.19); C193(1.10); C521(0.99)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C1484(0.90); C193(1.03); C521(0.73)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C1484(1.26); C193(1.00); C521(0.66)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C1322(1.02); C326(0.96)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C1484(1.20); C193(1.12); C521(0.78)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C1484(1.12); C193(1.26); C521(0.66)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C1484(1.22); C193(0.92); C521(0.82)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C1484(0.94); C193(1.03); C521(1.71)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C1484(0.96); C193(0.84); C521(0.76)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C1484(0.77); C193(0.95); C521(0.79)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C1484(0.85); C193(0.83); C521(1.05)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C1484(1.27); C193(0.85); C521(1.31)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C1484(0.99); C193(1.09); C521(0.63)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C1484(1.15); C193(0.98); C521(0.73)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C1322(1.06); C326(1.02)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C1484(1.21); C193(1.24); C521(0.59)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C1484(1.21); C218(1.11); C326(0.84); C521(0.98)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C1484(1.25); C218(1.14); C326(0.98); C521(0.81)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C1484(1.43); C218(1.36); C326(1.06); C521(1.52)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C1484(1.55); C218(1.45); C326(0.99); C521(0.87)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C1484(1.19); C218(1.10); C326(1.04); C521(1.08)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C1484(1.91); C218(1.48); C326(0.80); C521(0.95)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C1484(1.45); C218(1.16); C326(1.00); C521(1.34)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C1484(1.73); C218(1.39); C326(0.79); C521(3.16)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C1484(1.09); C218(1.10); C326(0.98); C521(1.14)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C1322(1.09); C326(1.19)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C1484(1.31); C218(1.27); C326(0.95); C521(1.33)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C1484(1.25); C218(1.07); C326(1.21); C521(1.25)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C1484(1.28); C218(1.02); C326(0.96); C521(1.27)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C1484(1.32); C218(1.08); C326(0.78); C521(1.55)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C1484(1.33); C218(1.40); C326(1.03); C521(1.52)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C218(0.96); C521(0.70)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C218(0.92); C521(0.74)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C218(0.93); C521(0.80)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C218(1.03); C521(0.77)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C1322(1.11); C326(1.45)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C218(0.91); C521(0.97)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C218(0.98); C521(0.99)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C218(1.06); C521(0.88)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C218(0.81); C521(0.81)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C218(0.78); C521(0.85)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C218(0.79); C521(0.88)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C218(0.98); C521(0.70)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C218(0.82); C521(0.79)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C218(1.00); C521(0.72)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C218(0.84); C521(0.83)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C1322(1.02); C326(0.94)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C218(0.88); C521(0.81)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C1484(0.81); C193(0.98)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C1484(0.71); C193(0.98)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C1484(1.01); C193(0.80)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C1484(1.07); C193(0.92)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C1484(0.78); C193(0.89)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C1484(0.94); C193(0.91)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C1484(0.86); C193(0.92)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C1484(0.73); C193(0.88)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C1484(1.14); C193(0.78)  LDD0811  [3]
 LDCM0468  Fragment33 HCT 116 C1484(1.29); C218(1.13); C326(0.95); C521(1.04)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C1322(0.94); C1484(1.06); C193(0.96); C326(1.69)  LDD0744  [3]
 LDCM0569  Fragment7 Jurkat _(20.00)  LDD1485  [2]
 LDCM0022  KB02 HCT 116 C61(1.19)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C61(0.90)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C61(1.06)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Filamin-B (FLNB) Filamin family O75369
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B) GADD45 family O75293
Polyubiquitin-C (UBC) Ubiquitin family P0CG48
SH3 domain-containing kinase-binding protein 1 (SH3KBP1) . Q96B97

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587