Details of the Target

General Information of Target

Target ID LDTP06900
Target Name Protein mono-ADP-ribosyltransferase PARP10 (PARP10)
Gene Name PARP10
Gene ID 84875
Synonyms
Protein mono-ADP-ribosyltransferase PARP10; EC 2.4.2.-; ADP-ribosyltransferase diphtheria toxin-like 10; ARTD10; Poly [ADP-ribose] polymerase 10; PARP-10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVAMAEAEAGVAVEVRGLPPAVPDELLTLYFENRRRSGGGPVLSWQRLGCGGVLTFREPA
DAERVLAQADHELHGAQLSLRPAPPRAPARLLLQGLPPGTTPQRLEQHVQALLRASGLPV
QPCCALASPRPDRALVQLPKPLSEADVRVLEEQAQNLGLEGTLVSLARVPQARAVRVVGD
GASVDLLLLELYLENERRSGGGPLEDLQRLPGPLGTVASFQQWQVAERVLQQEHRLQGSE
LSLVPHYDILEPEELAENTSGGDHPSTQGPRATKHALLRTGGLVTALQGAGTVTMGSGEE
PGQSGASLRTGPMVQGRGIMTTGSGQEPGQSGTSLRTGPMGSLGQAEQVSSMPMGSLEHE
GLVSLRPVGLQEQEGPMSLGPVGSAGPVETSKGLLGQEGLVEIAMDSPEQEGLVGPMEIT
MGSLEKAGPVSPGCVKLAGQEGLVEMVLLMEPGAMRFLQLYHEDLLAGLGDVALLPLEGP
DMTGFRLCGAQASCQAAEEFLRSLLGSISCHVLCLEHPGSARFLLGPEGQHLLQGLEAQF
QCVFGTERLATATLDTGLEEVDPTEALPVLPGNAHTLWTPDSTGGDQEDVSLEEVRELLA
TLEGLDLDGEDWLPRELEEEGPQEQPEEEVTPGHEEEEPVAPSTVAPRWLEEEAALQLAL
HRSLEPQGQVAEQEEAAALRQALTLSLLEQPPLEAEEPPDGGTDGKAQLVVHSAFEQDVE
ELDRALRAALEVHVQEETVGPWRRTLPAELRARLERCHGVSVALRGDCTILRGFGAHPAR
AARHLVALLAGPWDQSLAFPLAASGPTLAGQTLKGPWNNLERLAENTGEFQEVVRAFYDT
LDAARSSIRVVRVERVSHPLLQQQYELYRERLLQRCERRPVEQVLYHGTTAPAVPDICAH
GFNRSFCGRNATVYGKGVYFARRASLSVQDRYSPPNADGHKAVFVARVLTGDYGQGRRGL
RAPPLRGPGHVLLRYDSAVDCICQPSIFVIFHDTQALPTHLITCEHVPRASPDDPSGLPG
RSPDT
Target Bioclass
Enzyme
Family
ARTD/PARP family
Subcellular location
Nucleus, nucleolus
Function
ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity. Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA.
Uniprot ID
Q53GL7
Ensemble ID
ENST00000313028.12
HGNC ID
HGNC:25895
ChEMBL ID
CHEMBL2429708

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C50(0.00); C757(0.00)  LDD0241  [1]
Johansson_61
 Probe Info  		_(8.17)  LDD1485  [2]
DBIA
 Probe Info  		C50(117.72); C768(7.01)  LDD0209  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C434(0.00); C757(0.00); C542(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C434(0.00); C757(0.00); C542(0.00); C50(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C757(0.00); C542(0.00)  LDD0037  [4]
Compound 11
 Probe Info  		N.A.  LDD2213  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C50(1.53)  LDD1093  [6]
 LDCM0216  AC100 PaTu 8988t C434(0.89)  LDD1095  [6]
 LDCM0217  AC101 PaTu 8988t C434(0.79)  LDD1096  [6]
 LDCM0218  AC102 PaTu 8988t C434(0.70)  LDD1097  [6]
 LDCM0219  AC103 PaTu 8988t C434(1.28)  LDD1098  [6]
 LDCM0220  AC104 PaTu 8988t C434(0.83)  LDD1099  [6]
 LDCM0221  AC105 PaTu 8988t C434(0.82)  LDD1100  [6]
 LDCM0222  AC106 PaTu 8988t C434(1.11)  LDD1101  [6]
 LDCM0223  AC107 PaTu 8988t C434(0.74)  LDD1102  [6]
 LDCM0224  AC108 PaTu 8988t C434(1.06)  LDD1103  [6]
 LDCM0225  AC109 PaTu 8988t C434(1.05)  LDD1104  [6]
 LDCM0227  AC110 PaTu 8988t C434(0.88)  LDD1106  [6]
 LDCM0228  AC111 PaTu 8988t C434(1.18)  LDD1107  [6]
 LDCM0229  AC112 PaTu 8988t C434(1.20)  LDD1108  [6]
 LDCM0230  AC113 PaTu 8988t C50(0.89); C434(0.97)  LDD1109  [6]
 LDCM0231  AC114 PaTu 8988t C50(1.01); C434(1.20)  LDD1110  [6]
 LDCM0232  AC115 PaTu 8988t C50(1.10); C434(1.45)  LDD1111  [6]
 LDCM0233  AC116 PaTu 8988t C50(0.97); C434(1.13)  LDD1112  [6]
 LDCM0234  AC117 PaTu 8988t C50(1.06); C434(0.90)  LDD1113  [6]
 LDCM0235  AC118 PaTu 8988t C50(0.99); C434(0.92)  LDD1114  [6]
 LDCM0236  AC119 PaTu 8988t C50(1.10); C434(1.26)  LDD1115  [6]
 LDCM0238  AC120 PaTu 8988t C50(1.08); C434(1.08)  LDD1117  [6]
 LDCM0239  AC121 PaTu 8988t C50(0.93); C434(1.49)  LDD1118  [6]
 LDCM0240  AC122 PaTu 8988t C50(1.01); C434(0.82)  LDD1119  [6]
 LDCM0241  AC123 PaTu 8988t C50(1.03); C434(1.92)  LDD1120  [6]
 LDCM0242  AC124 PaTu 8988t C50(1.01); C434(1.56)  LDD1121  [6]
 LDCM0243  AC125 PaTu 8988t C50(1.15); C434(1.24)  LDD1122  [6]
 LDCM0244  AC126 PaTu 8988t C50(0.99); C434(1.32)  LDD1123  [6]
 LDCM0245  AC127 PaTu 8988t C50(0.98); C434(1.42)  LDD1124  [6]
 LDCM0246  AC128 PaTu 8988t C50(1.05); C434(1.07)  LDD1125  [6]
 LDCM0247  AC129 PaTu 8988t C50(1.15); C434(1.10)  LDD1126  [6]
 LDCM0249  AC130 PaTu 8988t C50(1.03); C434(1.09)  LDD1128  [6]
 LDCM0250  AC131 PaTu 8988t C50(1.02); C434(0.99)  LDD1129  [6]
 LDCM0251  AC132 PaTu 8988t C50(1.04); C434(1.02)  LDD1130  [6]
 LDCM0252  AC133 PaTu 8988t C50(1.07); C434(1.39)  LDD1131  [6]
 LDCM0253  AC134 PaTu 8988t C50(1.08); C434(1.14)  LDD1132  [6]
 LDCM0254  AC135 PaTu 8988t C50(1.04); C434(1.22)  LDD1133  [6]
 LDCM0255  AC136 PaTu 8988t C50(1.14); C434(1.05)  LDD1134  [6]
 LDCM0256  AC137 PaTu 8988t C50(1.00); C434(1.44)  LDD1135  [6]
 LDCM0257  AC138 PaTu 8988t C50(1.13); C434(1.39)  LDD1136  [6]
 LDCM0258  AC139 PaTu 8988t C50(1.03); C434(1.09)  LDD1137  [6]
 LDCM0260  AC140 PaTu 8988t C50(1.28); C434(1.65)  LDD1139  [6]
 LDCM0261  AC141 PaTu 8988t C50(1.16); C434(1.08)  LDD1140  [6]
 LDCM0262  AC142 PaTu 8988t C50(1.08); C434(1.12)  LDD1141  [6]
 LDCM0263  AC143 PaTu 8988t C488(1.08); C494(1.08); C50(1.17); C434(1.02)  LDD1142  [6]
 LDCM0264  AC144 PaTu 8988t C488(1.16); C494(1.16); C50(0.88); C434(1.27)  LDD1143  [6]
 LDCM0265  AC145 PaTu 8988t C488(1.15); C494(1.15); C50(1.23); C434(0.94)  LDD1144  [6]
 LDCM0266  AC146 PaTu 8988t C488(1.00); C494(1.00); C50(1.09); C434(1.65)  LDD1145  [6]
 LDCM0267  AC147 PaTu 8988t C488(1.02); C494(1.02); C50(1.21); C434(1.21)  LDD1146  [6]
 LDCM0268  AC148 PaTu 8988t C488(0.97); C494(0.97); C50(1.37); C434(1.66)  LDD1147  [6]
 LDCM0269  AC149 PaTu 8988t C488(1.02); C494(1.02); C50(1.38); C434(1.88)  LDD1148  [6]
 LDCM0271  AC150 PaTu 8988t C488(1.13); C494(1.13); C50(1.02); C434(1.54)  LDD1150  [6]
 LDCM0272  AC151 PaTu 8988t C488(1.06); C494(1.06); C50(1.30); C434(1.82)  LDD1151  [6]
 LDCM0273  AC152 PaTu 8988t C488(1.02); C494(1.02); C50(1.16); C434(1.33)  LDD1152  [6]
 LDCM0274  AC153 PaTu 8988t C488(1.45); C494(1.45); C50(1.34); C434(1.72)  LDD1153  [6]
 LDCM0621  AC154 PaTu 8988t C488(1.00); C494(1.00); C50(1.16); C434(1.86)  LDD2166  [6]
 LDCM0622  AC155 PaTu 8988t C488(0.93); C494(0.93); C50(1.07); C434(2.29)  LDD2167  [6]
 LDCM0623  AC156 PaTu 8988t C488(1.18); C494(1.18); C50(1.23); C434(1.97)  LDD2168  [6]
 LDCM0624  AC157 PaTu 8988t C488(1.05); C494(1.05); C50(0.90); C434(1.87)  LDD2169  [6]
 LDCM0276  AC17 PaTu 8988t C488(1.15); C494(1.15); C434(0.89)  LDD1155  [6]
 LDCM0277  AC18 PaTu 8988t C488(0.98); C494(0.98); C434(0.84)  LDD1156  [6]
 LDCM0278  AC19 PaTu 8988t C488(0.81); C494(0.81); C434(0.90)  LDD1157  [6]
 LDCM0279  AC2 PaTu 8988t C50(1.21)  LDD1158  [6]
 LDCM0280  AC20 PaTu 8988t C488(0.83); C494(0.83); C434(1.07)  LDD1159  [6]
 LDCM0281  AC21 PaTu 8988t C488(0.93); C494(0.93); C434(0.96)  LDD1160  [6]
 LDCM0282  AC22 PaTu 8988t C488(0.88); C494(0.88); C434(0.86)  LDD1161  [6]
 LDCM0283  AC23 PaTu 8988t C488(1.59); C494(1.59); C434(1.18)  LDD1162  [6]
 LDCM0284  AC24 PaTu 8988t C488(1.06); C494(1.06); C434(1.43)  LDD1163  [6]
 LDCM0290  AC3 PaTu 8988t C50(1.26)  LDD1169  [6]
 LDCM0301  AC4 PaTu 8988t C50(1.16)  LDD1180  [6]
 LDCM0308  AC46 PaTu 8988t C50(1.15); C434(1.18)  LDD1187  [6]
 LDCM0309  AC47 PaTu 8988t C50(1.09); C434(1.32)  LDD1188  [6]
 LDCM0310  AC48 PaTu 8988t C50(1.13); C434(1.27)  LDD1189  [6]
 LDCM0311  AC49 PaTu 8988t C50(1.61); C434(1.52)  LDD1190  [6]
 LDCM0312  AC5 PaTu 8988t C50(1.69)  LDD1191  [6]
 LDCM0313  AC50 PaTu 8988t C50(1.59); C434(1.64)  LDD1192  [6]
 LDCM0314  AC51 PaTu 8988t C50(0.59); C434(0.37)  LDD1193  [6]
 LDCM0315  AC52 PaTu 8988t C50(1.17); C434(1.27)  LDD1194  [6]
 LDCM0316  AC53 PaTu 8988t C50(1.70); C434(2.04)  LDD1195  [6]
 LDCM0317  AC54 PaTu 8988t C50(1.70); C434(1.83)  LDD1196  [6]
 LDCM0318  AC55 PaTu 8988t C50(1.25); C434(1.19)  LDD1197  [6]
 LDCM0319  AC56 PaTu 8988t C50(1.68); C434(1.39)  LDD1198  [6]
 LDCM0320  AC57 PaTu 8988t C488(0.79); C494(0.79)  LDD1199  [6]
 LDCM0321  AC58 PaTu 8988t C488(0.75); C494(0.75)  LDD1200  [6]
 LDCM0322  AC59 PaTu 8988t C488(1.04); C494(1.04)  LDD1201  [6]
 LDCM0324  AC60 PaTu 8988t C488(1.03); C494(1.03)  LDD1203  [6]
 LDCM0325  AC61 PaTu 8988t C488(1.04); C494(1.04)  LDD1204  [6]
 LDCM0326  AC62 PaTu 8988t C488(0.92); C494(0.92)  LDD1205  [6]
 LDCM0327  AC63 PaTu 8988t C488(1.06); C494(1.06)  LDD1206  [6]
 LDCM0328  AC64 PaTu 8988t C488(1.11); C494(1.11)  LDD1207  [6]
 LDCM0329  AC65 PaTu 8988t C488(1.31); C494(1.31)  LDD1208  [6]
 LDCM0330  AC66 PaTu 8988t C488(0.96); C494(0.96)  LDD1209  [6]
 LDCM0331  AC67 PaTu 8988t C488(1.17); C494(1.17)  LDD1210  [6]
 LDCM0349  AC83 PaTu 8988t C50(0.99); C434(0.83)  LDD1228  [6]
 LDCM0350  AC84 PaTu 8988t C50(1.14); C434(0.96)  LDD1229  [6]
 LDCM0351  AC85 PaTu 8988t C50(1.12); C434(0.88)  LDD1230  [6]
 LDCM0352  AC86 PaTu 8988t C50(1.22); C434(0.72)  LDD1231  [6]
 LDCM0353  AC87 PaTu 8988t C50(1.20); C434(0.85)  LDD1232  [6]
 LDCM0354  AC88 PaTu 8988t C50(1.03); C434(0.88)  LDD1233  [6]
 LDCM0355  AC89 PaTu 8988t C50(1.32); C434(0.82)  LDD1234  [6]
 LDCM0357  AC90 PaTu 8988t C50(0.85); C434(1.14)  LDD1236  [6]
 LDCM0358  AC91 PaTu 8988t C50(0.94); C434(0.91)  LDD1237  [6]
 LDCM0359  AC92 PaTu 8988t C50(1.29); C434(1.05)  LDD1238  [6]
 LDCM0360  AC93 PaTu 8988t C50(0.91); C434(0.96)  LDD1239  [6]
 LDCM0361  AC94 PaTu 8988t C50(0.98); C434(0.79)  LDD1240  [6]
 LDCM0362  AC95 PaTu 8988t C50(1.15); C434(0.90)  LDD1241  [6]
 LDCM0363  AC96 PaTu 8988t C50(1.11); C434(0.96)  LDD1242  [6]
 LDCM0364  AC97 PaTu 8988t C50(0.93); C434(1.12)  LDD1243  [6]
 LDCM0365  AC98 PaTu 8988t C434(0.84)  LDD1244  [6]
 LDCM0366  AC99 PaTu 8988t C434(0.89)  LDD1245  [6]
 LDCM0367  CL1 PaTu 8988t C488(1.14); C494(1.14); C50(1.01); C434(1.00)  LDD1246  [6]
 LDCM0368  CL10 PaTu 8988t C488(1.03); C494(1.03); C50(1.44); C434(1.46)  LDD1247  [6]
 LDCM0369  CL100 PaTu 8988t C50(1.10)  LDD1248  [6]
 LDCM0374  CL105 PaTu 8988t C488(0.77); C494(0.77); C434(0.99)  LDD1253  [6]
 LDCM0375  CL106 PaTu 8988t C488(1.00); C494(1.00); C434(1.07)  LDD1254  [6]
 LDCM0376  CL107 PaTu 8988t C488(1.24); C494(1.24); C434(0.91)  LDD1255  [6]
 LDCM0377  CL108 PaTu 8988t C488(1.23); C494(1.23); C434(1.03)  LDD1256  [6]
 LDCM0378  CL109 PaTu 8988t C488(1.12); C494(1.12); C434(1.36)  LDD1257  [6]
 LDCM0379  CL11 PaTu 8988t C488(0.92); C494(0.92); C50(1.15); C434(0.95)  LDD1258  [6]
 LDCM0380  CL110 PaTu 8988t C488(1.09); C494(1.09); C434(1.42)  LDD1259  [6]
 LDCM0381  CL111 PaTu 8988t C488(0.94); C494(0.94); C434(1.50)  LDD1260  [6]
 LDCM0390  CL12 PaTu 8988t C488(0.87); C494(0.87); C50(1.25); C434(0.91)  LDD1269  [6]
 LDCM0392  CL121 PaTu 8988t C50(1.18); C434(1.15)  LDD1271  [6]
 LDCM0393  CL122 PaTu 8988t C50(1.50); C434(1.51)  LDD1272  [6]
 LDCM0394  CL123 PaTu 8988t C50(1.69); C434(1.95)  LDD1273  [6]
 LDCM0395  CL124 PaTu 8988t C50(1.43); C434(1.60)  LDD1274  [6]
 LDCM0396  CL125 PaTu 8988t C488(1.28); C494(1.28)  LDD1275  [6]
 LDCM0397  CL126 PaTu 8988t C488(1.54); C494(1.54)  LDD1276  [6]
 LDCM0398  CL127 PaTu 8988t C488(1.01); C494(1.01)  LDD1277  [6]
 LDCM0399  CL128 PaTu 8988t C488(1.06); C494(1.06)  LDD1278  [6]
 LDCM0400  CL13 PaTu 8988t C488(1.04); C494(1.04); C50(1.49); C434(1.01)  LDD1279  [6]
 LDCM0401  CL14 PaTu 8988t C488(1.16); C494(1.16); C50(1.53); C434(1.29)  LDD1280  [6]
 LDCM0402  CL15 PaTu 8988t C488(1.12); C494(1.12); C50(1.23); C434(0.99)  LDD1281  [6]
 LDCM0403  CL16 PaTu 8988t C434(1.13)  LDD1282  [6]
 LDCM0404  CL17 PaTu 8988t C434(1.26)  LDD1283  [6]
 LDCM0405  CL18 PaTu 8988t C434(1.28)  LDD1284  [6]
 LDCM0406  CL19 PaTu 8988t C434(1.13)  LDD1285  [6]
 LDCM0407  CL2 PaTu 8988t C488(0.95); C494(0.95); C50(1.14); C434(0.86)  LDD1286  [6]
 LDCM0408  CL20 PaTu 8988t C434(1.12)  LDD1287  [6]
 LDCM0409  CL21 PaTu 8988t C434(1.54)  LDD1288  [6]
 LDCM0410  CL22 PaTu 8988t C434(1.35)  LDD1289  [6]
 LDCM0411  CL23 PaTu 8988t C434(1.30)  LDD1290  [6]
 LDCM0412  CL24 PaTu 8988t C434(1.27)  LDD1291  [6]
 LDCM0413  CL25 PaTu 8988t C434(1.43)  LDD1292  [6]
 LDCM0414  CL26 PaTu 8988t C434(1.36)  LDD1293  [6]
 LDCM0415  CL27 PaTu 8988t C434(1.39)  LDD1294  [6]
 LDCM0416  CL28 PaTu 8988t C434(1.48)  LDD1295  [6]
 LDCM0417  CL29 PaTu 8988t C434(1.08)  LDD1296  [6]
 LDCM0418  CL3 PaTu 8988t C488(0.89); C494(0.89); C50(1.14); C434(0.85)  LDD1297  [6]
 LDCM0419  CL30 PaTu 8988t C434(1.39)  LDD1298  [6]
 LDCM0429  CL4 PaTu 8988t C488(0.99); C494(0.99); C50(1.09); C434(1.12)  LDD1308  [6]
 LDCM0440  CL5 PaTu 8988t C488(1.03); C494(1.03); C50(1.30); C434(1.15)  LDD1319  [6]
 LDCM0451  CL6 PaTu 8988t C488(1.00); C494(1.00); C50(1.18); C434(1.03)  LDD1330  [6]
 LDCM0453  CL61 PaTu 8988t C50(1.08); C434(1.13)  LDD1332  [6]
 LDCM0454  CL62 PaTu 8988t C50(1.43); C434(1.54)  LDD1333  [6]
 LDCM0455  CL63 PaTu 8988t C50(1.35); C434(1.41)  LDD1334  [6]
 LDCM0456  CL64 PaTu 8988t C50(1.51); C434(1.60)  LDD1335  [6]
 LDCM0457  CL65 PaTu 8988t C50(1.18); C434(1.61)  LDD1336  [6]
 LDCM0458  CL66 PaTu 8988t C50(1.66); C434(1.29)  LDD1337  [6]
 LDCM0459  CL67 PaTu 8988t C50(1.46); C434(1.48)  LDD1338  [6]
 LDCM0460  CL68 PaTu 8988t C50(1.36); C434(1.44)  LDD1339  [6]
 LDCM0461  CL69 PaTu 8988t C50(1.72); C434(1.67)  LDD1340  [6]
 LDCM0462  CL7 PaTu 8988t C488(1.09); C494(1.09); C50(1.34); C434(1.08)  LDD1341  [6]
 LDCM0463  CL70 PaTu 8988t C50(1.29); C434(1.53)  LDD1342  [6]
 LDCM0464  CL71 PaTu 8988t C50(1.17); C434(1.17)  LDD1343  [6]
 LDCM0465  CL72 PaTu 8988t C50(1.30); C434(1.46)  LDD1344  [6]
 LDCM0466  CL73 PaTu 8988t C50(1.68); C434(2.26)  LDD1345  [6]
 LDCM0467  CL74 PaTu 8988t C50(1.29); C434(1.25)  LDD1346  [6]
 LDCM0473  CL8 PaTu 8988t C488(1.01); C494(1.01); C50(1.33); C434(1.12)  LDD1352  [6]
 LDCM0484  CL9 PaTu 8988t C488(1.05); C494(1.05); C50(1.32); C434(0.76)  LDD1363  [6]
 LDCM0486  CL91 PaTu 8988t C50(1.21)  LDD1365  [6]
 LDCM0487  CL92 PaTu 8988t C50(1.18)  LDD1366  [6]
 LDCM0488  CL93 PaTu 8988t C50(1.17)  LDD1367  [6]
 LDCM0489  CL94 PaTu 8988t C50(1.31)  LDD1368  [6]
 LDCM0490  CL95 PaTu 8988t C50(1.51)  LDD1369  [6]
 LDCM0491  CL96 PaTu 8988t C50(1.20)  LDD1370  [6]
 LDCM0492  CL97 PaTu 8988t C50(1.31)  LDD1371  [6]
 LDCM0493  CL98 PaTu 8988t C50(1.61)  LDD1372  [6]
 LDCM0494  CL99 PaTu 8988t C50(1.31)  LDD1373  [6]
 LDCM0201  EV-3 T cell C981(5.19)  LDD0515  [7]
 LDCM0573  Fragment11 Ramos C50(0.16)  LDD2190  [8]
 LDCM0575  Fragment13 Ramos C50(0.94)  LDD2192  [8]
 LDCM0576  Fragment14 Ramos C50(0.70)  LDD2193  [8]
 LDCM0578  Fragment27 Ramos C50(1.53)  LDD2197  [8]
 LDCM0588  Fragment30 Ramos C50(0.88)  LDD2199  [8]
 LDCM0589  Fragment31 Ramos C50(0.87)  LDD2200  [8]
 LDCM0468  Fragment33 PaTu 8988t C50(1.45); C434(1.69)  LDD1347  [6]
 LDCM0596  Fragment38 Ramos C50(0.65)  LDD2203  [8]
 LDCM0566  Fragment4 Ramos C50(1.23)  LDD2184  [8]
 LDCM0610  Fragment52 Ramos C50(0.57)  LDD2204  [8]
 LDCM0614  Fragment56 Ramos C50(0.77)  LDD2205  [8]
 LDCM0569  Fragment7 Jurkat _(8.17)  LDD1485  [2]
 LDCM0022  KB02 Ramos C50(0.62)  LDD2182  [8]
 LDCM0023  KB03 Jurkat C50(117.72); C768(7.01)  LDD0209  [3]
 LDCM0024  KB05 HMCB C434(4.14)  LDD3312  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribose glycohydrolase OARD1 (OARD1) . Q9Y530

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840