Details of the Target

General Information of Target

Target ID LDTP05825
Target Name Growth factor receptor-bound protein 10 (GRB10)
Gene Name GRB10
Gene ID 2887
Synonyms
GRBIR; KIAA0207; Growth factor receptor-bound protein 10; GRB10 adapter protein; Insulin receptor-binding protein Grb-IR
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMN
ASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAV
RRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK
VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASE
SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVK
ELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH
GLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF
STPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHP
STLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIK
NFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL
Target Bioclass
Other
Family
GRB7/10/14 family
Subcellular location
Cytoplasm
Function
Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.
Uniprot ID
Q13322
Ensemble ID
ENST00000335866.7
HGNC ID
HGNC:4564
ChEMBL ID
CHEMBL3621028

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EGI1 SNV: p.S71I .
HUH1 SNV: p.P160T DBIA    Probe Info 
KYM1 Deletion: p.S476VfsTer8 .
LS180 SNV: p.V299G DBIA    Probe Info 
OE33 SNV: p.E429K .
RKO SNV: p.V580A DBIA    Probe Info 
SKMEL24 SNV: p.P477L DBIA    Probe Info 
SUDHL4 SNV: p.R25H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Johansson_61
 Probe Info  		_(20.00)  LDD1485  [1]
AHL-Pu-1
 Probe Info  		C146(5.58)  LDD0170  [2]
DBIA
 Probe Info  		C321(0.91)  LDD0078  [3]
IA-alkyne
 Probe Info  		C380(0.00); C363(0.00); C547(0.00)  LDD0162  [4]
IPM
 Probe Info  		C223(0.00); C203(0.00)  LDD2156  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C146(5.58)  LDD0170  [2]
 LDCM0026  4SU-RNA+native RNA DM93 C146(11.07)  LDD0171  [2]
 LDCM0214  AC1 HCT 116 C194(0.89); C321(0.67); C389(1.10)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C194(0.88); C321(1.09); C389(0.88)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C194(0.92); C321(0.97); C389(0.87)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C194(0.90); C321(1.13); C389(0.90)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C194(0.81); C321(0.99); C389(0.87)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C194(0.86); C321(0.74); C389(0.91)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C194(0.86); C321(0.81); C389(0.88)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C194(0.85); C321(0.74); C389(0.89)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C194(0.87); C321(0.81); C389(0.92)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C194(0.79); C321(0.68); C389(0.91)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C194(0.89); C321(0.80); C389(0.85)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C194(0.82); C321(0.68); C389(0.94)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C194(0.86); C321(0.88); C389(1.15)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C194(0.96); C321(0.73); C389(0.90)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C194(0.89); C321(0.95); C389(0.91)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C194(0.83); C321(0.92); C389(1.11)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C194(0.89); C321(0.80)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C194(0.93); C321(0.92)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C194(0.93); C321(0.87)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C194(0.90); C321(0.90)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C194(1.05); C321(0.99)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C194(1.05); C321(0.97)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C194(0.93); C321(1.06)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C194(0.87); C321(0.93); C389(1.23)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C194(0.91); C321(1.07)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C194(1.12); C321(1.20)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C194(0.98); C321(1.12)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C194(1.15); C321(1.13)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C194(1.07); C321(1.13)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C194(0.93); C321(1.10)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C194(1.12); C321(1.09)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C194(1.06); C321(1.28)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C194(1.13); C389(1.47)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C194(1.06); C389(1.45)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C194(1.05); C389(1.38)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C194(1.05); C389(1.33)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C194(1.16); C389(1.36)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C194(1.05); C389(1.38)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C194(1.14); C389(1.10)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C194(1.14); C389(1.27)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C194(1.27); C389(1.25)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C194(1.09); C389(1.36)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C194(1.38); C389(0.77)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C194(1.47); C389(0.92)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C194(0.79); C321(0.95); C389(0.89)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C194(1.41); C389(0.60)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C194(1.38); C389(0.65)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C194(1.22); C389(1.20)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C194(0.77); C389(1.09)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C194(0.96); C389(1.06)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C194(1.08); C389(1.17)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C194(0.70); C389(1.36)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C194(1.08); C389(1.10)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C194(0.73); C389(1.03)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C194(0.65); C389(1.18)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C194(0.89); C389(1.03); C321(1.17)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C194(0.70); C389(1.08)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C194(0.78); C389(1.04)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C194(0.61); C389(1.05)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C194(0.48); C389(1.52)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C194(0.84); C389(1.23)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C194(0.60); C389(1.16)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C194(0.61); C389(1.11)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C194(0.66); C389(1.19)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C321(0.69); C194(1.04)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C321(0.85); C194(1.09)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C321(0.79); C194(1.18)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C194(0.93); C321(0.93); C389(1.42)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C321(0.66); C194(1.01)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C321(0.51); C194(0.97)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C321(0.61); C194(0.99)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C321(0.75); C194(1.08)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C321(0.63); C194(1.00)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C321(0.96); C194(1.08); C389(1.10)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C321(1.00); C389(1.00); C194(1.02)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C321(0.88); C194(1.09); C389(1.28)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C194(1.06); C321(1.12); C389(1.39)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C194(1.12); C321(1.38); C389(2.09)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C194(0.89); C321(1.20); C389(1.27)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C194(1.08); C321(1.40); C389(1.76)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C194(1.12); C321(1.12); C389(1.28)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C194(1.06); C321(1.38); C389(1.86)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C194(0.97); C321(1.00); C389(1.06)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C194(0.99); C321(1.12); C389(1.25)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C389(0.79); C321(0.97); C194(1.13)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C321(0.80); C194(0.96); C389(1.04)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C321(0.83); C194(0.87); C389(0.99)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C194(1.01); C389(1.11); C321(1.11)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C389(0.82); C321(0.94); C194(1.22)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C321(0.87); C194(0.91); C389(1.25)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C389(0.88); C321(0.93); C194(1.01)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C321(0.86); C389(0.92); C194(0.94)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C321(0.86); C389(0.97); C194(1.03)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C194(0.90); C321(0.94); C389(1.00)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C321(0.87); C389(0.99); C194(1.09)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C321(0.92); C194(1.05); C389(1.08)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C194(1.05); C389(1.16); C321(1.48)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C321(0.95); C389(0.96); C194(1.03)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C194(0.93); C389(0.94); C321(1.06)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C194(1.02); C389(1.07); C321(1.32)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C321(0.85); C194(0.95); C389(1.20)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C321(0.97); C194(1.07); C389(1.12)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C194(1.03); C321(1.05); C389(1.18)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C194(1.02); C389(1.08); C321(1.21)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C194(1.00); C389(1.06); C321(1.22)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C194(1.02); C321(1.03); C389(1.25)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C194(1.05); C389(1.13); C321(1.28)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C389(1.05); C194(1.08); C321(1.28)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C321(0.42); C389(0.89); C194(1.03)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C321(0.70); C389(0.93); C194(1.02)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C321(0.60); C389(0.88); C194(1.03)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C194(0.90); C321(1.07); C389(1.37)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C321(0.51); C194(0.95); C389(0.97)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C321(0.40); C389(0.84); C194(1.03)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C321(0.52); C389(0.96); C194(0.99)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C321(0.44); C389(0.89); C194(0.99)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C321(0.50); C194(1.07); C389(1.12)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C321(0.57); C389(1.01); C194(1.05)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C321(0.55); C389(0.93); C194(1.10)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C321(0.54); C389(0.92); C194(0.99)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C389(0.54); C321(0.92); C194(1.04)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C389(0.71); C321(0.84); C194(1.29)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C194(0.91); C321(0.92); C389(0.93)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C389(0.69); C321(0.92); C194(1.25)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C389(0.68); C321(0.96); C194(1.32)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C389(0.69); C194(0.98); C321(1.04)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C389(0.80); C321(0.88); C194(1.10)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C389(0.67); C321(1.05); C194(1.22)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C321(0.82); C389(0.94); C194(1.06)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C389(0.67); C321(1.06); C194(1.24)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C389(0.75); C321(1.09); C194(1.09)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C389(0.92); C194(0.97); C321(1.03)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C389(0.86); C321(0.87); C194(1.10)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C194(0.90); C389(0.91); C321(1.23)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C389(0.63); C321(0.85); C194(0.97)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C389(0.82); C321(0.86); C194(1.25)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C389(0.72); C321(1.11); C194(1.17)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C194(0.75); C321(1.01)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C194(0.63); C321(1.06)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C194(0.68); C321(1.02)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C194(0.77); C321(1.08)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C194(0.94); C321(0.98)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C194(0.88); C321(0.91)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C194(0.78); C321(1.01)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C194(0.93); C321(0.95)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C194(0.83); C321(0.89)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C194(0.70); C321(1.09)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C194(0.67); C321(0.96)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C194(0.75); C321(1.07)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C194(0.86); C321(1.14)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C194(0.76); C321(1.36)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C194(0.72); C321(1.04)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C194(0.82); C389(0.93); C321(1.06)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C194(0.85); C389(0.93); C321(1.04)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C194(0.93); C321(1.40); C389(0.96)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C194(0.84); C321(1.12); C389(1.32)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C194(0.90); C389(1.05); C321(1.12)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C321(0.91)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C389(0.69); C194(0.96)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C194(0.85); C389(0.92)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C321(0.75); C194(0.90); C389(1.24)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C194(0.87); C389(1.00); C321(1.02)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C194(0.90); C321(0.91); C389(1.38)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C321(0.87); C194(0.92); C389(0.94)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C321(0.87); C194(0.91); C389(1.17)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C194(0.97); C321(1.11)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C321(0.99); C194(1.18)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C194(0.93); C321(1.21)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C194(1.03); C321(1.10)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C321(0.65); C194(1.10)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C194(0.94); C389(0.97)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C321(0.72); C194(1.23)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C321(0.71); C194(1.14)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C321(0.98); C194(1.02); C389(1.44)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C194(1.01); C321(1.24); C389(1.58)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C194(0.93); C321(1.20); C389(1.62)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C194(1.03); C321(1.07); C389(1.47)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C194(1.01); C321(1.09); C389(1.48)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C389(0.96); C321(1.18); C194(1.25)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C321(0.89); C194(0.94); C389(1.17)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C194(0.91); C321(0.93); C389(0.99)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C389(0.88); C194(0.91)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C194(0.89); C389(0.90); C321(1.04)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C321(0.85); C194(1.01); C389(1.05)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C389(0.92); C194(0.97); C321(1.27)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C321(0.97); C194(1.11); C389(1.14)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C194(0.99); C389(1.06); C321(1.39)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C321(0.48); C389(1.05); C194(1.06)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C321(0.79); C194(1.00); C389(1.19)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C321(0.56); C194(0.95); C389(1.10)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C321(0.47); C389(0.95); C194(1.06)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C194(0.79); C389(0.86)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C194(0.71); C389(0.86)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C194(0.74); C389(0.80)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C389(0.91); C321(0.95); C194(1.10)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C321(0.97); C389(1.07); C194(1.10)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C321(0.88); C389(0.91); C194(1.07)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C389(0.96); C321(1.00); C194(1.17)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C389(0.81); C194(0.85)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C321(1.02); C389(1.04); C194(1.09)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C321(1.10); C389(1.21); C194(1.41)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C389(1.07); C321(1.34); C194(1.50)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C389(0.82); C321(1.14); C194(1.25)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C389(0.99); C194(1.04); C321(1.06)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C194(0.89); C321(0.97); C389(0.99)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C194(0.98); C321(0.98); C389(0.61)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C194(0.95); C321(0.96); C389(1.03)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C194(1.05); C321(0.97); C389(1.07)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C194(1.04); C321(1.12); C389(1.06)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C194(0.74); C389(0.86)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C194(1.09); C321(1.35); C389(1.00)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C194(0.95); C321(0.78); C389(1.06)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C194(0.82); C321(0.72); C389(0.97)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C194(0.76); C321(0.63); C389(1.07)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C194(0.86); C321(1.47); C389(1.04)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C194(0.86); C321(0.92); C389(1.09)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C194(0.86); C321(0.89); C389(1.19)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C194(0.89); C321(0.89); C389(1.02)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C194(0.94); C321(0.83); C389(1.06)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C194(0.96); C389(0.86)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C194(0.90); C321(0.65); C389(1.20)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C194(0.85); C321(0.96); C389(1.20)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C194(0.96); C321(1.25); C389(1.01)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C194(0.91); C321(1.22); C389(1.21)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C194(0.85); C321(0.76); C389(1.18)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C194(0.91); C321(0.93); C389(1.09)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C194(1.10); C321(0.75); C389(1.03)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C194(1.05); C321(0.96); C389(0.92)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C194(1.04); C321(1.05); C389(1.22)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C194(1.13); C321(1.17); C389(1.53)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C194(0.83); C389(0.94)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C194(1.05); C321(0.95); C389(1.48)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C194(1.06); C321(1.05); C389(0.92)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C194(1.07); C321(0.70); C389(1.18)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C194(0.94); C321(0.76); C389(1.14)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C194(1.16); C321(0.79); C389(1.26)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C194(1.10); C321(0.67); C389(1.27)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C194(1.06); C321(1.14); C389(1.14)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C194(0.98); C321(0.96); C389(1.09)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C194(1.04); C321(1.13); C389(1.22)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C194(1.11); C321(0.97); C389(1.11)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C194(0.72); C389(0.96)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C194(1.05); C321(1.11); C389(1.22)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C194(0.87); C321(0.95); C389(0.90)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C194(0.93); C321(0.89); C389(1.03)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C194(0.87); C321(0.84); C389(0.90)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C194(0.92); C321(1.02); C389(0.78)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C194(0.93); C321(0.93); C389(0.82)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C194(0.95); C321(0.85); C389(0.98)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C194(0.96); C321(0.99); C389(1.12)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C194(0.83); C321(0.92); C389(1.31)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C194(0.75); C321(0.75); C389(0.91)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C194(0.89); C389(0.81)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C194(0.88); C321(0.80); C389(1.15)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C194(0.91); C321(0.95); C389(0.97)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C194(0.99); C321(1.00); C389(1.26)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C194(0.91); C321(1.14); C389(0.88)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C194(0.89); C321(1.15); C389(1.13)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C194(0.87); C321(1.10); C389(0.92)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C194(0.89); C321(0.89); C389(1.06)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C194(0.98); C321(0.93); C389(1.26)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C194(0.92); C321(1.03); C389(0.93)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C194(0.81); C389(0.85)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C194(0.80); C321(0.93); C389(0.89)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C194(0.91); C321(0.86); C389(1.07)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C194(0.95); C321(0.97); C389(1.14)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C194(0.92); C321(0.86); C389(1.10)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C194(0.97); C321(1.02); C389(0.99)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C194(0.91); C321(1.20); C389(0.82)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C194(0.96); C321(1.12); C389(0.96)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C194(0.92); C321(1.33); C389(1.03)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C194(0.97); C321(1.06); C389(0.92)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C194(1.13); C321(1.14); C389(0.92)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C194(0.83); C389(0.94)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C194(1.03); C321(1.01); C389(1.22)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C194(0.97); C321(0.61); C389(1.52)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C194(1.02); C321(1.16); C389(1.28)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C194(1.02); C321(1.09); C389(1.03)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C194(0.90); C321(0.59); C389(1.12)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C194(0.93); C321(0.72); C389(1.30)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C194(0.86); C321(0.79); C389(1.30)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C194(0.92); C321(0.81); C389(1.11)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C194(0.90); C321(0.73); C389(1.57)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C194(0.96); C321(0.74); C389(1.59)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C380(1.12); C389(0.93); C194(0.87); C146(1.01)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C194(0.84); C321(0.89); C389(1.05)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C194(1.01); C321(1.42); C389(0.98)  LDD0744  [3]
 LDCM0569  Fragment7 Jurkat _(20.00)  LDD1485  [1]
 LDCM0022  KB02 HCT 116 C389(1.78); C321(1.60)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C389(3.07); C321(1.93)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C389(3.62); C321(2.09)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serotonin N-acetyltransferase (AANAT) Acetyltransferase family Q16613
Glycine amidinotransferase, mitochondrial (GATM) Amidinotransferase family P50440
Phenylalanine--tRNA ligase, mitochondrial (FARS2) Class-II aminoacyl-tRNA synthetase family O95363
Serine/threonine-protein kinase PAK 1 (PAK1) STE Ser/Thr protein kinase family Q13153
Receptor-type tyrosine-protein kinase FLT3 (FLT3) Tyr protein kinase family P36888
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Ephrin type-B receptor 1 (EPHB1) Tyr protein kinase family P54762
Insulin receptor (INSR) Tyr protein kinase family P06213
Proto-oncogene tyrosine-protein kinase Src (SRC) Tyr protein kinase family P12931
Tyrosine-protein kinase Blk (BLK) Tyr protein kinase family P51451
Tyrosine-protein kinase TXK (TXK) Tyr protein kinase family P42681
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Importin subunit alpha-4 (KPNA3) Importin alpha family O00505
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein c-Fos (FOS) BZIP family P01100
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) PI3K p85 subunit family P27986
Calcipressin-3 (RCAN3) RCAN family Q9UKA8
Tektin-4 (TEKT4) Tektin family Q8WW24
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
PRKCA-binding protein (PICK1) . Q9NRD5
Zinc finger MYND domain-containing protein 19 (ZMYND19) . Q96E35

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402