Details of the Target

General Information of Target

Target ID LDTP09038
Target Name Mixed lineage kinase domain-like protein (MLKL)
Gene Name MLKL
Gene ID 197259
Synonyms
Mixed lineage kinase domain-like protein; hMLKL
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL
PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI
AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD
LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS
LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKI
RKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
Target Bioclass
Transporter and channel
Family
Protein kinase superfamily
Subcellular location
Cytoplasm
Function
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZBP1, MLKL is phosphorylated by RIPK3 in the nucleus, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol.following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol. Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function.
Uniprot ID
Q8NB16
Ensemble ID
ENST00000306247.11
HGNC ID
HGNC:26617
ChEMBL ID
CHEMBL1938217

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ECC2 SNV: p.E159Q .
HCC1143 SNV: p.V308F .
HL60 SNV: p.Q413L .
MEWO SNV: p.G312E; p.E381K .
SNU869 SNV: p.I251M .
SUPT1 SNV: p.S259P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K230(5.45); K427(5.26); K95(9.68)  LDD0277  [2]
BTD
 Probe Info  		C18(0.94)  LDD2091  [3]
Johansson_61
 Probe Info  		_(14.66)  LDD1485  [4]
NAIA_5
 Probe Info  		C184(0.32)  LDD2228  [5]
DBIA
 Probe Info  		C184(1.10)  LDD0078  [6]
IA-alkyne
 Probe Info  		C448(0.00); C184(0.00)  LDD0162  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
Compound 10
 Probe Info  		N.A.  LDD2216  [9]
Compound 11
 Probe Info  		N.A.  LDD2213  [9]
IPM
 Probe Info  		N.A.  LDD0147  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C184(1.18)  LDD0531  [6]
 LDCM0215  AC10 PaTu 8988t C448(0.58); C184(1.40)  LDD1094  [6]
 LDCM0216  AC100 HCT 116 C184(0.91); C448(0.34)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C184(0.89); C448(0.35)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C184(0.96); C448(0.37)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C184(1.03); C448(0.22)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C184(0.89); C448(0.27)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C184(0.98); C448(0.25)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C184(1.01); C448(0.29)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C184(0.96); C448(0.34)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C184(1.09); C448(0.39)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C184(0.91); C448(0.33)  LDD0542  [6]
 LDCM0226  AC11 PaTu 8988t C448(0.47); C184(1.56)  LDD1105  [6]
 LDCM0227  AC110 HCT 116 C184(1.05); C448(0.33)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C184(0.95); C448(0.32)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C184(1.08); C448(0.35)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C448(0.68)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C448(0.55)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C448(0.46)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C448(0.42)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C448(0.55)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C448(0.59)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C448(0.68)  LDD0553  [6]
 LDCM0237  AC12 PaTu 8988t C448(0.52); C184(1.19)  LDD1116  [6]
 LDCM0238  AC120 HCT 116 C448(0.54)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C448(0.81)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C448(0.57)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C448(0.62)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C448(0.61)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C448(0.48)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C448(0.50)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C448(0.66)  LDD0562  [6]
 LDCM0259  AC14 PaTu 8988t C448(0.93); C184(1.49)  LDD1138  [6]
 LDCM0263  AC143 HCT 116 C448(0.58); C184(1.31)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C448(0.33); C184(1.05)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C448(0.53); C184(1.06)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C448(0.35); C184(1.23)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C448(0.34); C184(1.02)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C448(0.28); C184(0.94)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C448(0.30); C184(1.01)  LDD0586  [6]
 LDCM0270  AC15 PaTu 8988t C448(0.80); C184(1.61)  LDD1149  [6]
 LDCM0271  AC150 HCT 116 C448(0.61); C184(1.07)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C448(0.68); C184(0.98)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C448(0.35); C184(0.91)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C448(0.33); C184(1.12)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C184(1.08); C448(0.35)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C184(1.19); C448(0.42)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C184(1.07); C448(0.95)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C184(1.19); C448(0.73)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C184(1.08)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C184(0.87)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C184(1.01)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C184(1.08)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C184(0.97)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C184(0.90)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C184(0.93)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C184(1.00)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C184(0.99)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C184(0.92)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C184(1.01)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C184(0.97)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C184(1.00)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C184(1.21)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C184(1.06)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C184(1.20)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C184(0.93)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C184(1.08)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C184(0.92)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C184(0.90)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C184(1.01)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C184(1.12)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C184(1.19)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C184(1.01)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C184(1.12)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C184(1.16)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C184(1.21)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C184(1.36)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C184(1.19)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C184(1.13)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C184(1.10)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C184(1.17)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C448(0.87); C184(1.32)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C448(1.05); C184(1.23)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C448(0.82); C184(1.20)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C448(0.86); C184(1.42)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C184(1.28)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C448(0.84); C184(1.48)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C448(1.24); C184(1.32)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C448(1.07); C184(1.18)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C448(0.79); C184(1.26)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C448(0.71); C184(1.42)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C448(0.75); C184(1.05)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C448(0.86); C184(1.22)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C448(0.56)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C448(0.62)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C448(0.79)  LDD0639  [6]
 LDCM0323  AC6 PaTu 8988t C448(0.84); C184(1.12)  LDD1202  [6]
 LDCM0324  AC60 HCT 116 C448(0.58)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C448(0.59)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C448(0.66)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C448(0.63)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C448(0.54)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C448(0.42)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C448(0.43)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C448(0.39)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C184(0.97)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C184(0.83)  LDD0650  [6]
 LDCM0334  AC7 PaTu 8988t C448(0.63); C184(0.78)  LDD1213  [6]
 LDCM0335  AC70 HCT 116 C184(0.95)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C184(0.73)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C184(1.02)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C184(1.08)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C184(0.81)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C184(1.04)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C184(0.87)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C184(0.92)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C184(0.85)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C184(0.97)  LDD0661  [6]
 LDCM0345  AC8 PaTu 8988t C448(1.12); C184(0.98)  LDD1224  [6]
 LDCM0346  AC80 HCT 116 C184(0.73)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C184(0.92)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C184(0.73)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C448(0.42)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C448(0.42)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C448(0.69)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C448(0.74)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C448(0.91)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C448(0.68)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C448(0.60)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C448(0.95)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C448(0.48)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C448(0.37)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C448(0.73)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C448(0.62)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C448(0.61)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C448(0.56)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C448(0.61)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C448(0.22); C184(1.21)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C448(0.51); C184(1.16)  LDD0683  [6]
 LDCM0545  Acetamide MDA-MB-231 C18(1.76)  LDD2138  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C448(0.90); C184(1.58)  LDD1127  [6]
 LDCM0356  AKOS034007680 PaTu 8988t C448(0.57); C184(1.32)  LDD1235  [6]
 LDCM0275  AKOS034007705 PaTu 8988t C448(0.63); C184(1.27)  LDD1154  [6]
 LDCM0156  Aniline NCI-H1299 11.74  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C184(1.10)  LDD0078  [6]
 LDCM0498  BS-3668 MDA-MB-231 C18(0.94)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa C448(0.00); H329(0.00); H321(0.00)  LDD0222  [11]
 LDCM0367  CL1 HCT 116 C184(1.18)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C184(0.98)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C184(1.23)  LDD0686  [6]
 LDCM0370  CL101 PaTu 8988t C448(0.69); C184(1.07)  LDD1249  [6]
 LDCM0371  CL102 PaTu 8988t C448(0.67); C184(1.01)  LDD1250  [6]
 LDCM0372  CL103 PaTu 8988t C448(0.66); C184(1.95)  LDD1251  [6]
 LDCM0373  CL104 PaTu 8988t C448(0.89); C184(1.22)  LDD1252  [6]
 LDCM0374  CL105 HCT 116 C184(0.89)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C184(0.83)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C184(0.87)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C184(0.81)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C184(1.07)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C184(1.01)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C184(1.36)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C184(1.30)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C184(1.06)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C184(1.01)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C184(1.24)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C184(1.17)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C184(1.00)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C184(1.13)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C184(1.13)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C184(1.17)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C184(0.98)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C184(1.17)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C448(0.84); C184(1.15)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C448(0.89); C184(1.17)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C448(0.67); C184(1.14)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C448(0.72); C184(1.41)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C448(0.85)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C448(1.33)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C448(0.69)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C448(0.54)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C184(0.91)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C184(0.94)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C184(0.88)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C184(1.19)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C184(1.03)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C184(0.99)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C184(0.86)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C184(1.02)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C184(0.98)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C184(1.04)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C184(0.92)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C184(0.96)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C184(1.03)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C184(1.29)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C184(1.19)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C184(0.94)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C184(1.10)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C184(1.01)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C184(0.99)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C184(0.92)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C184(1.22)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C184(1.25)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C184(1.36)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C184(1.33)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C184(1.36)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C184(1.39)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C184(1.42)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C184(1.50)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C184(0.98)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C184(1.54)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C184(1.26)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C184(1.77)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C184(1.42)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C184(1.37)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C184(1.64)  LDD0752  [6]
 LDCM0436  CL46 PaTu 8988t C448(0.70)  LDD1315  [6]
 LDCM0437  CL47 PaTu 8988t C448(0.66)  LDD1316  [6]
 LDCM0438  CL48 PaTu 8988t C448(0.67)  LDD1317  [6]
 LDCM0439  CL49 PaTu 8988t C448(0.53)  LDD1318  [6]
 LDCM0440  CL5 HCT 116 C184(0.79)  LDD0757  [6]
 LDCM0441  CL50 PaTu 8988t C448(0.53)  LDD1320  [6]
 LDCM0442  CL51 PaTu 8988t C448(0.71)  LDD1321  [6]
 LDCM0443  CL52 PaTu 8988t C448(0.59)  LDD1322  [6]
 LDCM0444  CL53 PaTu 8988t C448(0.44)  LDD1323  [6]
 LDCM0445  CL54 PaTu 8988t C448(0.50)  LDD1324  [6]
 LDCM0446  CL55 PaTu 8988t C448(0.65)  LDD1325  [6]
 LDCM0447  CL56 PaTu 8988t C448(0.23)  LDD1326  [6]
 LDCM0448  CL57 PaTu 8988t C448(0.48)  LDD1327  [6]
 LDCM0449  CL58 PaTu 8988t C448(0.41)  LDD1328  [6]
 LDCM0450  CL59 PaTu 8988t C448(0.42)  LDD1329  [6]
 LDCM0451  CL6 HCT 116 C184(0.98)  LDD0768  [6]
 LDCM0452  CL60 PaTu 8988t C448(0.39)  LDD1331  [6]
 LDCM0453  CL61 HCT 116 C184(1.22)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C184(1.19)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C184(1.30)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C184(1.41)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C184(1.21)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C184(1.57)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C184(1.27)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C184(1.32)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C184(1.21)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C184(0.80)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C184(1.26)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C184(1.39)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C184(1.18)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C184(1.41)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C184(1.35)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C184(1.13); C448(0.61)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C184(1.10); C448(0.55)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C184(1.10); C448(0.48)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C184(1.30); C448(0.42)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C184(1.80)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C184(1.03); C448(1.17)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C184(1.11); C448(0.60)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C184(1.32); C448(0.36)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C184(1.33); C448(0.30)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C184(1.61); C448(0.36)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C184(1.21); C448(0.55)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C184(1.12); C448(0.50)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C184(1.22); C448(0.46)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C184(1.39); C448(0.51)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C184(1.63); C448(0.43)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C184(0.96)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C184(1.15); C448(0.65)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C184(1.19)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C184(1.16)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C184(1.02)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C184(1.42)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C184(1.54)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C184(1.18)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C184(1.14)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C184(1.20)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C184(1.19)  LDD0811  [6]
 LDCM0634  CY-0357 Hep-G2 C184(0.32)  LDD2228  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C184(2.64)  LDD1702  [3]
 LDCM0468  Fragment33 HCT 116 C184(1.22)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C184(2.07)  LDD0744  [6]
 LDCM0616  Fragment61 Jurkat _(8.66)  LDD1489  [4]
 LDCM0569  Fragment7 Jurkat _(14.66)  LDD1485  [4]
 LDCM0022  KB02 8305C C437(1.50)  LDD2248  [13]
 LDCM0023  KB03 MDA-MB-231 C184(1.55)  LDD1701  [3]
 LDCM0024  KB05 MOLM-13 C184(2.95); C448(2.42)  LDD3333  [13]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C18(1.75)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C18(1.01)  LDD2129  [3]
 LDCM0131  RA190 MM1.R C184(1.49)  LDD0304  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) TKL Ser/Thr protein kinase family Q9Y572
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein S100-A10 (S100A10) S-100 family P60903

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
14 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.