Details of the Target

General Information of Target

Target ID LDTP00678
Target Name Lysine-specific demethylase 6A (KDM6A)
Gene Name KDM6A
Gene ID 7403
Synonyms
UTX; Lysine-specific demethylase 6A; EC 1.14.11.68; Histone demethylase UTX; Ubiquitously-transcribed TPR protein on the X chromosome; Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein; [histone H3]-trimethyl-L-lysine(27) demethylase 6A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFV
RFHEDGARTKALLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYPKALSAYQRYY
SLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVN
TDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQ
VKATVLQQLGWMHHTVDLLGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKV
QDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGT
LYESCNQPQDAIKCYLNATRSKSCSNTSALAARIKYLQAQLCNLPQGSLQNKTKLLPSIE
EAWSLPIPAELTSRQGAMNTAQQNTSDNWSGGHAVSHPPVQQQAHSWCLTPQKLQHLEQL
RANRNNLNPAQKLMLEQLESQFVLMQQHQMRPTGVAQVRSTGIPNGPTADSSLPTNSVSG
QQPQLALTRVPSVSQPGVRPACPGQPLANGPFSAGHVPCSTSRTLGSTDTILIGNNHITG
SGSNGNVPYLQRNALTLPHNRTNLTSSAEEPWKNQLSNSTQGLHKGQSSHSAGPNGERPL
SSTGPSQHLQAAGSGIQNQNGHPTLPSNSVTQGAALNHLSSHTATSGGQQGITLTKESKP
SGNILTVPETSRHTGETPNSTASVEGLPNHVHQMTADAVCSPSHGDSKSPGLLSSDNPQL
SALLMGKANNNVGTGTCDKVNNIHPAVHTKTDNSVASSPSSAISTATPSPKSTEQTTTNS
VTSLNSPHSGLHTINGEGMEESQSPMKTDLLLVNHKPSPQIIPSMSVSIYPSSAEVLKAC
RNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFC
TNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKI
WHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGRRRKGPFK
TIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPG
SRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDL
YEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNK
LQSVKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWH
GRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKM
EDLMQVYDQFTLAPPLPSASS
Target Bioclass
Enzyme
Family
UTX family
Subcellular location
Nucleus
Function
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression.
Uniprot ID
O15550
Ensemble ID
ENST00000377967.9
HGNC ID
HGNC:12637
ChEMBL ID
CHEMBL2069164

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.37  LDD0402  [1]
Johansson_61
 Probe Info  		_(5.42)  LDD1485  [2]
AHL-Pu-1
 Probe Info  		C402(6.08)  LDD0168  [3]
DBIA
 Probe Info  		C1023(1.66); C384(2.00); C797(2.13)  LDD0080  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
Lodoacetamide azide
 Probe Info  		C374(0.00); C384(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
WYneO
 Probe Info  		N.A.  LDD0022  [8]
ENE
 Probe Info  		C797(0.00); C384(0.00)  LDD0006  [8]
IPM
 Probe Info  		N.A.  LDD0005  [8]
VSF
 Probe Info  		C797(0.00); C402(0.00); C4(0.00)  LDD0007  [8]
AOyne
 Probe Info  		10.60  LDD0443  [9]
NAIA_5
 Probe Info  		C1023(0.00); C384(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C402(6.08)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C402(4.74)  LDD0169  [3]
 LDCM0214  AC1 HEK-293T C164(0.81); C374(0.82); C797(0.96)  LDD0812  [4]
 LDCM0215  AC10 HCT 116 C374(1.11); C797(0.96)  LDD0532  [4]
 LDCM0216  AC100 HEK-293T C1023(0.79); C164(0.81); C293(1.27); C374(1.13)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C1023(0.85); C164(0.80); C293(1.11); C374(1.31)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C1023(0.77); C164(0.72); C293(0.84); C374(1.13)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C1023(0.73); C164(0.57); C293(1.14); C374(1.07)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C1023(0.60); C164(0.55); C293(1.06); C374(1.42)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C1023(1.04); C164(1.18); C293(1.66); C374(1.02)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C1023(1.47); C164(1.81); C293(1.33); C374(1.13)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C1023(0.85); C164(0.75); C293(1.39); C374(1.27)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C1023(1.09); C164(1.34); C293(1.19); C374(1.01)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C1023(0.99); C164(1.12); C293(1.18); C374(0.98)  LDD0823  [4]
 LDCM0226  AC11 HCT 116 C374(1.04); C797(1.23)  LDD0543  [4]
 LDCM0227  AC110 HEK-293T C1023(0.60); C164(0.49); C293(1.93); C374(1.25)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C1023(0.52); C164(0.41); C293(2.49); C374(0.95)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C1023(0.59); C164(0.47); C293(2.24); C374(1.01)  LDD0827  [4]
 LDCM0230  AC113 HCT 116 C374(0.84)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C374(1.06)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C374(0.85)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C374(0.98)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C374(0.97)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C374(1.11)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C374(0.94)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C374(1.15); C797(0.95)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C374(1.10)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C374(0.90)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C374(0.94)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C374(0.86)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C374(1.08)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C374(1.12)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C374(1.06)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C374(0.92)  LDD0562  [4]
 LDCM0246  AC128 HEK-293T C164(1.43); C293(1.00); C374(0.97); C797(1.23)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C164(1.60); C293(1.02); C374(0.89); C797(1.02)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C164(1.12); C293(0.91); C374(0.79); C797(0.93)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C164(1.08); C293(1.08); C374(0.79); C797(0.98)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C164(1.49); C293(0.93); C374(0.80); C797(1.09)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C164(0.66); C293(1.12); C374(0.67); C797(0.82)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C164(1.39); C293(1.05); C374(0.91); C797(0.79)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C164(0.62); C293(0.99); C374(0.80); C797(0.82)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C164(0.48); C293(1.18); C374(0.96); C797(0.70)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C164(0.59); C293(1.12); C374(0.93); C797(0.74)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C164(0.85); C293(1.29); C374(0.92); C797(0.74)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C164(1.25); C293(1.32); C374(0.80); C797(0.75)  LDD0856  [4]
 LDCM0259  AC14 HCT 116 C374(0.87); C797(1.24)  LDD0576  [4]
 LDCM0260  AC140 HEK-293T C164(0.74); C293(1.20); C374(0.86); C797(0.84)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C164(0.73); C293(1.31); C374(0.81); C797(0.73)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C164(0.66); C293(1.19); C374(0.78); C797(1.00)  LDD0860  [4]
 LDCM0263  AC143 HEK-293T C1023(0.65); C164(0.56); C293(3.05); C374(0.99)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C1023(0.63); C164(0.63); C293(1.03); C374(0.81)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C1023(0.65); C164(0.61); C293(0.71); C374(0.83)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C1023(0.72); C164(0.68); C293(1.22); C374(0.95)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C1023(0.61); C164(0.56); C293(1.04); C374(0.79)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C1023(0.67); C164(0.62); C293(1.05); C374(0.76)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C1023(0.95); C164(1.07); C293(0.78); C374(0.75)  LDD0867  [4]
 LDCM0270  AC15 HCT 116 C374(0.84); C797(1.18)  LDD0587  [4]
 LDCM0271  AC150 HEK-293T C1023(0.73); C164(0.68); C293(0.92); C374(1.08)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C1023(0.77); C164(0.66); C293(0.96); C374(0.78)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C1023(0.81); C164(0.70); C293(1.05); C374(0.90)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C1023(0.80); C164(0.71); C293(0.63); C374(0.83)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C1023(0.80); C164(0.72); C293(0.95); C374(1.09)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C1023(0.79); C164(0.69); C293(1.58); C374(0.83)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C1023(0.68); C164(0.58); C293(1.16); C374(0.82)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C1023(0.55); C164(0.38); C293(0.94); C374(0.93)  LDD2165  [4]
 LDCM0276  AC17 HCT 116 C797(0.85)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C797(1.25)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C797(0.94)  LDD0595  [4]
 LDCM0279  AC2 HEK-293T C164(0.84); C374(0.81); C797(0.85)  LDD0877  [4]
 LDCM0280  AC20 HCT 116 C797(0.80)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C797(0.88)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C797(0.76)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C797(0.74)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C797(0.76)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C374(1.46)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C374(1.28)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C374(1.11)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C374(0.99)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C374(1.31)  LDD0606  [4]
 LDCM0290  AC3 HEK-293T C164(0.96); C374(0.93); C797(0.96)  LDD0888  [4]
 LDCM0291  AC30 HCT 116 C374(1.29)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C374(1.40)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C374(1.32)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C374(1.60)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C374(1.29)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C374(0.74); C797(0.95)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C374(0.69); C797(1.05)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C374(0.84); C797(0.87)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C374(0.75); C797(1.10)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C374(0.67); C797(1.46)  LDD0617  [4]
 LDCM0301  AC4 HEK-293T C164(1.00); C374(0.86); C797(1.09)  LDD0899  [4]
 LDCM0302  AC40 HCT 116 C374(0.69); C797(1.13)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C374(0.71); C797(0.94)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C374(0.81); C797(1.10)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C374(0.87); C797(0.96)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C374(0.76); C797(1.15)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C374(0.81); C797(1.28)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C797(0.76); C374(1.25)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C797(0.74); C374(0.91)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C797(0.82); C374(1.18)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C797(1.20); C374(1.40)  LDD0628  [4]
 LDCM0312  AC5 HEK-293T C164(0.86); C374(0.81); C797(0.92)  LDD0910  [4]
 LDCM0313  AC50 HCT 116 C374(1.20); C797(1.39)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C797(0.67); C374(1.37)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C797(0.74); C374(1.31)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C374(0.98); C797(1.08)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C797(1.05); C374(1.15)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C374(1.07); C797(1.20)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C374(1.19); C797(1.87)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C374(1.32)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C374(0.81)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C374(0.82)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C797(1.34); C374(1.44)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C374(1.08)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C374(0.81)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C374(0.96)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C374(0.90)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C374(0.96)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C374(0.98)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C374(0.80)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C374(1.09)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C374(1.54)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C374(1.62)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C797(0.93); C374(1.14)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C374(2.16)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C374(1.51)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C374(2.04)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C374(1.94)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C374(1.61)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C374(1.77)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C374(1.56)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C374(1.82)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C374(1.54)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C374(1.81)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C797(1.02); C374(1.35)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C374(1.59)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C374(1.81)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C374(1.61)  LDD0665  [4]
 LDCM0349  AC83 HEK-293T C1023(1.14); C1361(0.98); C293(0.65); C374(1.01)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C1023(0.75); C1361(0.98); C293(0.75); C374(1.27)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C1023(0.88); C1361(1.02); C293(0.75); C374(0.94)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C1023(0.97); C1361(0.85); C293(0.70); C374(1.16)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C1023(0.83); C1361(0.92); C293(0.64); C374(1.23)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C1023(0.89); C1361(1.02); C293(0.70); C374(1.15)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C1023(0.58); C1361(0.99); C293(0.81); C374(1.32)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C1023(0.65); C1361(1.00); C293(0.63); C374(1.15)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C1023(0.73); C1361(0.93); C293(0.77); C374(0.99)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C1023(0.73); C1361(0.82); C293(0.81); C374(1.16)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C1023(0.60); C1361(1.11); C293(1.07); C374(0.98)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C1023(0.57); C1361(1.08); C293(1.42); C374(1.12)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C1023(0.80); C1361(1.12); C293(0.76); C374(1.01)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C1023(0.49); C1361(0.93); C293(1.06); C374(0.91)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C1023(0.39); C1361(1.53); C293(1.00); C374(0.92)  LDD0962  [4]
 LDCM0365  AC98 HEK-293T C1023(0.94); C164(1.07); C293(1.35); C374(1.12)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C1023(1.10); C164(1.58); C293(0.91); C374(2.03)  LDD0964  [4]
 LDCM0248  AKOS034007472 HCT 116 C374(1.01); C797(1.08)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C797(1.13); C374(1.17)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C797(1.17); C374(1.21)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C79(0.96); C4(0.76); C797(0.75)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C374(0.98)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C374(1.14)  LDD0685  [4]
 LDCM0369  CL100 HEK-293T C164(0.73); C374(0.82); C797(0.78)  LDD0967  [4]
 LDCM0370  CL101 HCT 116 C374(0.96); C797(1.03)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C374(0.88); C797(1.16)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C374(0.84); C797(1.22)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C374(0.91); C797(1.29)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C797(0.67)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C797(0.82)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C797(0.77)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C797(0.74)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C797(0.93)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C374(0.96)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C797(0.76)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C797(0.76)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C374(1.45)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C374(1.35)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C374(3.55)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C374(1.58)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C374(1.78)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C374(0.85); C797(1.71)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C374(0.83); C797(1.01)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C374(1.02); C797(1.12)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C374(1.18)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C374(0.88); C797(0.99)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C797(0.87); C374(1.27)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C797(0.87); C374(1.31)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C374(1.13); C797(1.20)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C797(1.30); C374(1.32)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C374(1.03)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C374(0.96)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C374(1.00)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C374(0.97)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C374(1.20)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C374(1.24)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C374(1.41)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C797(1.03)  LDD0720  [4]
 LDCM0404  CL17 HEK-293T C1361(1.13); C293(0.73); C374(1.44); C384(0.88)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C1361(1.11); C293(1.22); C374(1.10); C384(1.12)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C1361(1.09); C293(1.19); C374(1.75); C384(0.93)  LDD1004  [4]
 LDCM0407  CL2 HCT 116 C374(1.15)  LDD0724  [4]
 LDCM0408  CL20 HEK-293T C1361(0.94); C293(0.90); C374(0.91); C384(0.95)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C1361(1.39); C293(0.85); C374(1.04); C384(0.94)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C1361(1.05); C293(1.09); C374(1.02); C384(0.89)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C1361(1.05); C293(0.89); C374(0.93); C384(1.07)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C1361(1.10); C293(0.77); C374(0.80); C384(1.10)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C1361(1.05); C293(0.71); C374(0.74); C384(0.90)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C1361(0.96); C293(0.88); C374(1.00); C384(1.12)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C1361(0.93); C293(0.83); C374(0.89); C384(1.19)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C1361(1.09); C293(0.82); C374(0.96); C384(1.00)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C1361(1.05); C293(0.92); C374(1.07); C384(0.96)  LDD1015  [4]
 LDCM0418  CL3 HCT 116 C374(0.96)  LDD0735  [4]
 LDCM0419  CL30 HEK-293T C1361(1.17); C293(1.33); C374(0.76); C384(1.21)  LDD1017  [4]
 LDCM0420  CL31 HEK-293T C164(0.82); C293(1.11); C384(0.95); C797(0.64)  LDD1018  [4]
 LDCM0421  CL32 HCT 116 C797(1.04)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C797(1.09)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C797(1.04)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C797(1.13)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C797(0.88)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C797(1.01)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C797(0.92)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C374(0.91)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C797(0.91)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C797(0.88)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C797(0.82)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C797(0.94)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C797(0.85)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C797(0.85)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C374(1.31)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C374(0.95)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C374(1.18)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C374(1.29)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C374(1.59)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C374(1.10)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C374(1.12)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C374(1.10)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C374(0.80)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C374(1.12)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C374(1.12)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C374(1.06)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C374(1.01)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C374(1.16)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C374(1.07)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C374(1.60)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C374(0.98)  LDD0769  [4]
 LDCM0453  CL61 HEK-293T C293(1.18); C374(0.94); C797(0.71)  LDD1051  [4]
 LDCM0454  CL62 HEK-293T C293(1.75); C374(1.41); C797(0.77)  LDD1052  [4]
 LDCM0455  CL63 HEK-293T C293(1.65); C374(1.23); C797(0.60)  LDD1053  [4]
 LDCM0456  CL64 HEK-293T C293(1.03); C374(1.33); C797(0.83)  LDD1054  [4]
 LDCM0457  CL65 HEK-293T C293(1.49); C374(1.04); C797(0.89)  LDD1055  [4]
 LDCM0458  CL66 HEK-293T C293(1.46); C374(1.07); C797(0.69)  LDD1056  [4]
 LDCM0459  CL67 HEK-293T C293(1.12); C374(1.09); C797(0.93)  LDD1057  [4]
 LDCM0460  CL68 HEK-293T C293(1.20); C374(1.42); C797(0.69)  LDD1058  [4]
 LDCM0461  CL69 HEK-293T C293(1.23); C374(0.93); C797(0.80)  LDD1059  [4]
 LDCM0462  CL7 HCT 116 C374(1.45)  LDD0779  [4]
 LDCM0463  CL70 HEK-293T C293(1.24); C374(0.66); C797(0.82)  LDD1061  [4]
 LDCM0464  CL71 HEK-293T C293(1.70); C374(0.90); C797(0.83)  LDD1062  [4]
 LDCM0465  CL72 HEK-293T C293(1.16); C374(0.88); C797(0.88)  LDD1063  [4]
 LDCM0466  CL73 HEK-293T C293(1.15); C374(0.70); C797(0.74)  LDD1064  [4]
 LDCM0467  CL74 HEK-293T C293(2.05); C374(0.72); C797(0.55)  LDD1065  [4]
 LDCM0469  CL76 HCT 116 C374(1.28); C797(0.78)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C374(1.14); C797(0.67)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C374(1.08); C797(0.89)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C374(1.10); C797(0.91)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C374(1.12)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C374(1.02); C797(0.90)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C374(1.07); C797(0.72)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C374(1.06); C797(0.71)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C374(1.30); C797(0.94)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C374(0.99); C797(0.73)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C374(1.28); C797(0.62)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C374(1.46); C797(0.81)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C374(1.20); C797(0.69)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C374(0.94); C797(0.73)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C374(0.91); C797(0.81)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C374(0.99)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C374(1.07); C797(0.74)  LDD0802  [4]
 LDCM0486  CL91 HEK-293T C164(1.12); C374(0.79); C797(1.16)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C164(0.85); C374(0.77); C797(1.01)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C164(0.97); C374(0.99); C797(0.99)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C164(0.70); C374(0.71); C797(0.74)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C164(0.53); C374(0.70); C797(0.88)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C164(0.85); C374(0.71); C797(0.75)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C164(0.92); C374(0.94); C797(1.16)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C164(0.86); C374(0.81); C797(0.83)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C164(0.97); C374(0.78); C797(1.00)  LDD1092  [4]
 LDCM0468  Fragment33 HEK-293T C293(1.66); C374(0.70); C797(0.56)  LDD1066  [4]
 LDCM0427  Fragment51 HCT 116 C797(1.09)  LDD0744  [4]
 LDCM0569  Fragment7 Jurkat _(5.42)  LDD1485  [2]
 LDCM0022  KB02 HCT 116 C1023(1.66); C384(2.00); C797(2.13)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C1023(1.23); C384(1.40); C797(1.05)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C1023(1.97); C384(1.65); C797(1.46)  LDD0082  [4]
 LDCM0628  OTUB2-COV-1 HEK-293T C384(1.00)  LDD2207  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein goosecoid-2 (GSC2) Paired homeobox family O15499
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
WD repeat-containing protein 5 (WDR5) WD repeat WDR5/wds family P61964

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.