Details of the Target

General Information of Target

Target ID LDTP14076
Target Name Nuclear protein AMMECR1 (AMMECR1)
Gene Name AMMECR1
Gene ID 9949
Synonyms
Nuclear protein AMMECR1; AMME syndrome candidate gene 1 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAHRCLRLWGRGGCWPRGLQQLLVPGGVGPGEQPCLRTLYRFVTTQARASRNSLLTDIIA
AYQRFCSRPPKGFEKYFPNGKNGKKASEPKEVMGEKKESKPAATTRSSGGGGGGGGKRGG
KKDDSHWWSRFQKGDIPWDDKDFRMFFLWTALFWGGVMFYLLLKRSGREITWKDFVNNYL
SKGVVDRLEVVNKRFVRVTFTPGKTPVDGQYVWFNIGSVDTFERNLETLQQELGIEGENR
VPVVYIAESDGSFLLSMLPTVLIIAFLLYTIRRGPAGIGRTGRGMGGLFSVGETTAKVLK
DEIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKA
TAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRGN
FGGQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDI
KGRASIFKVHLRPLKLDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSDSI
NQKHFEQAIERVIGGLEKKTQVLQPEEKKTVAYHEAGHAVAGWYLEHADPLLKVSIIPRG
KGLGYAQYLPKEQYLYTKEQLLDRMCMTLGGRVSEEIFFGRITTGAQDDLRKVTQSAYAQ
IVQFGMNEKVGQISFDLPRQGDMVLEKPYSEATARLIDDEVRILINDAYKRTVALLTEKK
ADVEKVALLLLEKEVLDKNDMVELLGPRPFAEKSTYEEFVEGTGSLDEDTSLPEGLKDWN
KEREKEKEEPPGEKVAN
Target Bioclass
Other
Subcellular location
Nucleus
Uniprot ID
Q9Y4X0
Ensemble ID
ENST00000262844.10
HGNC ID
HGNC:467

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IM95 SNV: p.V8E .
Ishikawa (Heraklio) 02 ER Deletion: p.Q74RfsTer89 .
OSRC2 SNV: p.S111L .
OVK18 SNV: p.W164R .
RT112 SNV: p.E308K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.87  LDD0402  [1]
STPyne
 Probe Info  		K165(1.04)  LDD2218  [2]
Johansson_61
 Probe Info  		_(20.00)  LDD1485  [3]
AHL-Pu-1
 Probe Info  		C175(2.38)  LDD0170  [4]
IA-alkyne
 Probe Info  		C175(0.09)  LDD2206  [5]
DBIA
 Probe Info  		C175(9.25)  LDD0080  [6]
NAIA_5
 Probe Info  		C175(0.00); C153(0.00)  LDD2224  [7]
TFBX
 Probe Info  		C39(0.00); C33(0.00)  LDD0027  [8]
IPM
 Probe Info  		C39(0.00); C175(0.00); C33(0.00)  LDD2156  [9]
AOyne
 Probe Info  		12.80  LDD0443  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C175(2.38)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C175(2.23)  LDD0171  [4]
 LDCM0156  Aniline NCI-H1299 12.12  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C175(0.87)  LDD2227  [7]
 LDCM0569  Fragment7 Jurkat _(20.00)  LDD1485  [3]
 LDCM0022  KB02 HCT 116 C175(9.25)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C175(12.32)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C175(3.53)  LDD0082  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C175(0.09)  LDD2206  [5]
 LDCM0628  OTUB2-COV-1 HEK-293T C175(0.78)  LDD2207  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tensin-2 (TNS2) PTEN phosphatase protein family Q63HR2
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Lysine-specific demethylase hairless (HR) . O43593
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Zinc finger protein 124 (ZNF124) Krueppel C2H2-type zinc-finger protein family Q15973
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Low-density lipoprotein receptor-related protein 6 (LRP6) LDLR family O75581
Tektin-4 (TEKT4) Tektin family Q8WW24
RNA-binding protein with multiple splicing (RBPMS) . Q93062

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
3 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.